CN114144144A - 低轮廓假体二尖瓣 - Google Patents

低轮廓假体二尖瓣 Download PDF

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CN114144144A
CN114144144A CN202080052112.5A CN202080052112A CN114144144A CN 114144144 A CN114144144 A CN 114144144A CN 202080052112 A CN202080052112 A CN 202080052112A CN 114144144 A CN114144144 A CN 114144144A
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valve
prosthetic valve
ventricular
native
prosthetic
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埃里克·松-桑·冯
卡伦·特索克-基·黄
伊弗雷姆·本-亚伯拉罕
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Neovasc Tiara Inc
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Neovasc Tiara Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/243—Deployment by mechanical expansion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/005—Rosette-shaped, e.g. star-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter

Abstract

一种用于治疗天然瓣膜的低轮廓假体瓣膜，该假体瓣膜包括具有扩张构型和收缩构型的径向可扩张框架。假体瓣膜的心房端部形成与天然瓣膜的心房表面接合的张开形状。张开形状在最初扩张时朝向天然瓣膜的心室向下张开，然后在完全扩张时使张开形状倒置以形成朝向心室渐缩并且朝向天然瓣膜的心房张开的渐缩形状。假体瓣膜还具有多个假体瓣膜小叶，多个假体瓣膜小叶打开以及闭合以控制流体流动通过假体瓣膜。

Description

低轮廓假体二尖瓣
优先权要求
本申请是非临时的并且要求于2019年6月20日提交的美国临时专利申请No.62/864,008(代理案卷号5131.019PRV)的权益；该美国临时专利申请的全部内容通过参引并入本文中。
背景技术
二尖瓣反流、也称为二尖瓣功能不全，是严重的心脏疾病，其中，二尖瓣不能正常关闭并且阻止逆行血流通过天然二尖瓣。这种情况会损害心脏功能并且会使人衰弱或危及生命。
目前用于二尖瓣功能不全的治疗包括传统的天然瓣膜外科手术修复。侵入性较小的经导管治疗正在开发。
附图说明
在不一定按比例绘制的附图中，相似的附图标记可以描述不同视图中的类似的部件。具有不同字母后缀的相似的附图标记可以表示类似部件的不同实例。附图总体上通过示例而非限制的方式来图示本文中论述的各种实施方式。
图1是心脏的左心室的示意图，其示出了心缩期间的血流。
图2是在二尖瓣中具有脱垂小叶的心脏的左心室的示意图。
图3A是患有心肌病的患者中的心脏的示意图，其中，心脏扩张并且小叶不相接。
图3B示出了小叶的正常闭合。
图3C示出了扩张心脏中的异常闭合。
图4图示了具有受损的乳头肌的心脏的左心室中的二尖瓣反流。
图5A至图5B图示了二尖瓣的解剖结构。
图6A示出了低轮廓假体瓣膜的示例的俯视图。
图6B示出了图6A中的示例的心室锚固件。
图6C示出了可以附接至图6A中的瓣膜的心室锚固件的覆盖物。
图6D示出了图6A中的瓣膜的立体图。
图7A示出了低轮廓假体瓣膜的另一示例的俯视图。
图7B示出了图7A中的示例的心室锚固件。
图7C示出了可以用在图7B的心室锚固件上的覆盖物的示例。
图7D示出了图7A中的示例的立体图。
图8A示出了低轮廓假体瓣膜的另一示例的俯视图。
图8B示出了图8A的处于部分部署构型的假体瓣膜。
图8C示出了图8A的处于完全部署构型的假体瓣膜。
图8D示出了图8A的假体瓣膜布置在天然二尖瓣中。
图9A至图9F示出了以可释放的方式联接至假体瓣膜的输送导管。
图10A至图10C示出了用于以可释放的方式将假体瓣膜与输送导管联接的锁定机构。
图11示出了用于以可释放的方式将假体瓣膜与输送导管联接的锁定机构的侧视图。
图12A至图12B示出了用于以可释放的方式将假体瓣膜与输送导管联接的锁定机构。
图13A至图13D图示了用于将假体瓣膜部署在天然瓣膜中的方法的示例。
图14示出了假体瓣膜在天然瓣膜中的示例。
图15A至图15D示出了用于将假体瓣膜部署在天然瓣膜中的方法的另一示例。
具体实施方式
传统的二尖瓣外科手术修复可能是有效的治疗，但需要心脏直视手术、较长的住院时间和恢复期。侵入性较小的经导管治疗正在开发并且很有前景，但植入可能具有挑战性而且许多尚未获得进行商业流通的监管批准。因此，需要改进的装置来治疗二尖瓣功能不全。这些挑战中的至少一些挑战通过本文中所公开的示例得以解决。
虽然本文中公开的示例涉及用于治疗二尖瓣反流的可植入假体二尖瓣，但本领域技术人员将理解的是这并非意在限制，并且本文中公开的装置和方法也可以用于治疗其他心脏瓣膜比如三尖瓣、主动脉瓣、肺动脉瓣等以及身体中的其他瓣膜比如静脉瓣膜或者用于控制流体或其他物质流动的任何解剖结构。
心脏解剖学
图1中图示了正常心脏H的处于心缩的左心室LV。左心室LV正在收缩并且血液沿箭头方向向外流动穿过主动脉瓣AV、三尖瓣。由于二尖瓣构造为当左心室中的压力高于左心房LA中的压力时防止回流的“止回阀”，因此防止了血液通过二尖瓣MV的回流或“反流”。如图1中图示的，二尖瓣MV包括一对小叶，所述一对小叶具有均匀地相接以闭合的自由边缘FE。小叶LF的相反端部沿着称为瓣环AN的环形区域附接至周围的心脏结构。小叶LF的自由边缘FE通过腱索CT(本文中也称为腱)紧固至左心室LV的下部部分，腱索CT包括紧固在瓣膜小叶LF中的每个瓣膜小叶的下表面上方的多个分支腱。腱CT又附接至从左心室的下部部分向上延伸的乳头肌PM以及室间隔IVS。
现在参照图2至图4，心脏中的许多结构缺陷可以导致二尖瓣脱垂，因为不足的张力经由腱传递至小叶。当另一小叶LF1保持正常轮廓时，两个瓣膜小叶没有适当地相接，并且将发生如由箭头所示的从左心室LV到左心房LA中的泄漏。
在心脏扩张并且增大的尺寸阻止瓣膜小叶LF适当地相接的患有心肌病的患者中也会发生反流，如图3A中所示。心脏的扩大导致二尖瓣环变大，从而使得自由边缘FE在心缩期间不能相接。前小叶的自由边缘和后小叶的自由边缘通常沿着如图3B中所示的接合线C相接，但在患有心肌病的患者中可能会留有明显的间隙G，如图3C中所示。
在乳头肌PM的功能受损的患有缺血性心脏病的患者中也可能发生二尖瓣反流，如图4中图示的。当左心室LV在心缩期间收缩时，乳头肌PM不能充分收缩以实现适当的闭合。如图示的，小叶LF1和小叶LF2于是脱垂。再次发生如由箭头所示的从左心室LV至左心房LA的泄漏。
图5A更清楚地图示了二尖瓣MV的解剖结构，二尖瓣MV是具有前侧部ANT和后侧部POST的二叶瓣。瓣膜包括前(主动脉)小叶AL和后(壁侧)小叶PL。腱索CT将瓣膜小叶AL、PL与前外侧乳头肌ALPM和后内侧乳头肌PMPM联接。瓣膜小叶AL、PL沿着称为前外侧连合ALC和后内侧连合PMC的线彼此连结。瓣环AN外接瓣膜小叶，并且在前小叶的相对侧部上的与瓣环的前部部分相邻的两个区域称为左纤维三角区LFT和右纤维三角区RFT。这些区域通常由实线三角形表示。图5B更清楚地图示了左纤维三角区LFT和右纤维三角区RFT。
假体瓣膜
假体瓣膜作为对二尖瓣反流的治疗已经通过手术植入心脏中。这些瓣膜中的一些瓣膜是从动物中获得的瓣膜、比如猪瓣膜，并且其他瓣膜是具有或不具有组织覆盖物的假体机械瓣膜。最近，已经使用微创导管技术来将假体瓣膜输送至心脏。这些瓣膜通常包括用于将假体瓣膜紧固至患者心脏的锚固件以及联接至锚固件的瓣膜机构。瓣膜机构通常是机械瓣膜、具有动物组织的瓣膜或其组合。假体瓣膜一旦植入，就会接管发生故障的天然瓣膜，从而减少或消除瓣膜功能不全。这些瓣膜中的一些瓣膜难以输送并且一些瓣膜难以准确地锚固。其他尺寸较大的瓣膜可能阻塞心脏的室。虽然这些瓣膜中的一些瓣膜看起来很有前途，但仍需要改进瓣膜以解决这些挑战中的至少一些挑战。以下说明书公开了假体瓣膜、用于假体瓣膜的输送系统以及将瓣膜输送的方法的示例，这些示例可以克服与现有假体瓣膜相关联的挑战中的一些挑战。
图6A图示了以平面剖视图示出的低轮廓假体二尖瓣600的示例。假体二尖瓣600是由多个相互连接的支柱形成的可扩张框架并且可以从诸如不锈钢、镍钛合金或其他生物兼容材料的平坦的片材材料切割。假体二尖瓣600可以是可球囊扩张或自扩张的。可扩张框架在从片材材料切割后处于平坦平面构型并且可以进行热处理并且定形成如将在以下描述的期望的形状。平面图案包括多个同心环形环602、604，同心环形环602、604由围绕假体的周边延伸的多个支柱形成。随着环更接近假体瓣膜的中心，环的直径和周长更小。因此，环602比环604具有更大的直径和更大的周长。相邻环与多个径向延伸的支柱612联接在一起以形成围绕假体瓣膜周向布置的多个封闭单元，其中，相邻的封闭单元共用至少一个公共支柱。每个环602、604可以包括全部具有相同几何结构的多个周向定向的支柱。例如，最外环602包括联接在一起以形成环形环的多个叉骨形支柱。叉骨形支柱在环602中可以全部相同并且叉骨形支柱可以包括与弧形支柱联接在一起的两个相对倾斜的支柱，弧形支柱在两个相对倾斜的支柱之间的拐点处形成叉骨形支柱中的突起或峰。
从环602径向向内布置的下一相邻环604类似地由联接在一起的多个叉骨形支柱形成。环604中的叉骨形支柱可以在环604中全部相同并且它们可以类似地由与弧形支柱联接在一起的两个相对倾斜的支柱形成，弧形支柱在两个相对倾斜的支柱之间的拐点处形成叉骨形支柱中的突起或峰。环604中的支柱的尺寸和角度可以与环602不同，这是因为这两个环彼此同心并且环604比外环602具有更小的直径和周长。从假体的中心径向地向外延伸的多个线性支柱612将环602和环604联接在一起以形成封闭单元610。形成在环602与环604之间的封闭单元610可以全部具有相同的几何结构，或者封闭单元610可以变化。
支柱可以是叉骨形状以远离叉骨的顶点转移应力和应变，从而允许对于给定的最大应变实现更大的角度运动范围，或者允许对于相同的给定运动范围发生更低的最大应变。
Y形支柱616联接至叉骨形第二环604，其中，Y的尾部朝向假体的中心径向地向内延伸，从而形成柠檬形的封闭单元，该封闭单元在封闭单元的相反侧部上具有峰和谷并且在封闭单元的另外两个侧部上具有尖端部。Y的尾部可以联接在一起以限定假体中的中心开孔618。在该示例中，中心开孔618是星形的，其中，三个尖臂径向地向外延伸以形成星形状。
多个内部封闭单元620、此处为三个封闭单元620由在封闭单元620的相反侧部上的两个V形支柱622形成，V形支柱622联接至相邻Y形支柱616的尾部以形成封闭单元620。每个封闭单元620包含连合突部606和两个心室锚固支柱614。
连合突部606可以邻近假体的中心并且可以包括多个缝合孔，使得假体瓣膜小叶可以缝合至连合突部。连合突部606可以是具有穿过中间的用于接纳假体小叶的狭缝的矩形形状支柱。在该示例中，存在附接至连合突部的三个假体瓣膜小叶(未示出)，从而形成三尖瓣假体瓣膜。假体瓣膜小叶未图示以便观察可扩张框架。连合突部布置在形成心室锚固突部的支柱614之间，心室锚固突部将假体锚固至天然瓣膜的心室部分、比如天然瓣膜的前部分(比如纤维三角区)和天然瓣膜的后部分。支柱614形成心室锚固件的部分。两个支柱614布置在连合突部606的两侧上。支柱614的一个端部联接至Y形支柱616的尾部，并且支柱614的相反端部是可以径向向外弯曲的自由端部。自由端部可以包括用于附接覆盖物的通孔(未示出)。覆盖物可以是任何材料比如像涤纶的聚合物，并且覆盖物形成用于接合组织的柔软的无损伤梢部的脚部。涤纶或其他聚合物覆盖物材料提供了更大的表面积并且因此减少了心室锚固突部刺穿组织的机会。在扩张期间，心室突部于是可以远离瓣膜框架成角度以允许锚固在天然瓣膜的纤维三角区上或心室侧的任何其他前部分上或者天然瓣膜的后瓣环上的任何部分上。
多个锚固突部608可以径向地向内面向装置的中心，锚固突部608此处为蘑菇头形状的突部608或T形头部，锚固突部608允许假体附接至如将在下面进行描述的输送导管。在该示例或任何其他示例中，T形或蘑菇头锚固突部可以省略并且简单地具有穿过突部的开孔，这允许销或其他连接器元件布置在开孔中以用于与输送导管进行可释放联接，如将在下面进行更详细描述的。锚固突部608布置在将Y形支柱616的两个尾部连结在一起的支柱的一部分上。因此，在该示例中，存在可以与输送导管进行作用的三个连接点。
图6B图示了假体瓣膜600，其中，覆盖物624布置在支柱614和假体框架的上方以形成有助于形成心室锚固件的脚部。这是由阴影区域示出的。脚部包括扩大的头部区域和较窄的本体。同样，扩大的头部提供了更大的表面积并且因此使锚固期间施加至组织的压力最小化以消除或减少组织创伤。图6B的其他方面与图6A相同。
图6C示出了覆盖物624的示例，该覆盖物624可以附接至支柱614以形成心室锚固件的无损伤梢部。覆盖物可以是涤纶或其他聚合物或具有期望机械性能的任何材料。覆盖物624具有扩大的头部区域和细长形的本体区域。扩大的头部区域提供了较大的表面积以减少锚固期间与组织的接触压力，以便消除或减少组织刺穿和创伤。
图6D是图6A至图6B中示出的假体瓣膜600的立体图，但其中覆盖物630被示出布置在可扩张框架的上方并且在定形之后布置在可扩张框架的上方。除了布置在心室锚固件614的上方以形成无损伤锚固突部的覆盖物外，相同的材料或类似材料还可以布置在支柱和封闭单元中的任一者或全部的上方，以使瓣周泄漏最小化并且促进组织向内生长。图6D示出了定形之后的处于完全部署构型的假体瓣膜600，其中，假体沿心房方向向上张开(或沿心室方向渐缩)并且作为假体的流入端部的上心房端部直径最大并且瓣膜在作为流出端部的心室端部上渐缩至较小直径。框架的漏斗形状也可以描述为抛物面状，其中，抛物面的凹面部分向上面向心房并且抛物面的凸面部分向下面向心室。假体瓣膜具有中间扩张构型，在中间扩张构型中，抛物面是倒置的使得假体从上端部至下端部向外张开，因此沿心室的方向张开或者沿心房的方向渐缩。如果呈抛物面形状，则于是抛物面的凹面部分向下面向心室而抛物面的凸面部分向上面向心房。下面更详细地说明和描述了该中间扩张构型。假体瓣膜600还包括三个连合柱，其中，三个假体瓣膜小叶632联接至连合柱以形成假体瓣膜机构。
图7A图示了以平面剖视图示出的低轮廓假体二尖瓣700的示例。假体二尖瓣700是由多个相互连接的支柱形成的可扩张框架并且可以从诸如不锈钢、镍钛合金或其他生物兼容材料的平坦的片材材料切割。假体二尖瓣700可以是可球囊扩张或自扩张的。可扩张框架在从片材材料切割后处于平坦平面构型并且可以进行热处理并且定形成如将在以下描述的期望的形状。平坦图案包括多个同心环形环702、704，同心环形环702、704由围绕假体的周边延伸的多个支柱形成。随着环更接近假体瓣膜的中心，环的直径和周长更小。因此，环702比环704具有更大的直径和更大的周长。相邻环与多个径向延伸的支柱712联接在一起以形成围绕假体瓣膜周向布置的多个封闭单元，其中，相邻的封闭单元共用至少一个公共支柱。每个环702、704可以包括全部具有相同几何结构的多个周向定向的支柱。例如，最外环702包括联接在一起以形成环形环的多个叉骨形支柱。叉骨形支柱在环702中可以全部相同并且叉骨形支柱可以包括与弧形支柱联接在一起的两个相对倾斜的支柱，弧形支柱在两个相对倾斜的支柱之间的拐点处形成叉骨形支柱中的突起或峰。
从环702径向向内布置的下一相邻环704类似地由联接在一起的多个叉骨形支柱形成。环704中的叉骨形支柱可以在环704中全部相同并且它们可以类似地由与弧形支柱联接在一起的两个相对倾斜的支柱形成，弧形支柱在两个相对倾斜的支柱之间的拐点处形成叉骨形支柱中的突起或峰。环704中的支柱的尺寸和角度可以与环702不同，这是因为这两个环彼此同心并且环704比外环702具有更小的直径和周长。从假体的中心径向地向外延伸的多个线性支柱712将环702和环704联接在一起以形成封闭单元710。形成在环702与环704之间的封闭单元710可以全部具有相同的几何结构，或者封闭单元710可以变化。连接支柱的使环联接在一起以形成封闭单元的构型产生了格子结构，该格子结构一旦定形就提供例如类似于雏菊的花状形状。
支柱可以是叉骨形状以远离叉骨的顶点转移应力和应变，从而允许对于给定的最大应变实现更大的角度运动范围，或者允许对于相同的给定运动范围发生更低的最大应变。
Y形支柱716联接至叉骨形第二环704，其中，Y的尾部朝向假体的中心径向地向内延伸，从而形成数个泪滴形的封闭单元以及与图6A中的示例大致相同的数个柠檬形的封闭单元，泪滴形的封闭单元在泪滴形状的相反侧部上具有尖端部。Y的尾部可以与V形支柱联接在一起以限定假体中的内部封闭单元720与中心开孔718。在该示例中，中心开孔718具有中心圆孔，中心圆孔具有从中心圆孔径向地向外延伸的多个尖臂。
内部封闭单元720由V形支柱722形成，V形支柱722联接至相邻Y形支柱716的尾部以形成封闭单元720。封闭单元720包含三个连合突部706并且三个V形支柱从封闭单元720径向地向外延伸，三个V形支柱形成构造成与天然瓣膜的心室下表面接合的心室锚固件724。心室锚固件的腿部可以联接至Y形支柱的尾部，并且V的顶点(或V的槽或V的自由端部)可以包括延伸穿过该顶点的定尺寸成接纳缝合线的孔，使得与图6C中的覆盖物类似的覆盖物可以附接至锚固件以形成无损伤梢部。
连合突部706可以邻近假体的中心并且可以包括多个缝合孔，使得假体瓣膜小叶可以缝合至连合突部。连合突部706可以是具有穿过中间的用于接纳假体小叶的狭缝的矩形形状支柱。在该示例中，存在附接至连合突部的三个假体瓣膜小叶(未示出)，从而形成三尖瓣假体瓣膜。假体瓣膜小叶未图示以便观察可扩张框架。连合突部布置在相邻的心室锚固件724之间，心室锚固件724将假体锚固至天然瓣膜的心室部分、比如天然瓣膜的前部分(比如纤维三角区)和天然瓣膜的后部分。心室锚固件的自由端部可以径向地向外弯曲。自由端部可以包括用于附接覆盖物的通孔(未示出)。覆盖物可以是任何材料比如像涤纶那样的聚合物，并且覆盖物形成用于接合组织的柔软的无损伤梢部的脚部。涤纶或其他聚合物覆盖物材料提供了更大的表面积并且因此减少了心室锚固突部刺穿组织的机会。在扩张期间，心室突部于是可以远离瓣膜框架成角度以允许锚固在天然瓣膜的纤维三角区上或心室侧的任何其他前部分上或者天然瓣膜的后瓣环上的任何部分上。
联接至连合706的多个锚固突部708可以径向地向内面向装置的中心，锚固突部708此处为蘑菇头形状的突部708或T形头部，锚固突部708允许假体附接至如将在下面进行描述的输送导管。除了连合上的三个锚固突部708外，还有三个附加锚固突部726联接至将两个相邻Y形支柱716的尾部连结的支柱，并且锚固突部726径向地向内面向假体的中心。锚固突部726也可以是蘑菇头形状或T形状或其他形状。两个锚固突部708、726都可以用于以可释放的方式将假体与输送导管联接。因此，在该示例中，存在可以与输送导管进行作用的六个连接点。图7A中的示例的其他方面可以与图6A中的示例基本类似。
图7B图示了假体瓣膜700，其中，覆盖物730布置在心室锚固件714和假体框架的上方以形成有助于形成心室锚固件的脚部。脚部包括扩大的头部区域和较窄的本体。同样，扩大的头部提供了更大的表面积并且因此使锚固期间施加至组织的压力最小化以消除或减少组织创伤。图7B的其他方面与图7A相同。
图7C示出了覆盖物730的示例，该覆盖物730可以附接至心室锚固件714以形成心室锚固件的无损伤梢部。覆盖物可以是涤纶或其他聚合物或具有期望机械性能的任何材料。覆盖物730具有扩大的头部区域和细长形的本体区域。扩大的头部区域提供了较大的表面积以减少锚固期间与组织的接触压力，以便消除或减少组织刺穿和创伤。
图7D是图7A至图7B中示出的假体瓣膜700的立体图，但其中为了观察可扩张框架的支柱并且在定形之后移除了覆盖物。除了布置在心室锚固件的上方的覆盖物外，相同的材料或类似材料还可以布置在支柱和封闭单元中的任一者或全部的上方。图7D示出了定形之后的处于完全扩张构型的假体瓣膜700，其中，假体沿心房方向张开(或朝向心室渐缩)并且作为假体的流入端部的上心房端部直径最大并且瓣膜在作为流出端部的心室端部上渐缩至较小直径。框架的漏斗形状也可以描述为抛物面状，其中，抛物面的凹面部分向上面向心房并且抛物面的凸面部分向下面向心室。假体瓣膜具有中间扩张构型，在中间扩张构型中，假体朝向心房渐缩或朝向心室张开，并且如果呈抛物面形状，则抛物面是倒置的使得假体从上端部至下端部向外张开并且抛物面的凹面部分向下面向心室而抛物面的凸面部分向上面向心房。下面更详细地说明和描述了该中间扩张构型。
图8A图示了以平面剖视图示出的低轮廓假体二尖瓣800的另一示例。假体瓣膜800与图6A至图6D中的假体瓣膜600基本类似，其中主要区别在于增加了心室瓣830或心室翼830以帮助将假体锚固至天然瓣膜的心室侧部并且捕获相邻的天然瓣膜小叶。假体二尖瓣800是由多个相互连接的支柱形成的可扩张框架并且可以从诸如不锈钢、镍钛合金或其他生物兼容材料的平坦的片材材料切割。假体二尖瓣800可以是可球囊扩张或自扩张的。可扩张框架在从片材材料切割后处于平坦平面构型并且可以进行热处理并且定形成如将在以下描述的期望的形状。平坦图案包括多个同心环形环802、804，同心环形环802、804由围绕假体的周边延伸的多个支柱形成。随着环更接近假体瓣膜的中心，环的直径和周长更小。因此，环802比环804具有更大的直径和更大的周长。相邻环与多个径向延伸的支柱812联接在一起以形成围绕假体瓣膜周向布置的多个封闭单元，其中，相邻的封闭单元共用至少一个公共支柱。每个环802、804可以包括全部具有相同几何结构的多个周向定向的支柱。例如，最外环802包括联接在一起以形成环形环的多个叉骨形支柱。叉骨形支柱在环802中可以全部相同并且叉骨形支柱可以包括与弧形支柱联接在一起的两个相对倾斜的支柱，弧形支柱在两个相对倾斜的支柱之间的拐点处形成叉骨形支柱中的突起或峰。
从环802径向向内布置的下一相邻环804类似地由联接在一起的多个叉骨形支柱形成。环804中的叉骨形支柱可以在环804中全部相同并且它们可以类似地由与弧形支柱联接在一起的两个相对倾斜的支柱形成，弧形支柱在两个相对倾斜的支柱之间的拐点处形成叉骨形支柱中的突起或峰。环804中的支柱的尺寸和角度可以与环802不同，这是因为这两个环彼此同心并且环804比外环802具有更小的直径和周长。从假体的中心径向地向外延伸的多个线性支柱812将环802和环804联接在一起以形成封闭单元810。形成在环802与环804之间的封闭单元810可以全部具有相同的几何结构，或者封闭单元810可以变化。
支柱可以是叉骨形状以远离叉骨的顶点转移应力和应变，从而允许对于给定的最大应变实现更大的角度运动范围，或者允许对于相同的给定运动范围发生更低的最大应变。
Y形支柱816联接至叉骨形第二环804，其中，Y的尾部朝向假体的中心径向地向内延伸，从而形成柠檬形的封闭单元，该封闭单元在封闭单元的相反侧部上具有峰和谷并且在封闭单元的另外两个侧部上具有尖端部。Y形支柱还可以联接至叉骨形第二环804，其中，Y的尾部朝向假体的中心径向地向内延伸以形成数个泪滴形的封闭单元，泪滴形的封闭单元在泪滴形状的相反侧部上具有尖端部。Y的尾部可以联接在一起以限定假体中的中心开孔818。在该示例中，中心开孔818是星形的，其中，三个尖臂径向地向外延伸以形成星形状。
多个内部封闭单元820、此处为三个封闭单元820由在封闭单元820的相反侧部上的两个V形支柱822形成，V形支柱822联接至相邻Y形支柱816的尾部以形成封闭单元820。每个封闭单元820包含连合突部806和两个心室锚固支柱814。
连合突部806可以邻近假体的中心并且可以包括多个缝合孔，使得假体瓣膜小叶可以缝合至连合突部。连合突部806可以是具有穿过中间的用于接纳假体小叶的狭缝的矩形形状支柱。在该示例中，存在附接至连合突部的三个假体瓣膜小叶(未示出)，从而形成三尖瓣假体瓣膜。假体瓣膜小叶未图示以便观察可扩张框架。连合突部布置在形成心室锚固突部的支柱814之间，心室锚固突部将假体锚固至天然瓣膜的心室部分、比如天然瓣膜的前部分(比如纤维三角区)和天然瓣膜的后部分。支柱814形成心室锚固件的部分。两个支柱814布置在连合突部806的两侧上。支柱814的一个端部联接至Y形支柱816的尾部，并且支柱814的相反端部是可以径向向外弯曲的自由端部。自由端部可以包括用于附接、比如缝合覆盖物(未示出)的通孔。覆盖物可以是任何材料比如像涤纶那样的聚合物，并且覆盖物形成用于接合组织的柔软的无损伤梢部的脚部。涤纶或其他聚合物覆盖物材料提供了更大的表面积并且因此减少了心室锚固突部刺穿组织的机会。在扩张期间，心室突部于是可以远离瓣膜框架成角度以允许锚固在天然瓣膜的纤维三角区或心室侧的任何其他前部分上或者天然瓣膜的后瓣环上的任何部分上。心室锚固件还可以有助于捕获心室锚固件与可扩张框架的外表面之间的天然瓣膜小叶。如果假体瓣膜具有心室翼或心室瓣(如下所述)，则天然瓣膜小叶还可以由翼或瓣捕获并且这可能有助于将天然瓣膜小叶保持在流动路径之外。可以存在任意数目的心室锚固件，但在该示例中存在三个心室锚固件。
多个锚固突部808可以径向地向内面向装置的中心，锚固突部808此处为蘑菇头形状的突部或T形头部，锚固突部808允许假体附接至如将在下面进行描述的输送导管。锚固突部808布置在将Y形支柱816的两个尾部连结在一起的支柱的一部分上。因此，在该示例中，存在可以与输送导管进行作用的三个连接点。
假体瓣膜800还包括弧形支柱830，该弧形支柱830具有沿相反方向倾斜的相反端部并且在拐点处具有弯曲连接器。在此，存在三个弧形支柱830并且弧形支柱的每个端部联接至Y形支柱818的臂以形成瓣或翼。瓣或翼在假体的心室侧部上形成第二心室锚固件，也有助于捕获天然瓣膜小叶。瓣或翼在输送和初始部署期间可以朝向心室向下延伸远离假体然后瓣或翼在完全扩张构型中径向地向外并远离锚固件延伸以形成围绕可扩张框架周向布置的凸缘，凸缘可以与天然瓣膜的瓣环正下方的心室部分接合使得瓣环被捕获在瓣或翼与上环之间。上心房的张开区域和下心室的翼或瓣因此提供了可以用作夹持件的上肩部和下肩部，上肩部和下肩部可以将天然瓣膜瓣环捕获或夹置在上肩部与下肩部之间，从而为将假体锚固到天然解剖结构中提供了良好的组织紧抓。此外，心室翼或心室瓣还可以有助于捕获天然瓣膜小叶并且将天然瓣膜小叶移出流动通道以确保最佳的瓣膜功能。在此，示出了三个支柱830，但可以使用任意数目的支柱830。心室锚固件814与先前在图6A中所描述的基本相同并且可以结合瓣或翼使用以便进一步有助于将假体瓣膜紧固至天然瓣膜。
图8B图示了定形之后的并且处于部分部署构型的图8A的假体瓣膜800，在部分部署构型中，随着心房直径朝向心室增大以形成锥体区域或张开区域，心房端部已经扩张成锥形形状。扩张构型可以是具有向下面向心室但仍布置在瓣膜瓣环850上方的凹面部分的抛物面。为方便起见，未示出输送导管。瓣830或翼830从可扩张框架轴向地向下延伸并且穿过瓣环850通过天然瓣膜孔口。瓣830或翼830在该部分部署构型中大致平行于假体的纵向轴线延伸。与图6B中的覆盖物624类似的覆盖物(未示出)可以布置在支柱814和假体框架的任何部分或所有部分的上方以形成有助于形成心室锚固件的脚部。脚部可以包括扩大的头部区域和较窄的本体。同样，扩大的头部提供了更大的表面积并且因此在锚固期间使施加至组织的压力最小化以消除或减少组织创伤。图8B的其他方面与图8A相同。
图8C示出了图8B的处于完全部署构型的假体瓣膜800，在完全部署构型中，心房锥体已经倒置以形成现在的具有向上面向心房但位于瓣环850上方的凹面部分的抛物面。然后，锥体可以配装到天然瓣膜中并且张开的锥体的壁可以防止瓣膜滑动通过天然瓣膜孔口。另外，瓣830或翼830现在已经径向地向外扩张，所以瓣830或翼830正交或者否则横向于假体的纵向轴线以形成凸缘，该凸缘可以锚固抵靠天然瓣膜的心室侧部上的下表面。另外，假体瓣膜还具有心室锚固件并且示出的心室锚固件径向地向外延伸以与瓣环的下侧部接合，例如在天然瓣膜的前侧部上的纤维三角区上或者在天然瓣膜的后部分上接合。同样，可以在心室锚固件814上方布置像图6B中的覆盖物624那样的覆盖物以形成心室锚固件的无损伤梢部。覆盖物可以是涤纶或类似聚合物或具有期望机械性能的任何材料。覆盖物可以具有扩大的头部区域和细长形的本体区域。扩大的头部区域提供了更大的表面积以减少锚固期间与组织的接触压力，以便消除或减少组织刺穿和创伤。
图8D示出了图8A的假体瓣膜800完全部署在天然二尖瓣MV中。当完全部署时，张开部的较大直径部分静置在左心房LA中并且防止假体迁移到左心室LV中。心室锚固突部814可以包括两个前锚固突部和后锚固突部，前锚固突部用于锚固在天然瓣膜的前部分上的纤维三角区上，后锚固突部锚固在天然瓣膜的后部分比如后架上。心室翼830或心室瓣830还布置在心室侧部上以进一步有助于锚固在天然瓣膜的心室侧部上。图8D示出了联接至可扩张框架的覆盖物860比如涤纶或类似聚合物、织物、或组织。示出了附接至连合柱的假体小叶862。连合柱上的锚固突部808用于以可释放的方式将假体与输送导管联接。在此，存在三个锚固突部。
与输送导管的可释放联接
图9A至图9F图示了可以用于携带本文中公开的假体瓣膜中的任一假体瓣膜的输送导管。输送导管能够以可释放的方式联接至假体使得一旦假体已经被正确地定位和部署，假体瓣膜就从输送导管中释放并且留在适当位置，同时从患者移除输送系统。
图9A示出了包括外护套902和渐缩的无损伤远端梢部904的输送导管900的外表面。可以在插入和扩张假体瓣膜之前移除渐缩的无损伤远端梢部904。
图9B示出外护套902总体上为具有单个腔906的管状轴，腔906延伸穿过该轴。腔906构造成容纳本文中公开的假体瓣膜中的任一假体瓣膜并且提供使假体瓣膜在输送期间保持在折叠构型中的约束。
图9C示意性地示出了布置在外护套902的腔906中的假体908。假体908可以是本文中公开的假体瓣膜中的任一假体瓣膜并且被约束在折叠构型中。
图9D示出了外护套902向近端收回将假体908的约束移除并且允许假体部分地自扩张，但护套仍布置在假体的以可释放的方式与输送导管接合的部分的上方并且这提供了防止假体倒置和完全扩张的约束。在此，仅图示了假体的以可释放的方式联接至输送导管的部分。为方便起见，从图9D至图9F中已经省略了假体瓣膜的其余部分。当外护套906向近端收回时，假体自扩张以形成部分部署的假体，在部分部署中，形成具有向下面向患者心脏的心室的凹部部分的抛物面。因此，形成了倒锥体形状，其中，锥体的小端部面向心房并且锥体的大端部向下面向心室。仅具有连接器突部的假体臂保持联接至输送导管。突部的示例包括先前在上面描述的蘑菇头形突部或T形突部。在该输送和扩张阶段，假体在心房中保持于天然瓣膜的上方。
图9E示出了外护套902进一步向近端收回(或布置在外护套902的腔906中的中间轴910向远端前进)允许假体瓣膜继续打开和倒置，使得在抛物面的凹面部分面向心房的情况下抛物面面向相反的方向。假体瓣膜908保持联接至输送导管900。
图9F示出了一旦假体瓣膜已经被正确地定位并扩张到天然瓣膜中，假体瓣膜908就从输送导管900中释放。在此，内轴912以可滑动的方式布置在中间轴910的腔中。当内轴912向远端前进时，盘914或帽914移动远离联接至中间轴910的毂。毂包括捕获假体的蘑菇头部或T形头部的槽916。因此，当帽914移动远离毂和槽914时，蘑菇头部或T形头部变得不受约束并且可以自由地自扩张离开槽914。一旦离开槽，假体908然后与输送导管900分离。以下描述了关于联接机构的其他细节。
