SG10201510152RA - Diagnostic methods and compositions for treatment of cancer - Google Patents

Diagnostic methods and compositions for treatment of cancer

Info

Publication number
SG10201510152RA
SG10201510152RA SG10201510152RA SG10201510152RA SG10201510152RA SG 10201510152R A SG10201510152R A SG 10201510152RA SG 10201510152R A SG10201510152R A SG 10201510152RA SG 10201510152R A SG10201510152R A SG 10201510152RA SG 10201510152R A SG10201510152R A SG 10201510152RA
Authority
SG
Singapore
Prior art keywords
cancer
compositions
treatment
diagnostic methods
diagnostic
Prior art date
Application number
SG10201510152RA
Inventor
Maike Schmidt
Laura Sanders
Rajiv Raja
Rajesh D Patel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of SG10201510152RA publication Critical patent/SG10201510152RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6851Quantitative amplification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
SG10201510152RA 2009-07-13 2010-07-12 Diagnostic methods and compositions for treatment of cancer SG10201510152RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22512009P 2009-07-13 2009-07-13
US35173310P 2010-06-04 2010-06-04

Publications (1)

Publication Number Publication Date
SG10201510152RA true SG10201510152RA (en) 2016-01-28

Family

ID=43227992

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012002432A SG177640A1 (en) 2009-07-13 2010-07-12 Diagnostic methods and compositions for treatment of cancer
SG10201510152RA SG10201510152RA (en) 2009-07-13 2010-07-12 Diagnostic methods and compositions for treatment of cancer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012002432A SG177640A1 (en) 2009-07-13 2010-07-12 Diagnostic methods and compositions for treatment of cancer

Country Status (13)

Country Link
US (2) US20110076271A1 (en)
EP (1) EP2454380A2 (en)
JP (2) JP6095367B2 (en)
KR (1) KR20120106935A (en)
CN (2) CN102482715A (en)
AU (1) AU2010273585B2 (en)
BR (1) BR112012000735A2 (en)
CA (1) CA2766403A1 (en)
HK (1) HK1226108A1 (en)
IL (1) IL216926A0 (en)
MX (1) MX2012000620A (en)
SG (2) SG177640A1 (en)
WO (1) WO2011008696A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011153224A2 (en) * 2010-06-02 2011-12-08 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
WO2012151574A1 (en) 2011-05-05 2012-11-08 Duke University Methods of developing a prognosis for pancreatic cancer and predicting responsiveness to cancer therapeutics
EP2798081A1 (en) * 2011-12-29 2014-11-05 Baylor Research Institute Biomarkers for kawasaki disease
AU2013207778B2 (en) 2012-01-13 2017-10-12 Genentech, Inc. Biological markers for identifying patients for treatment with VEGF antagonists
CA2867588A1 (en) * 2012-03-30 2013-10-03 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
MX2014014821A (en) * 2012-06-26 2015-02-12 Hoffmann La Roche Blood plasma biomarkers for bevacizumab combination therapies for treatment of breast cancer.
WO2014058915A2 (en) 2012-10-08 2014-04-17 St. Jude Children's Research Hospital Therapies based on control of regulatory t cell stability and function via a neuropilin-1:semaphorin axis
MX2016000172A (en) * 2013-07-23 2016-03-09 Genentech Inc Model of colorectal cancer.
CN103911451A (en) * 2014-04-11 2014-07-09 蒋晓东 Method for screening lung cancer target people for anti-angiogenesis targeted drug therapy
CN107076750B (en) * 2014-07-18 2020-06-23 赛诺菲 Method for predicting the outcome of a treatment with aflibercept in a patient suspected of having cancer
US10364289B2 (en) * 2014-12-03 2019-07-30 Samsung Life Public Welfare Foundation Antibody binding to neuropilin 1 and use thereof
WO2017066659A1 (en) * 2015-10-16 2017-04-20 The Trustees Of Columbia University In The City Of New York Jag1 expression predicts therapeutic response in nash
CN110087676A (en) * 2016-03-29 2019-08-02 巴黎大学迪德罗特第七分校 The composition of the extracellular vesica of secretory of the cell comprising expression NFATC4 for treating cancer
AU2017248766A1 (en) * 2016-04-15 2018-11-01 Genentech, Inc. Methods for monitoring and treating cancer
US11499973B2 (en) 2016-05-17 2022-11-15 Duke University Methods of predicting responsiveness of a cancer to a VEGF targeting agent and methods of prognosing and treating cancer
EP3467508A4 (en) * 2016-06-03 2020-04-29 Samsung Life Public Welfare Foundation Anti-nrp1 antibody screening method
CN106282376A (en) * 2016-09-27 2017-01-04 上海交通大学医学院附属第九人民医院 A kind of antisense RNA probes for detecting BMP9 gene expression
WO2018127599A1 (en) * 2017-01-09 2018-07-12 Secarna Pharmaceuticals Gmbh & Co Kg Oligonucleotides inhibiting the expression of nrp1
CA3052670A1 (en) 2017-03-01 2018-09-07 Genentech, Inc. Diagnostic and therapeutic methods for cancer
CN109828114A (en) * 2017-11-23 2019-05-31 复旦大学附属肿瘤医院 MFAP5 albumen is as the method and application in the kit of screening interferon alfa liver cancer sensitive group
CN109828111A (en) * 2017-11-23 2019-05-31 复旦大学附属肿瘤医院 Purposes of the MFAP5 in the preparation that preparation screening alpha interferon intervenes liver cancer sensitive group marker
BR112021002728A2 (en) * 2018-08-17 2021-08-10 F. Hoffmann-La Roche Ag methods of evaluating atrial fibrillation, aiding in the evaluation of atrial fibrillation, diagnosing heart failure and predicting the risk of hospitalization, computer-implemented method for evaluating atrial fibrillation, kit and in vitro uses
CN110893238A (en) * 2018-09-13 2020-03-20 常州大学 Application of substance for inhibiting activity and expression quantity of vascular endothelial growth factor in preparation of product for inhibiting lymph node metastasis
BR112021004329A2 (en) 2018-10-23 2021-08-03 Regeneron Pharmaceuticals, Inc. anti-npr1 antibodies and their uses
CN112213495B (en) * 2020-09-18 2022-10-28 广州中医药大学第三附属医院(广州中医药大学第三临床医学院、广州中医药大学附属骨伤科医院、广州中医药大学骨伤科研究所) Marker for auxiliary diagnosis or diagnosis of femoral head necrosis

