DE60120193T2 - Pyrazolverbindungen als protein-kinasehemmer - Google Patents

Pyrazolverbindungen als protein-kinasehemmer Download PDF

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Publication number
DE60120193T2
DE60120193T2 DE60120193T DE60120193T DE60120193T2 DE 60120193 T2 DE60120193 T2 DE 60120193T2 DE 60120193 T DE60120193 T DE 60120193T DE 60120193 T DE60120193 T DE 60120193T DE 60120193 T2 DE60120193 T2 DE 60120193T2
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ring
optionally substituted
aliphatic
substituted
membered
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DE60120193T
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English (en)
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DE60120193D1 (de
Inventor
Ronald Abingdom KNEGTEL
David Newbury BEBBINGTON
Hayley Oxon BINCH
Julian Ashbury GOLEC
Sanjay Oxon PATEL
Vertex Pharmaceuticals Inc. Jean-Damien Bishops Itchington CHARRIER
David Purton KAY
Robert Arlington DAVIES
Pan Arlington LI
Marion Stow WANNAMAKER
Cornelia Pelham FORSTER
Albert C. Cambridge PIERCE
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
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  • Urology & Nephrology (AREA)
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DE60120193T 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer Expired - Lifetime DE60120193T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23279500P 2000-09-15 2000-09-15
US232795P 2000-09-15
US25788700P 2000-12-21 2000-12-21
US257887P 2000-12-21
US28694901P 2001-04-27 2001-04-27
US286949P 2001-04-27
PCT/US2001/028740 WO2002022601A1 (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60120193D1 DE60120193D1 (de) 2006-07-06
DE60120193T2 true DE60120193T2 (de) 2007-03-29

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ID=27398347

Family Applications (8)

Application Number Title Priority Date Filing Date
DE60120194T Expired - Lifetime DE60120194T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120198T Expired - Lifetime DE60120198T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119748T Expired - Lifetime DE60119748T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119749T Expired - Lifetime DE60119749T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60124744T Expired - Lifetime DE60124744T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60128709T Expired - Lifetime DE60128709T2 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase-inhibitoren
DE60120193T Expired - Lifetime DE60120193T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60110616T Expired - Lifetime DE60110616T3 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Family Applications Before (6)

Application Number Title Priority Date Filing Date
DE60120194T Expired - Lifetime DE60120194T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120198T Expired - Lifetime DE60120198T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119748T Expired - Lifetime DE60119748T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119749T Expired - Lifetime DE60119749T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60124744T Expired - Lifetime DE60124744T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60128709T Expired - Lifetime DE60128709T2 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase-inhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60110616T Expired - Lifetime DE60110616T3 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

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US (7) US7098330B2 (OSRAM)
EP (8) EP1318814B1 (OSRAM)
JP (9) JP4105948B2 (OSRAM)
KR (4) KR20030032035A (OSRAM)
CN (3) CN100355750C (OSRAM)
AP (1) AP2003002762A0 (OSRAM)
AT (8) ATE327992T1 (OSRAM)
AU (9) AU2001290944A1 (OSRAM)
BR (1) BR0114088A (OSRAM)
CA (8) CA2422379C (OSRAM)
DE (8) DE60120194T2 (OSRAM)
DK (1) DK1318997T3 (OSRAM)
ES (3) ES2266259T3 (OSRAM)
HU (4) HUP0302411A2 (OSRAM)
IL (6) IL154817A0 (OSRAM)
MX (8) MXPA03002294A (OSRAM)
NO (4) NO20031190L (OSRAM)
NZ (4) NZ545284A (OSRAM)
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