在图9A至图9F的示例中，在假体瓣膜与输送导管之间仅存在3个连接件。可以使用附加的连接点，比如通过如图7A中所看到的在心室锚固件上增加突部使得存在6个连接点。可以使用任意数目的连接点，可以使用连合上的连接器或心室锚固件上的连接器的任意组合。此外，在该示例中或在假体与输送导管之间存在多个可释放连接件的任何示例中，连接件可以全部同时地、以连续的方式一个接一个单独地并且彼此独立地、或者按期望的分组或分阶段地被释放。
图10A至图10C示出了可以用于以可释放的方式将假体瓣膜与输送系统联接的联接机构的另一示例。该示例与图9A至图9F中示出的示例类似，其中主要区别在于，毂上的槽区域与盘或帽是反向的。为了方便起见，图10A至图10C中省略了外护套。
在图10A中，输送导管包括内轴1006和以可滑动的方式布置在内轴1006上的中间轴1004。假体瓣膜1002以可释放的方式联接至输送导管。同样，仅示出了假体瓣膜的联接至输送导管的部分。假体瓣膜1002可以是本文中公开的假体瓣膜中的任一假体瓣膜。此外，在该视图中，假体部分地部署并且扩张以形成具有凹面部分向下面向心室的抛物面。抛物面也可以被描述为倒锥体，其中，锥体的小端部面向心房并且锥体的大端部向下面向心室。
在图10B中，外护套(未示出)进一步收回允许假体继续扩张和倒置使得假体形成锥体，其中，较大直径端面向心房并且较小直径端面向心室。具有槽1010的毂1008联接至内轴1006。槽1010定尺寸成接纳假体上的T形头部或蘑菇头部并且在盘1012或帽1012与毂1008对接时保持假体上的T形头部或蘑菇头部。盘1012或帽1012联接至中间轴1004。
在图10C中，内轴1006向远端前进使毂1008移动远离帽1012或盘1012，从而暴露槽1010并且允许假体的蘑菇头部或T形头部从输送导管释放。或者可以将中间轴1004向近端收回以使盘或帽与毂分开，或者可以使用中间轴1004向近端收回与内轴1006向远端前进的组合以使两者分开并且将假体瓣膜从输送导管释放。
在图10A至图10C的示例中，在假体瓣膜与输送导管之间仅存在3个连接。可以使用附加的连接点，比如通过如图7A中所看到的在心室锚固件上增加突部使得存在6个连接点。可以使用任意数目的连接点，可以使用连合上的或心室锚固件上的连接器的任意组合。
图11示出了假体瓣膜与输送导管之间的可释放连接的侧视图并且突出了锁定机构的示例，该锁定机构允许假体瓣膜以可释放的方式与输送导管联接。
输送导管1100包括外护套1102，外护套1102以可滑动的方式布置在中间轴1104上，中间轴1104以可滑动的方式布置在内轴1106上。所有三个轴可以相对于彼此向近端或向远端移动。外护套1102包括容纳假体瓣膜1116的腔。假体瓣膜1116可以是本文中公开的假体瓣膜中的任一假体瓣膜。该图仅示出了假体瓣膜的以可释放的方式联接至输送导管的部分。为了方便起见，已经省略了瓣膜的其余部分。具有槽1110的毂1108联接至中间轴。帽1112或盘1112联接至内轴1106。比如蘑菇头部或T形头部的突部1114可以配装在毂中的槽1110中并且当帽1112与毂对接时，突部1114被捕获并且因此假体瓣膜联接至输送导管。一旦假体瓣膜完全部署和定位，内轴1106就可以相对于中间轴1104移动使得帽移动远离毂，从而允许突部1114从槽1110释放并且使假体瓣膜与输送导管解除联接。
图12A至图12B图示了用于以可释放的方式将假体瓣膜与输送导管联接的锁定机构的另一示例。
图12A示出了输送导管1200，该输送导管1200包括：外护套(未图示)，外护套用于容纳假体瓣膜；中间轴1202，中间轴1202以可滑动的方式布置在外护套中；以及内轴1210，内轴1210以可滑动的方式布置在中间轴1202中。帽1206联接至中间轴1202并且毂1208具有销1212，销1212从毂向近端延伸并且与输送导管1200的纵向轴线平行。在此，仅示出了假体瓣膜1204的以可释放的方式与输送导管联接的臂或部分。假体瓣膜1204可以是本文中公开的示例中的任一示例，并且包括具有穿过突部梢部的开孔的突部1214。销1212可以布置在开孔中以在帽与销对接时以可释放的方式将假体瓣膜与输送导管联接。
图12B示出了假体瓣膜1204从输送导管1200的释放。在此，中间轴1202向近端收回或内轴1210向远端前进，或者轴1202向近端运动和轴1210向远端运动两者的组合使帽1206移动远离销1212，从而允许假体瓣膜1204上的连接器突部中的开孔1214滑动脱离销，由此使假体瓣膜与输送导管解除联接。
在用于使假体与输送导管联接以及解除联接的锁定机构的示例中的任一示例中，可能期望重新捕获假体瓣膜。这可以在假体瓣膜从输送导管释放之前的任何时间完成。因此，如果假体需要重新定位或者出于一些其他原因，医生决定不植入假体，则操作者可以允许假体返回至假体的具有面向下游的凹面的无偏置形状并且假体可以被重新套上和约束在其收缩构型中。一旦重新定位假体或者做出部署假体的决定，就可以重新开始部署程序。
输送方法
图13A至图13D图示了将假体瓣膜输送至患者中的二尖瓣的方法的示例。
在图13A中，使用本领域已知的技术比如经皮穿过腹股沟中的静脉或经由切口并通过导引丝将护套1302引入到患者的心脏中。护套1302穿过隔膜壁从右心房RA经隔膜前进至左心房LA。承载假体瓣膜1306比如本文中描述的假体瓣膜中的任一假体瓣膜的输送导管1304穿过护套1302前进到左心房中。将输送导管的远端梢部定位或操纵成使得远端梢部邻近天然二尖瓣MV。护套可以向近端收回或者输送导管向远端前进经过护套，以部分地暴露假体瓣膜1306。
在图13B中护套从假体瓣膜1306移除，由此移除约束并且允许假体瓣膜1306扩张成中间构型。中间构型是凹面表面向下面向心室的锥体形状或抛物面。锥体的较小直径部分面向左心房并且锥体的较大直径部分面向心室。假体瓣膜仍然联接至输送导管并且在左心房LA中布置于二尖瓣MV上方。
在图13C中假体瓣膜1306进一步扩张并且可选地在向假体施加远端压力而抵靠二尖瓣MV的情况下，假体1306倒置使得锥体现在的大直径部分面向左心房LA并且小直径部分面向左心室LV。锥体可以是抛物面形状，其中凹面部分面向左心房LA并且凸面部分面向左心室。心室锚固突部还径向地向外扩张以接合天然瓣膜的心室部分。例如，假体瓣膜可以具有与天然二尖瓣的前部分上的纤维三角区接合的两个前心室锚固件1308和与心室侧部上的天然瓣膜的后部分接合的后心室锚固件1310。如果后部分具有瓣环后架区域，则后心室锚固件可以着落在那里。
在图13D中，假体瓣膜1306完全部署且锚固到天然瓣膜中并且输送导管和护套已经从患者移除。
图14示出了布置在天然二尖瓣MV中的假体瓣膜1402。当完全部署时，锥体的较大直径部分静置在左心房LA中并且防止假体迁移到左心室中。心室锚固突部可以包括后锚固突部1404和两个前锚固突部1406，前锚固突部1406用于锚固在天然瓣膜的前部分上的纤维三角区上，后锚固突部1404锚固在天然瓣膜的后部分比如后架上。图14示出了不具有覆盖物并且不具有假体小叶的情况以便示出心室锚固突部1404、1406的支柱和连合突部1408的支柱。在该示例中，所有三个心室锚固件和所有三个连合突部均包括用于与比如先前描述的那些输送导管进行可释放联接的锚固突部。
图15A至图15D图示了部署比如图8A至图8C中的示例的假体瓣膜的另一示例。
在图15A中，使用本领域已知的技术比如经皮穿过腹股沟中的静脉或经由切口并通过导引丝将护套1502引入到患者的心脏中。护套1502穿过隔膜壁从右心房RA经隔膜前进至左心房LA。承载假体瓣膜1506比如图8A至图8C中的瓣膜的输送导管1504穿过护套1502前进到左心房中。将输送导管的远端梢部定位或操纵成使得远端梢部邻近天然二尖瓣MV。护套可以向近端收回或者输送导管向远端前进经过护套，以部分地暴露假体瓣膜1506。
在图15B中护套从假体瓣膜1506移除，由此移除约束并且允许假体瓣膜1506扩张成中间构型。中间构型是凹面表面向下面向心室的锥体形状或抛物面。锥体的较小直径部分面向左心房并且锥体的较大直径部分面向心室。假体瓣膜仍然联接至输送导管并且左心房LA中布置于二尖瓣MV上方。翼1508或瓣1508从假体瓣膜1506轴向地向下延伸并且可以与假体瓣膜的纵向轴线大致平行。翼或瓣穿过天然瓣膜的孔口。
在图15C中假体瓣膜1506进一步扩张并且可选地在向假体施加远端压力而抵靠二尖瓣MV的情况下，假体1506倒置使得锥体现在的大直径部分面向左心房LA并且小直径部分面向左心室LV。锥体可以是抛物面形状，其中凹面部分面向左心房LA并且凸面部分面向左心室。心室锚固突部在存在的情况下还径向地向外扩张以接合天然瓣膜的心室部分。例如，假体瓣膜可以具有与天然二尖瓣的前部分上的纤维三角区接合的两个前心室锚固件和与心室侧部上的天然瓣膜的后部分接合的后心室锚固件。如果后部分具有瓣环后架区域，则后心室锚固件可以着落在那里。翼1508或瓣1508径向地向外扩张使得翼1508或瓣1508垂直或者否则横向于假体的纵向轴线以形成下凸缘，该下凸缘可以接合心室表面上的二尖瓣的底部以进一步锚固装置，同时也有助于捕获天然小叶。
在图15D中，假体瓣膜1506完全部署且锚固到天然瓣膜中并且输送导管和护套已经从患者移除。
覆盖物
附图中的许多附图仅图示了可扩张假体瓣膜框架，没有附接至框架的假体瓣膜小叶，并且也没有附接至框架的覆盖物。然而，如上面所描述的，可以将覆盖物比如组织、聚合物或织物应用于心室锚固件以有助于形成脚部，脚部能够在不刺穿组织或对组织造成创伤的情况下与天然瓣膜中的组织接合。
另外，在本文中公开的示例中的任一示例中，覆盖物可以应用于框架的全部或框架的部分。覆盖物可以是织物比如涤纶、或组织比如心包组织、或任何其他生物相容性材料。覆盖物可以应用于框架以防止框架周围的瓣周泄漏，以及促进组织向内生长以有助于将假体进一步锚固并紧固至天然解剖结构。例如，覆盖物可以应用于搁置抵靠心房底的锥形凸缘，或者覆盖物可以应用于搁置抵靠瓣环的心室部分的心室凸缘，或者覆盖物可以应用于两者。整个框架可能被覆盖，或者仅部分被覆盖。
此外，如所讨论的，为方便起见，这些示例总体上未图示附接至假体瓣膜框架的假体瓣膜小叶。然而，假体瓣膜小叶在本领域是已知的并且通常两个假体小叶或三个假体小叶可以应用于框架以形成二尖瓣假体瓣膜或三尖瓣假体瓣膜。当然，可以使用任意数目的小叶比如单个假体小叶，或四个小叶或多于四个小叶。假体瓣膜小叶可以是组织比如心包组织，或者假体瓣膜小叶可以是织物、聚合物或本领域已知的其他材料。
注释和示例
以下非限制性示例详细说明本主题的一些方面以解决挑战并提供本文中讨论的益处等。
在示例1中，一种用于治疗患者中的天然瓣膜的低轮廓假体瓣膜包括：径向可扩张框架，所述可扩张框架具有扩张构型、收缩构型、心房端部和心室端部，其中，在所述收缩构型中，所述可扩张框架定尺寸和定形状成用于微创性地输送至所述天然瓣膜，其中，在所述扩张构型中，所述可扩张框架构造成与所述天然瓣膜接合，其中，所述心房端部在所述扩张构型中形成张开形状并构造成与所述天然瓣膜的心房表面接合，其中，所述张开形状在最初扩张时朝向所述天然瓣膜的心室向下张开，然后在完全扩张时将所述张开形状倒置以形成朝向所述天然瓣膜的所述心室渐缩并且朝向所述天然瓣膜的心房张开的渐缩形状；以及多个假体瓣膜小叶，所述多个假体瓣膜小叶具有自由端部和联接至所述可扩张框架的内部部分的相反端部、打开构型和闭合构型，其中，在所述打开构型中，所述多个假体瓣膜小叶的所述自由端部远离彼此布置，从而形成供流体沿顺行方向流动穿过的开孔，并且其中，在所述闭合构型中，所述自由端部布置成比在所述打开构型中更靠近在一起，从而基本上使所述开孔闭合并且防止流体沿逆行方向流动穿过所述开孔。
示例2是根据示例1所述的假体瓣膜，所述假体瓣膜还包括多个连合柱，所述多个连合柱各自具有自由端部和相反端部，所述相反端部联接至所述可扩张框架，所述自由端部在所述可扩张框架处于所述扩张构型时面向所述心室，并且其中，所述多个假体瓣膜小叶联接至所述多个连合柱。
示例3是根据示例1至2中的任一项所述的假体瓣膜，其中，所述自由端部包括延伸穿过所述自由端部的多个开孔，所述多个开孔定尺寸成接纳将所述多个假体瓣膜小叶紧固至所述多个连合柱的缝合丝状件。
示例4是根据示例1至3中的任一项所述的假体瓣膜，其中，所述多个连合柱各自具有联接至所述自由端部的锁定突部，所述锁定突部构造成以可释放的方式将所述假体瓣膜与输送导管联接。
示例5是根据示例1至4中的任一项所述的假体瓣膜，所述假体瓣膜还包括多个心室锚固件，所述心室锚固件联接至所述可扩张框架的所述心室端部，所述心室锚固件在所述扩张构型中从所述可扩张框架径向地向外延伸，并且所述心室锚固件构造成与所述天然瓣膜的心室侧部接合。
示例6是根据示例1至5中的任一项所述的假体瓣膜，其中，所述多个心室锚固件中的至少一个心室锚固件和所述多个连合柱中的至少一个连合柱布置在所述可扩张框架中的由多个支柱界定的公共的封闭单元中。
示例7是根据示例1至6中的任一项所述的假体瓣膜，其中，所述多个心室锚固件各自包括联接至所述心室锚固件的下部分的锁定突部，所述心室锚固件上的所述锁定突部构造成以可释放的方式将所述假体瓣膜与输送导管联接。
示例8是根据示例1至7中的任一项所述的假体瓣膜，其中，所述多个心室锚固件包括前心室锚固件和后心室锚固件，所述前心室锚固件构造成与天然心脏中的天然二尖瓣的前部分上的纤维三角区接合，所述后心室锚固件构造成与所述二尖瓣的瓣环的后部分或所述天然瓣膜的后心室部分接合。
示例9是根据示例1至8中的任一项所述的假体瓣膜，其中，所述多个心室锚固件包括覆盖元件，所述覆盖元件布置在联接至所述可扩张框架的至少两个支柱的上方。
示例10是根据示例1至9中的任一项所述的假体瓣膜，其中，所述多个心室锚固件包括联接至所述可扩张框架的V形支柱，其中，所述V形支柱的顶点构造成与组织接合，所述假体瓣膜还包括布置在所述V形支柱上方的覆盖元件。
示例11是根据示例1至10中的任一项所述的假体瓣膜，其中，所述可扩张框架包括联接在一起以形成抛物面形状的多个环形环。
示例12是根据示例1至11中的任一项所述的假体瓣膜，其中，所述多个环形环包括联接在一起的具有减小的直径的多个同心环。
示例13是根据示例1至12中的任一项所述的假体瓣膜，其中，相邻的环形环联接在一起以形成围绕所述可扩张框架周向地延伸的多个封闭单元。
示例14是根据示例1至13中的任一项所述的假体瓣膜，所述假体瓣膜还包括所述心室端部上的多个心室翼，其中，所述多个心室翼具有扩张构型和收缩构型，其中，在所述收缩构型中，所述多个心室翼与所述假体瓣膜的纵向轴线大致平行，并且其中，在所述扩张构型中，所述多个心室翼从所述纵向轴线径向地向外延伸以形成构造成与所述天然瓣膜的心室表面接合的凸缘。
示例15是一种用于治疗患者中的天然瓣膜的低轮廓假体瓣膜系统，所述系统包括：示例1至14中的任一项所述的假体瓣膜；以及输送导管，所述输送导管以可释放的方式联接至所述假体瓣膜，所述输送导管构造成将所述假体瓣膜输送至所述天然瓣膜。
示例16是根据示例15所述的系统，其中，所述输送导管包括用于以可释放的方式接合所述假体瓣膜的锁定元件。
示例17是一种用于将假体瓣膜输送至患者心脏中的天然瓣膜的方法，所述方法包括：提供承载所述假体瓣膜的输送导管；将所述假体瓣膜定位成邻近所述天然瓣膜；部分地部署所述假体瓣膜，使得所述假体瓣膜形成布置在所述天然瓣膜上方并且朝向所述心脏的心室张开的张开形状；将所述张开形状倒置，使得最初的张开形状变成布置在所述天然瓣膜上方并且朝向所述心室渐缩的渐缩形状；使所述假体瓣膜的心室端部上的多个心室锚固件或多个心室翼径向地扩张以与所述天然瓣膜的心室表面接合；以及将所述假体瓣膜从所述输送导管释放。
示例18是根据示例17所述的方法，其中，使所述多个心室锚固件或所述多个心室翼径向地扩张包括将所述多个心室锚固件中的至少一些心室锚固件锚固在所述天然瓣膜的纤维三角区或者所述天然瓣膜的后心室部分上。
示例19是根据示例17至18中的任一项所述的方法，其中，使所述多个心室锚固件或所述多个心室翼径向地扩张包括使所述多个心室翼从与所述假体瓣膜的纵向轴线大致平行的位置径向地扩张至从所述纵向轴线径向地向外延伸的位置，以及使所述多个心室翼与所述天然瓣膜的心室表面接合。
示例20是根据示例17至19中的任一项所述的方法，所述方法还包括减少或消除通过所述假体瓣膜的反流。
示例21是根据示例17至20中的任一项所述的方法，其中，所述天然瓣膜是二尖瓣。
示例22是根据示例17至21中的任一项所述的方法，其中，将所述假体瓣膜从所述输送导管释放包括将所述假体瓣膜上的多个连合柱与所述输送导管断开接合。
示例23是根据示例17至22中的任一项所述的方法，其中，将所述假体瓣膜从所述输送导管释放包括将所述多个心室锚固件上的多个锁定突部与所述输送导管断开接合。
在示例24中，示例1至23中的任一者或任何组合的设备或方法可以可选地构造成使得所有列举的元件或选项是可供使用或从中选择的。
以上详细描述包括对附图的参照，附图形成了详细描述的一部分。附图通过图示的方式示出了可以实施本发明的具体实施方式。这些实施方式在本文中也称为“示例”。这样的示例可以包括除了所示出或所描述的那些元件之外的元件。然而，本发明人还设想了仅提供所示出或所描述的那些元件的示例。此外，本发明人还设想关于本文中所示出或所描述的特定示例(或其一个或更多个方面)或关于本文中示出或描述的其他示例(或其一个或更多个方面)而使用所示出或所描述的那些元件(或其一个或更多个方面)的任何组合或置换的示例。
在本文件与通过引用并入的任何文件之间的使用不一致的情况下，则以本文件中的用法为准。
在本文件中，如在专利文献中是常见的术语“一”或“一个”独立于“至少一个”或“一个或更多个”的任何其他实例或用法而用于包括一个或多于一个。在本文件中，除非另有说明，否则术语“或”用于表示非排他性的，使得“A或B”包括“A但无B”、“B但无A”以及“A和B”。在本文件中，术语“包括”和“在……中”用作相应的术语“包含”和“其中”的普通英文等同物。另外，在所附权利要求中，术语“包括”和“包含”是开放式的，也就是说，权利要求中的包括除在这些术语之后列举的那些元件之外的元件的系统、装置、物品、组合物、配方、或过程仍然被认为是落入该权利要求的范围内。此外，在所附权利要求中，术语“第一”、“第二”、以及“第三”等仅用作标记，并非意在对其对象规定数量要求。
以上描述意在为说明性的而非限制性的。例如，以上描述的示例(或其一个或更多个方面)可以以彼此组合的方式使用。比如由本领域普通技术人员在查阅以上描述后，可以使用其他实施方式。提供摘要以允许读者快速确定本技术公开的本质。递交的摘要应理解为不用于解释或限制权利要求的范围或意义。另外，在以上详细描述中，各种特征可以被组合在一起以精简本公开。这不应被解释为意指未要求保护的公开特征对于任何权利要求都是必须的。相反，发明主题可以在于比特定的公开实施方式的所有特征少。因此，所附权利要求作为示例或实施方式在此并入到具体实施方式中，其中每个权利要求单独本身作为单独的实施方式，并且可以预期的是，这些实施方式可以以各种组合或置换而彼此组合。本发明的范围应参照所附权利要求以及这些权利要求所授权的等同方案的全部范围来确定。

Claims (23)

1.一种用于治疗患者中的天然瓣膜的低轮廓假体瓣膜，所述瓣膜包括：
径向可扩张框架，所述可扩张框架具有扩张构型、收缩构型、心房端部和心室端部，
其中，在所述收缩构型中，所述可扩张框架定尺寸和定形状成用于微创性地输送至所述天然瓣膜，
其中，在所述扩张构型中，所述可扩张框架构造成与所述天然瓣膜接合，
其中，所述心房端部在所述扩张构型中形成张开形状并构造成与所述天然瓣膜的心房表面接合，
其中，所述张开形状在最初扩张时朝向所述天然瓣膜的心室向下张开，然后在完全扩张时使所述张开形状倒置以形成朝向所述天然瓣膜的所述心室渐缩并且朝向所述天然瓣膜的心房张开的渐缩形状；以及
多个假体瓣膜小叶，所述多个假体瓣膜小叶具有自由端部和联接至所述可扩张框架的内部部分的相反端部、打开构型和闭合构型，
其中，在所述打开构型中，所述多个假体瓣膜小叶的所述自由端部远离彼此布置，从而形成供流体沿顺行方向流动穿过的开孔，并且
其中，在所述闭合构型中，所述自由端部布置成比在所述打开构型中更靠近在一起，从而基本上使所述开孔闭合并且防止流体沿逆行方向流动穿过所述开孔。
2.根据权利要求1所述的假体瓣膜，还包括多个连合柱，所述多个连合柱各自具有自由端部和相反端部，所述相反端部联接至所述可扩张框架，所述自由端部在所述可扩张框架处于所述扩张构型时面向所述心室，并且其中，所述多个假体瓣膜小叶联接至所述多个连合柱。
3.根据权利要求2所述的假体瓣膜，其中，所述自由端部包括延伸穿过所述自由端部的多个开孔，所述多个开孔定尺寸成接纳将所述多个假体瓣膜小叶紧固至所述多个连合柱的缝合丝状件。
4.根据权利要求2所述的假体瓣膜，其中，所述多个连合柱各自具有联接至所述自由端部的锁定突部，所述锁定突部构造成以可释放的方式将所述假体瓣膜与输送导管联接。
5.根据权利要求1所述的假体瓣膜，所述假体瓣膜还包括多个心室锚固件，所述心室锚固件联接至所述可扩张框架的所述心室端部，所述心室锚固件在所述扩张构型中从所述可扩张框架径向地向外延伸，并且所述心室锚固件构造成与所述天然瓣膜的心室侧部接合。
6.根据权利要求5所述的假体瓣膜，其中，所述多个心室锚固件中的至少一个心室锚固件和所述多个连合柱中的至少一个连合柱布置在所述可扩张框架中的由多个支柱界定的公共的封闭单元中。
7.根据权利要求5所述的假体瓣膜，其中，所述多个心室锚固件各自包括联接至所述心室锚固件的下部分的锁定突部，所述心室锚固件上的所述锁定突部构造成以可释放的方式将所述假体瓣膜与输送导管联接。
8.根据权利要求5所述的假体瓣膜，其中，所述多个心室锚固件包括前心室锚固件和后心室锚固件，所述前心室锚固件构造成与天然心脏中的天然二尖瓣的前部分上的纤维三角区接合，所述后心室锚固件构造成与所述二尖瓣的瓣环的后部分或所述天然瓣膜的后心室部分接合。
9.根据权利要求5所述的假体瓣膜，其中，所述多个心室锚固件包括覆盖元件，所述覆盖元件布置在联接至所述可扩张框架的至少两个支柱的上方。
10.根据权利要求5所述的假体瓣膜，其中，所述多个心室锚固件包括联接至所述可扩张框架的V形支柱，其中，所述V形支柱的顶点构造成与组织接合，所述假体瓣膜还包括布置在所述V形支柱上方的覆盖元件。
11.根据权利要求1所述的假体瓣膜，其中，所述可扩张框架包括联接在一起以形成抛物面形状的多个环形环。
12.根据权利要求11所述的假体瓣膜，其中，所述多个环形环包括联接在一起的具有减小的直径的多个同心环。
13.根据权利要求11所述的假体瓣膜，其中，相邻的环形环联接在一起以形成围绕所述可扩张框架周向地延伸的多个封闭单元。
14.根据权利要求1所述的假体瓣膜，所述假体瓣膜还包括所述心室端部上的多个心室翼，其中，所述多个心室翼具有扩张构型和收缩构型，
其中，在所述收缩构型中，所述多个心室翼与所述假体瓣膜的纵向轴线大致平行，并且
其中，在所述扩张构型中，所述多个心室翼从所述纵向轴线径向地向外延伸以形成构造成与所述天然瓣膜的心室表面接合的凸缘。
15.一种用于治疗患者中的天然瓣膜的低轮廓假体瓣膜系统，所述系统包括：
权利要求1所述的假体瓣膜；以及
输送导管，所述输送导管以可释放的方式联接至所述假体瓣膜，所述输送导管构造成将所述假体瓣膜输送至所述天然瓣膜。
16.根据权利要求15所述的系统，其中，所述输送导管包括用于以可释放的方式接合所述假体瓣膜的锁定元件。
17.一种用于将假体瓣膜输送至患者心脏中的天然瓣膜的方法，所述方法包括：
提供承载所述假体瓣膜的输送导管；
将所述假体瓣膜定位成邻近所述天然瓣膜；
部分地部署所述假体瓣膜，使得所述假体瓣膜形成布置在所述天然瓣膜上方并且朝向所述心脏的心室张开的张开形状；
使所述张开形状倒置，使得最初的张开形状变成布置在所述天然瓣膜上方并且朝向所述心室渐缩的渐缩形状；
使所述假体瓣膜的心室端部上的多个心室锚固件或多个心室翼径向地扩张以与所述天然瓣膜的心室表面接合；以及
将所述假体瓣膜从所述输送导管释放。
18.根据权利要求17所述的方法，其中，使所述多个心室锚固件或所述多个心室翼径向地扩张包括将所述多个心室锚固件中的至少一些心室锚固件锚固在所述天然瓣膜的纤维三角区或者所述天然瓣膜的后心室部分上。
19.根据权利要求17所述的方法，其中，使所述多个心室锚固件或所述多个心室翼径向地扩张包括使所述多个心室翼从与所述假体瓣膜的纵向轴线大致平行的位置径向地扩张至从所述纵向轴线径向地向外延伸的位置，以及使所述多个心室翼与所述天然瓣膜的心室表面接合。
20.根据权利要求17所述的方法，所述方法还包括减少或消除通过所述假体瓣膜的反流。
21.根据权利要求17所述的方法，其中，所述天然瓣膜是二尖瓣。
22.根据权利要求17所述的方法，其中，将所述假体瓣膜从所述输送导管释放包括将所述假体瓣膜上的多个连合柱与所述输送导管断开接合。
23.根据权利要求17所述的方法，其中，将所述假体瓣膜从所述输送导管释放包括将所述多个心室锚固件上的多个锁定突部与所述输送导管断开接合。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11931254B2 (en) 2019-06-20 2024-03-19 Neovasc Tiara Inc. Low profile prosthetic mitral valve

Family Cites Families (1678)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB243370A (en) 1924-11-20 1926-08-26 Charles Choffel Improvements in or relating to carburettors for internal combustion engines
NL246112A (zh) 1958-01-27 Eastman Kodak Co
US6203542B1 (en) 1995-06-07 2001-03-20 Arthrocare Corporation Method for electrosurgical treatment of submucosal tissue
US6837887B2 (en) 1995-06-07 2005-01-04 Arthrocare Corporation Articulated electrosurgical probe and methods
US6149620A (en) 1995-11-22 2000-11-21 Arthrocare Corporation System and methods for electrosurgical tissue treatment in the presence of electrically conductive fluid
US6231608B1 (en) 1995-06-07 2001-05-15 Crosscart, Inc. Aldehyde and glycosidase-treated soft and bone tissue xenografts
SE510577C2 (sv) 1996-05-08 1999-06-07 Carag Ag Anordning vid implantat
US6315791B1 (en) 1996-12-03 2001-11-13 Atrium Medical Corporation Self-expanding prothesis
US6045497A (en) 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US6183411B1 (en) 1998-09-21 2001-02-06 Myocor, Inc. External stress reduction device and method
US6395024B1 (en) 1997-05-20 2002-05-28 Triflo Medical, Inc. Mechanical heart valve
US6613278B1 (en) 1998-11-13 2003-09-02 Regeneration Technologies, Inc. Tissue pooling process
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US7658727B1 (en) 1998-04-20 2010-02-09 Medtronic, Inc Implantable medical device with enhanced biocompatibility and biostability
US6221104B1 (en) 1998-05-01 2001-04-24 Cor Restore, Inc. Anterior and interior segment cardiac restoration apparatus and method
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
AU745832B2 (en) 1998-07-13 2002-04-11 Acorn Cardiovascular, Inc. Cardiac disease treatment device and method
US7569062B1 (en) 1998-07-15 2009-08-04 St. Jude Medical, Inc. Mitral and tricuspid valve repair
EP2111800B1 (en) 1998-07-29 2016-06-15 Edwards Lifesciences AG Transventricular implant tools and devices
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US6406488B1 (en) 1998-08-27 2002-06-18 Heartstent Corporation Healing transmyocardial implant
US7118600B2 (en) 1998-08-31 2006-10-10 Wilson-Cook Medical, Inc. Prosthesis having a sleeve valve
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
ATE322230T1 (de) 1998-09-10 2006-04-15 Percardia Inc Tmr vorrichtung
US6641610B2 (en) 1998-09-10 2003-11-04 Percardia, Inc. Valve designs for left ventricular conduits
US6200341B1 (en) 1998-09-25 2001-03-13 Sulzer Carbomedics Inc. Mechanical heart valve assembly with super-elastic lock wire
US6432126B1 (en) 1998-09-30 2002-08-13 C.R. Bard, Inc. Flexible vascular inducing implants
US6248112B1 (en) 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
ES2234311T3 (es) 1998-09-30 2005-06-16 Medtronic, Inc. Procedimiento que permite reducir la mineralizacion de un tejido utilizado para un transplante.