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4018653A (en) 1971-10-29 1977-04-19 U.S. Packaging Corporation Instrument for the detection of Neisseria gonorrhoeae without culture
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4424279A (en) 1982-08-12 1984-01-03 Quidel Rapid plunger immunoassay method and apparatus
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
JP3040121B2 (en) 1988-01-12 2000-05-08 ジェネンテク,インコーポレイテッド Methods of treating tumor cells by inhibiting growth factor receptor function
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
JP3068180B2 (en) 1990-01-12 2000-07-24 アブジェニックス インコーポレイテッド Generation of heterologous antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ATE158021T1 (en) 1990-08-29 1997-09-15 Genpharm Int PRODUCTION AND USE OF NON-HUMAN TRANSGENT ANIMALS FOR THE PRODUCTION OF HETEROLOGUE ANTIBODIES
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US20030206899A1 (en) 1991-03-29 2003-11-06 Genentech, Inc. Vascular endothelial cell growth factor antagonists
US6582959B2 (en) 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
LU91067I2 (en) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab and its variants and immunochemical derivatives including immotoxins
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
BR9207175A (en) 1992-10-28 1995-12-12 Genentech Inc Composition containing vascular endothelial cell growth factor antagonist polypeptide monoclonal antibody amino acid sequence and method of treatment of tumor in mammal
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
US5635388A (en) 1994-04-04 1997-06-03 Genentech, Inc. Agonist antibodies against the flk2/flt3 receptor and uses thereof
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
CA2761116A1 (en) 1995-04-27 1996-10-31 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AU710696C (en) 1995-09-08 2002-10-24 Genentech Inc. VEGF-related protein
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
KR100489174B1 (en) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-anilinoquinazoline derivatives
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
BR9710362A (en) 1996-07-13 1999-08-17 Glaxo Group Ltd Pharmaceutical formulation compound uses a compound processes of treatment of a human or animal suffering from a mediated by abnormal activity of protein tyrosine kinase and for the preparation of a compound
KR20080059467A (en) 1996-12-03 2008-06-27 아브게닉스, 인크. Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
AU740738B2 (en) 1997-04-07 2001-11-15 Genentech Inc. Humanized antibodies and methods for forming humanized antibodies
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
TR199903123T2 (en) 1997-04-07 2000-05-22 Genentech, Inc. Anti-Vegf antikorlar�.
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
WO1998050356A1 (en) 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
EP0984692A4 (en) 1997-05-30 2001-02-21 Merck & Co Inc Novel angiogenesis inhibitors
DE69838172T2 (en) 1997-08-22 2008-04-10 Astrazeneca Ab OXINDOLYLCHINAZOLE DERIVATIVES AS ANGIOGENESEHEMMER
JP2001518470A (en) 1997-09-26 2001-10-16 メルク エンド カムパニー インコーポレーテッド Novel angiogenesis inhibitors
JP2001522853A (en) 1997-11-11 2001-11-20 ファイザー・プロダクツ・インク Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
DK1034298T3 (en) 1997-12-05 2012-01-30 Scripps Research Inst Humanization of murine antibody
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
IL138608A0 (en) 1998-04-02 2001-10-31 Genentech Inc Antibody variants and fragments thereof
WO1999061422A1 (en) 1998-05-29 1999-12-02 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
UA60365C2 (en) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Isothiazole derivatives, a method for preparing thereof, a pharmaceutical composition and a method for treatment of hyperproliferative disease of mammal
WO2000042072A2 (en) 1999-01-15 2000-07-20 Genentech, Inc. Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
JP2003529774A (en) 2000-03-31 2003-10-07 ジェネンテック・インコーポレーテッド Compositions and methods for detecting and quantifying gene expression
US6998234B2 (en) * 2000-11-03 2006-02-14 Oncotech, Inc. Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
AR042586A1 (en) 2001-02-15 2005-06-29 Sugen Inc 3- (4-AMIDOPIRROL-2-ILMETILIDEN) -2-INDOLINONE AS INHIBITORS OF PROTEIN KINASE; YOUR PHARMACEUTICAL COMPOSITIONS; A METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF PROTEINQUINASE; A METHOD TO TREAT OR PREVENT AN AFFECTION RELATED TO PROTEINQUINASE
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
KR100976076B1 (en) 2003-05-22 2010-08-17 아보트 러보러터리즈 Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
RU2005136988A (en) 2003-05-30 2006-06-10 Дженентек, Инк. (Us) ANTIBODY TREATMENT AGAINST VEGF
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
US7758859B2 (en) 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
CN102895663A (en) * 2004-04-14 2013-01-30 健泰科生物技术公司 Compositions containing EGFL 7 antagonist for modulating vascular development and methods
US20060009360A1 (en) 2004-06-25 2006-01-12 Robert Pifer New adjuvant composition
JP2007070633A (en) 2005-09-06 2007-03-22 Lg Electronics Inc Printing ink and fluorescent substance slurry composition, printer using the same and plasma display panel and method for producing the same
UA96139C2 (en) * 2005-11-08 2011-10-10 Дженентек, Інк. Anti-neuropilin-1 (nrp1) antibody
ITRM20060337A1 (en) * 2006-06-27 2007-12-28 Biosoot Srl GENE TEM8 (TUMOR ENDOTELIAL MARKER 8) AND ITS FORMS OF EXPRESSION AND DIAGNOSTIC AND THERAPEUTIC USE
WO2008128233A1 (en) * 2007-04-15 2008-10-23 University Of Chicago Methods and compositions concerning the vegfr-2 gene (kinase domain receptor, kdr)
BRPI0817158A2 (en) * 2007-11-09 2015-04-14 Genentech Inc "Method to Identify a Kidney Cancer Patient, Kit, Methods and Compound Set"
US20100029491A1 (en) * 2008-07-11 2010-02-04 Maike Schmidt Methods and compositions for diagnostic use for tumor treatment

