DE69932607D1 - Verfahren und vorrichtung zur erstellung eines arrays für schnelle molekulare profilidentifizierungen - Google Patents

Verfahren und vorrichtung zur erstellung eines arrays für schnelle molekulare profilidentifizierungen

Info

Publication number
DE69932607D1
DE69932607D1 DE69932607T DE69932607T DE69932607D1 DE 69932607 D1 DE69932607 D1 DE 69932607D1 DE 69932607 T DE69932607 T DE 69932607T DE 69932607 T DE69932607 T DE 69932607T DE 69932607 D1 DE69932607 D1 DE 69932607D1
Authority
DE
Germany
Prior art keywords
array
tumors
hundreds
tissue
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69932607T
Other languages
English (en)
Other versions
DE69932607T2 (de
Inventor
B Leighton
Juha Kononen
Olli Kallioniemi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69932607D1 publication Critical patent/DE69932607D1/de
Publication of DE69932607T2 publication Critical patent/DE69932607T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Clinical Laboratory Science (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Polymerisation Methods In General (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
DE69932607T 1998-02-25 1999-02-24 Verfahren und vorrichtung zur erstellung eines arrays für schnelle molekulare profilidentifizierungen Expired - Lifetime DE69932607T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7597998P 1998-02-25 1998-02-25
US75979P 1998-02-25
PCT/US1999/004001 WO1999044063A2 (en) 1998-02-25 1999-02-24 Tumor tissue microarrays for rapid molecular profiling

Publications (2)

Publication Number Publication Date
DE69932607D1 true DE69932607D1 (de) 2006-09-14
DE69932607T2 DE69932607T2 (de) 2007-10-25

Family

ID=22129137

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69939503T Expired - Lifetime DE69939503D1 (de) 1998-02-25 1999-02-24 Verfahren und Vorrichtung zur Vorbereitung von Gewebeproben für parallele Analysen
DE69932607T Expired - Lifetime DE69932607T2 (de) 1998-02-25 1999-02-24 Verfahren und vorrichtung zur erstellung eines arrays für schnelle molekulare profilidentifizierungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69939503T Expired - Lifetime DE69939503D1 (de) 1998-02-25 1999-02-24 Verfahren und Vorrichtung zur Vorbereitung von Gewebeproben für parallele Analysen

Country Status (11)