US6458092B1 (en) 1998-09-30 2002-10-01 C. R. Bard, Inc. Vascular inducing implants
US6475239B1 (en) 1998-10-13 2002-11-05 Sulzer Carbomedics Inc. Method for making polymer heart valves with leaflets having uncut free edges
US6102945A (en) 1998-10-16 2000-08-15 Sulzer Carbomedics, Inc. Separable annuloplasty ring
AU768737B2 (en) 1998-10-28 2004-01-08 Cellon S.A. Textured and porous silicone rubber
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
US6001056A (en) 1998-11-13 1999-12-14 Baxter International Inc. Smooth ventricular assist device conduit
US6540780B1 (en) 1998-11-23 2003-04-01 Medtronic, Inc. Porous synthetic vascular grafts with oriented ingrowth channels
US6692520B1 (en) 1998-12-15 2004-02-17 C. R. Bard, Inc. Systems and methods for imbedded intramuscular implants
WO2000038595A1 (fr) 1998-12-28 2000-07-06 Alexandr Vasilievich Samkov Prothese de valvule du coeur
US6383147B1 (en) 1999-01-26 2002-05-07 Edwards Lifesciences Corporation Anatomical orifice sizers and methods of orifice sizing
EP1990024A3 (en) 1999-01-26 2014-05-28 Edwards Lifesciences Corporation Flexible heart valve
IL144593A0 (en) 1999-01-27 2002-05-23 Viacor Inc Cardiac valve procedure methods and devices
DE19904975A1 (de) 1999-02-06 2000-09-14 Impella Cardiotech Ag Vorrichtung zur intravasalen Herzklappenoperation
US20030068815A1 (en) 1999-02-11 2003-04-10 Stone Kevin R. Sterilized xenograft tissue
NO308575B1 (no) 1999-02-17 2000-10-02 Sumit Roy Flerbruksventil
DE19910233A1 (de) 1999-03-09 2000-09-21 Jostra Medizintechnik Ag Anuloplastieprothese
US7563267B2 (en) 1999-04-09 2009-07-21 Evalve, Inc. Fixation device and methods for engaging tissue
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
DE60045096D1 (de) 1999-04-09 2010-11-25 Evalve Inc Verfahren und vorrichtung zur herzklappenreperation
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US6231602B1 (en) 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
EP1171059B1 (en) 1999-04-23 2005-11-02 St. Jude Medical ATG, Inc. Artificial heart valve attachment apparatus
US6620170B1 (en) 1999-04-26 2003-09-16 C. R. Bard, Inc. Devices and methods for treating ischemia by creating a fibrin plug
US6582419B1 (en) 1999-04-28 2003-06-24 St. Jude Medical, Inc. Aortic heart valve prosthesis sizer and marker
DE19919625C2 (de) 1999-04-29 2002-10-31 Symetis Ag Zuerich In-vitro-Verfahren zum Herstellen einer homologen Herzklappe und durch dieses Verfahren herstellbare Klappe
DE60029404T2 (de) 1999-05-14 2007-02-22 C.R. Bard, Inc. Wirkstoffabgabesysteme
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
DE60044531D1 (de) 1999-06-25 2010-07-22 Vahid Saadat Gerät zur gewebebehandlung
SE514718C2 (sv) 1999-06-29 2001-04-09 Jan Otto Solem Anordning för behandling av bristande tillslutningsförmåga hos mitralisklaffapparaten
US7192442B2 (en) 1999-06-30 2007-03-20 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6610071B1 (en) 1999-07-26 2003-08-26 Beth Israel Deaconess Medical Center Suture system
EP1400204A1 (en) 1999-08-05 2004-03-24 Broncus Technologies, Inc. Methods and devices for creating collateral channels in the lungs
US7022088B2 (en) 1999-08-05 2006-04-04 Broncus Technologies, Inc. Devices for applying energy to tissue
US6293951B1 (en) 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US6350281B1 (en) 1999-09-14 2002-02-26 Edwards Lifesciences Corp. Methods and apparatus for measuring valve annuluses during heart valve-replacement surgery
AU771470B2 (en) 1999-09-20 2004-03-25 Atritech, Inc. Method and apparatus for closing a body lumen
EP1214106B1 (en) 1999-09-22 2003-11-19 Baxter International Inc. Cardiac valve and method for preparing a biological tissue
US6358278B1 (en) 1999-09-24 2002-03-19 St. Jude Medical, Inc. Heart valve prosthesis with rotatable cuff
IT1307268B1 (it) 1999-09-30 2001-10-30 Sorin Biomedica Cardio Spa Dispositivo per interventi di riparazione o sostituzione valvolarecardiaca.
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US6416547B1 (en) 1999-10-06 2002-07-09 Edwards Lifesciences Corporation Heart valve carrier and rinse cage
FR2799364B1 (fr) 1999-10-12 2001-11-23 Jacques Seguin Dispositif d'annuloplastie utilisable par voie mini-invasive
CA2286929A1 (en) 1999-10-18 2001-04-18 Anthony Paolitto Valve surgery apparatus
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
JP2001120582A (ja) 1999-10-22 2001-05-08 Gunze Ltd 人工心臓弁およびその作製方法
US20070043435A1 (en) 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
FR2815844B1 (fr) 2000-10-31 2003-01-17 Jacques Seguin Support tubulaire de mise en place, par voie percutanee, d'une valve cardiaque de remplacement
FR2800984B1 (fr) 1999-11-17 2001-12-14 Jacques Seguin Dispositif de remplacement d'une valve cardiaque par voie percutanee
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
GB9928905D0 (en) 1999-12-08 2000-02-02 Aortech Europ Ltd Prosthesis
GB0114345D0 (en) 2001-06-13 2001-08-08 Aortech Europ Ltd Heart valve prosthesis and method of manufacture
US7632309B1 (en) 1999-12-13 2009-12-15 St. Jude Medical, Inc. Pyrolytic carbon and metal/metalloid carbide composites
SE9904569L (sv) 1999-12-14 2001-05-14 Jcl Technic Ab Kärlventil, såsom hjärtklaff,samt förfarande för dess framställning
EP1239795B1 (en) 1999-12-23 2006-12-06 Edwards Lifesciences Corporation Enhanced visualization of medical implants
NL1014095C2 (nl) 2000-01-17 2001-07-18 Cornelis Hendrikus Anna Witten Implantaatklep voor implantatie in een bloedvat.
JP2003520645A (ja) 2000-01-25 2003-07-08 エドワーズ ライフサイエンシーズ コーポレイション 人工心臓弁上での組織の過剰増殖を予防する生物活性コーティング
NZ520462A (en) 2000-01-27 2004-08-27 3F Therapeutics Inc Prosthetic heart valve
ES2286097T7 (es) 2000-01-31 2009-11-05 Cook Biotech, Inc Valvulas de endoprotesis.
US7296577B2 (en) 2000-01-31 2007-11-20 Edwards Lifescience Ag Transluminal mitral annuloplasty with active anchoring
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
EP1900343B1 (en) 2000-01-31 2015-10-21 Cook Biotech Incorporated Stent valves
EP1251803B1 (en) 2000-02-02 2005-06-01 Robert V. Snyders Artificial heart valve
AU3803801A (en) 2000-02-03 2001-08-14 Cook Inc Implantable vascular device
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
US6378221B1 (en) 2000-02-29 2002-04-30 Edwards Lifesciences Corporation Systems and methods for mapping and marking the thickness of bioprosthetic sheet
US20030208261A1 (en) 2000-03-03 2003-11-06 Thorpe Patricia E. Bulbous valve and stent for treating vascular reflux
US6679264B1 (en) 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
EP1261294B1 (en) 2000-03-10 2006-11-29 Paracor Medical, Inc. Expandable cardiac harness for treating congestive heart failure
US7037332B2 (en) 2000-03-15 2006-05-02 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence
US6537198B1 (en) 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
US6953476B1 (en) 2000-03-27 2005-10-11 Neovasc Medical Ltd. Device and method for treating ischemic heart disease
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
ITPC20000013A1 (it) 2000-04-13 2000-07-13 Paolo Ferrazzi Dispositivo endoventricolare e metodo relativo per il trattamento e la correzione di miocardiopatie.
EP1276439B1 (de) 2000-04-27 2010-03-24 Corlife GbR Individuelle venenklappenprothese
US8252044B1 (en) 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US8632583B2 (en) 2011-05-09 2014-01-21 Palmaz Scientific, Inc. Implantable medical device having enhanced endothelial migration features and methods of making the same
US6419695B1 (en) 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
NZ522752A (en) 2000-05-25 2004-08-27 Bioring S Device for shrinking or reinforcing the heart valvular orifices
US6902522B1 (en) 2000-06-12 2005-06-07 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
WO2002000099A2 (en) 2000-06-23 2002-01-03 Viacor Incorporated Automated annular plication for mitral valve repair
EP1512383B1 (en) 2000-06-26 2013-02-20 Rex Medical, L.P. A vascular system for valve leaflet apposition
US6695878B2 (en) 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
EP1401358B1 (en) 2000-06-30 2016-08-17 Medtronic, Inc. Apparatus for performing a procedure on a cardiac valve
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US7077861B2 (en) 2000-07-06 2006-07-18 Medtentia Ab Annuloplasty instrument
ES2249459T3 (es) 2000-07-11 2006-04-01 Alessandro Verona Biomaterial que incluye tejido de cornea animal.
DE10033858B4 (de) 2000-07-12 2006-01-26 Max Hauser Süddeutsche Chirurgiemechanik GmbH Vorrichtung zum Spreizen von Gewebe, Gewebeteilen, Organen, Knochen oder anderen Körperteilen bei chirurgischen Eingriffen in menschlichen oder tierischen Körpern
CA2415942C (en) 2000-07-12 2009-10-06 Edwards Lifesciences Corporation Method and apparatus for forming a heart valve wireform
US6409758B2 (en) 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
US7399271B2 (en) 2004-01-09 2008-07-15 Cardiokinetix, Inc. Ventricular partitioning device
US7862500B2 (en) 2002-08-01 2011-01-04 Cardiokinetix, Inc. Multiple partitioning devices for heart treatment
EP1179353A1 (de) 2000-08-11 2002-02-13 B. Braun Melsungen Ag Antithrombogene Implantate mit Beschichtung aus Polyphosphazenen und einem pharmakologisch aktiven Wirkstoff
EP1309360B1 (en) 2000-08-15 2006-04-19 SurModics, Inc. Medicament incorporation matrix
US6572652B2 (en) 2000-08-29 2003-06-03 Venpro Corporation Method and devices for decreasing elevated pulmonary venous pressure
US6458155B1 (en) 2000-09-01 2002-10-01 Edwards Lifesciences Corporation Fresh donor heart valve sizer and method of use
DE10046550A1 (de) 2000-09-19 2002-03-28 Adiam Life Science Ag Prothetische Mitral-Herzklappe
US8784482B2 (en) 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
US8956407B2 (en) 2000-09-20 2015-02-17 Mvrx, Inc. Methods for reshaping a heart valve annulus using a tensioning implant
ATE346571T1 (de) 2000-09-21 2006-12-15 St Jude Medical Ventilprothesen mit blattelementen aus verstärktem kunststoff
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
US6602288B1 (en) 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6616684B1 (en) 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
ATE292939T1 (de) 2000-10-30 2005-04-15 Childrens Medical Center Aus gewebe hergestellte gefässstrukturen
WO2002039908A2 (en) 2000-11-16 2002-05-23 Hill J Donald Automatic suture fixation apparatus and method
WO2002041789A2 (en) 2000-11-21 2002-05-30 Rex Medical, L.P. Percutaneous aortic valve
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
DE10060660A1 (de) 2000-12-06 2002-06-20 Frey Rainer Verfahren zur Konservierung von biologischen Prothesen, konservierte biologische Prothese und Konservierungslösung
US20040093075A1 (en) 2000-12-15 2004-05-13 Titus Kuehne Stent with valve and method of use thereof
DE10064948C1 (de) 2000-12-20 2002-07-11 Auto Tissue Gmbh Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens
US6964682B2 (en) 2000-12-21 2005-11-15 Edwards Lifesciences Corporation Heart valve holder that resist suture looping
DE10065824B4 (de) 2000-12-28 2018-10-31 Jotec Gmbh Endovaskulärer Stent zur Implantation in den aufsteigenden Ast der Aorta
US7591826B2 (en) 2000-12-28 2009-09-22 Cardiac Dimensions, Inc. Device implantable in the coronary sinus to provide mitral valve therapy
EP1355590B1 (en) 2001-01-30 2008-12-10 Edwards Lifesciences AG Medical system for remodeling an extravascular tissue structure
US6955689B2 (en) 2001-03-15 2005-10-18 Medtronic, Inc. Annuloplasty band and method
US6503272B2 (en) 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
DE60104647T2 (de) 2001-03-27 2005-08-11 William Cook Europe Aps Gefässtransplantat für die Aorta
EP1383448B1 (en) 2001-03-29 2008-06-04 Viacor, Inc. Apparatus for improving mitral valve function
CA2821193C (en) 2001-04-27 2015-09-08 Satterfield, Richard C. Prevention of myocardial infarction induced ventricular expansion and remodeling
AU2002338528B2 (en) 2001-05-02 2008-01-24 Nicox S.A. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
US6800090B2 (en) 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6676702B2 (en) 2001-05-14 2004-01-13 Cardiac Dimensions, Inc. Mitral valve therapy assembly and method
US6858039B2 (en) 2002-07-08 2005-02-22 Edwards Lifesciences Corporation Mitral valve annuloplasty ring having a posterior bow
ITMI20011012A1 (it) 2001-05-17 2002-11-17 Ottavio Alfieri Protesi anulare per valvola mitrale
AU2002259297B2 (en) 2001-05-24 2006-02-02 Chase Medical, L.P. Apparatus, kit, and method for use during ventricular restoration
GB0113121D0 (en) 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
CA2446596C (en) 2001-06-08 2010-03-30 Rex Medical, L.P. Vascular device with valve for approximating vessel wall
EP1266641B1 (en) 2001-06-11 2004-10-06 SORIN BIOMEDICA CARDIO S.p.A. An annuloplasty prosthesis and a method for its manufacture
NL1018302C1 (nl) 2001-06-15 2002-07-17 Eric Berreklouw Applicator voor een prothese, samenstel omvattende een dergelijke applicator alsmede spanstelsel voor het laden van een dergelijke applicator.
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
EP1408882B1 (en) 2001-07-26 2009-02-11 3F Therapeutics, Inc Method of cutting material for use in implantable medical device
FR2828091B1 (fr) 2001-07-31 2003-11-21 Seguin Jacques Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US20040249443A1 (en) 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
US6726716B2 (en) 2001-08-24 2004-04-27 Edwards Lifesciences Corporation Self-molding annuloplasty ring
US6675809B2 (en) 2001-08-27 2004-01-13 Richard S. Stack Satiation devices and methods
US6845776B2 (en) 2001-08-27 2005-01-25 Richard S. Stack Satiation devices and methods
US6908482B2 (en) 2001-08-28 2005-06-21 Edwards Lifesciences Corporation Three-dimensional annuloplasty ring and template
US6716158B2 (en) 2001-09-07 2004-04-06 Mardil, Inc. Method and apparatus for external stabilization of the heart
US6562069B2 (en) 2001-09-19 2003-05-13 St. Jude Medical, Inc. Polymer leaflet designs for medical devices
US7060023B2 (en) 2001-09-25 2006-06-13 The Foundry Inc. Pericardium reinforcing devices and methods of using them
US6695769B2 (en) 2001-09-25 2004-02-24 The Foundry, Inc. Passive ventricular support devices and methods of using them
EP1429690B1 (en) 2001-09-26 2006-11-29 Edwards Lifesciences Corporation Low-profile heart valve sewing ring
US6790237B2 (en) 2001-10-09 2004-09-14 Scimed Life Systems, Inc. Medical stent with a valve and related methods of manufacturing
CA2458595C (en) 2001-10-11 2007-12-04 Peter M. Wilson Bronchial flow control devices and methods of use
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US6893431B2 (en) 2001-10-15 2005-05-17 Scimed Life Systems, Inc. Medical device for delivering patches
US6923936B2 (en) 2001-10-23 2005-08-02 Medtronic Minimed, Inc. Sterile device and method for producing same
CA2464757A1 (en) 2001-11-07 2003-05-15 4Sc Ag Selective antibacterial agents
US6805710B2 (en) 2001-11-13 2004-10-19 Edwards Lifesciences Corporation Mitral valve annuloplasty ring for molding left ventricle geometry
US20050177180A1 (en) 2001-11-28 2005-08-11 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
US7871430B2 (en) 2001-11-29 2011-01-18 Cook Incorporated Medical device delivery system
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
JP4230915B2 (ja) 2001-12-21 2009-02-25 シムチャ ミロ 輪状形成リング用移植システム
EP2181669A3 (en) 2001-12-28 2011-11-23 Edwards Lifesciences AG Device for treating mitral insufficiency
US7189258B2 (en) 2002-01-02 2007-03-13 Medtronic, Inc. Heart valve system
US6756449B2 (en) 2002-02-27 2004-06-29 Medtronic, Inc. AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods
US7048754B2 (en) 2002-03-01 2006-05-23 Evalve, Inc. Suture fasteners and methods of use
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US6719786B2 (en) 2002-03-18 2004-04-13 Medtronic, Inc. Flexible annuloplasty prosthesis and holder
ATE518501T1 (de) 2002-03-27 2011-08-15 Sorin Biomedica Cardio Srl Annuloplastieprothese mit perforiertem element
NL1020288C1 (nl) 2002-04-02 2003-05-07 Eric Berreklouw Samenstel omvattende een stabilisator en een in of rondom een door lichaamsweefsel, omgeven doorgang te positioneren instrument.
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
ATE407709T1 (de) 2002-04-09 2008-09-15 Numat As Medizinische prothesevorrichtungen mit verbesserer biokompatibilität
US7108685B2 (en) 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
US7160320B2 (en) 2002-04-16 2007-01-09 The International Heart Institute Of Montana Foundation Reed valve for implantation into mammalian blood vessels and heart with optional temporary or permanent support
FR2838631B1 (fr) 2002-04-23 2004-12-24 Engeneering And Technological Procede de realisation d'une prothese de valve cardiaque aortique ou mitrale et prothese de valve cardiaque aortique ou mitrale ainsi obtenue
US6761735B2 (en) 2002-04-25 2004-07-13 Medtronic, Inc. Heart valve fixation process and apparatus
ES2318130T3 (es) 2002-05-08 2009-05-01 Cardiac Dimensions, Inc. Dispositivo para modificar la forma de una valvula mitral.
US7351256B2 (en) 2002-05-10 2008-04-01 Cordis Corporation Frame based unidirectional flow prosthetic implant
US7485141B2 (en) 2002-05-10 2009-02-03 Cordis Corporation Method of placing a tubular membrane on a structural frame
US20030225447A1 (en) 2002-05-10 2003-12-04 Majercak David Christopher Method of making a medical device having a thin wall tubular membrane over a structural frame
DE10221076A1 (de) 2002-05-11 2003-11-27 Ruesch Willy Gmbh Stent
RU2341296C2 (ru) 2002-05-24 2008-12-20 Энджиотек Интернэшнл Аг Композиции и способы покрытия медицинских имплантатов
US20050107811A1 (en) 2002-06-13 2005-05-19 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US6986775B2 (en) 2002-06-13 2006-01-17 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20060122633A1 (en) 2002-06-13 2006-06-08 John To Methods and devices for termination
US7578843B2 (en) 2002-07-16 2009-08-25 Medtronic, Inc. Heart valve prosthesis
US7172625B2 (en) 2002-07-16 2007-02-06 Medtronic, Inc. Suturing rings for implantable heart valve prostheses
ATE407629T1 (de) 2002-07-26 2008-09-15 Emphasys Medical Inc Bronchiale durchflussvorrichtung mit einer membranabdichtung
DE10235237A1 (de) 2002-08-01 2004-02-12 Symetis Ag In-vitro-Verfahren zum Herstellen einer homologen "gestenteten" Tissue eingineerten Herzklappe
EP1545371B1 (en) 2002-08-01 2016-04-13 Robert A. Levine Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation
DE10362367B3 (de) 2002-08-13 2022-02-24 Jenavalve Technology Inc. Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen
DE10301026B4 (de) 2002-08-13 2014-10-30 Jenavalve Technology Inc. Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen
AU2003265468B2 (en) 2002-08-15 2009-01-08 Cook Medical Technologies Llc Implantable vascular device
AU2003265477B2 (en) 2002-08-15 2009-08-13 Cook Medical Technologies Llc Stent and method of forming a stent with integral barbs
CA2503258C (en) 2002-08-28 2011-08-16 Heart Leaflet Technologies, Inc. Method and device for treating diseased valve
US7455690B2 (en) 2002-08-29 2008-11-25 Mitralsolutions, Inc. Methods for controlling the internal circumference of an anatomic orifice or lumen
KR100442330B1 (ko) 2002-09-03 2004-07-30 주식회사 엠아이텍 스텐트 및 이 스텐트의 제조방법
DE10242154A1 (de) 2002-09-05 2004-03-18 Sievers, Hans-Heinrich, Prof.Dr. Gefäßprothese, insbesondere zum Ersatz der Aorta ascendens
US7137184B2 (en) 2002-09-20 2006-11-21 Edwards Lifesciences Corporation Continuous heart valve support frame and method of manufacture
CO5500017A1 (es) 2002-09-23 2005-03-31 3F Therapeutics Inc Valvula mitral protesica
CN100553590C (zh) 2002-10-01 2009-10-28 安普尔医药公司 修整心瓣体环的装置
WO2004032724A2 (en) 2002-10-10 2004-04-22 The Cleveland Clinic Foundation Method and apparatus for replacing a mitral valve with a stentless bioprosthetic valve having chordae
AU2003295380A1 (en) 2002-11-12 2004-06-03 Myocor, Inc. Devices and methods for heart valve treatment
WO2004043293A2 (en) 2002-11-13 2004-05-27 Viacor, Inc. Cardiac valve procedure methods and devices
ATE439809T1 (de) 2002-11-27 2009-09-15 Carag Ag Implantat zum verschliessen einer kírperíffnung
FR2847800B1 (fr) 2002-11-28 2005-10-14 Perouse Laboratoires Valve prothetique interchangeable
GB0229274D0 (en) 2002-12-16 2003-01-22 Anson Medical Ltd Instrument for testing pulsatile endurance of vascular implants
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
WO2004066805A2 (en) 2003-01-27 2004-08-12 Corassist Cardiovascular Ltd. In vivo device for improving diastolic ventricular function
EP1610752B1 (en) 2003-01-31 2013-01-02 Boston Scientific Limited Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same
GB2398245B (en) 2003-02-06 2007-03-28 Great Ormond Street Hospital F Valve prosthesis
PT1444993E (pt) 2003-02-10 2007-01-31 Heraeus Gmbh W C Liga metálica melhorada para dispositivos médicos e implantes
US7077801B2 (en) 2003-02-19 2006-07-18 Corlife Gbr Methods and devices for improving cardiac output
US20040254600A1 (en) 2003-02-26 2004-12-16 David Zarbatany Methods and devices for endovascular mitral valve correction from the left coronary sinus
ES2325016T3 (es) 2003-02-28 2009-08-24 Edward G. Shifrin Corrector extravenoso para la reparacion de valvulas venosas insuficientes.