Also Published As

Publication number Publication date
AU2010273585B2 (en) 2015-04-23
SG177640A1 (en) 2012-02-28
US20140302056A2 (en) 2014-10-09
WO2011008696A3 (en) 2011-04-14
JP6095367B2 (en) 2017-03-15
AU2010273585A1 (en) 2012-01-19
CA2766403A1 (en) 2011-01-20
MX2012000620A (en) 2012-01-27
CN106148547A (en) 2016-11-23
JP2012532628A (en) 2012-12-20
WO2011008696A2 (en) 2011-01-20
CN102482715A (en) 2012-05-30
EP2454380A2 (en) 2012-05-23
IL216926A0 (en) 2012-02-29
US20110076271A1 (en) 2011-03-31
US20140099326A1 (en) 2014-04-10
JP2017099389A (en) 2017-06-08
BR112012000735A2 (en) 2016-11-16
HK1226108A1 (en) 2017-09-22
KR20120106935A (en) 2012-09-27

Similar Documents

Publication Publication Date Title
IL258794B (en) Methods and compositions for diagnosis and treatment of cancer
HK1226108A1 (en) Diagnostic methods and compositions for treatment of cancer
ZA201105472B (en) Methods and compositions for diagnosis and treatment of cancer
IL218575A0 (en) Treatment of cancer
EP2751570A4 (en) Methods and compositions for the treatment and diagnosis of cancer
HK1178074A1 (en) Compositions and methods for the diagnosis and treatment of tumor
EP2480687A4 (en) Methods and compositions for the diagnosis and treatment of thyroid cancer
HK1159498A1 (en) Methods and compositions for the treatment of cancer
ZA201006988B (en) Method and compositions for treatment of cancer
IL240560A0 (en) Compositions and methods for the diagnosis and treatment of tumor
EP2723924A4 (en) Methods and compositions for the treatment and diagnosis of cancer
EP2340027A4 (en) Methods and compositions for the treatment of cancer
IL214349A0 (en) Compositions and methods for the treatment of cancer
EP2437738A4 (en) Methods and compositions for the treatment of cancer
GB0902040D0 (en) Composition for treatment of skin
EP2515652A4 (en) Compositions and methods for treatment of vitiligo
EP2411031A4 (en) Methods and compositions for the treatment of cancer
EP2547368A4 (en) Methods and compositions for the treatment of cancer
GB0916686D0 (en) Treatment of cancer
GB201017857D0 (en) Methods for diagnosis and methods of treatment
GB0921757D0 (en) Treatment of cancer