Country Link
EP (3) EP1715340B1 (de)
JP (2) JP4374139B2 (de)
AT (2) ATE407360T1 (de)
AU (1) AU754047B2 (de)
CA (2) CA2318984C (de)
CY (2) CY1105756T1 (de)
DE (2) DE69939503D1 (de)
DK (2) DK1715340T3 (de)
ES (2) ES2317380T3 (de)
PT (2) PT1715340E (de)
WO (1) WO1999044063A2 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969614B1 (en) * 1999-02-16 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Services Methods for the isolation and analysis of cellular protein content
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
WO2001020044A2 (en) * 1999-09-17 2001-03-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Signal counting for in situ hybridization
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
US7003403B1 (en) 2000-06-15 2006-02-21 The United States Of America As Represented By The Department Of Health And Human Services Quantifying gene relatedness via nonlinear prediction of gene
WO2001098525A2 (en) 2000-06-22 2001-12-27 Clinomics Laboratories, Inc. Frozen tissue microarrays and methods for using the same
WO2002008765A2 (en) * 2000-07-26 2002-01-31 Stanford University Basal cell markers in breast cancer and uses thereof
WO2002008281A2 (en) * 2000-07-26 2002-01-31 Stanford University Bstp-cad protein and related reagents and methods of use thereof
WO2002008260A2 (en) * 2000-07-26 2002-01-31 Stanford University Bstp-ecg1 protein and related reagents and methods of use thereof
ATE402760T1 (de) * 2000-08-15 2008-08-15 Bioforce Nanosciences Inc Vorrichtung zur bildung von nanomolekularen netzwerken
WO2002077231A2 (en) * 2000-11-13 2002-10-03 Incyte Genomics, Inc. Nucleic acid-associated proteins
US7079673B2 (en) * 2002-02-05 2006-07-18 University Of Medicine & Denistry Of Nj Systems for analyzing microtissue arrays
US7171030B2 (en) 2000-11-30 2007-01-30 University Of Medicine & Denistry Of New Jersey Systems for analyzing microtissue arrays
US6466690C1 (en) 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
US6716619B1 (en) 2001-02-08 2004-04-06 Clinomics Biosciences, Inc. Stylet for use with tissue microarrayer and molds
US6534307B1 (en) 2001-02-08 2003-03-18 Clinomics Biosciences, Inc. Frozen tissue microarrayer
CA2438433A1 (en) * 2001-02-14 2002-08-22 Tularik Inc. Methods for the diagnosis and treatment of tumors employing the hepsin gene
WO2002064838A2 (en) * 2001-02-14 2002-08-22 Tularik Inc. Amplified cancer gene wip1
ATE380860T1 (de) * 2001-03-19 2007-12-15 Beecher Instr Gewebe-array-instrument
US6387633B1 (en) * 2001-05-11 2002-05-14 Supratek Pharma, Inc. Method for identifying unstable genes
WO2003029480A2 (en) 2001-08-31 2003-04-10 The Government Of The United States Of America, Asrepresented By The Secretary Of The Department Of Health And Human Services Measurements of multiple molecules using a cryoarray
EP1451340B1 (de) 2001-11-09 2014-01-08 Life Technologies Corporation Identifizierung, überwachung und behandlung einer krankheit sowie charakterisierung eines biologischen zustands unter verwendung von genexpressionsprofilen
ES2263974T3 (es) 2002-05-24 2006-12-16 Monsanto Technology Llc Sistema y procedimiento para desnuclear semillas y disponer los nucleos de las semillas para su analisis.
HU2464U (en) * 2002-06-25 2003-03-28 Szekeres Gyoergy Dr Hand instrument set for constructing tissue array
US20050112622A1 (en) * 2003-08-11 2005-05-26 Ring Brian Z. Reagents and methods for use in cancer diagnosis, classification and therapy
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US7690325B2 (en) 2004-04-30 2010-04-06 Bioforce Nanosciences, Inc. Method and apparatus for depositing material onto a surface
US7854899B2 (en) 2004-08-26 2010-12-21 The United States Of America As Represented By The Secretary Of Health And Human Services Template methods and devices for preparing sample arrays
US8484000B2 (en) 2004-09-02 2013-07-09 Vialogy Llc Detecting events of interest using quantum resonance interferometry
US7405056B2 (en) 2005-03-02 2008-07-29 Edward Lam Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
WO2007086915A2 (en) 2005-05-12 2007-08-02 Applied Genomics, Inc. Reagents and methods for use in cancer diagnosis, classification and therapy
US8114615B2 (en) 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis
DE102008000036B4 (de) * 2008-01-10 2010-09-30 Leica Biosystems Nussloch Gmbh Verfahren zum Anfertigen histologischer Schnitte und Mikrotom mit einer Aufbring- und Schneideinrichtung
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
JP5629939B2 (ja) * 2010-09-09 2014-11-26 株式会社パソロジー研究所 パイルアップ組織アレイ
EP2629078B1 (de) 2010-11-19 2019-04-17 Olympus Corporation Verfahren zur herstellung biologischer proben
US10018631B2 (en) 2011-03-17 2018-07-10 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
DE102011075039A1 (de) 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Stanzvorrichtung mit beleuchteter Aufnahmeplatte
DE102011075037A1 (de) 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Stanzvorrichtung mit Aufnahmeplatte
US20140193052A1 (en) * 2011-08-23 2014-07-10 Yoshiko Yoshihara Information processing system, information processing method, information processing apparatus, control method thereof and control program
JP2013185920A (ja) * 2012-03-07 2013-09-19 Pathology Institute 組織アレイシートの製造方法およびその製造装置
FR2998823B1 (fr) * 2012-11-30 2015-06-05 Oberthur Technologies Dispositif de decoupe pour test de delaminage
EP3013983B1 (de) 2013-06-25 2023-02-15 Prognosys Biosciences, Inc. Räumlich codierte biologische assays mit einer mikrofluidischen vorrichtung
JP6367741B2 (ja) * 2015-03-12 2018-08-01 学校法人北里研究所 生体組織標本アレイ切片、生体組織標本アレイ、シート状生体組織標本アレイ、生体組織標本ブロック及びそれらの製造方法
SG11201707515SA (en) 2015-04-10 2017-10-30 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
EP4165207A1 (de) 2020-06-10 2023-04-19 10X Genomics, Inc. Verfahren zur bestimmung einer position eines analyten in einer biologischen probe
AU2021294334A1 (en) 2020-06-25 2023-02-02 10X Genomics, Inc. Spatial analysis of DNA methylation
CN116593262B (zh) * 2023-07-13 2023-09-26 南京普恩瑞生物科技有限公司 基于pdx/pdtx肿瘤活组织生物样本和数据库的分子标志物检测产品及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2563343B1 (fr) * 1984-04-19 1986-06-13 Rhone Poulenc Sante Dispositif pour effectuer des prelevements dans des milieux semi-solides
IT8521051V0 (it) * 1985-03-08 1985-03-08 Lepetit Spa Formatore di pozzetti.
US4820504A (en) 1986-02-12 1989-04-11 City Of Hope Multi-specimen tissue blocks and slides
GB8626920D0 (en) * 1986-11-11 1986-12-10 Gadson D R Examination of multiple samples for analysis
US4914022A (en) * 1987-10-21 1990-04-03 Amc Cancer Research Center Method for preparing multiple tissue samples for microscopic investigation and testing
EP0332322A2 (de) * 1988-02-26 1989-09-13 Elsevier Science Publishing Co., Inc. Datenerfassungs, speicherungs-und verarbeitungsssystem
US5002377A (en) 1988-07-07 1991-03-26 City Of Hope Multi-specimen slides for immunohistologic procedures
JPH0835921A (ja) * 1994-07-22 1996-02-06 Kanagawa Kagaku Gijutsu Akad 試料ブロック及びその自動検査装置
IL134702A (en) * 1997-09-11 2004-03-28 Bioventures Inc High density arrays and methods of making the same