US20040220655A1 (en) 2003-03-03 2004-11-04 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
ATE452601T1 (de) 2003-03-12 2010-01-15 Cook Inc Herzklappenprothese, welche rückfluss zulässt
US7381210B2 (en) 2003-03-14 2008-06-03 Edwards Lifesciences Corporation Mitral valve repair system and method for use
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
EP1605871B1 (en) 2003-03-20 2008-07-23 Aortech International PLC Valve
CH696185A5 (fr) 2003-03-21 2007-02-15 Afksendiyos Kalangos Dispositif de renfort intraparietal pour prothèse biologique et prothèse biologique renforcée.
KR100466839B1 (ko) 2003-03-28 2005-01-17 주식회사 사이언씨티 대동맥판막 성형기구 세트 및 이를 이용한 치료방법
US7871434B2 (en) 2003-04-01 2011-01-18 Cook Incorporated Percutaneously deployed vascular valves
DE602004024972D1 (de) 2003-04-08 2010-02-25 Cook Inc Intraluminale stützvorrichtung mit graft
US7530995B2 (en) 2003-04-17 2009-05-12 3F Therapeutics, Inc. Device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US7159593B2 (en) 2003-04-17 2007-01-09 3F Therapeutics, Inc. Methods for reduction of pressure effects of cardiac tricuspid valve regurgitation
US8221492B2 (en) 2003-04-24 2012-07-17 Cook Medical Technologies Artificial valve prosthesis with improved flow dynamics
ATE531338T1 (de) 2003-04-28 2011-11-15 Kips Bay Medical Inc Elastisches venöses implantat
GB0309616D0 (en) 2003-04-28 2003-06-04 Angiomed Gmbh & Co Loading and delivery of self-expanding stents
DE602004018059D1 (de) 2003-04-30 2009-01-15 Medtronic Vascular Inc Perivaskulares Reparatursystem für Leckagen
DE602004023350D1 (de) 2003-04-30 2009-11-12 Medtronic Vascular Inc Perkutaneingesetzte provisorische Klappe
JP4444918B2 (ja) 2003-05-15 2010-03-31 学校法人早稲田大学 脱細胞化方法及び生体組織処理装置
DE10322024A1 (de) 2003-05-16 2004-12-02 Symetis Ag Bioreaktor zum Herstellen einer Gewebeprothese, insbesondere Herzklappe
EP2191790A3 (en) 2003-05-19 2012-10-17 SeptRx, Inc. Tissue distention device and related methods for therapeutic intervention
EP1626681B1 (en) 2003-05-19 2009-07-01 Cook Incorporated Implantable medical device with constrained expansion
WO2004103223A1 (en) 2003-05-20 2004-12-02 The Cleveland Clinic Foundation Apparatus and methods for repair of a cardiac valve
US7520947B2 (en) 2003-05-23 2009-04-21 Ati Properties, Inc. Cobalt alloys, methods of making cobalt alloys, and implants and articles of manufacture made therefrom
ATE481057T1 (de) 2003-05-28 2010-10-15 Cook Inc Ventilprothese mit gefässbefestigungsvorrichtung
US7445593B2 (en) 2003-06-18 2008-11-04 The Texas A&M University System Device for proactive modulation of cardiac strain patterns
US6974862B2 (en) 2003-06-20 2005-12-13 Kensey Nash Corporation High density fibrous polymers suitable for implant
CN1849102B (zh) 2003-07-08 2011-01-19 文托技术有限公司 用于主动脉瓣狭窄治疗中通过动脉输送的可植入式修复装置及其方法
US7201772B2 (en) 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
NZ527025A (en) 2003-07-16 2007-01-26 David Peter Shaw Prosthetic valves for medical application
IES20030531A2 (en) 2003-07-17 2005-09-21 Medtronic Vascular Connaught Methods and devices for placing a fistula device in fluid communication with a target vessel
EP1646332B1 (en) 2003-07-18 2015-06-17 Edwards Lifesciences AG Remotely activated mitral annuloplasty system
ATE442107T1 (de) 2003-07-21 2009-09-15 Univ Pennsylvania Perkutane herzklappe
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
DE10334868B4 (de) 2003-07-29 2013-10-17 Pfm Medical Ag Implantierbare Einrichtung als Organklappenersatz, dessen Herstellungsverfahren sowie Grundkörper und Membranelement dafür
WO2005011534A1 (en) 2003-07-31 2005-02-10 Cook Incorporated Prosthetic valve devices and methods of making such devices
FR2858543B1 (fr) 2003-08-08 2006-02-03 Assist Publ Hopitaux De Paris Anneau aortique et ancillaire pour sa pose
WO2005016400A1 (en) 2003-08-14 2005-02-24 Blue Medical Devices B.V. Endoluminal prosthesis comprising a therapeutic agent
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
DE10340265A1 (de) 2003-08-29 2005-04-07 Sievers, Hans-Hinrich, Prof. Dr.med. Prothese zum Ersatz der Aorten- und/oder Mitralklappe des Herzens
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20050075725A1 (en) 2003-10-02 2005-04-07 Rowe Stanton J. Implantable prosthetic valve with non-laminar flow
BRPI0414870A (pt) 2003-10-03 2006-11-28 Edwards Lifesciences Corp anéis de anuloplastia para reparo de válvulas mitrais anormais
US7842084B2 (en) 2005-06-21 2010-11-30 3F Therapeutics, Inc. Method and systems for sizing, folding, holding, and delivering a heart valve prosthesis
US20050075713A1 (en) 2003-10-06 2005-04-07 Brian Biancucci Minimally invasive valve replacement system
US20060259137A1 (en) 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
EP3821852A3 (en) 2003-10-06 2021-09-22 Medtronic 3F Therapeutics, Inc. Minimally invasive valve replacement system
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US10219899B2 (en) 2004-04-23 2019-03-05 Medtronic 3F Therapeutics, Inc. Cardiac valve replacement systems
US7604650B2 (en) 2003-10-06 2009-10-20 3F Therapeutics, Inc. Method and assembly for distal embolic protection
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
CA2542658A1 (en) 2003-10-17 2005-05-06 Edwards Lifesciences Ag Heart valve leaflet locator
ITBO20030631A1 (it) 2003-10-23 2005-04-24 Roberto Erminio Parravicini Apparecchiatura protesica valvolare, in particolare per applicazioni cardiache.
US7070616B2 (en) 2003-10-31 2006-07-04 Cordis Corporation Implantable valvular prosthesis
US7347869B2 (en) 2003-10-31 2008-03-25 Cordis Corporation Implantable valvular prosthesis
SE526861C2 (sv) 2003-11-17 2005-11-15 Syntach Ag Vävnadslesionsskapande anordning samt en uppsättning av anordningar för behandling av störningar i hjärtrytmregleringssystemet
CN100556469C (zh) 2003-12-03 2009-11-04 梅奥医学教育和研究基金会 用于磁性地为医疗器械涂覆活细胞的套件和设备
ES2661071T3 (es) 2003-12-04 2018-03-27 Boston Scientific Scimed, Inc. Sistema de suministro de un dispositivo de contención de orejuela auricular izquierda
WO2005062837A2 (en) 2003-12-19 2005-07-14 Cardiac Dimensions, Inc. Device for modifying the shape of a body organ
WO2005058210A1 (en) 2003-12-19 2005-06-30 Patrick Leahy An anti-reflux system
US20050137696A1 (en) 2003-12-23 2005-06-23 Sadra Medical Apparatus and methods for protecting against embolization during endovascular heart valve replacement
WO2005062980A2 (en) 2003-12-23 2005-07-14 Sadra Medical, Inc. Repositionable heart valve
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
PT2749254E (pt) 2003-12-23 2015-10-16 Boston Scient Scimed Inc Válvula cardíaca reposicionável
US8246675B2 (en) 2003-12-23 2012-08-21 Laboratoires Perouse Kit for implanting in a duct
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
EP2745805B2 (en) 2003-12-23 2022-05-18 Boston Scientific Scimed, Inc. Repositionable heart valve
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
EP1557138B1 (de) 2004-01-21 2012-12-05 Admedes Schuessler GmbH Expandierbarer Stent mit Koppeleinrichtung
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
US7597711B2 (en) 2004-01-26 2009-10-06 Arbor Surgical Technologies, Inc. Heart valve assembly with slidable coupling connections
CA2554595C (en) 2004-02-03 2016-03-29 Atria Medical Inc. Device and method for controlling in-vivo pressure
EP1561437B1 (en) 2004-02-06 2009-10-28 Sangomed S.R.L. External support for restoring competence to venous valves by traction of their intercommissural walls
EP1727499B1 (en) 2004-02-20 2012-06-13 Cook Medical Technologies LLC Prosthetic valve with spacing member
US8206439B2 (en) 2004-02-23 2012-06-26 International Heart Institute Of Montana Foundation Internal prosthesis for reconstruction of cardiac geometry
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
EP2368525B1 (en) 2004-03-08 2019-09-18 Pulmonx, Inc Implanted bronchial isolation devices
AU2005221234C1 (en) 2004-03-11 2009-10-29 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
US8777974B2 (en) 2004-03-19 2014-07-15 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
NL1025830C2 (nl) 2004-03-26 2005-02-22 Eric Berreklouw Samenstel omvattende een ring voor bevestiging in een door lichaamsweefsel omgeven doorgang alsmede een applicator voor het in de doorgang plaatsen van de ring.
US20050228494A1 (en) 2004-03-29 2005-10-13 Salvador Marquez Controlled separation heart valve frame
JP4838709B2 (ja) 2004-03-30 2011-12-14 トーヨーエイテック株式会社 基材の製造方法
JP2007530244A (ja) 2004-03-31 2007-11-01 メッド・インスティテュート・インコーポレイテッド 人工弁を有する腔内グラフト
US7993397B2 (en) 2004-04-05 2011-08-09 Edwards Lifesciences Ag Remotely adjustable coronary sinus implant
US7294148B2 (en) 2004-04-29 2007-11-13 Edwards Lifesciences Corporation Annuloplasty ring for mitral valve prolapse
NL1026076C2 (nl) 2004-04-29 2005-11-01 Univ Eindhoven Tech Vormdeel vervaardigd door middel van elektro-spinnen en een werkwijze voor de vervaardiging daarvan evenals de toepassing van een dergelijk vormdeel.
WO2005107862A1 (en) 2004-04-30 2005-11-17 Flea Street Translational, Llc Methods and devices for modulation of heart valve function
ES2407684T3 (es) 2004-05-05 2013-06-13 Direct Flow Medical, Inc. Válvula cardiaca sin estent con estructura de soporte formada en el sitio
US8052748B2 (en) 2004-05-14 2011-11-08 St. Jude Medical, Inc. Systems and methods for holding annuloplasty rings
EP3628239B1 (en) 2004-05-14 2022-04-27 Evalve, Inc. Locking mechanisms for fixation devices for engaging tissue
US7785615B2 (en) 2004-05-28 2010-08-31 Cordis Corporation Biodegradable medical implant with encapsulated buffering agent
US7803182B2 (en) 2004-05-28 2010-09-28 Cordis Corporation Biodegradable vascular device with buffering agent
WO2006007401A2 (en) 2004-06-16 2006-01-19 Machine Solutions, Inc. Tissue prothesis processing technology
EP1913900A1 (de) 2004-06-29 2008-04-23 SIEVERS, Hans-Hinrich, Dr. Ringprothese für Anuloplastie
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
JP4896014B2 (ja) 2004-07-15 2012-03-14 ミカルディア・コーポレーション 心臓の解剖学的構造を再成形するための磁気装置および方法
WO2006023175A2 (en) 2004-07-19 2006-03-02 St. Jude Medical, Inc. Heart valve support and lid liner system and methods
US7585369B2 (en) 2004-08-04 2009-09-08 Larson Marian L Apparatus for coating medical devices
EP1786367B1 (en) 2004-08-27 2013-04-03 Cook Medical Technologies LLC Placement of multiple intraluminal medical devices within a body vessel
EP1791495B2 (en) 2004-09-01 2022-06-01 Cook Medical Technologies LLC Delivery system which facilitates hydration of an intraluminal medical device
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
FR2874812B1 (fr) 2004-09-07 2007-06-15 Perouse Soc Par Actions Simpli Valve protheique interchangeable
FR2874813B1 (fr) 2004-09-07 2007-06-22 Perouse Soc Par Actions Simpli Prothese valvulaire
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
US20060135962A1 (en) 2004-09-09 2006-06-22 Kick George F Expandable trans-septal sheath
AU2005284739B2 (en) 2004-09-14 2011-02-24 Edwards Lifesciences Ag Device and method for treatment of heart valve regurgitation
JP5124274B2 (ja) 2004-09-27 2013-01-23 エヴァルヴ インコーポレイテッド 組織の把持および評価のための方法および装置
US8182530B2 (en) 2004-10-02 2012-05-22 Christoph Hans Huber Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
CA2581763A1 (en) 2004-10-13 2006-04-27 Medtronic, Inc. Self-fixating implantable scaffolds for the administration of biological or pharmaceutical substances
US20060079736A1 (en) 2004-10-13 2006-04-13 Sing-Fatt Chin Method and device for percutaneous left ventricular reconstruction
EP1833425B1 (en) 2004-12-01 2011-02-23 Cook Incorporated Sensing delivery system for intraluminal medical devices
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
US7758640B2 (en) 2004-12-16 2010-07-20 Valvexchange Inc. Cardiovascular valve assembly
US7674238B2 (en) 2004-12-23 2010-03-09 Boston Scientific Scimed, Inc. Methods and apparatus for emboli removal
EA200701377A1 (ru) 2004-12-24 2008-02-28 Селксел Пти Лтд. Имплантируемый биоматериал и способ его получения
US8287583B2 (en) 2005-01-10 2012-10-16 Taheri Laduca Llc Apparatus and method for deploying an implantable device within the body
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
AU2006212750B2 (en) 2005-02-07 2011-11-17 Evalve, Inc. Methods, systems and devices for cardiac valve repair
WO2011034973A2 (en) 2005-02-07 2011-03-24 Abbott Vascular Methods, systems and devices for cardiac valve repair
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
ITTO20050074A1 (it) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl Protesi valvola cardiaca
EP1693025A1 (en) 2005-02-17 2006-08-23 Universität Zürich Method of manufacturing a tissue-engineered prosthesis
ES2558534T3 (es) 2005-02-18 2016-02-05 The Cleveland Clinic Foundation Aparato para sustituir una válvula cardíaca
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US20060195186A1 (en) 2005-02-28 2006-08-31 Drews Michael J Connectors for two piece heart valves and methods for implanting such heart valves
US7955385B2 (en) 2005-02-28 2011-06-07 Medtronic Vascular, Inc. Device, system, and method for aiding valve annuloplasty
CN101340861B (zh) 2005-02-28 2011-08-10 梅德坦提亚国际有限公司 用于改善心脏瓣膜功能的装置和成套工具
EP1863546B1 (en) 2005-03-11 2015-10-07 Wake Forest University Health Sciences Production of tissue engineered heart valves
FR2882916B1 (fr) 2005-03-14 2007-06-15 Assist Publ Hopitaux De Paris Dispositif de mesure du diametre d'un panneau aortique
WO2006102063A2 (en) 2005-03-19 2006-09-28 Cook Biotech Incorporated Prosthetic implants including ecm composite material
KR100691503B1 (ko) 2005-03-21 2007-03-09 (주) 태웅메디칼 식도용 스텐트
US7842085B2 (en) 2005-03-23 2010-11-30 Vaso Adzich Annuloplasty ring and holder combination
US7575595B2 (en) 2005-03-23 2009-08-18 Edwards Lifesciences Corporation Annuloplasty ring and holder combination
US7736385B2 (en) 2005-03-24 2010-06-15 Cook Incorporated Exchangeable delivery system with distal protection
EP2767260B1 (en) 2005-03-25 2019-07-03 St. Jude Medical, Cardiology Division, Inc. Apparatus for controlling the internal circumference of an anatomic orifice or lumen
FR2883721B1 (fr) 2005-04-05 2007-06-22 Perouse Soc Par Actions Simpli Necessaire destine a etre implante dans un conduit de circulation du sang, et endoprothese tubulaire associee
US8062359B2 (en) 2005-04-06 2011-11-22 Edwards Lifesciences Corporation Highly flexible heart valve connecting band
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
SE531468C2 (sv) 2005-04-21 2009-04-14 Edwards Lifesciences Ag En anordning för styrning av blodflöde
WO2006116761A2 (en) 2005-04-27 2006-11-02 Stout Medical Group, L.P. Expandable support device and methods of use
EP1719476B1 (en) 2005-05-06 2011-11-23 Sorin Biomedica Cardio S.R.L. Annuloplasty prosthesis
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
CA2608347A1 (en) 2005-05-13 2006-11-23 Cook Incorporated Medical device delivery systems that facilitate medical device placement in the presence of ultrasonic waves
EP2151216B1 (en) 2005-05-17 2013-03-13 Syntach AG A device for treatment of disorders in the heart rhythm regulation system
WO2006125055A2 (en) 2005-05-17 2006-11-23 Cook Incorporated Prosthetic valve devices and methods of making and using such devices
US8500798B2 (en) 2005-05-24 2013-08-06 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US8663312B2 (en) 2005-05-27 2014-03-04 Hlt, Inc. Intravascular cuff
EP1895942B1 (en) 2005-05-27 2020-05-13 Medtronic, Inc. Gasket with collar for prosthetic heart valves
EP3072475B1 (en) 2005-05-27 2018-10-03 HLT, Inc. Stentless support structure
US7739971B2 (en) 2005-06-07 2010-06-22 Edwards Lifesciences Corporation Systems and methods for assembling components of a fabric-covered prosthetic heart valve
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US8685083B2 (en) 2005-06-27 2014-04-01 Edwards Lifesciences Corporation Apparatus, system, and method for treatment of posterior leaflet prolapse
US8663277B2 (en) 2005-06-29 2014-03-04 Ethicon, Inc. Braided barbed suture
DE602006017383D1 (de) 2005-07-08 2010-11-18 Beijing Balance Medical Co Ltd Klappenstück und schlauch mit ventilklappe zur rep
US7682391B2 (en) 2005-07-13 2010-03-23 Edwards Lifesciences Corporation Methods of implanting a prosthetic mitral heart valve having a contoured sewing ring
EP1919397B1 (en) 2005-07-13 2013-01-02 Medtronic, Inc. Two-piece percutaneous prosthetic heart valves
DE102005032974B4 (de) 2005-07-14 2013-11-07 Siemens Aktiengesellschaft Verfahren zur 3D-Visualisierung vaskulärer Einsatzstücke im menschlichen Körper mit dem C-Bogen
DE602006009113D1 (de) 2005-07-15 2009-10-22 Cleveland Clinic Foundation Vorrichtung zur Ummodellierung eines Herzklappenrings
US8790396B2 (en) 2005-07-27 2014-07-29 Medtronic 3F Therapeutics, Inc. Methods and systems for cardiac valve delivery
US20070027528A1 (en) 2005-07-29 2007-02-01 Cook Incorporated Elliptical implantable device
EP1912697B1 (en) 2005-07-29 2016-09-14 CVDevices, LLC. Devices and methods for controlling blood perfusion pressure using a retrograde cannula
EP1933756B1 (en) 2005-08-19 2016-07-20 CHF Technologies Inc. Steerable lesion excluding heart implants for congestive heart failure
US7455689B2 (en) 2005-08-25 2008-11-25 Edwards Lifesciences Corporation Four-leaflet stented mitral heart valve
US9492277B2 (en) 2005-08-30 2016-11-15 Mayo Foundation For Medical Education And Research Soft body tissue remodeling methods and apparatus
EP1928512B1 (en) 2005-09-01 2012-11-14 Cook Medical Technologies LLC Attachment of material to an implantable frame by cross-linking
JP4958907B2 (ja) 2005-09-07 2012-06-20 メドテンチア インターナショナル エルティーディ オーワイ 心臓弁の機能を改善するための機器および方法
US7530253B2 (en) 2005-09-09 2009-05-12 Edwards Lifesciences Corporation Prosthetic valve crimping device
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
DE102005044009A1 (de) 2005-09-14 2007-03-22 Biophan Europe Gmbh Biologische oder künstliche Klappenprothese zur Verwendung im menschlichen und/oder tierischen Körper zum Einsatz einer Organklappe oder Gefäßklappe
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
CA2622433A1 (en) 2005-09-21 2007-04-05 Medtronic, Inc. Composite heart valve apparatus manufactured using techniques involving laser machining of tissue
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
EP1945142B1 (en) 2005-09-26 2013-12-25 Medtronic, Inc. Prosthetic cardiac and venous valves
US20070073391A1 (en) 2005-09-28 2007-03-29 Henry Bourang System and method for delivering a mitral valve repair device
FR2891134B1 (fr) 2005-09-29 2008-08-22 Jean Noel Fabiani Prothese annulaire pour plastie valvulaire aortique, procede pour plastie valvulaire aortique et combinaison de la prothese annulaire et d'une prothese pour segment aortique
US8048152B2 (en) 2005-09-30 2011-11-01 Medtronic, Inc. Method of implanting an annuloplasty prosthesis
US9265605B2 (en) 2005-10-14 2016-02-23 Boston Scientific Scimed, Inc. Bronchoscopic lung volume reduction valve
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US7503928B2 (en) 2005-10-21 2009-03-17 Cook Biotech Incorporated Artificial valve with center leaflet attachment
US8092525B2 (en) 2005-10-26 2012-01-10 Cardiosolutions, Inc. Heart valve implant
EP1951154B1 (en) 2005-10-26 2018-01-24 St. Jude Medical, Inc. Saddle-shaped mitral valve annuloplasty prostheses
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
EP1951155B1 (en) 2005-11-02 2021-05-12 MedicalTree Patents Ltd. Artificial valve for implantation
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
FR2892939B1 (fr) 2005-11-10 2010-01-22 Groupement Coeur Artificiel Total Carpentier Matra Carmat Materiau hemocompatible composite et son procede d'obtention
WO2007058857A2 (en) 2005-11-10 2007-05-24 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
CN100362971C (zh) 2005-11-16 2008-01-23 程英升 贲门支架
DE602006006394D1 (de) 2005-11-16 2009-06-04 Micardia Corp Magnetische Befestigung eines Katheters an ein Implantat
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
GB0524087D0 (en) 2005-11-25 2006-01-04 Symetis Ag Biodegradable scaffold
FR2894131B1 (fr) 2005-12-02 2008-12-05 Perouse Soc Par Actions Simpli Dispositif de traitement d'un vaisseau sanguin, et necessaire de traitement associe.
CA2631662C (en) 2005-12-07 2014-08-05 Arbor Surgical Technologies, Inc. Connection systems for two piece prosthetic heart valve assemblies
US9125742B2 (en) 2005-12-15 2015-09-08 Georgia Tech Research Foundation Papillary muscle position control devices, systems, and methods
EP1959865B1 (en) 2005-12-15 2014-12-10 The Cleveland Clinic Foundation Apparatus for treating a regurgitant valve
ATE472985T1 (de) 2005-12-22 2010-07-15 Symetis Sa Stentventile als klappenersatz und relevante verfahren und operationssysteme
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
CA2634891C (en) 2005-12-23 2014-09-23 Vysera Biomedical Limited A medical device suitable for treating reflux from a stomach to an oesophagus
EP1803420B1 (en) 2005-12-28 2009-07-01 Sorin Biomedica Cardio S.R.L. Annuloplasty prosthesis with an auxetic structure
EP1968482B1 (en) 2006-01-04 2009-06-17 Nanopowers S.A. Artificial contractile tissue
US9717468B2 (en) 2006-01-10 2017-08-01 Mediguide Ltd. System and method for positioning an artificial heart valve at the position of a malfunctioning valve of a heart through a percutaneous route
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
EP1991168B1 (en) 2006-02-16 2016-01-27 Transcatheter Technologies GmbH Minimally invasive heart valve replacement
US8219229B2 (en) 2006-03-02 2012-07-10 Edwards Lifesciences Corporation Virtual heart valve
US7431692B2 (en) 2006-03-09 2008-10-07 Edwards Lifesciences Corporation Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ
DE102006013113B4 (de) 2006-03-22 2008-12-11 Vielberg, Heinrich, Dr. med. Ventilgetriebe
EP2004095B1 (en) 2006-03-28 2019-06-12 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
RU2325874C2 (ru) 2006-04-04 2008-06-10 Александр Васильевич Самков Протез клапана сердца
FR2899096B1 (fr) 2006-04-04 2008-12-05 Perouse Soc Par Actions Simpli Dispositif de traitement d'un conduit de circulation du sang et procede de preparation de ce dispositif
JP5198431B2 (ja) 2006-04-12 2013-05-15 メドトロニック ヴァスキュラー インコーポレイテッド 螺旋アンカを有する弁形成装置
US7806926B2 (en) 2006-04-14 2010-10-05 Edwards Lifesciences Corporation Holders for prosthetic aortic heart valves
US9707113B2 (en) 2006-04-19 2017-07-18 Cook Medical Technologies Llc Twin bifurcated stent graft
CN101442958B (zh) 2006-04-28 2012-09-05 麦德托尼克公司 心脏瓣膜替换设备
JP5016667B2 (ja) 2006-04-29 2012-09-05 メドトロニック，インコーポレイテッド 複数部材の人工心臓弁アセンブリ並びにそれを用いた装置及びその使用方法
WO2007130537A1 (en) 2006-05-05 2007-11-15 Children's Medical Center Corporation Transcatheter heart valve prostheses
CN101489503B (zh) 2006-05-15 2012-01-11 爱德华生命科学公司 用于改变心脏几何形状的系统和方法
AU2006343492A1 (en) 2006-05-17 2007-11-22 Syntach Ag A controllable device, a kit and a method for treatment of disorders in the heart rhythm regulation system
US8932348B2 (en) 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function
CA2654359A1 (en) 2006-05-19 2007-11-29 Mitralsolutions, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
AU2007268123A1 (en) 2006-05-25 2007-12-06 Deep Vein Medical, Inc. Device for regulating blood flow
EP2020958B1 (en) 2006-05-30 2012-05-30 Cook Medical Technologies LLC Artificial valve prosthesis
CA2652471C (en) 2006-06-01 2014-09-09 Edwards Lifesciences Corporation Prosthetic insert for improving heart valve function
EP2032079B1 (en) 2006-06-02 2015-08-12 Medtronic, Inc. Annuloplasty prosthesis with in vivo shape identification
CA2653358C (en) 2006-06-02 2012-03-13 Medtronic, Inc. Annuloplasty ring and method
ITTO20060413A1 (it) 2006-06-07 2007-12-08 Arrigo Lessana Dispositivo sostitutivo delle corde tendinee di una valvola atrioventricolare
EP1864687B1 (en) 2006-06-09 2013-07-31 Eidgenössische Technische Hochschule Zürich Scaffolds for artificial heart valves and vascular structures
US20080004696A1 (en) 2006-06-29 2008-01-03 Valvexchange Inc. Cardiovascular valve assembly with resizable docking station
JP4981374B2 (ja) 2006-07-10 2012-07-18 パーパス株式会社 細胞又は組織の培養装置及び培養方法
US20080021546A1 (en) 2006-07-18 2008-01-24 Tim Patz System for deploying balloon-expandable heart valves
RU2325873C2 (ru) 2006-07-20 2008-06-10 Александр Васильевич Самков Створка искусственного клапана сердца и способ ее изготовления
US8020503B2 (en) 2006-07-31 2011-09-20 Edwards Lifesciences Corporation Automated surgical implant sewing system and method
US7363821B2 (en) 2006-08-28 2008-04-29 Cordis Corporation Systems and methods for fatigue testing stents
US20080058924A1 (en) 2006-09-01 2008-03-06 Aaron Ingle Saddle-shaped annuloplasty ring
EP2063823B1 (en) 2006-09-01 2018-10-31 Carag AG Devices, system, kit and method for epicardial access
ATE470410T1 (de) 2006-09-08 2010-06-15 Edwards Lifesciences Corp Integriertes system zum einsatz eines herzventils
US8414643B2 (en) 2006-09-19 2013-04-09 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
FR2906454B1 (fr) 2006-09-28 2009-04-10 Perouse Soc Par Actions Simpli Implant destine a etre place dans un conduit de circulation du sang.
US9211115B2 (en) 2006-09-28 2015-12-15 Bioventrix, Inc. Location, time, and/or pressure determining devices, systems, and methods for deployment of lesion-excluding heart implants for treatment of cardiac heart failure and other disease states
US7534261B2 (en) 2006-10-02 2009-05-19 Edwards Lifesciences Corporation Sutureless heart valve attachment
US7575592B2 (en) 2006-10-03 2009-08-18 St. Jude Medical, Inc. Synthetic blood vessel grafts
US8029556B2 (en) 2006-10-04 2011-10-04 Edwards Lifesciences Corporation Method and apparatus for reshaping a ventricle
US8163011B2 (en) 2006-10-06 2012-04-24 BioStable Science & Engineering, Inc. Intra-annular mounting frame for aortic valve repair
FR2906998B1 (fr) 2006-10-16 2009-04-10 Perouse Soc Par Actions Simpli Implant destine a etre place dans un conduit de circulation du sang.
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
CA2666485C (en) 2006-10-27 2015-10-06 Edwards Lifesciences Corporation Biological tissue for surgical implantation
DE102006052564B3 (de) 2006-11-06 2007-12-13 Georg Lutter Mitralklappenstent
WO2008057568A1 (en) 2006-11-07 2008-05-15 William A. Cook Australia Pty. Ltd Fenestrations for stent graft arrangements and stent graft including the same
EP1920789A1 (en) 2006-11-11 2008-05-14 Universitätsklinikum Hamburg-Eppendorf Pouch-like construct comprising mammalian tissue
SE530568C2 (sv) 2006-11-13 2008-07-08 Medtentia Ab Anordning och metod för förbättring av funktionen hos en hjärtklaff
WO2008060553A1 (en) 2006-11-14 2008-05-22 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Transcatheter coronary sinus mitral valve annuloplasty procedure and coronary artery and myocardial protection device
JP2010511469A (ja) 2006-12-05 2010-04-15 バルテック カーディオ，リミティド セグメント化リング配置
EP2104470B1 (en) 2006-12-06 2022-10-26 Medtronic Corevalve, LLC. System and method for transapical delivery of an annulus anchored self-expanding valve
FR2909857B1 (fr) 2006-12-14 2009-03-06 Perouse Soc Par Actions Simpli Endovalve.
DE602006013167D1 (de) 2006-12-19 2010-05-06 Sorin Biomedica Cardio Srl Instrument zum in-situ-Einsetzen von Herzklappenprothesen
EP2954876B1 (en) 2006-12-19 2018-12-19 St. Jude Medical, Inc. Method of making a prosthetic heart valve including stent structure and tissue leaflets
US8057539B2 (en) 2006-12-19 2011-11-15 Sorin Biomedica Cardio S.R.L. System for in situ positioning of cardiac valve prostheses without occluding blood flow
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
FR2910269B1 (fr) 2006-12-22 2009-02-27 Corevalve Inc Materiel de traitement d'une valve cardiaque,en particulier d'une valve mitrale
US9107750B2 (en) 2007-01-03 2015-08-18 St. Jude Medical, Cardiology Division, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
EP1943942B1 (en) 2007-01-15 2010-01-06 Jen-Ping Chang Examining device for examining an aortic valve and a pulmonary valve competency
US9510943B2 (en) 2007-01-19 2016-12-06 Medtronic, Inc. Stented heart valve devices and methods for atrioventricular valve replacement
EP3488822B1 (en) 2007-01-26 2020-10-21 Medtronic, Inc. Annuloplasty device for tricuspid valve repair
DE102007005900A1 (de) 2007-02-01 2008-08-07 Endosmart Gesellschaft für innovative Medizintechnik mbH Instrument zum operativen Entfernen einer defekten Herzklappe
US9415567B2 (en) 2007-02-05 2016-08-16 Boston Scientific Scimed, Inc. Synthetic composite structures
JP5313928B2 (ja) 2007-02-05 2013-10-09 ボストン サイエンティフィック リミテッド 経皮的な弁およびシステム
WO2008097592A2 (en) 2007-02-05 2008-08-14 Boston Scientific Limited Synthetic composite structures
JP2010517624A (ja) 2007-02-05 2010-05-27 ボストン サイエンティフィック リミテッド 経皮的手技用の弁、システム及び方法
WO2008098226A1 (en) 2007-02-09 2008-08-14 Edwards Lifesciences Corporation Progressively sized annuloplasty rings
WO2008101113A1 (en) 2007-02-14 2008-08-21 Edwards Lifesciences Corporation Suture and method for repairing heart
ATE515244T1 (de) 2007-02-15 2011-07-15 Cook Inc Künstliche klappenprothese mit freiem blattabschnitt
EP2124826B2 (en) 2007-02-15 2020-09-23 Medtronic, Inc. Multi-layered stents
EP2117476B1 (de) 2007-02-16 2014-01-22 Universität Zürich Rohrförmige stützprothese mit herzklappe insbesondere für aortenklappenersatz
EP2129333B1 (en) 2007-02-16 2019-04-03 Medtronic, Inc Replacement prosthetic heart valves
EP1958598A1 (de) 2007-02-16 2008-08-20 Universität Zürich Wachstumsfähige, rohrförmige Stützprothese
DE102007010305A1 (de) 2007-02-22 2008-08-28 Jotec Gmbh Vorrichtung zum Freisetzen eines selbstexpandierenden Stents in ein Körpergefäß
US8221505B2 (en) 2007-02-22 2012-07-17 Cook Medical Technologies Llc Prosthesis having a sleeve valve
US20080208328A1 (en) 2007-02-23 2008-08-28 Endovalve, Inc. Systems and Methods For Placement of Valve Prosthesis System
US20080208327A1 (en) 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US8100959B2 (en) 2007-03-09 2012-01-24 Pulmonx Corporation Loading device for a pulmonary implant
US8303622B2 (en) 2007-03-14 2012-11-06 St. Jude Medical, Inc. Heart valve chordae replacement methods and apparatus
FR2913879B1 (fr) 2007-03-21 2009-06-12 Perouse Soc Par Actions Simpli Dispositif de largage d'un implant expansible radialement, necessaire de traitement et procede de largage associe
JP5114548B2 (ja) 2007-04-13 2013-01-09 イエナバルブ テクノロジー インク 心臓弁の機能不全または狭窄症を治療するための医療用デバイス
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US8409274B2 (en) 2007-04-26 2013-04-02 St. Jude Medical, Inc. Techniques for attaching flexible leaflets of prosthetic heart valves to supporting structures
US8529620B2 (en) 2007-05-01 2013-09-10 Ottavio Alfieri Inwardly-bowed tricuspid annuloplasty ring
FR2915678B1 (fr) 2007-05-02 2010-04-16 Lapeyre Ind Llc Valve cardiaque prothetique mecanique
US8147504B2 (en) 2007-05-05 2012-04-03 Medtronic, Inc. Apparatus and methods for delivering fasteners during valve replacement
FR2915903B1 (fr) 2007-05-10 2010-06-04 Carpentier Matra Carmat Procede pour la realisation d'un objet hemocompatible de configuration complexe et objet ainsi obtenu.
AU2008250552B2 (en) 2007-05-15 2012-03-08 Jenavalve Technology Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
US8403979B2 (en) 2007-05-17 2013-03-26 Cook Medical Technologies Llc Monocuspid prosthetic valve having a partial sinus
EP1994912B1 (en) 2007-05-21 2010-03-03 Berardino Della Sala Electromagnetically closable non-return valve for biological liquid pumps
FR2916627B1 (fr) 2007-05-30 2010-09-17 Perouse Lab Necessaire de traitement d'un conduit de circulation du sang
ES2788453T3 (es) 2007-06-04 2020-10-21 St Jude Medical Llc Válvulas cardíacas protésicas
FR2916959B1 (fr) 2007-06-08 2009-09-04 Perouse Soc Par Actions Simpli Necessaire destine a etre implante dans un conduit de circulation de sang
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
AU2008269018B2 (en) 2007-06-26 2014-07-31 St. Jude Medical, Inc. Apparatus and methods for implanting collapsible/expandable prosthetic heart valves
DE102007031146A1 (de) 2007-06-27 2009-01-08 Aesculap Ag Sinusflicken zum Ersatz von defekten Sinus an der Aortenwurzel
DE102007031148A1 (de) 2007-06-27 2009-01-08 Aesculap Ag Aortensinusprothese
DE602007009082D1 (de) 2007-07-12 2010-10-21 Sorin Biomedica Cardio Srl Komprimierungsvorrichtung für eine erweiterbare Herzklappenprothese
US9308086B2 (en) 2010-09-21 2016-04-12 Hocor Cardiovascular Technologies Llc Method and system for balloon counterpulsation during aortic valve replacement
US8663319B2 (en) 2007-07-23 2014-03-04 Hocor Cardiovascular Technologies Llc Methods and apparatus for percutaneous aortic valve replacement
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US9566178B2 (en) 2010-06-24 2017-02-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
EP3045147B8 (en) 2007-08-21 2017-05-31 Symetis SA A replacement valve
EP3075355A1 (en) 2007-08-23 2016-10-05 Direct Flow Medical, Inc. Translumenally implantable heart valve with formed in place support
JP5419875B2 (ja) 2007-08-24 2014-02-19 セント ジュード メディカル インコーポレイテッド 人工大動脈心臓弁
US8834551B2 (en) 2007-08-31 2014-09-16 Rex Medical, L.P. Vascular device with valve for approximating vessel wall
US8092363B2 (en) 2007-09-05 2012-01-10 Mardil, Inc. Heart band with fillable chambers to modify heart valve function
US20090105794A1 (en) 2007-09-07 2009-04-23 Ziarno W Andrew Microprocessor controlled delivery system for cardiac valve prosthesis
CN103393485B (zh) 2007-09-07 2016-08-10 爱德华兹生命科学公司 用于输送瓣环成形术环的活动支架
FR2920664B1 (fr) 2007-09-11 2010-09-10 Perouse Lab Dispositif de traitement d'un conduit de circulation du sang
FR2932376B1 (fr) 2008-06-11 2011-04-01 Perouse Lab Dispositif de traitement d'un conduit de circulation du sang
DE102007043830A1 (de) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Herzklappenstent
EP3245980B1 (en) 2007-09-26 2022-07-20 St. Jude Medical, LLC Collapsible prosthetic heart valves
JP5570993B2 (ja) 2007-10-12 2014-08-13 スピレーション インコーポレイテッド 弁装填具の方法、システム、および装置
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
WO2009052188A1 (en) 2007-10-15 2009-04-23 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
US20090105813A1 (en) 2007-10-17 2009-04-23 Sean Chambers Implantable valve device
US8647381B2 (en) 2007-10-25 2014-02-11 Symetis Sa Stents, valved-stents, and methods and systems for delivery thereof
US8597349B2 (en) 2007-11-05 2013-12-03 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with non-expanding stent posts and retrieval features
US8715337B2 (en) 2007-11-09 2014-05-06 Cook Medical Technologies Llc Aortic valve stent graft
WO2009067432A1 (en) 2007-11-19 2009-05-28 Cook Incorporated Valve frame
DE102007061301A1 (de) 2007-12-10 2009-06-18 Aesculap Ag Ummantelung zur Wiederherstellung der Klappenfunktion variköser Venen und Verwendung der Ummantelung in der Chirurgie
HUE056405T2 (hu) 2007-12-14 2022-02-28 Edwards Lifesciences Corp Vitorlarögzítõ keret egy billentyûprotézishez
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
EP2072027B1 (en) 2007-12-21 2020-06-17 Medtentia International Ltd Oy pre-annuloplasty device and method
US20090171456A1 (en) 2007-12-28 2009-07-02 Kveen Graig L Percutaneous heart valve, system, and method
JP2011508652A (ja) 2008-01-04 2011-03-17 インターベンショナル アンド サージカル イノベーションズ，エルエルシー 血流制御装置
JP5591120B2 (ja) 2008-01-16 2014-09-17 セント ジュード メディカル インコーポレイテッド 折りたたみ可能／拡張可能な人工心臓弁の送達及び回収システム
US9089422B2 (en) 2008-01-24 2015-07-28 Medtronic, Inc. Markers for prosthetic heart valves
US8628566B2 (en) 2008-01-24 2014-01-14 Medtronic, Inc. Stents for prosthetic heart valves
US8157852B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US9364324B2 (en) 2008-01-24 2016-06-14 Medtronic Vascular, Inc. Infundibular reducer device delivery system and related methods
EP2082690B1 (en) 2008-01-24 2012-06-20 Kardium, Inc. Medical device to assist diastolic function and prevent ventricular enlargement
EP3572044B1 (en) 2008-01-24 2021-07-28 Medtronic, Inc. Stents for prosthetic heart valves
US7993395B2 (en) 2008-01-25 2011-08-09 Medtronic, Inc. Set of annuloplasty devices with varying anterior-posterior ratios and related methods
US8790367B2 (en) 2008-02-06 2014-07-29 Guided Delivery Systems Inc. Multi-window guide tunnel
CA2713865C (en) 2008-02-08 2017-06-20 Heartware, Inc. Ventricular assist device for intraventricular placement
WO2009101617A2 (en) 2008-02-11 2009-08-20 Corassist Cardiovascular Ltd. Ventricular function assisting devices and methods of use thereof
WO2009108615A1 (en) 2008-02-25 2009-09-03 Medtronic Vascular Inc. Infundibular reducer devices
WO2009106545A1 (en) 2008-02-26 2009-09-03 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
EP3915525A1 (en) 2008-02-28 2021-12-01 Medtronic, Inc. Prosthetic heart valve systems
DE102008012438B4 (de) 2008-02-29 2014-12-24 Nvt Ag Mechanische Aortenklappe für die endovaskuläre Implantation
US8460368B2 (en) 2008-02-29 2013-06-11 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
DE102008012113A1 (de) 2008-03-02 2009-09-03 Transcatheter Technologies Gmbh Stent, welcher vom expandierten Zustand erneut im Durchmesser kontrolliert verringerbar ist
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
DE102008015781B4 (de) 2008-03-26 2011-09-29 Malte Neuss Vorrichtung zum Verschluss von Defekten im Gefäßsystem
ATE507801T1 (de) 2008-03-27 2011-05-15 Ab Medica Spa KLAPPENPROTHESE ZUR IMPLANTATION IN KÖRPERGEFÄßE
US7815673B2 (en) 2008-04-01 2010-10-19 Medtronic Vascular, Inc. Double-walled stent system
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
WO2009126629A1 (en) 2008-04-09 2009-10-15 Georgia Tech Research Corporation Annuloplasty rings and methods for heart valve repair
US8262725B2 (en) 2008-04-16 2012-09-11 Cardiovascular Technologies, Llc Transvalvular intraannular band for valve repair
FR2930137B1 (fr) 2008-04-18 2010-04-23 Corevalve Inc Materiel de traitement d'une valve cardiaque, en particulier d'une valve mitrale.
WO2009130631A2 (en) 2008-04-21 2009-10-29 Simcha Milo Surgical stapling systems
EP2282700B1 (en) 2008-04-23 2016-11-02 Medtronic, Inc. Stented heart valve devices
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
EP2293718B1 (en) 2008-05-09 2017-07-26 Edwards Lifesciences Corporation Degenerative valvular disease specific annuloplasty rings
US8152844B2 (en) 2008-05-09 2012-04-10 Edwards Lifesciences Corporation Quick-release annuloplasty ring holder
US20090287303A1 (en) 2008-05-13 2009-11-19 Edwards Lifesciences Corporation Physiologically harmonized tricuspid annuloplasty ring
US8668668B2 (en) 2008-05-14 2014-03-11 Onset Medical Corporation Expandable iliac sheath and method of use
ATE554731T1 (de) 2008-05-16 2012-05-15 Sorin Biomedica Cardio Srl Atraumatische prothetische herzklappenprothese
GB0809357D0 (en) 2008-05-22 2008-07-02 Punjabi Prakash Heart valve repair device
JP5341181B2 (ja) 2008-06-05 2013-11-13 メドトロニック，インコーポレイテッド ツーピース型の人工心臓弁アセンブリための接続システム
DK3653173T3 (da) 2008-06-06 2021-05-03 Edwards Lifesciences Corp Transkateterhjerteklap med lav profil
US9192472B2 (en) 2008-06-16 2015-11-24 Valtec Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
WO2009153769A1 (en) 2008-06-20 2009-12-23 Vysera Biomedical Limited A biomaterial
US8206635B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
US8500821B2 (en) 2008-06-20 2013-08-06 Vysera Biomedical Limited Esophageal valve device for placing in the cardia
JP5762955B2 (ja) 2008-06-23 2015-08-12 ルーメン・バイオメディカル・インコーポレイテッドＬｕｍｅｎ Ｂｉｏｍｅｄｉｃａｌ， Ｉｎｃ． 経皮的心臓弁置換および類似処置時の塞栓予防
EP2331016B8 (en) 2008-07-15 2020-06-03 St. Jude Medical, LLC Axially anchoring collapsible and re-expandable prosthetic heart valves for various disease states
EP4215162A1 (en) 2008-07-15 2023-07-26 St. Jude Medical, LLC Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
JP5123433B2 (ja) 2008-07-17 2013-01-23 エヌヴェーテー アーゲー 人工心臓弁システム
WO2010011674A1 (en) 2008-07-21 2010-01-28 Bioventrix Cardiac anchor structures
EP3878408A1 (en) 2008-07-21 2021-09-15 Jenesis Surgical, LLC Endoluminal support apparatus
RU2373900C1 (ru) 2008-07-23 2009-11-27 Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" Протез клапана сердца
US9232992B2 (en) 2008-07-24 2016-01-12 Aga Medical Corporation Multi-layered medical device for treating a target site and associated method
EP2326264B1 (en) 2008-07-27 2017-11-15 Pi-R-Squared Ltd. Fracturing calcifications in heart valves
BRPI0916696A2 (pt) 2008-07-29 2015-11-17 St Jude Medical Cardiology Div método e sistema para ajuste a longo prazo de um dispositivo de implante
US8337390B2 (en) 2008-07-30 2012-12-25 Cube S.R.L. Intracardiac device for restoring the functional elasticity of the cardiac structures, holding tool for the intracardiac device, and method for implantation of the intracardiac device in the heart
WO2010020660A1 (en) 2008-08-19 2010-02-25 Dsm Ip Assets B.V. Implantable valve prosthesis and method for manufacturing such a valve
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
JP5611948B2 (ja) 2008-08-25 2014-10-22 カーディオキネティックス・インコーポレイテッドＣａｒｄｉｏｋｉｎｅｔｉｘ， Ｉｎｃ． 回収可能心臓用装置
EP2358308B1 (en) 2008-09-15 2019-11-27 Medtronic, Inc. Tools for remodeling tissue
EP2358307B1 (en) 2008-09-15 2021-12-15 Medtronic Ventor Technologies Ltd. Prosthetic heart valve having identifiers for aiding in radiographic positioning
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
EP2344075B1 (en) 2008-09-19 2018-12-05 Edwards Lifesciences Corporation Annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation
EP3517075B1 (en) 2008-09-19 2023-02-22 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
EP2367505B1 (en) 2008-09-29 2020-08-12 Edwards Lifesciences CardiAQ LLC Heart valve
CA2739275C (en) 2008-10-01 2017-01-17 Impala, Inc. Delivery system for vascular implant
EP2344090B8 (en) 2008-10-09 2017-11-08 Xsat (Pty) Ltd. A stent deployment device
NL1036038C (en) 2008-10-09 2010-04-14 Univ Eindhoven Tech Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof.
EP3851076A1 (en) 2008-10-10 2021-07-21 MedicalTree Patent Ltd. An improved artificial valve
EP2349097A4 (en) 2008-10-10 2015-08-26 Kirk Promotion Ltd IMPROVED ARTIFICIAL HEARTLAP
EP2340075B1 (en) 2008-10-10 2013-03-06 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
WO2010040528A1 (en) 2008-10-10 2010-04-15 Universitaetsklinikum Heidelberg Arrangement for implanting and method for implanting
CA2776458C (en) 2008-10-10 2022-04-26 Peter Forsell An improved artifical valve
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
US8449625B2 (en) 2009-10-27 2013-05-28 Edwards Lifesciences Corporation Methods of measuring heart valve annuluses for valve replacement
CA2740443C (en) 2008-10-20 2016-06-21 Corassist Cardiovascular Ltd. Ventricular function assisting device and a method and apparatus for implanting it
WO2010051025A1 (en) 2008-10-30 2010-05-06 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valve delivery system and methods
US9682242B2 (en) 2008-11-14 2017-06-20 Bal Seal Engineering, Inc. Connector with low lead insertion force and method of reducing same
EP2358297B1 (en) 2008-11-21 2019-09-11 Percutaneous Cardiovascular Solutions Pty Limited Heart valve prosthesis
EP2370138B1 (en) 2008-11-25 2020-12-30 Edwards Lifesciences Corporation Apparatus for in situ expansion of prosthetic device
US9050189B2 (en) 2008-12-04 2015-06-09 Georgia Tech Research Corporation Method and apparatus for minimally invasive heart valve procedures
US8591573B2 (en) 2008-12-08 2013-11-26 Hector Daniel Barone Prosthetic valve for intraluminal implantation
JP5718820B2 (ja) 2008-12-12 2015-05-13 コーニンクレッカ フィリップス エヌ ヴェ 心臓弁置換術に対する自動ロードマッピング
US8177802B2 (en) 2008-12-16 2012-05-15 Medtronic Vascular, Inc. Apparatus for percutaneously creating native tissue venous valves
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
WO2010071810A1 (en) 2008-12-19 2010-06-24 Andy Christopher Kiser Methods and devices for endoscopic access to the heart
WO2012176195A2 (en) 2011-06-23 2012-12-27 Valtech Cardio, Ltd. Closure element for use with annuloplasty structure
US8808368B2 (en) 2008-12-22 2014-08-19 Valtech Cardio, Ltd. Implantation of repair chords in the heart
US8926696B2 (en) 2008-12-22 2015-01-06 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US8545553B2 (en) 2009-05-04 2013-10-01 Valtech Cardio, Ltd. Over-wire rotation tool
EP2201911B1 (en) 2008-12-23 2015-09-30 Sorin Group Italia S.r.l. Expandable prosthetic valve having anchoring appendages
EP2381895B1 (en) 2008-12-31 2021-07-07 Medtronic, Inc. Semi-rigid annuloplasty ring and band and method of making an annuloplasty ring
EP2384165B1 (en) 2009-01-02 2017-06-28 Deep Vein Medical, Inc. Device for regulating blood flow
US8372140B2 (en) 2009-01-07 2013-02-12 Cook Medical Technologies Llc Implantable valve prosthesis with independent frame elements
US9402720B2 (en) 2009-01-12 2016-08-02 Valve Medical Ltd. Modular percutaneous valve structure and delivery method
US9681950B2 (en) 2009-01-12 2017-06-20 Valve Medical Ltd. System and method for placing a percutaneous valve device
US8998982B2 (en) 2009-01-12 2015-04-07 Valve Medical Ltd. Method and apparatus for fine adjustment of a percutaneous valve structure
US9204965B2 (en) 2009-01-14 2015-12-08 Lc Therapeutics, Inc. Synthetic chord
AU2010206732A1 (en) 2009-01-22 2011-08-25 St. Jude Medical, Cardiology Division, Inc. Post-operative adjustment tool, minimally invasive attachment apparatus, and adjustable tricuspid ring
JP2012515625A (ja) 2009-01-22 2012-07-12 セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド 移植可能な装置の長期的な調整のための磁気的ドッキングシステムおよび方法
JP5687634B2 (ja) 2009-02-06 2015-03-18 セント・ジュード・メディカル，インコーポレイテッド 調節可能な弁輪形成リング支持体
WO2010090720A1 (en) 2009-02-06 2010-08-12 St. Jude Medical, Inc. Robotic heart valve annulus sizer
BRPI1007767A2 (pt) 2009-02-09 2017-06-27 St Jude Medical Cardiology Div Inc dispositivo de colocação, e, aparelho de afixação reversível
US20120010636A1 (en) 2009-02-11 2012-01-12 Nanyang Technological University Multi-layered surgical prosthesis
WO2010091653A1 (de) 2009-02-11 2010-08-19 Georg Lutter Katheter
DE102009009158B4 (de) 2009-02-16 2010-11-04 Siemens Aktiengesellschaft Lokalisierung eines medizinischen Instruments in einem präinvasiv aufgenommenen Tomographie-Bilddatensatz
BRPI1013346A2 (pt) 2009-02-20 2016-03-29 St Jude Medical ferramenta de crimpar, sistema para substituição de válvula cardíaca protética, e , método para colpasar uma válvula cardíaca protética.