Also Published As

Publication number Publication date
DE69932607T2 (de) 2007-10-25
CA2627799A1 (en) 1999-09-02
WO1999044063A2 (en) 1999-09-02
EP1980852A1 (de) 2008-10-15
AU754047B2 (en) 2002-10-31
WO1999044063A3 (en) 1999-11-04
JP4374139B2 (ja) 2009-12-02
CY1105756T1 (el) 2010-12-22
PT1715340E (pt) 2008-12-16
ES2272057T3 (es) 2007-04-16
EP1715340A3 (de) 2006-11-29
DK1715340T3 (da) 2009-01-26
JP2002505432A (ja) 2002-02-19
CY1108634T1 (el) 2014-04-09
EP1715340B1 (de) 2008-09-03
EP1715340A2 (de) 2006-10-25
ES2317380T3 (es) 2009-04-16
EP1068528A2 (de) 2001-01-17
WO1999044063B1 (en) 1999-12-02
EP1068528B1 (de) 2006-08-02
JP2009244269A (ja) 2009-10-22
CA2318984C (en) 2009-04-28
PT1068528E (pt) 2006-12-29
AU2875799A (en) 1999-09-15
ATE407360T1 (de) 2008-09-15
DE69939503D1 (de) 2008-10-16
ATE335199T1 (de) 2006-08-15
CA2318984A1 (en) 1999-09-02
DK1068528T3 (da) 2006-11-27

Similar Documents

Publication Publication Date Title
DE69932607D1 (de) Verfahren und vorrichtung zur erstellung eines arrays für schnelle molekulare profilidentifizierungen
Kononen et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens
DE60031589T2 (de) Gleichzeitige Messung der Genexpression und genomischer Abweichungen mittels Nukleinsäuremikromatrizen
EP1204765B1 (de) Verfahren zur relativen quantifizierung der methylierung von cytosin basen in dna-proben
US20060166253A1 (en) Tumor tissue microarrays for rapid molecular profiling
DE69032920T2 (de) Verfahren und Zusammensetzungen für chromosomenspezifische Färbung
WO2002088382A2 (de) Verfahren zur analyse von nukleinsäureketten
WO2003020968A2 (de) Verfahren zur analyse von nukleinsäurekettensequenzen und der genexpression
CN102292451A (zh) 用于单分子全基因组分析的方法和装置
DE50004066D1 (de) Verfahren zur identifikation von cytosin-methylierungsmustern in genomischen dna-proben
EP0834575A3 (de) Verfahren die Zielnukleinsäuren-Patronen auf Oligonukleotid-Matrizzen benutzen
Ahmed Molecular techniques for studying gene expression in carcinogenesis
WO2002088381A2 (de) Verfahren zur bestimmung der genexpression
DE60038109T2 (de) Verfahren zur Analyse von AFLP Reaktionsmischungen unter Verwendung von Primer Verlängerungstechniken
Langdon Characterization and authentication of cancer cell lines: an overview
Lee et al. Techniques for Identifying Cancer Genes
Bayani et al. 2 Methods of genetic analysis applied to pediatric cancer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: EISENFUEHR, SPEISER & PARTNER, 28217 BREMEN