US8348997B2 (en) 2009-02-24 2013-01-08 Medtronic Vascular, Inc. One-way replacement valve
US8109990B2 (en) 2009-02-24 2012-02-07 Cook Medical Technologies Llc Low profile support frame and related intraluminal medical devices
US20100217382A1 (en) 2009-02-25 2010-08-26 Edwards Lifesciences Mitral valve replacement with atrial anchoring
EP2400923B1 (en) 2009-02-25 2017-01-04 JenaValve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
WO2010098857A1 (en) 2009-02-27 2010-09-02 St. Jude Medical, Inc. Stent features for collapsible prosthetic heart valves
US8021420B2 (en) 2009-03-12 2011-09-20 Medtronic Vascular, Inc. Prosthetic valve delivery system
RU2393818C1 (ru) 2009-03-19 2010-07-10 Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" Реимплантируемый протез клапана сердца и инструмент для его установки
WO2010111621A1 (en) 2009-03-26 2010-09-30 Sorin Group Usa, Inc. Annuloplasty sizers for minimally invasive procedures
GB0905444D0 (en) 2009-03-30 2009-05-13 Ucl Business Plc Heart valve prosthesis
EP2413843B1 (en) 2009-03-30 2020-04-22 Suzhou Jiecheng Medical Technology Co. Ltd. Sutureless valve prostheses and devices for delivery
US8986370B2 (en) 2009-04-10 2015-03-24 Lon Sutherland ANNEST Implantable scaffolding containing an orifice for use with a prosthetic or bio-prosthetic valve
CA2758067A1 (en) 2009-04-10 2010-10-14 Cardiokinetix, Inc. Sealing and filling ventricular partitioning devices to improve cardiac function
US9968358B2 (en) 2009-04-15 2018-05-15 Microvention, Inc. Implant delivery system
EP2419050B2 (en) 2009-04-15 2023-10-18 Edwards Lifesciences CardiAQ LLC Vascular implant and delivery system
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
CA2778129C (en) 2009-04-28 2014-09-02 Dc Devices, Inc. Devices, systems and methods to treat heart failure
NZ624106A (en) 2009-04-29 2015-12-24 Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
US9034034B2 (en) 2010-12-22 2015-05-19 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
EP2427143B1 (en) 2009-05-04 2017-08-02 V-Wave Ltd. Device for regulating pressure in a heart chamber
US8523881B2 (en) 2010-07-26 2013-09-03 Valtech Cardio, Ltd. Multiple anchor delivery tool
EP2427142B1 (en) 2009-05-08 2017-11-01 Koninklijke Philips N.V. Ultrasonic planning and guidance of implantable medical devices
US8403982B2 (en) 2009-05-13 2013-03-26 Sorin Group Italia S.R.L. Device for the in situ delivery of heart valves
ES2549429T3 (es) 2009-05-13 2015-10-28 Sorin Group Italia S.R.L. Dispositivo de suministro in situ de válvulas cardiacas
US9168105B2 (en) 2009-05-13 2015-10-27 Sorin Group Italia S.R.L. Device for surgical interventions
FR2945440B1 (fr) 2009-05-14 2012-12-07 Perouse Lab Dispositif de traitement et necessaire de traitement d'un conduit de circulation du sang
US8075611B2 (en) 2009-06-02 2011-12-13 Medtronic, Inc. Stented prosthetic heart valves
DE102009024648B4 (de) 2009-06-03 2018-05-09 Aesculap Ag Markierte Venen-Ummantelung, insbesondere zur Wiederherstellung der Venenklappenfunktion variköser Venen
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
FR2947716B1 (fr) 2009-07-10 2011-09-02 Cormove Implant prothetique ameliore
US8439970B2 (en) 2009-07-14 2013-05-14 Edwards Lifesciences Corporation Transapical delivery system for heart valves
EP2453970B1 (en) 2009-07-14 2017-09-20 Edwards Lifesciences Corporation Transapical delivery system for heart valves
EP2453942B1 (en) 2009-07-15 2014-08-13 Technical University of Denmark Polymer coating comprising 2-methoxyethyl acrylate units synthesized by surface-initiated atom transfer radical polymerization
EP2453843B1 (en) 2009-07-17 2015-09-30 Kirk Promotion LTD. Artificial valve for implantation
EP2456483B1 (en) 2009-07-22 2017-11-01 The Texas A&M University System Diastolic recoil device for treatment of cardiac pathologies
US20110022165A1 (en) 2009-07-23 2011-01-27 Edwards Lifesciences Corporation Introducer for prosthetic heart valve
EP2459127B1 (en) 2009-07-27 2015-09-23 Endologix, Inc. Stent graft
US8500757B2 (en) 2009-07-28 2013-08-06 Edwards Lifesciences Corporation Surgical puncture cinch and closure system
WO2011022658A1 (en) 2009-08-20 2011-02-24 Cook Incorporated Loading apparatus and system for expandable intraluminal medical devices
WO2011025945A1 (en) 2009-08-27 2011-03-03 Medtronic Inc. Transcatheter valve delivery systems and methods
JP5866668B2 (ja) 2009-08-28 2016-02-17 メドトロニック ３エフ セラピュティックス インコーポレイテッド クリンプ装置及び使用方法
CN102905646B (zh) 2009-08-28 2016-01-20 美敦力3F医疗有限公司 外科输送装置和使用方法
IN2012DN02041A (zh) 2009-08-28 2015-08-21 3F Therapeutics Inc
EP2475328B1 (en) 2009-09-11 2014-08-27 GI Dynamics, Inc. Anchors with open heads
EP2633821B1 (en) 2009-09-15 2016-04-06 Evalve, Inc. Device for cardiac valve repair
EP2480167B1 (en) 2009-09-21 2017-08-16 Medtronic Inc. Stented transcatheter prosthetic heart valve delivery system
US20110313515A1 (en) 2010-06-21 2011-12-22 Arshad Quadri Replacement heart valve
EP2482749B1 (en) 2009-10-01 2017-08-30 Kardium Inc. Kit for constricting tissue or a bodily orifice, for example, a mitral valve
AU2010306762C1 (en) 2009-10-14 2016-04-21 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
EP2493417B1 (en) 2009-10-26 2017-06-21 Cardiokinetix, Inc. Ventricular volume reduction
US8277502B2 (en) 2009-10-29 2012-10-02 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
RU140821U1 (ru) 2009-11-02 2014-05-20 Симетис Са Аортальный биопротез и системы для его доставки в место имплантации
GR1007028B (el) 2009-11-11 2010-10-22 Ευσταθιος-Ανδρεας Αγαθος Υποστηρικτης βιοπροσθετικων βαλβιδων με διαγλωχινικο συνδεσμο σχηματος καρδιας
DE102009055969A1 (de) 2009-11-27 2011-06-01 Transcatheter Technologies Gmbh Vorrichtung und Set zum Falten oder Entfalten eines medizinischen Implantats und Verfahren
WO2011067770A1 (en) 2009-12-02 2011-06-09 Valtech Cardio, Ltd. Delivery tool for implantation of spool assembly coupled to a helical anchor
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
CA2783282C (en) 2009-12-08 2018-04-03 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
CN102858272B (zh) 2009-12-15 2015-07-15 爱德华兹生命科学公司 治疗脉管通道的膨胀设备
PT2513200T (pt) 2009-12-18 2018-06-11 Coloplast As Um biomaterial
US8869982B2 (en) 2009-12-18 2014-10-28 Edwards Lifesciences Corporation Prosthetic heart valve packaging and deployment system
US20110146361A1 (en) 2009-12-22 2011-06-23 Edwards Lifesciences Corporation Method of Peening Metal Heart Valve Stents
CN102113921A (zh) 2009-12-30 2011-07-06 微创医疗器械(上海)有限公司 一种介入式心脏瓣膜
US20110160838A1 (en) 2009-12-31 2011-06-30 Blanzy Jeffrey S Endoprosthesis containing multi-phase ferrous steel
US9504562B2 (en) 2010-01-12 2016-11-29 Valve Medical Ltd. Self-assembling modular percutaneous valve and methods of folding, assembly and delivery
US8449608B2 (en) 2010-01-22 2013-05-28 Edwards Lifesciences Corporation Tricuspid ring
EP2351540A1 (en) 2010-01-27 2011-08-03 Jönsson, Anders Device and method for reducing cardiac valve regurgitation
US9107749B2 (en) 2010-02-03 2015-08-18 Edwards Lifesciences Corporation Methods for treating a heart
US20110190697A1 (en) 2010-02-03 2011-08-04 Circulite, Inc. Vascular introducers having an expandable section
JP5778183B2 (ja) 2010-02-03 2015-09-16 メドトロニック ジービーアイ インコーポレイテッド セミフレキシブル弁形成リング
US8839957B2 (en) 2010-02-15 2014-09-23 Michael C. Murad Prosthetic heart valve packaging system
US8475523B2 (en) 2010-02-17 2013-07-02 Medtronic, Inc. Distal tip assembly for a heart valve delivery catheter
DE102010008382A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Verfahren zum Crimpen bzw. Falten eines medizinischen Implantats an einer Einrichtung zum Verbringen oder Einführen desselben unter Einsatz von Zero-Pressure-Crimping sowie Einrichtungen
US8518106B2 (en) 2010-02-17 2013-08-27 Medtronic, Inc. Catheter assembly with valve crimping accessories
US8926693B2 (en) 2010-02-17 2015-01-06 Medtronic, Inc. Heart valve delivery catheter with safety button
DE102010008362A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Medizinisches Implantat, welches aus einem nicht expandierten Zustand expandierbar ist
DE102010008338A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Einrichtung, vorgesehen, um an einem Katheter befestigt oder mit diesem verbunden zu werden, Katheter und Verfahren
US8292948B2 (en) 2010-02-17 2012-10-23 Medtronic Vascular, Inc. Apparatus and methods for creating a venous valve from autologous tissue
DE102010008360A1 (de) 2010-02-17 2011-09-29 Transcatheter Technologies Gmbh Medizinisches Implantat, in welchem beim Crimpen bzw. Falten Lücken verbleiben, Verfahren und Einrichtung zum Verbringen
US20110208293A1 (en) 2010-02-23 2011-08-25 Medtronic, Inc. Catheter-Based Heart Valve Therapy System with Sizing Balloon
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
US9414914B2 (en) 2010-02-24 2016-08-16 Medtronic Ventor Technologies Ltd. Catheter assembly with valve crimping accessories
US9522062B2 (en) 2010-02-24 2016-12-20 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US10433956B2 (en) 2010-02-24 2019-10-08 Medtronic Ventor Technologies Ltd. Mitral prosthesis and methods for implantation
EP2538878B1 (en) 2010-02-25 2021-11-24 JenaValve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8361144B2 (en) 2010-03-01 2013-01-29 Colibri Heart Valve Llc Percutaneously deliverable heart valve and methods associated therewith
DK3335670T3 (da) 2010-03-05 2022-07-11 Edwards Lifesciences Corp Mekanismer til fastholdelse af klapproteser
US8679404B2 (en) 2010-03-05 2014-03-25 Edwards Lifesciences Corporation Dry prosthetic heart valve packaging system
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
ES2365317B1 (es) 2010-03-19 2012-08-03 Xavier Ruyra Baliarda Banda protésica, en particular para la reparación de una válvula mitral.
JP2013521977A (ja) 2010-03-23 2013-06-13 ボストン サイエンティフィック サイムド，インコーポレイテッド 弁輪形成装置
NZ602706A (en) 2010-03-23 2014-02-28 Edwards Lifesciences Corp Methods of conditioning sheet bioprosthetic tissue
DE102010012677B4 (de) 2010-03-24 2017-08-10 Fehling Instruments Gmbh & Co. Kg Spreizer für die Aortenklappenrekonstruktion
SE535140C2 (sv) 2010-03-25 2012-04-24 Jan Otto Solem En implanterbar anordning, kit och system för förbättring av hjärtfunktionen, innefattande medel för generering av longitudinell rörelse av mitralisklaffen
SE535690C2 (sv) 2010-03-25 2012-11-13 Jan Otto Solem En implanterbar anordning och kit för hjärtunderstöd, innefattande medel för generering av longitudinell rörelse av mitralisklaffen
US9480557B2 (en) 2010-03-25 2016-11-01 Medtronic, Inc. Stents for prosthetic heart valves
US8992599B2 (en) 2010-03-26 2015-03-31 Thubrikar Aortic Valve, Inc. Valve component, frame component and prosthetic valve device including the same for implantation in a body lumen
US9320597B2 (en) 2010-03-30 2016-04-26 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512400B2 (en) 2010-04-09 2013-08-20 Medtronic, Inc. Transcatheter heart valve delivery system with reduced area moment of inertia
US8998980B2 (en) 2010-04-09 2015-04-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512401B2 (en) 2010-04-12 2013-08-20 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US8579963B2 (en) 2010-04-13 2013-11-12 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with stability tube and method
US8357195B2 (en) 2010-04-15 2013-01-22 Medtronic, Inc. Catheter based annuloplasty system and method
US10512537B2 (en) 2010-04-16 2019-12-24 Abiomed, Inc. Flow optimized polymeric heart valve
US9833314B2 (en) 2010-04-16 2017-12-05 Abiomed, Inc. Percutaneous valve deployment
US8465541B2 (en) 2010-04-19 2013-06-18 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with expandable stability tube
US8764811B2 (en) 2010-04-20 2014-07-01 Medtronic Vascular, Inc. Controlled tip release stent graft delivery system and method
EP3858293A1 (en) 2010-04-21 2021-08-04 Medtronic, Inc. Prosthetic valve with sealing members
US8740976B2 (en) 2010-04-21 2014-06-03 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with flush report
US8876892B2 (en) 2010-04-21 2014-11-04 Medtronic, Inc. Prosthetic heart valve delivery system with spacing
US8623075B2 (en) 2010-04-21 2014-01-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with controlled expansion of prosthetic heart valve
CN102858275A (zh) 2010-04-23 2013-01-02 美敦力公司 用于假体心脏瓣膜的植入的输送系统以及方法
US8568474B2 (en) 2010-04-26 2013-10-29 Medtronic, Inc. Transcatheter prosthetic heart valve post-dilatation remodeling devices and methods
AU2011248658B2 (en) 2010-04-27 2014-09-11 Medtronic Inc. Transcatheter prosthetic heart valve delivery device with biased release features
JP5688865B2 (ja) 2010-04-27 2015-03-25 メドトロニック，インコーポレイテッド 受動的トリガリリースを備える経カテーテル補綴心臓弁送達装置
CA2991641C (en) 2010-04-29 2020-12-15 Vinay Badhwar Automatic suturing apparatus and methods of use
US8974475B2 (en) 2010-04-30 2015-03-10 Medtronic, Inc. Methods and devices for cardiac valve repair or replacement
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
CN102883684B (zh) 2010-05-10 2015-04-08 爱德华兹生命科学公司 人工心脏瓣膜
US9554901B2 (en) 2010-05-12 2017-01-31 Edwards Lifesciences Corporation Low gradient prosthetic heart valve
US9433501B2 (en) 2010-05-19 2016-09-06 Direct Flow Medical, Inc. Inflation media for implants
EP2387977B1 (en) 2010-05-20 2013-11-06 JenaValve Technology Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
IT1400327B1 (it) 2010-05-21 2013-05-24 Sorin Biomedica Cardio Srl Dispositivo di supporto per protesi valvolari e corrispondente corredo.
US8790394B2 (en) 2010-05-24 2014-07-29 Valtech Cardio, Ltd. Adjustable artificial chordeae tendineae with suture loops
EP2575681B1 (en) 2010-05-25 2022-06-22 JenaValve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US9387077B2 (en) 2010-05-27 2016-07-12 Medtronic Vascular Galway Catheter assembly with prosthesis crimping and prosthesis retaining accessories
US9098899B2 (en) 2010-05-27 2015-08-04 Koninklijke Philips N.V. Determining the specific orientation of an object
US9561102B2 (en) 2010-06-02 2017-02-07 Medtronic, Inc. Transcatheter delivery system and method with controlled expansion and contraction of prosthetic heart valve
EP2575685B1 (en) 2010-06-07 2019-02-13 Valtech Cardio, Ltd. Apparatus for guide-wire based advancement of a rotation assembly
JP5833832B2 (ja) 2010-06-30 2015-12-16 テルモ株式会社 生体移植片移送器具及び生体移植片の移送方法
PL2590595T3 (pl) 2010-07-09 2016-01-29 Highlife Sas Przezcewnikowa proteza zastawki przedsionkowo- komorowej
US9592119B2 (en) 2010-07-13 2017-03-14 C.R. Bard, Inc. Inflatable medical devices
ES2478515T3 (es) 2010-07-15 2014-07-22 St. Jude Medical, Inc. Retenedores para sistemas de colocación de válvula cardiaca transcatéter
US9132009B2 (en) * 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US20120130468A1 (en) 2010-07-27 2012-05-24 Fred Khosravi Methods and apparatus for treating neurovascular venous outflow obstruction
ES2471367T3 (es) 2010-07-30 2014-06-26 Institut Quimic De Sarria Implante bioactivo
WO2012018599A1 (en) 2010-08-03 2012-02-09 Cook Medical Technologies Llc Two valve caval stent for functional replacement of incompetent tricuspid valve
WO2012019052A2 (en) 2010-08-04 2012-02-09 Micardia Corporation Percutaneous transcatheter repair of heart valves
EP2605724B1 (en) 2010-08-17 2018-05-16 St. Jude Medical, LLC Delivery system for collapsible heart valve
EP3357457B1 (en) 2010-08-17 2019-06-05 St. Jude Medical, LLC Tip for medical implant delivery system
WO2012027384A2 (en) 2010-08-23 2012-03-01 Edwards Lifesciences Corporation Color-coded prosthetic valve system and methods for using the same
US9039759B2 (en) 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
CA2808885C (en) 2010-08-24 2017-01-10 John F. Migliazza Flexible annuloplasty ring with select control points
CA2809262C (en) 2010-08-24 2020-03-10 Southern Lights Ventures 2002 Limited Biomaterials with enhanced properties and devices made therefrom
WO2012026965A2 (en) 2010-08-24 2012-03-01 St. Jude Medical, Inc. Staged deployment devices and methods for transcatheter heart valve delivery systems
WO2012030370A1 (en) 2010-08-31 2012-03-08 Edwards Lifesciences Corporation Physiologic tricuspid annuloplasty ring
EP2422748B1 (de) 2010-08-31 2016-01-27 Biotronik AG Medizinisches Implantat, insbesondere Klappenimplantat, zur Implantation in einen tierischen und/oder menschlichen Körper sowie Verfahren, insbesondere Herstellungsverfahren, zur Herstellung einer Implantationsvorrichtung für das medizinische Implantat
AU2011296361B2 (en) 2010-09-01 2015-05-28 Medtronic Vascular Galway Prosthetic valve support structure
AU2011295854B2 (en) 2010-09-01 2016-07-21 Mvalve Technologies Ltd. Cardiac valve support structure
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
EP4257084A3 (en) 2010-09-10 2024-01-17 Boston Scientific Medical Device Limited Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device
US10076327B2 (en) 2010-09-14 2018-09-18 Evalve, Inc. Flexible actuator mandrel for tissue apposition systems
DE102010037529A1 (de) 2010-09-14 2012-03-15 Transcatheter Technologies Gmbh Einrichtung, vorgesehen, um an einem Katheter befestigt oder mit diesem verbunden zu werden, Katheter und Verfahren
EP2616008B1 (en) 2010-09-17 2018-10-24 St. Jude Medical, Cardiology Division, Inc. Assembly for loading a self-expanding collapsible heart valve
FR2964855B1 (fr) 2010-09-17 2013-10-18 Ct Hospitalier Regional Universitaire D Amiens Implant destine a etre place dans un passage sanguin auriculo-ventriculaire
AU2011302640B2 (en) 2010-09-17 2014-11-06 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery
EP2616006B1 (en) 2010-09-17 2018-08-29 St. Jude Medical, Cardiology Division, Inc. Retainers for transcatheter heart valve delivery systems
US9011527B2 (en) 2010-09-20 2015-04-21 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
ES2651744T3 (es) 2010-09-20 2018-01-29 St. Jude Medical, Cardiology Division, Inc. Dispositivo de entrega provisto de un vástago curvado y un miembro de enderezamiento para la implantación transcatéter de una válvula aórtica
WO2012040655A2 (en) 2010-09-23 2012-03-29 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
EP2618779B1 (en) 2010-09-24 2016-08-03 Symetis SA Stent valve and delivery apparatus
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
WO2012043898A1 (ko) 2010-09-29 2012-04-05 Kim June-Hong 관상정맥동과 삼천판막의 조직보호기구, 매듭 전달 기구 및 이들을 포함하는 승모판막 서클라지 시술용 장치
CA2813254A1 (en) 2010-09-30 2012-04-12 BioStable Science & Engineering, Inc. Aortic valve devices
JP5877205B2 (ja) 2010-09-30 2016-03-02 バイオステイブル サイエンス アンド エンジニアリング インコーポレイテッド 大動脈弁の修復のための弁輪内装着フレーム
LT3669829T (lt) 2010-10-05 2021-10-25 Edwards Lifesciences Corporation Protezinis širdies vožtuvas
WO2012054776A1 (en) 2010-10-21 2012-04-26 Medtronic Inc Mitral bioprosthesis with low ventricular profile
GB201017921D0 (en) 2010-10-22 2010-12-01 Ucl Business Plc Prothesis delivery system
US8562663B2 (en) 2010-10-26 2013-10-22 Medtronic Ventor Technologies Ltd. Devices and methods for loading a prosthesis onto a delivery system
US20120116496A1 (en) 2010-11-05 2012-05-10 Chuter Timothy A Stent structures for use with valve replacements
US20120116498A1 (en) 2010-11-05 2012-05-10 Chuter Timothy A Aortic valve prostheses
IT1402571B1 (it) 2010-11-12 2013-09-13 Ht Consultant Di Giovanni Righini Sistema protesico per valvola cardio-vascolare con struttura di ancoraggio separata
WO2012068175A2 (en) 2010-11-16 2012-05-24 Trivascular, Inc. Advanced endovascular graft and delivery system
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
DE102010051632B4 (de) 2010-11-17 2013-09-12 Hans-Hinrich Sievers Gestentete biologische Herzklappe
EP2640316B1 (en) 2010-11-18 2017-03-15 Pavilion Medical Innovations, LLC Tissue restraining devices and methods of use
US9078750B2 (en) 2010-11-30 2015-07-14 Edwards Lifesciences Corporation Ergonomic mitral heart valve holders
US8932350B2 (en) 2010-11-30 2015-01-13 Edwards Lifesciences Corporation Reduced dehiscence annuloplasty ring
CA2819424C (en) 2010-12-14 2020-07-21 Transcatheter Technologies Gmbh Apparatus comprising an aligning device, set and method
US9579197B2 (en) 2010-12-15 2017-02-28 Medtronic Vascular, Inc. Systems and methods for positioning a heart valve using visual markers
DE102010061371A1 (de) 2010-12-20 2012-06-21 Transcatheter Technologies Gmbh Vorrichtung mit individuellen Schaftfasern und Set zum Falten oder Entfalten eines medizinischen Implantats und Verfahren
EP2468215A1 (en) 2010-12-22 2012-06-27 Centre Hospitaller Universitaire Vaudois (CHUV) Annuloplasty ring
US9044221B2 (en) 2010-12-29 2015-06-02 Neochord, Inc. Exchangeable system for minimally invasive beating heart repair of heart valve leaflets
WO2012094406A1 (en) 2011-01-04 2012-07-12 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
US8948848B2 (en) 2011-01-07 2015-02-03 Innovative Cardiovascular Solutions, Llc Angiography catheter
ES2710002T3 (es) 2011-01-11 2019-04-22 Hans Reiner Figulla Prótesis valvular para reemplazar una válvula auriculoventricular del corazón
EP2474287A1 (en) 2011-01-11 2012-07-11 Symetis Sa Delivery catheter for stent-valve, and sub-assembly therefor
CN103517688A (zh) 2011-01-11 2014-01-15 汉斯·赖纳·菲古拉 用来替代心脏房室瓣的瓣膜假体
EP2663355B1 (en) 2011-01-11 2019-08-28 Symetis SA Apparatus useful for transcatheter aortic valve implantation
CA3098835C (en) 2011-01-18 2023-09-19 Loma Vista Medical, Inc. Inflatable medical devices
DE102011009555A1 (de) 2011-01-21 2012-07-26 Aesculap Ag Gefäßprothese mit integrierter Aortenklappe
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
ES2610079T3 (es) 2011-01-31 2017-04-25 St. Jude Medical, Inc. Herramienta para el ajuste de un dispositivo anatómico protésico
US9138316B2 (en) 2011-01-31 2015-09-22 St. Jude Medical, Inc. Adjustable annuloplasty ring sizing indicator
EP3106131A1 (en) 2011-01-31 2016-12-21 St. Jude Medical, Inc. Adjustable annuloplasty ring, adjustment and positioning tool and holder
ES2568627T3 (es) 2011-01-31 2016-05-03 St. Jude Medical, Inc. Conjunto de ajuste para un dispositivo de válvula protésica ajustable
ES2589503T3 (es) 2011-01-31 2016-11-14 St. Jude Medical, Inc. Característica de bloqueo antirrotación
US9717593B2 (en) 2011-02-01 2017-08-01 St. Jude Medical, Cardiology Division, Inc. Leaflet suturing to commissure points for prosthetic heart valve
EP2484309B1 (en) 2011-02-02 2019-04-10 Shlomo Gabbay Heart valve prosthesis
EP2670357B1 (en) 2011-02-02 2019-03-20 St. Jude Medical, LLC System for loading a collapsible heart valve into a delivery device
CN107334512B (zh) 2011-02-10 2021-04-13 可维亚媒体公司 用于建立和保持房内压力释放孔的装置
US20120209375A1 (en) 2011-02-11 2012-08-16 Gilbert Madrid Stability device for use with percutaneous delivery systems
EP2486893B1 (en) 2011-02-14 2017-07-05 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
EP2486894B1 (en) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
EP2675397B1 (en) 2011-02-15 2015-09-23 Medivalve Ltd. Percutaneous positioning device
GB2488530A (en) 2011-02-18 2012-09-05 David J Wheatley Heart valve
EP2676638B1 (en) 2011-02-18 2017-07-12 Piolax Medical Devices, Inc. Stent for abdominal cavity-vein shunt
EP2677965B1 (en) 2011-02-25 2017-06-21 University of Connecticut Prosthetic heart valve
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
PL218575B1 (pl) 2011-02-28 2014-12-31 Fundacja Rozwoju Kardiochirurgii Im Prof Zbigniewa Religi Sposób wytwarzania warstw powierzchniowych na implantach medycznych
US9445898B2 (en) 2011-03-01 2016-09-20 Medtronic Ventor Technologies Ltd. Mitral valve repair
WO2012118508A1 (en) 2011-03-03 2012-09-07 Empire Technology Development Llc Temporary perfusion channel percutaneous delivery of balloon-expandable stents
WO2012127309A1 (en) 2011-03-21 2012-09-27 Ontorfano Matteo Disk-based valve apparatus and method for the treatment of valve dysfunction
US8936650B2 (en) 2011-03-23 2015-01-20 The Regents Of The University Of California Mesh enclosed tissue constructs
US10016461B2 (en) 2012-12-03 2018-07-10 The Regents Of The University Of California Apparatus and process for growing a heart valve in three-dimensions
EP3536282A1 (en) 2011-03-23 2019-09-11 Daidalos Solutions B.V. Medical instrument, ring prosthesis, stent and stented valve
US11213393B2 (en) 2011-04-01 2022-01-04 Edwards Lifesciences Corporation Compressible heart valve annulus sizing templates
US8945212B2 (en) 2011-04-01 2015-02-03 W. L. Gore & Associates, Inc. Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom
US8961599B2 (en) 2011-04-01 2015-02-24 W. L. Gore & Associates, Inc. Durable high strength polymer composite suitable for implant and articles produced therefrom
WO2012137208A1 (en) 2011-04-04 2012-10-11 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Device and method for heart valve repair
EP2699169B1 (en) 2011-04-20 2018-02-14 The Board of Trustees of The Leland Stanford Junior University Systems for endoluminal valve creation
US9381082B2 (en) 2011-04-22 2016-07-05 Edwards Lifesciences Corporation Devices, systems and methods for accurate positioning of a prosthetic valve
US9554897B2 (en) * 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
EP2520250B1 (en) 2011-05-04 2014-02-19 Medtentia International Ltd Oy Medical device for a cardiac valve implant
EP2520251A1 (en) 2011-05-05 2012-11-07 Symetis SA Method and Apparatus for Compressing Stent-Valves
EP2522307B1 (en) 2011-05-08 2020-09-30 ITSO Medical AB Device for delivery of medical devices to a cardiac valve
EP2522308B1 (de) 2011-05-10 2015-02-25 Biotronik AG Mechanische Transkatheter-Herzklappenprothese
US9486604B2 (en) 2011-05-12 2016-11-08 Medtronic, Inc. Packaging and preparation tray for a delivery system
US9144494B2 (en) 2011-05-12 2015-09-29 Medtronic, Inc. Delivery catheter system with micro and macro movement control
CA2835212A1 (en) 2011-05-13 2012-11-22 Heartware, Inc. Intravascular blood pump and method of implantation
CN103826569B (zh) 2011-05-16 2016-06-15 Hlt公司 用于假体的翻转输送装置
EP2709559B1 (en) 2011-05-17 2015-01-21 Boston Scientific Scimed, Inc. Annuloplasty ring with anchors fixed by curing polymer
EP2709560B1 (en) 2011-05-17 2015-08-05 Boston Scientific Scimed, Inc. Annuloplasty ring with piercing wire and segmented wire lumen
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
ES2841108T3 (es) 2011-05-26 2021-07-07 On X Life Tech Inc Manguito de costura de válvula cardíaca
AU2012262538B2 (en) 2011-05-27 2015-09-17 Cormatrix Cardiovascular, Inc. Sterilized, acellular extracellular matrix compositions and methods of making thereof
US9402721B2 (en) 2011-06-01 2016-08-02 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
EP2713894B1 (en) 2011-06-01 2021-01-20 NeoChord, Inc. System for minimally invasive repair of heart valve leaflets
ES2439070T3 (es) 2011-06-01 2014-01-21 Nvt Ag Sistema de despliegue de prótesis de válvula cardiaca
US9101471B2 (en) 2011-06-13 2015-08-11 Edwards Lifesciences Corporation Systems and delivery handles for delivering prosthetic heart valves disposed on valve holders
US20120315260A1 (en) 2011-06-13 2012-12-13 Svetlana A. Ivanova Compositions and Methods to Prevent and Treat Biofilms
US9532887B2 (en) 2011-06-15 2017-01-03 St. Jude Medical, Inc. Multi-layer stent
US8840664B2 (en) 2011-06-15 2014-09-23 Edwards Lifesciences Corporation Heart valve prosthesis anchoring device and methods
CN107496054B (zh) 2011-06-21 2020-03-03 托尔福公司 人工心脏瓣膜装置及相关系统和方法
EP3395298A1 (en) 2011-06-27 2018-10-31 University of Maryland, Baltimore Transapical mitral valve repair device
US9364326B2 (en) 2011-06-29 2016-06-14 Mitralix Ltd. Heart valve repair devices and methods
US9358107B2 (en) 2011-06-30 2016-06-07 Edwards Lifesciences Corporation Systems, dies, and methods for processing pericardial tissue
US8926588B2 (en) 2011-07-05 2015-01-06 Medtronic Vascular, Inc. Steerable delivery catheter
DE102011106928B4 (de) 2011-07-08 2019-02-07 Admedes Schuessler Gmbh Verfahren, Vorrichtung und Verwendung eines Verfahrens zum elektrochemischen Abtragen eines Werkstoffs
DE102011107551B4 (de) 2011-07-11 2015-05-28 Universitätsklinikum Schleswig-Holstein Anuloplastiering
EP2731550B1 (en) 2011-07-12 2016-02-24 Boston Scientific Scimed, Inc. Coupling system for a replacement valve
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
EP2734157B1 (en) 2011-07-21 2018-09-05 4Tech Inc. Apparatus for tricuspid valve repair using tension
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US8893370B2 (en) 2011-07-28 2014-11-25 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve
US8931159B2 (en) 2011-07-28 2015-01-13 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve
CN104039271B (zh) 2011-07-29 2016-09-07 卡内基梅隆大学 用于心脏重建手术的人工瓣膜化导管及其生产方法
GB201113060D0 (en) 2011-07-29 2011-09-14 Univ Ulster Tissue scaffold
EP2554139A1 (en) 2011-08-05 2013-02-06 Centre Hospitalier Universitaire Vaudois Actuating device for a surgical implant
WO2013021375A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
CN103857361B (zh) 2011-08-05 2017-03-29 加州理工学院 经皮的心瓣膜递送系统
US9872770B2 (en) 2011-08-11 2018-01-23 St. Jude Medical, Inc. Apparatus and method for heart valve repair
WO2013028387A2 (en) 2011-08-11 2013-02-28 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
US9060860B2 (en) 2011-08-18 2015-06-23 St. Jude Medical, Cardiology Division, Inc. Devices and methods for transcatheter heart valve delivery
US11185403B2 (en) 2011-08-31 2021-11-30 Cook Medical Technologies Llc Endoluminal prosthesis assembly
US9265599B2 (en) 2011-08-31 2016-02-23 Cleveland Clinic Foundation Retention system for an endoluminal device
CN103220999B (zh) 2011-09-09 2016-04-06 新干工业株式会社 带瓣支架、带瓣支架形成用基材以及带瓣支架的生产方法
CA2848251C (en) 2011-09-12 2019-08-06 Highlife Sas Transcatheter valve prosthesis
DE102011054176B4 (de) 2011-09-12 2016-02-04 Highlife Sas Behandlungs-Katheter-System
ES2616030T3 (es) 2011-09-12 2017-06-09 Highlife Sas Sistema de catéter de tratamiento
DE102014102653A1 (de) 2014-02-28 2015-09-03 Highlife Sas Transkatheter-Klappenprothese
DE102014102725A1 (de) 2014-02-28 2015-09-17 Highlife Sas Transkatheter-Klappenprothese
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US9422615B2 (en) 2011-09-16 2016-08-23 W. L. Gore & Associates, Inc. Single step shape memory alloy expansion
US8920493B2 (en) 2011-09-16 2014-12-30 St. Jude Medical, Cardiology Division, Inc. Systems and methods for holding annuloplasty rings
EP2572684B1 (de) 2011-09-23 2016-05-04 Biotronik AG Freigabevorrichtung zum Lösen eines medizinischen Implantats von einem Katheter sowie Katheter mit einer Freigabevorrichtung
US8900295B2 (en) 2011-09-26 2014-12-02 Edwards Lifesciences Corporation Prosthetic valve with ventricular tethers
US9554904B2 (en) 2011-09-28 2017-01-31 Medtronic CV Luxembourg S.a.r.l. Distal tip assembly for a heart valve delivery catheter
CA2850179A1 (en) 2011-09-30 2013-04-04 Bioventrix, Inc. Remote pericardial hemostasis for ventricular access and reconstruction or other organ therapies
CA2851145C (en) 2011-10-05 2019-04-16 Boston Scientific Scimed, Inc. Profile reduction seal for prosthetic heart valve
FR2980968B1 (fr) 2011-10-10 2013-12-27 Assist Publ Hopitaux De Paris Prothese cardiovasculaire en polymere biodegradable comprenant un element tubulaire logeant une valve et procede de fabrication de ladite prothese
EP2765954B1 (en) 2011-10-13 2021-12-22 The Research Foundation Of State University Of New York Polymeric heart valve
JP6133309B2 (ja) 2011-10-19 2017-05-24 トゥエルヴ， インコーポレイテッド 人工心臓弁デバイス
US9039757B2 (en) * 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
EP3943047B1 (en) 2011-10-19 2023-08-30 Twelve, Inc. Device for heart valve replacement
US9827093B2 (en) 2011-10-21 2017-11-28 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US8945146B2 (en) 2011-10-24 2015-02-03 Medtronic, Inc. Delivery system assemblies and associated methods for implantable medical devices
CN102423505B (zh) 2011-10-27 2014-12-10 上海微创医疗器械（集团）有限公司 膜式渗透汽化式固定人工生物瓣的方法及装置
US9192496B2 (en) 2011-10-31 2015-11-24 Merit Medical Systems, Inc. Systems and methods for sheathing an implantable device
US8986368B2 (en) 2011-10-31 2015-03-24 Merit Medical Systems, Inc. Esophageal stent with valve
CN102499993B (zh) 2011-11-01 2014-01-15 上海微创医疗器械（集团）有限公司 一种边缘刚性化人工生物瓣膜的制备方法
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
EP2591754B1 (en) 2011-11-10 2015-02-25 Medtentia International Ltd Oy A device and a method for improving the function of a heart valve
EP3449969B1 (en) 2011-11-10 2023-02-01 Medtronic, Inc. System for deploying a device to a distal location across a diseased vessel
US9545298B2 (en) 2011-11-10 2017-01-17 Transaortic Medical, Inc. System for deploying a device to a distal location across a diseased vessel
EP2591755A1 (en) 2011-11-12 2013-05-15 Medtentia International Ltd Oy Device and method for improving fixation of a medical device
US8851286B2 (en) 2011-11-15 2014-10-07 Boston Scientific Scimed Inc. Dual sterilization containment vessel
WO2013074671A1 (en) 2011-11-15 2013-05-23 Boston Scientific Scimed, Inc. Medical device with keyed locking structures
US8721587B2 (en) 2011-11-17 2014-05-13 Medtronic, Inc. Delivery system assemblies and associated methods for implantable medical devices
FR2982763B1 (fr) 2011-11-17 2015-07-17 Ct Hospitalier Regional Universitaire D Amiens Implant destine a etre place dans un passage de circulation du sang et dispositif de traitement associe
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US9480558B2 (en) 2011-12-05 2016-11-01 Medtronic, Inc. Transcatheter valve having reduced seam exposure
CA3051684C (en) 2011-12-06 2020-06-16 Aortic Innovations Llc Device for endovascular aortic repair and method of using the same
WO2013086413A1 (en) 2011-12-09 2013-06-13 Edwards Lifesciences Corporation Prosthetic heart valve improved commissure supports
US9345574B2 (en) 2011-12-09 2016-05-24 Edwards Lifesciences Corporation Force-based heart valve sizer
EP2886084B1 (en) 2011-12-12 2018-02-14 David Alon Heart valve repair device
ES2606877T3 (es) 2011-12-13 2017-03-28 Boston Scientific Scimed, Inc. Válvula cardíaca descalcificante
US9078645B2 (en) 2011-12-19 2015-07-14 Edwards Lifesciences Corporation Knotless suture anchoring devices and tools for implants
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
CA2860225A1 (en) 2011-12-20 2013-06-27 Boston Scientific Scimed, Inc. Apparatus for endovascularly replacing a heart valve
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
WO2013096541A1 (en) 2011-12-21 2013-06-27 The Trustees Of The University Of Pennsylvania Platforms for mitral valve replacement
AU2012268911B2 (en) 2011-12-22 2014-04-24 Cook Medical Technologies Llc Endoluminal prosthesis comprising a valve replacement and at least one fenestration
EP2793743B1 (en) 2011-12-23 2020-11-04 MyoPowers Medical Technologies France SAS Medical device comprising an artificial contractile structure
EP2609893B1 (en) 2011-12-29 2014-09-03 Sorin Group Italia S.r.l. A kit for implanting prosthetic vascular conduits
EP2609894B1 (en) 2011-12-31 2015-04-01 Fundacja Rozwoju Kardiochirurgii Im. Prof. Zbigniewa Religi Heart valve
EP2800602B1 (en) 2012-01-06 2017-08-02 Emboline, Inc. Integrated embolic protection devices
JP6250553B2 (ja) 2012-01-10 2017-12-20 エドワーズ ライフサイエンシーズ カーディアック エルエルシー 第２の支柱フィーチャを用いた連接型支持構造
EP2620125B1 (en) 2012-01-24 2017-10-11 Medtentia International Ltd Oy An arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve
EP2806805B1 (en) 2012-01-25 2016-05-25 St. Jude Medical, Inc. Apparatus for heart valve repair
FR2986149B1 (fr) 2012-01-26 2014-12-26 Ct Hospitalier Universitaire De Clermont Fd Dispositif de remplacement d'au moins un cordage de la valve mitrale et kit comprenant au moins deux dispositifs
WO2013115141A1 (ja) 2012-01-30 2013-08-08 川澄化学工業株式会社 胆管ステント
ES2649462T3 (es) 2012-01-31 2018-01-12 Mitral Valve Technologies Sàrl Sistemas, dispositivos de soporte de válvula mitral
CA2863503A1 (en) 2012-02-01 2013-08-08 Hlt, Inc. Invertible tissue valve and method
ES2597754T3 (es) 2012-02-01 2017-01-20 St. Jude Medical, Inc. Sistema de administración de sujetador para reparación de válvula cardiaca y método de uso
WO2013116617A1 (en) 2012-02-02 2013-08-08 St. Jude Medical, Cardiology Division, Inc. Apparatus and method for heart valve repair
WO2013119849A1 (en) 2012-02-07 2013-08-15 Intervene, Inc. Systems and methods for endoluminal valve creation
WO2013120082A1 (en) 2012-02-10 2013-08-15 Kassab Ghassan S Methods and uses of biological tissues for various stent and other medical applications
EP2814427B1 (en) 2012-02-15 2018-12-12 Children's Hospital Boston Right ventricular papillary approximation
CA3097321A1 (en) 2012-02-22 2013-08-29 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
JP2015508004A (ja) 2012-02-28 2015-03-16 ムバルブ・テクノロジーズ・リミテッド 単リング型心臓弁支持構造体
EP3542758B1 (en) 2012-02-29 2022-12-14 Valcare, Inc. Percutaneous annuloplasty system with anterior-posterior adjustment
US9770332B2 (en) 2012-03-06 2017-09-26 Highlife Sas Treatment catheter member with encircling function
JP6001280B2 (ja) 2012-03-09 2016-10-05 学校法人金沢医科大学 心臓矯正ネットの製造方法
JP6084775B2 (ja) 2012-03-09 2017-02-22 学校法人金沢医科大学 心臓矯正ネット
US10071186B2 (en) 2012-03-12 2018-09-11 Colorado State University Research Foundation Glycosaminoglycan and synthetic polymer material for blood-contacting applications
WO2013135792A1 (en) 2012-03-14 2013-09-19 Universite Catholique De Louvain Device for excision of heart valve
EP2641569B1 (en) 2012-03-23 2015-01-28 Sorin Group Italia S.r.l. A collapsible valve prosthesis
US9066800B2 (en) 2012-03-28 2015-06-30 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US9023098B2 (en) 2012-03-28 2015-05-05 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US8926694B2 (en) 2012-03-28 2015-01-06 Medtronic Vascular Galway Limited Dual valve prosthesis for transcatheter valve implantation
US9101467B2 (en) 2012-03-30 2015-08-11 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
ES2552382T3 (es) 2012-04-04 2015-11-27 Sorin Group Italia S.R.L. Dispositivo de soporte para prótesis de válvulas cardíacas
AU2013245201B2 (en) 2012-04-05 2017-10-05 Mvalve Technologies Ltd. Cardiac valve support structure
WO2013155474A1 (en) 2012-04-12 2013-10-17 California Institute Of Technology Percutaneous heart valve delivery systems
CN104244869A (zh) 2012-04-12 2014-12-24 梅迪瓦尔夫有限公司 体内成像辅助装置(ima)
US9999501B2 (en) 2012-04-18 2018-06-19 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
CN102764169B (zh) 2012-04-19 2015-07-29 杭州启明医疗器械有限公司 人工心脏瓣膜及其瓣膜支架
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US9168122B2 (en) 2012-04-26 2015-10-27 Rex Medical, L.P. Vascular device and method for valve leaflet apposition
US9427303B2 (en) 2012-04-27 2016-08-30 Cook Medical Technologies Llc Anti-aspiration valve
EP2841020B1 (en) 2012-04-27 2017-07-26 Cook Medical Technologies LLC Anti-aspiration prosthesis
US20130289699A1 (en) 2012-04-30 2013-10-31 St. Jude Medical, Cardiology Division, Inc. Aortic valve holder with stent protection and/or ability to decrease valve profile
EP2846736B1 (en) 2012-05-09 2018-02-28 Boston Scientific Scimed, Inc. Reduced profile valve with locking elements
US9642702B2 (en) 2012-05-15 2017-05-09 Valve Medical Ltd. System and method for assembling a folded percutaneous valve
WO2013173587A1 (en) 2012-05-16 2013-11-21 Edwards Lifesciences Corporation Devices and methods for reducing cardiac valve regurgitation
US9878127B2 (en) 2012-05-16 2018-01-30 Jenavalve Technology, Inc. Catheter delivery system for heart valve prosthesis
EP3508173A1 (en) 2012-05-16 2019-07-10 Edwards Lifesciences Corporation Systems for placing a coaptation member between valvular leaflets
ES2807506T3 (es) 2012-05-20 2021-02-23 Tel Hashomer Medical Res Infrastructure & Services Ltd Válvula mitral protésica
US9474600B2 (en) 2012-05-24 2016-10-25 Shanghai Cingular Biotech Corporation Prosthetic heart valve
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9642700B2 (en) 2012-05-31 2017-05-09 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve having a polymeric stent
DE102012010798A1 (de) 2012-06-01 2013-12-05 Universität Duisburg-Essen Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
US9301835B2 (en) 2012-06-04 2016-04-05 Edwards Lifesciences Corporation Pre-assembled bioprosthetic valve and sealed conduit
WO2013184630A1 (en) 2012-06-05 2013-12-12 Merit Medical Systems, Inc. Esophageal stent
CN104519831B (zh) 2012-06-05 2016-06-22 卡迪奥奇斯公司 内假体和用于植入这种内假体的递送装置
FR2991162B1 (fr) 2012-06-05 2015-07-17 Ass Marie Lannelongue Endoprothese, notamment vasculaire ou cardiaque, avec elements thrombogenes
CN104470579B (zh) 2012-06-06 2018-06-01 洋红医疗有限公司 人工肾脏瓣膜
NZ702283A (en) 2012-06-06 2016-09-30 Loma Vista Medical Inc Inflatable medical devices
CN104507419A (zh) 2012-06-07 2015-04-08 波士顿科学国际有限公司 用于置换原生心脏瓣膜的装置
GB2517609B (en) 2012-06-08 2017-05-31 Cameron Int Corp Artificial heart system
US9526610B2 (en) 2012-06-12 2016-12-27 Medtronic, Inc. Method and device for percutaneous valve annuloplasty
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
WO2013190344A1 (en) 2012-06-22 2013-12-27 Pierre Squara Heart valve prostheses
US9289292B2 (en) 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
US20140005776A1 (en) 2012-06-29 2014-01-02 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US9918837B2 (en) 2012-06-29 2018-03-20 St. Jude Medical, Cardiology Division, Inc. System to assist in the release of a collapsible stent from a delivery device
EP2866847B1 (en) 2012-07-02 2018-08-22 Boston Scientific Scimed, Inc. Prosthetic heart valve formation
US9498202B2 (en) 2012-07-10 2016-11-22 Edwards Lifesciences Corporation Suture securement devices
CA2875669C (en) 2012-07-12 2017-02-14 Boston Scientific Scimed, Inc. Low profile heart valve delivery system and method
US9510934B2 (en) 2012-07-20 2016-12-06 Cook Medical Technologies Llc Implantable medical device having a sleeve
US9271856B2 (en) 2012-07-25 2016-03-01 Medtronic Vascular Galway Delivery catheter with distal moving capsule for transapical prosthetic heart valve delivery
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
US10376360B2 (en) 2012-07-27 2019-08-13 W. L. Gore & Associates, Inc. Multi-frame prosthetic valve apparatus and methods
US9364358B2 (en) 2012-07-27 2016-06-14 Medinol Ltd. Catheter with retractable cover and pressurized fluid
US9254141B2 (en) 2012-08-02 2016-02-09 St. Jude Medical, Inc. Apparatus and method for heart valve repair
EP2695586B1 (en) 2012-08-10 2019-05-08 Sorin Group Italia S.r.l. A valve prosthesis and kit
US9468525B2 (en) 2012-08-13 2016-10-18 Medtronic, Inc. Heart valve prosthesis
CN102805676B (zh) 2012-08-14 2015-06-17 杭州启明医疗器械有限公司 人造瓣膜置换装置的压缩装置
DE102012107465A1 (de) 2012-08-15 2014-05-22 Pfm Medical Ag Implantierbare Einrichtung zur Verwendung im menschlichen und/oder tierischen Körper zum Ersatz einer Organklappe
EP2884906B1 (en) 2012-08-17 2020-05-06 On-X Life Technologies Inc. Biological chord repair system
US9649212B2 (en) 2012-08-30 2017-05-16 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter comprising a release device
US9717595B2 (en) 2012-09-05 2017-08-01 Medtronic Vascular Galway Trans-aortic delivery system with containment capsule centering device
DE102012216742A1 (de) 2012-09-19 2014-03-20 Hans-Hinrich Sievers Herzklappenprothese
US9597436B2 (en) 2012-09-21 2017-03-21 Osaka University Advanced heart failure treatment material as myocardial/cardiovascular regeneration device
CN105078615B (zh) 2012-09-21 2018-10-09 上海微创心通医疗科技有限公司 用于植入体输送系统的内管组件
US9283078B2 (en) 2012-09-21 2016-03-15 Materialise N.V. Patient-specific intraluminal implants
US9585748B2 (en) 2012-09-25 2017-03-07 Edwards Lifesciences Corporation Methods for replacing a native heart valve and aorta with a prosthetic heart valve and conduit
EP2900150B1 (en) 2012-09-29 2018-04-18 Mitralign, Inc. Plication lock delivery system
EP2712633B1 (de) 2012-10-02 2015-04-29 Biotronik AG Bioprosthetische Komponenten für ein Implantat, insbesondere teilvernetzte biologische Herzklappen
EP2906147A1 (en) 2012-10-09 2015-08-19 Biotronik AG Crimping tool for a prosthetic device and method for crimping a prosthetic device with a crimping tool
FR2996747B1 (fr) 2012-10-11 2015-02-06 Cormove Implant destine a etre insere dans un conduit de circulation du sang
FR2996748B1 (fr) 2012-10-12 2015-02-06 Cormove Dispositif de traitement d'un conduit de circulation du sang
US9801721B2 (en) 2012-10-12 2017-10-31 St. Jude Medical, Cardiology Division, Inc. Sizing device and method of positioning a prosthetic heart valve
US9295549B2 (en) 2012-10-12 2016-03-29 St. Jude Medical, Cardiology Division, Inc. Valve holder and loading integration
EP2908779B1 (en) 2012-10-18 2018-04-18 Loma Vista Medical, Inc. Reinforced inflatable medical devices
EP2908778B1 (en) 2012-10-19 2016-11-23 Boston Scientific Scimed, Inc. Anti-thrombus feature for implanted medical devices
US9949828B2 (en) 2012-10-23 2018-04-24 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
EP3730066A1 (en) 2012-10-23 2020-10-28 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
WO2014066081A1 (en) 2012-10-24 2014-05-01 Cook Medical Technologies Llc Anti-reflux prosthesis
FR2997288B1 (fr) 2012-10-25 2015-01-23 Cormove Dispositif de mise en place d'une etancheite autour d'un implant dans un passage de circulation du sang, et necessaire de traitement associe
US9192751B2 (en) 2012-10-26 2015-11-24 Medtronic, Inc. Elastic introducer sheath
DE102012219752A1 (de) 2012-10-29 2014-04-30 Aesculap Ag Stabilisator für Operationen am schlagenden Herzen
US9636441B2 (en) 2012-11-05 2017-05-02 Robert Jarvik Support stent for transvalvular conduit
US20140128964A1 (en) 2012-11-08 2014-05-08 Symetis Sa Stent Seals and Methods for Sealing an Expandable Stent
US20140135907A1 (en) 2012-11-09 2014-05-15 Medtronic CV Luxembourg S.a.r.l. Medical Device Delivery System and Methods of Delivering Medical Devices
US9144493B2 (en) 2012-11-14 2015-09-29 Medtronic Vascular Galway Limited Valve prosthesis deployment assembly and method
FR2998166B1 (fr) 2012-11-16 2016-02-26 Engin Oder Prothese annulaire pour la therapie de la valve mitrale par annulo-plastie
JP6341211B2 (ja) 2012-11-20 2018-06-13 インノブハート エッセ．エッレ．エッレ． 人工心弁移植用ガイドワイヤシステムを心室内部に配置させるための装置
EP4147676A1 (en) 2012-11-20 2023-03-15 Innovheart S.r.l. Device for deploying guide structures for operational procedures within the cardiac chambers
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
EP2922592B1 (en) 2012-11-21 2022-09-21 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic heart valves
WO2014081942A1 (en) 2012-11-21 2014-05-30 Concert Medical, Llc Preformed guidewire
US9199348B2 (en) 2012-11-27 2015-12-01 Medtronic, Inc. Prosthetic valve crimping
WO2014089424A1 (en) 2012-12-07 2014-06-12 Valcare, Inc. Methods, devices, and systems for percutaneously anchoring annuloplasty rings
EP2742911A1 (de) 2012-12-17 2014-06-18 Hans Reiner Figulla Klappenprothese zum Ersatz einer Atrioventricularklappe
US10321986B2 (en) 2012-12-19 2019-06-18 W. L. Gore & Associates, Inc. Multi-frame prosthetic heart valve
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9398952B2 (en) 2012-12-19 2016-07-26 W. L. Gore & Associates, Inc. Planar zone in prosthetic heart valve leaflet
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US10966820B2 (en) 2012-12-19 2021-04-06 W. L. Gore & Associates, Inc. Geometric control of bending character in prosthetic heart valve leaflets
US10039638B2 (en) 2012-12-19 2018-08-07 W. L. Gore & Associates, Inc. Geometric prosthetic heart valves
US9008769B2 (en) 2012-12-21 2015-04-14 Backbeat Medical, Inc. Methods and systems for lowering blood pressure through reduction of ventricle filling
WO2015094401A1 (en) 2013-12-19 2015-06-25 Backbeat Medical, Inc. Methods and systems for controlling blood pressure by controlling atrial pressure
WO2014102268A1 (en) 2012-12-27 2014-07-03 Transcatheter Technologies Gmbh Apparatus and set for folding or unfolding a medical implant comprising a clamping mechanism, implant and method
CN104884002B (zh) 2012-12-31 2017-04-05 爱德华兹生命科学公司 适于植入后扩张的外科心脏瓣膜
DE102013200152A1 (de) 2013-01-08 2014-07-10 AdjuCor GmbH Herzunterstützungsvorrichtung mit einer selbst-expandierenden Schale
EP2752170B1 (en) 2013-01-08 2017-02-22 Cook Medical Technologies LLC Multi valve anti-reflux prosthesis
US9066801B2 (en) * 2013-01-08 2015-06-30 Medtronic, Inc. Valve prosthesis and method for delivery
WO2014108903A1 (en) 2013-01-09 2014-07-17 4Tech Inc. Soft tissue anchors
US9955990B2 (en) 2013-01-10 2018-05-01 Intervene, Inc. Systems and methods for endoluminal valve creation
FR3001121B1 (fr) 2013-01-18 2016-01-15 Ladjali Mustapha Dr Pince de traitement d'un tissu corporel et necessaire de traitement associe
US20150351906A1 (en) 2013-01-24 2015-12-10 Mitraltech Ltd. Ventricularly-anchored prosthetic valves
EP2948100B1 (en) 2013-01-25 2021-05-05 Medtentia International Ltd Oy A system for cardiac valve repair
EP2948102B1 (en) 2013-01-25 2019-01-16 Medtentia International Ltd Oy A valve for short time replacement, for taking over the function of and/or for temporary or partial support of a native valve in a heart
CN105050543B (zh) 2013-01-25 2018-03-20 梅德坦提亚国际有限公司 用于收集腱索和/或瓣叶的医疗系统、装置及其方法
US20150351911A1 (en) 2013-01-25 2015-12-10 Medtentia International Ltd Oy A Medical Device And Method For Facilitating Selection Of An Annuloplasty Implant
WO2014114797A1 (en) 2013-01-25 2014-07-31 Medtentia International Ltd Oy Temporary atrium support device
US10413401B2 (en) 2013-02-01 2019-09-17 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
EP2950752B1 (en) 2013-02-04 2022-07-27 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
AU2014213982A1 (en) 2013-02-06 2015-08-13 Symetis Sa Prosthetic valve, delivery apparatus and delivery method
US10105220B2 (en) 2013-02-21 2018-10-23 St. Jude Medical, Cardiology Division, Inc. Transapical passive articulation delivery system design
EP2769681B1 (en) 2013-02-22 2019-08-21 Biotronik AG Release device for detaching a medical implant from an insertion device and an insertion device comprising a release device
EP2769742A1 (en) 2013-02-22 2014-08-27 Cardiatis S.A. MRI visible medical device.
CN104000672B (zh) 2013-02-25 2016-06-15 上海微创心通医疗科技有限公司 心脏瓣膜假体
US9155616B2 (en) 2013-02-28 2015-10-13 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with expandable microspheres
EP2961358B1 (en) 2013-02-28 2019-06-26 Boston Scientific Scimed, Inc. Implantable medical devices for reduced tissue inflammation
EP3427696A1 (en) 2013-03-01 2019-01-16 Cormatrix Cardiovascular, Inc. Anchored cardiovascular valve
EP2964152B1 (en) 2013-03-07 2021-04-28 Medtronic Vascular Galway Prosthesis for transcatheter valve implantation
ITPI20130015A1 (it) 2013-03-07 2014-09-08 S M Scienzia Machinale S R L Apparecchiatura e metodo per la produzione di un oggetto tridimensionale biocompatibile
EP2964277B1 (en) 2013-03-08 2018-10-24 St. Jude Medical, Cardiology Division, Inc. Method of preparing a tissue swatch for a bioprosthetic device
CN111772877A (zh) 2013-03-08 2020-10-16 卡内基梅隆大学 可扩展的可植入导管
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9119713B2 (en) 2013-03-11 2015-09-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve replacement
US9744032B2 (en) 2013-03-11 2017-08-29 Cook Medical Technologies Llc Endoluminal prosthesis comprising a valve and an axially extendable segment
US8986375B2 (en) 2013-03-12 2015-03-24 Medtronic, Inc. Anti-paravalvular leakage component for a transcatheter valve prosthesis
CA2900655C (en) 2013-03-12 2019-05-21 Edwards Lifesciences Corporation Rapidly deployable surgical heart valves
EP2967853B1 (en) 2013-03-12 2019-11-06 Medtronic Inc. Heart valve prosthesis
WO2014164302A1 (en) 2013-03-12 2014-10-09 Edwards Lifesciences Corporation Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves
DK2967834T3 (da) 2013-03-13 2021-04-06 Jenesis Surgical Llc Leddelte kommissurklapstents
JP6449842B2 (ja) 2013-03-13 2019-01-09 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ インプラントに適した耐久性のある高強度のポリマー複合体及び該ポリマー複合体から製造された物品
JP6329570B2 (ja) 2013-03-14 2018-05-23 ４テック インコーポレイテッド テザーインターフェースを有するステント
EP2967807B1 (en) 2013-03-14 2020-07-22 Valve Medical Ltd. Temporary valve
CN105163687B (zh) 2013-03-14 2019-08-13 心肺医疗股份有限公司 栓子保护装置和使用方法
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
WO2014160330A1 (en) 2013-03-14 2014-10-02 Millepede, Llc. Systems and methods for reshaping a heart valve
US9687346B2 (en) 2013-03-14 2017-06-27 Edwards Lifesciences Corporation Multi-stranded heat set annuloplasty rings
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
EP2777616B1 (en) 2013-03-14 2020-08-19 Edwards Lifesciences CardiAQ LLC Prosthesis for atraumatically grasping intralumenal tissue
CA2905544C (en) 2013-03-15 2020-08-18 Symetis Sa Improvements relating to transcatheter stent-valves
US9232994B2 (en) 2013-03-15 2016-01-12 Medtronic Vascular Galway Limited Stented prosthetic heart valve and methods for making
EP3231394A1 (en) 2013-03-15 2017-10-18 Hlt, Inc. Low-profile prosthetic valve structure
EP2967863B1 (en) 2013-03-15 2018-01-31 Edwards Lifesciences Corporation Valved aortic conduits
US9289297B2 (en) 2013-03-15 2016-03-22 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
WO2014145399A1 (en) 2013-03-15 2014-09-18 Valcare, Inc. Systems and methods for delivery of annuloplasty rings
CN105101911B (zh) 2013-03-15 2018-10-26 托尔福公司 人造心瓣装置、人造二尖瓣以及相关系统和方法
US9232998B2 (en) 2013-03-15 2016-01-12 Cardiosolutions Inc. Trans-apical implant systems, implants and methods
US20140276979A1 (en) 2013-03-15 2014-09-18 Lsi Solutions, Inc. Method and devices for securing bidirectional suture loops using coaxial mechanical fasteners
US8906086B2 (en) 2013-03-15 2014-12-09 Cook Medical Technologies Llc Endovascular stent graft with self-closing perfusion branch
EP2777617B1 (en) 2013-03-15 2022-09-14 Edwards Lifesciences CardiAQ LLC Prosthesis with outer skirt
CN103190968B (zh) 2013-03-18 2015-06-17 杭州启明医疗器械有限公司 一种支架以及具有该支架的安装稳固的人造瓣膜置换装置
FR2998167B1 (fr) 2013-03-20 2015-01-09 Marco Vola Dispositif pour realiser une annuloplastie par voie transapicale de la valve mitrale
DE102013205519B4 (de) 2013-03-27 2019-05-23 Fehling Instruments Gmbh & Co. Kg Spreizer für den Vorhof des Herzens
EP2789312A1 (en) 2013-04-09 2014-10-15 Epygon Sasu Expandable stent-valve and method for manufacturing a stent
FR3004638B1 (fr) 2013-04-19 2015-05-29 Invalv Lab Implant, notamment destine a etre place dans une valve auriculo-ventriculaire cardiaque, comportant un systeme d'ecartement des bras proximaux
EP2986256B1 (en) 2013-04-19 2019-04-10 Strait Access Technologies Holdings (Pty) Ltd A prosthetic heart valve
FR3004917B1 (fr) 2013-04-25 2016-06-10 Bernard Pain Appareil de mesure du diametre d'une valve aortique
JP6557217B2 (ja) 2013-05-01 2019-08-07 アニュメド， インコーポレイテッド 個別化された大動脈弁補綴具
DE102013208038B4 (de) 2013-05-02 2016-09-08 Michael Siegenthaler Katheterbasierendes Herzunterstützungssystem
US9375311B2 (en) 2013-05-03 2016-06-28 Medtronic, Inc. Prosthetic valves and associated appartuses, systems and methods
WO2014178971A1 (en) 2013-05-03 2014-11-06 Cormatrix Cardiovascular, Inc. Prosthetic tissue valves and methods for anchoring same to cardiovascular structures
KR101429005B1 (ko) 2013-05-06 2014-08-12 부산대학교 산학협력단 심장판막 고정장치
US9937330B2 (en) 2013-05-07 2018-04-10 Cook Medical Technologies Llc System, method, and kit for providing the diameter of a balloon during treatment
EP2994072B1 (en) 2013-05-09 2022-01-19 Mitrassist Medical Ltd. Heart valve assistive prosthesis
EP2803335B1 (en) 2013-05-14 2017-09-27 Venus MedTech (HangZhou), Inc. Apparatus for folding or unfolding a medical implant, and implant
EP2999435B1 (en) 2013-05-20 2022-12-21 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems
EP3326583B1 (en) 2013-05-20 2018-12-12 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
CN105555204B (zh) 2013-05-21 2018-07-10 V-波有限责任公司 用于递送减小左房压力的装置的设备
EP2805695A1 (en) 2013-05-21 2014-11-26 Medtentia International Ltd Oy Medical system for annuloplasty
EP2805678B1 (en) 2013-05-22 2017-05-17 Medtentia International Ltd Oy Stitching device
WO2014189509A1 (en) 2013-05-22 2014-11-27 Nadav Yellin Transcatheter prosthetic valve for mitral or tricuspid valve replacement
EP3003452B1 (en) 2013-05-24 2019-09-11 Bioventrix, Inc. Cardiac tissue penetrating devices
CN104173121B (zh) 2013-05-27 2016-05-25 上海微创心通医疗科技有限公司 用于输送植入体的电动手柄及输送系统
US20140358224A1 (en) 2013-05-30 2014-12-04 Tendyne Holdlings, Inc. Six cell inner stent device for prosthetic mitral valves
FR3006582B1 (fr) 2013-06-05 2015-07-17 Mustapha Ladjali Dispositif de traitement d'un tissu corporel et necessaire de traitement associe
EP3597150A1 (en) 2013-06-06 2020-01-22 David Alon Heart valve repair and replacement
EP3007651B1 (en) 2013-06-14 2020-08-05 Cardiosolutions, Inc. Mitral valve spacer
EP3010442B1 (en) 2013-06-16 2016-12-07 Pi-Cardia Ltd. Percutaneous emboli protection sleeve
US9883942B2 (en) 2013-06-18 2018-02-06 St. Jude Medical, Cardiology Division, Inc. Transapical introducer
DE102013106352A1 (de) 2013-06-18 2014-12-18 Universität Zu Lübeck Herzunterstützungssystem sowie Herzunterstützungsverfahren
FR3006884B1 (fr) 2013-06-18 2016-06-24 Laboratoires Invalv Dispositif atraumatique d'introduction d'un element tubulaire creux dans un organe biologique
WO2014204807A1 (en) 2013-06-19 2014-12-24 Aga Medical Corporation Collapsible valve having paravalvular leak protection
US9320841B2 (en) 2013-06-21 2016-04-26 Corvivo, Inc. Ventricular assist device
AU2014302505B2 (en) 2013-06-25 2019-11-28 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
EP3019092B1 (en) 2013-07-10 2022-08-31 Medtronic Inc. Helical coil mitral valve annuloplasty systems
EP3019091B1 (en) 2013-07-11 2019-10-30 Edwards Lifesciences Corporation Knotless suture fastener installation system
US9237948B2 (en) 2013-07-11 2016-01-19 Medtronic, Inc. Delivery system with projections
EP2826443B1 (en) 2013-07-16 2017-06-28 Venus MedTech (HangZhou), Inc. Set comprising an apparatus and a medical implant
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
CN109771100B (zh) 2013-07-22 2021-07-16 梅约医学教育与研究基金会 用于使引导导管自对中的装置
FR3008885B1 (fr) 2013-07-26 2016-12-30 Landanger Dispositif chirurgical notamment pour la pose de prothese de cordage mitrale
EP2832318B1 (en) 2013-07-31 2017-04-05 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a force limiter, a displacement limiter and/or a brake frame assembly
EP2832316B1 (en) 2013-07-31 2017-03-29 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a displacement limiter, a force limiter and/or a brake frame assembly
JP6499653B2 (ja) 2013-07-31 2019-04-10 シーヴィ デヴァイシズ，エルエルシー 単一体のシステムと装置およびその逆行性灌流利用方法
EP2832315B1 (en) 2013-07-31 2017-11-22 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a brake frame assembly, a force limiter and/or a displacement limiter
EP2918245B1 (en) 2014-03-14 2017-05-03 Venus MedTech (HangZhou), Inc. Heart valve comprising a crown piece interconnected to leaflets, a top cuff and a bottom cuff; and a medical implant
EP2918246B1 (en) 2014-03-14 2018-08-08 Venus MedTech (HangZhou), Inc. Heart valve assembly comprising twofold sealing
EP2832317B1 (en) 2013-07-31 2017-02-15 Venus MedTech (HangZhou), Inc. Implant delivery device for folding or unfolding a medical implant based on a knot
WO2015017689A1 (en) 2013-08-01 2015-02-05 Robert Vidlund Epicardial anchor devices and methods
EP2835112B1 (en) 2013-08-08 2021-01-27 Sorin Group Italia S.r.l. Heart valve prosthesis
ES2801773T3 (es) 2013-08-14 2021-01-13 Sorin Group Italia Srl Aparato para el reemplazo de cuerdas
RS61521B1 (sr) 2013-08-14 2021-03-31 Mitral Valve Tech Sarl Zamena aparata srčanog zaliska
US20150051696A1 (en) 2013-08-14 2015-02-19 Boston Scientific Scimed, Inc. Medical guidewire
EP3038664B1 (en) 2013-08-29 2020-03-11 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with lyophilized tissue
DK2842581T3 (en) 2013-08-30 2019-02-18 Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin Bag-like structure with paracrine activity and process for its preparation
EP4098226A1 (en) 2013-08-30 2022-12-07 JenaValve Technology, Inc. Endoprosthesis comprising a radially collapsible frame and a prosthetic valve
CA2922132A1 (en) 2013-08-30 2015-03-05 Bioventrix, Inc. Heart anchor positioning devices, methods, and systems for treatment of congestive heart failure and other conditions
EP3043745B1 (en) 2013-09-12 2020-10-21 St. Jude Medical, Cardiology Division, Inc. Stent designs for prosthetic heart valves
US9566153B2 (en) 2013-09-12 2017-02-14 St. Jude Medical, Cardiology Division, Inc. Alignment of an implantable medical device
US10398550B2 (en) 2013-09-12 2019-09-03 St. Jude Medical, Cardiology Division, Inc. Atraumatic interface in an implant delivery device
GB201316349D0 (en) 2013-09-13 2013-10-30 Ucl Business Plc Vascular implant
WO2015036617A2 (en) 2013-09-16 2015-03-19 Symetis Sa Method and apparatus for compressing/loading stent-valves
EP2853237A1 (en) 2013-09-25 2015-04-01 Universität Zürich Biological heart valve replacement, particularly for pediatric patients, and manufacturing method
EP3049025B1 (en) 2013-09-27 2018-01-10 Universität Zürich Controlling tissue engineered heart valve geometry by using predefined inserts during culture
WO2015048738A1 (en) 2013-09-30 2015-04-02 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
EP3052053B1 (en) 2013-10-05 2020-08-12 Sino Medical Sciences Technology, Inc. Device for mitral valve regurgitation method
US10869681B2 (en) 2013-10-17 2020-12-22 Cedars-Sinai Medical Center Device to percutaneously treat heart valve embolization
US9788944B2 (en) 2013-10-21 2017-10-17 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve implantation access sheaths
JP6220969B2 (ja) 2013-10-22 2017-10-25 コンシーヴァルブ エルエルシー ステント装着した心臓弁または生体補綴弁の狭窄、閉塞、または石灰化を阻害するための方法
US10182910B2 (en) 2013-10-23 2019-01-22 Biotronik Ag Method for fitting an implant to a catheter
US10646333B2 (en) 2013-10-24 2020-05-12 Medtronic, Inc. Two-piece valve prosthesis with anchor stent and valve component
US9662202B2 (en) 2013-10-24 2017-05-30 Medtronic, Inc. Heart valve prosthesis
US9414913B2 (en) 2013-10-25 2016-08-16 Medtronic, Inc. Stented prosthetic heart valve
WO2015063118A1 (en) 2013-10-28 2015-05-07 Symetis Sa Stent-valve, delivery apparatus and method of use
CN104586542B (zh) 2013-10-31 2017-01-04 上海微创心通医疗科技有限公司 一种将植入体装载到输送系统中的装置和方法
EP2870946B1 (en) 2013-11-06 2018-10-31 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
PL2870945T3 (pl) 2013-11-08 2016-12-30 System do wprowadzania implantów naczyniowych
EP3068346B1 (en) 2013-11-11 2021-03-03 Edwards Lifesciences CardiAQ LLC Method for manufacturing a valve stent frame
US9839765B2 (en) 2013-11-12 2017-12-12 St. Jude Medical, Cardiology Division, Inc. Transfemoral mitral valve repair delivery device
EP3068345B1 (en) 2013-11-15 2020-08-26 Guy's And St. Thomas' NHS Foundation Trust Information markers for heart prostheses
EP3071149B1 (en) 2013-11-19 2022-06-01 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
US9603600B2 (en) 2013-11-20 2017-03-28 James E. Coleman Actuator for deployable implant
US9848880B2 (en) 2013-11-20 2017-12-26 James E. Coleman Adjustable heart valve implant
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9504565B2 (en) 2013-12-06 2016-11-29 W. L. Gore & Associates, Inc. Asymmetric opening and closing prosthetic valve leaflet
WO2015089334A1 (en) 2013-12-11 2015-06-18 Cedars-Sinai Medical Center Methods, devices and systems for transcatheter mitral valve replacement in a double-orifice mitral valve
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
CN103735337B (zh) 2013-12-31 2016-08-17 金仕生物科技（常熟）有限公司 人工心脏瓣膜成形环
CN103750922B (zh) 2013-12-31 2016-07-13 金仕生物科技（常熟）有限公司 制备人工心脏瓣膜瓣叶的方法
US9943408B2 (en) 2014-01-08 2018-04-17 St. Jude Medical, Cardiology Division, Inc. Basket delivery system
US9539090B2 (en) 2014-01-16 2017-01-10 Cook Medical Technologies Llc Transaortic valve access device
EP2896387A1 (en) 2014-01-20 2015-07-22 Mitricares Heart valve anchoring device
US10327890B2 (en) 2014-01-22 2019-06-25 Biotronik Ag Thermochemically treated miniature tubes as semifinished products for vascular stents
WO2015112839A1 (en) 2014-01-23 2015-07-30 President And Fellows Of Harvard College Engineered polymeric valves, tubular structures, and sheets and uses thereof
US9820852B2 (en) 2014-01-24 2017-11-21 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs
US9750603B2 (en) 2014-01-27 2017-09-05 Medtronic Vascular Galway Stented prosthetic heart valve with variable stiffness and methods of use
EP3099270B1 (en) 2014-01-28 2021-05-05 Sanford Health Pararenal and thoracic arch stent graft
WO2015117025A1 (en) 2014-01-31 2015-08-06 Cedars-Sinai Medical Center Pigtail for optimal aortic valvular complex imaging and alignment
CA3160505A1 (en) 2014-02-04 2015-08-13 Innovheart S.R.L. Prosthetic device for a heart valve
WO2015119721A1 (en) 2014-02-07 2015-08-13 C. R. Bard, Inc. Eptfe valves
EP2904989A1 (en) 2014-02-11 2015-08-12 Kephalios S.A.S. Adjustable annuloplasty device
EP4324405A2 (en) 2014-02-14 2024-02-21 Edwards Lifesciences Corporation Percutaneous leaflet augmentation
WO2015126711A1 (en) 2014-02-18 2015-08-27 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
EP3107496B1 (en) 2014-02-18 2018-07-04 St. Jude Medical, Cardiology Division, Inc. Bowed runners for paravalvular leak protection
HUE057160T2 (hu) 2014-02-18 2022-04-28 Edwards Lifesciences Corp Hajlékony összekötõkeret
EP2907479A1 (en) 2014-02-18 2015-08-19 Medtentia International Ltd Oy A system and a method for delivery of an annuloplasty implant
CN106170269B (zh) 2014-02-21 2019-01-11 爱德华兹生命科学卡迪尔克有限责任公司 用于瓣膜替代品的受控部署的递送装置
CA3189691A1 (en) 2014-02-21 2015-08-27 Mitral Valve Technologies Sarl Devices, systems and methods for delivering a prosthetic mitral valve and anchoring device
US10426880B2 (en) 2014-02-25 2019-10-01 MI-VAD, Inc. Ventricular assist device and method
EP3110367B1 (en) 2014-02-28 2020-04-29 Highlife SAS Transcatheter valve prosthesis
EP3110370B1 (en) 2014-02-28 2019-05-22 Highlife SAS Transcatheter valve prosthesis
EP2918248A1 (en) 2014-03-11 2015-09-16 Epygon Sasu An expandable stent-valve and a delivery device
EP2918247A1 (en) 2014-03-11 2015-09-16 Epygon Sasu A prosthetic valve and a delivery device
EP2918249B1 (de) 2014-03-14 2020-04-29 Venus MedTech (HangZhou), Inc. Supraclaviculäres kathetersystem für einen transseptalen zugang zum linken vorhof und linken ventrikel
US9668861B2 (en) 2014-03-15 2017-06-06 Rex Medical, L.P. Vascular device for treating venous valve insufficiency
GB2527075A (en) 2014-03-17 2015-12-16 Daassist As Percutaneous system, devices and methods
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
CR20160398A (es) 2014-03-18 2016-11-10 St Jude Medical Cardiology Div Inc Fijador/sujetador de celda basculante/ alterna para reemplazo de válvula mitral
EP2921135B1 (en) 2014-03-18 2017-02-01 Nvt Ag Prosthetic heart valve handling system
EP2921139B1 (en) 2014-03-18 2018-11-21 Nvt Ag Heartvalve implant
JP6411043B2 (ja) 2014-03-20 2018-10-24 学校法人東邦大学 弁尖形成用テンプレート
EP2923665B1 (de) 2014-03-26 2018-10-17 Biotronik AG Kathetervorrichtung zur minimalinvasiven Implantation eines Gefäßimplantats, insbesondere für die interventionelle, kathetergestützte Aortenklappenimplantation
US10143551B2 (en) 2014-03-31 2018-12-04 St. Jude Medical, Cardiology Division, Inc. Paravalvular sealing via extended cuff mechanisms
EP3967271A1 (en) 2014-04-01 2022-03-16 Medtronic CV Luxembourg S.à.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
EP2926840B1 (de) 2014-04-02 2018-05-09 Biotronik AG Verfahren zur Aufbereitung von biologischem Gewebe zur trockenen Verwendung in einem Implantat
PL2929860T3 (pl) 2014-04-07 2018-01-31 Nvt Ag Urządzenie do wszczepiania w serce ssaka
US11116496B2 (en) 2014-04-08 2021-09-14 Lsi Solutions, Inc. Surgical suturing device for a replacement anatomical structure and methods thereof
CN106456043B (zh) 2014-04-16 2019-12-31 博洛尼亚大学 具有用于测量瓣膜内电阻抗的集成电子电路的心脏瓣膜假体和用于监测假体功能的系统
US10368989B2 (en) 2014-04-17 2019-08-06 Medtronic Vascular Galway Hinged transcatheter prosthetic heart valve delivery system
US10321987B2 (en) 2014-04-23 2019-06-18 Medtronic, Inc. Paravalvular leak resistant prosthetic heart valve system
FR3020265B1 (fr) 2014-04-24 2019-09-06 Cormove Dispositif de mise en place d'une etancheite autour d'un implant dans un passage de circulation du sang, et necessaire de traitement associe
US10154904B2 (en) 2014-04-28 2018-12-18 Edwards Lifesciences Corporation Intravascular introducer devices
CN106572907B (zh) 2014-05-06 2019-07-26 帝斯曼知识产权资产管理有限公司 制造人工瓣膜的方法和利用所述方法得到的瓣膜
EP3139861B1 (en) 2014-05-06 2020-05-27 DSM IP Assets B.V. Method of making a prosthetic valve and valve obtained therewith
BR112016025723B1 (pt) 2014-05-06 2022-02-22 Dsm Ip Assets B.V. Válvula protética, conjunto de folhetos e método de fabricação da referida válvula protética
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
USRE49792E1 (en) 2014-05-14 2024-01-09 Corcym S.R.L. Implant device and implantation kit
ES2795358T3 (es) 2014-05-16 2020-11-23 St Jude Medical Cardiology Div Inc Sellado subanular para protección de fugas paravalvulares
EP3563800B1 (en) 2014-05-21 2023-10-11 SWAT Medical AB Improved embolic protection device
WO2015179468A1 (en) 2014-05-21 2015-11-26 St. Jude Medical, Cardiology Division, Inc. Self-expanding heart valves for coronary perfusion and sealing
JP6755858B2 (ja) 2014-05-21 2020-09-16 マレティ，オスカーＭＡＬＥＴＩ， Ｏｓｃａｒ 下肢に逆流を生じる疾患を治療するための人工弁
EP3145450B1 (en) 2014-05-22 2019-07-17 St. Jude Medical, Cardiology Division, Inc. Stents with anchoring sections
US9757232B2 (en) 2014-05-22 2017-09-12 Edwards Lifesciences Corporation Crimping apparatus for crimping prosthetic valve with protruding anchors
FR3021208B1 (fr) 2014-05-23 2021-03-12 Thomas Modine Prothese de valve cardiaque mitrale ou tricuspide
US9687345B2 (en) 2014-05-29 2017-06-27 Edwards Lifesciences Cardiaq Llc Prosthesis, delivery device and methods of use
FR3021863A1 (fr) 2014-06-05 2015-12-11 Bernard Pain Dispositif d'introduction transcatheter dans la racine aortique au niveau de la jonction sino tubulaire
FR3021860A1 (fr) 2014-06-05 2015-12-11 Bernard Pain Dispositif transcatheter pour l'ablation de tissus calcifies au niveau des volets d'une valve aortique
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
EP2954875B1 (en) 2014-06-10 2017-11-15 St. Jude Medical, Cardiology Division, Inc. Stent cell bridge for cuff attachment
FR3021862B1 (fr) 2014-06-10 2016-05-20 Vygon Kit d'operation pour mise en place de valve aortique
WO2015191946A1 (en) 2014-06-12 2015-12-17 The Cleveland Clinic Foundation Device, system, and method for treating a regurgitant heart valve
US10350063B2 (en) 2014-06-17 2019-07-16 Consiglio Nazionale Delle Ricerche Process of manufacturing a heart valve made of a polymeric material and the heart valve thereby obtained
JP6714518B2 (ja) 2014-06-18 2020-06-24 ポラレス・メディカル・インコーポレイテッド 弁膜逆流の治療のための僧帽弁インプラント
CN106573129B (zh) 2014-06-19 2019-09-24 4科技有限公司 心脏组织束紧
EP3160396B1 (en) 2014-06-24 2022-03-23 Polares Medical Inc. Systems for anchoring an implant
US9700412B2 (en) 2014-06-26 2017-07-11 Mitralix Ltd. Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices
US10687815B2 (en) 2014-07-02 2020-06-23 Medtentia International Ltd Oy Clip for a medical implant
WO2016001407A1 (en) 2014-07-03 2016-01-07 Medtentia International Ltd Oy An annuloplasty system
CN104055604B (zh) 2014-07-07 2016-06-01 宁波健世生物科技有限公司 一种带锚定装置的心脏瓣膜植入器械
FR3023704B1 (fr) 2014-07-15 2016-08-26 Mustapha Ladjali Dispositif de traitement endovasculaire d'une valve cardiaque en vue d'un remplacement valvulaire percutane
EP3154474B1 (de) 2014-07-16 2021-11-10 P+F Products + Features GmbH Herzklappenprothese zum perkutanen ersatz einer trikuspidalklappe, set und system mit einer derartigen herzklappenprothese
ES2843250T3 (es) 2014-07-16 2021-07-16 Medira Ag Prótesis valvular cardiaca para la sustitución percutánea de una válvula tricúspide y sistema con una prótesis valvular cardiaca de este tipo
EP3169245B1 (en) 2014-07-17 2021-03-17 Coremedic AG Medical apparatus for heart valve repair
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
EP2979667B2 (de) 2014-07-30 2020-10-28 Biotronik AG Einführvorrichtung für ein medizinisches implantat in einen menschlichen und/oder tierischen körper
WO2016016899A1 (en) 2014-07-30 2016-02-04 Mitraltech Ltd. Articulatable prosthetic valve
ES2725883T3 (es) 2014-08-01 2019-09-30 Alvimedica Tibbi Ueruenler Sanayi Ve Dis Ticaret A S Prótesis de válvula aórtica, particularmente adecuada para implantación transcatéter
US9801719B2 (en) 2014-08-15 2017-10-31 Edwards Lifesciences Corporation Annulus rings with suture clips
WO2016028585A1 (en) 2014-08-18 2016-02-25 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
WO2016028583A1 (en) 2014-08-18 2016-02-25 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
US20170273788A1 (en) 2014-09-08 2017-09-28 Medtentia International Ltd Oy Annuloplasty Implant
JP5738461B1 (ja) 2014-09-08 2015-06-24 重之 尾崎 弁尖サイザー
EP3193791B1 (en) 2014-09-09 2018-08-22 Occlutech Holding AG A flow regulating device in the heart
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
GB2530487B (en) 2014-09-17 2016-12-28 Cardiomech As Device for heart repair
EP3000436B1 (de) 2014-09-24 2017-04-05 Alexander Lauten System zum Ersatz einer an einer Entzündung oder einer Infektion erkrankten Klappe des Herzens
EP3213718B1 (en) 2014-09-24 2019-06-26 Sorin Group Italia S.r.l. A holder for heart valve prostheses, corresponding storage arrangement, delivery instrument and kit
ES2676060T3 (es) 2014-09-26 2018-07-16 Nvt Ag Dispositivo implantable para el tratamiento de la regurgitación de la válvula mitral
RU2017114607A (ru) 2014-09-28 2018-10-29 Кардиокинетикс, Инк. Устройства для терапии нарушений функции сердца
US10390950B2 (en) 2014-10-03 2019-08-27 St. Jude Medical, Cardiology Division, Inc. Flexible catheters and methods of forming same
DE102014114762B3 (de) 2014-10-10 2016-03-03 Asanus Medizintechnik Gmbh Aortenklappenklemme und Instrumentensatz zur Aortenklappenrekonstruktion
JP2017530814A (ja) 2014-10-13 2017-10-19 シメティス・ソシエテ・アノニムＳｙｍｅｔｉｓ Ｓａ ステント弁のためのカテーテル送達システム
EP3009104B1 (en) 2014-10-14 2019-11-20 St. Jude Medical, Cardiology Division, Inc. Flexible catheter and methods of forming same
EP3206629B1 (en) 2014-10-14 2021-07-14 Valtech Cardio, Ltd. Apparatus for heart valve leaflet restraining
FR3027212A1 (fr) 2014-10-16 2016-04-22 Seguin Jacques Implant intervalvulaire pour valve mitrale
US10105225B2 (en) 2014-10-22 2018-10-23 Medtronic, Inc. Devices, systems and methods for tissue approximation, including approximating mitral valve leaflets
EP3212097B1 (en) 2014-10-30 2018-07-11 Peter Osypka Stiftung Transmyocardial insertion unit
US10213307B2 (en) 2014-11-05 2019-02-26 Medtronic Vascular, Inc. Transcatheter valve prosthesis having an external skirt for sealing and preventing paravalvular leakage
EP3220856B1 (en) 2014-11-17 2022-01-26 Mitrassist Medical Ltd. Heart valve prosthesis
DE102014223522A1 (de) 2014-11-18 2016-05-19 Hans-Hinrich Sievers Biologische Herzklappenprothese
EP3223874B1 (en) 2014-11-24 2019-09-25 Biotronik AG Method for producing a storable molded body made of bacterial cellulose and a molded body produced according to the method
CN106999178B (zh) 2014-12-02 2019-12-24 4科技有限公司 偏心组织锚定器
CR20170245A (es) 2014-12-05 2017-09-14 Edwards Lifesciences Corp Cateter dirigible con cable de tracción
CA2967866C (en) 2014-12-18 2019-10-22 W.L. Gore & Associates, Inc. Prosthetic valves with mechanically coupled leaflets
WO2016098877A1 (ja) 2014-12-19 2016-06-23 国立研究開発法人国立循環器病研究センター 人工弁形成基材及び人工弁
EP3037064B1 (en) 2014-12-23 2018-03-14 Venus MedTech (HangZhou), Inc. Minimally invasive mitral valve replacement with brim
EP3237033B1 (en) 2014-12-22 2020-08-05 Syntach AG An implantable hydraulic displacement actuator and system.
US10092428B2 (en) 2014-12-30 2018-10-09 Cook Medical Technologies Llc Low profile prosthesis delivery device
WO2016110735A1 (en) 2015-01-05 2016-07-14 David Alon Heart ventricle remodeling
EP3242630A2 (en) * 2015-01-07 2017-11-15 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
US9579195B2 (en) 2015-01-13 2017-02-28 Horizon Scientific Corp. Mitral bileaflet valve
WO2016118522A1 (en) 2015-01-21 2016-07-28 Medtronic Inc. Prosthetic valve sizer and assembly including same
WO2016124615A2 (en) 2015-02-02 2016-08-11 Symetis Sa Stent seals and method of production
WO2016126832A1 (en) 2015-02-03 2016-08-11 Boston Scientific Scimed, Inc. Methods, devices, and systems for treating pericardial tissue
JP6718459B2 (ja) 2015-02-05 2020-07-08 テンダイン ホールディングス，インコーポレイテッド 拡張可能な心外膜パッド及びデバイス並びにそれらの送達方法
US10231834B2 (en) 2015-02-09 2019-03-19 Edwards Lifesciences Corporation Low profile transseptal catheter and implant system for minimally invasive valve procedure
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
US20160235525A1 (en) 2015-02-12 2016-08-18 Medtronic, Inc. Integrated valve assembly and method of delivering and deploying an integrated valve assembly
WO2016130173A1 (en) 2015-02-13 2016-08-18 W.L. Gore & Associates, Inc. Coherent single layer high strength synthetic polymer composites for prosthetic valves
EP3261583B1 (en) 2015-02-24 2019-02-13 Rijksuniversiteit Groningen Mechanical heart valve prosthesis for the right ventricle
FR3033494B1 (fr) 2015-03-10 2017-03-24 Carmat Endoprothese tissulaire et procede pour sa realisation
US10758349B2 (en) 2015-03-13 2020-09-01 Medtronic Vascular, Inc. Delivery device for prosthetic heart valve with capsule adjustment device
US20180116843A1 (en) 2015-03-20 2018-05-03 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath
US9962260B2 (en) 2015-03-24 2018-05-08 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
CN107157622B (zh) 2015-03-26 2019-12-17 杭州启明医疗器械股份有限公司 使用安全的瓣膜支架以及具有该瓣膜支架的瓣膜置换装置
DE102015206099A1 (de) 2015-04-02 2016-10-06 Hans-Hinrich Sievers Herzklappenprothese
DE102015206098B4 (de) 2015-04-02 2018-09-27 Hans-Hinrich Sievers Implantationshilfe für eine biologische Herzklappenprothese sowie Herzklappenprothesensystem
DE102015206097A1 (de) 2015-04-02 2016-10-06 Hans-Hinrich Sievers Herzklappenprothese
FR3034642B1 (fr) 2015-04-07 2021-01-15 Benjamin Faurie Introducteur pour ensemble de remplacement d'une valve cardiaque ou pour ensemble d'angioplastie coronaire
EP3078350B1 (en) 2015-04-09 2018-01-31 Frid Mind Technologies 3d filter for prevention of stroke
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10792471B2 (en) 2015-04-10 2020-10-06 Edwards Lifesciences Corporation Expandable sheath
US10327896B2 (en) 2015-04-10 2019-06-25 Edwards Lifesciences Corporation Expandable sheath with elastomeric cross sectional portions
US10368986B2 (en) 2015-04-15 2019-08-06 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US9931790B2 (en) 2015-04-16 2018-04-03 Siemens Healthcare Gmbh Method and system for advanced transcatheter aortic valve implantation planning
JP6694948B2 (ja) 2015-04-16 2020-05-20 テンダイン ホールディングス，インコーポレイテッド 経カテーテル人工弁の送達、再配置及び回収のための装置及び方法
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
KR101588310B1 (ko) 2015-04-22 2016-01-25 (주)태웅메디칼 심낭막을 이용한 인공심장판막 및 그 제조방법
US9782256B2 (en) 2015-04-27 2017-10-10 Venus Medtech (Hangzhou) Inc Heart valve assembly
EP3087952A1 (en) 2015-04-29 2016-11-02 Kephalios S.A.S. An annuloplasty system and a method for monitoring the effectiveness of an annuloplasty treatment
CN106175985B (zh) 2015-04-29 2018-08-24 上海微创心通医疗科技有限公司 用于输送植入体的驱动手柄及输送系统
US10232564B2 (en) 2015-04-29 2019-03-19 Edwards Lifesciences Corporation Laminated sealing member for prosthetic heart valve
US10925709B2 (en) 2015-04-30 2021-02-23 Silk Road Medical, Inc. Systems and methods for transcatheter aortic valve treatment
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
US10709555B2 (en) 2015-05-01 2020-07-14 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
ES2903274T3 (es) 2015-05-01 2022-03-31 Feops Nv Método y sistema para determinar el riesgo de anomalías de conducción cardíaca
US9629720B2 (en) 2015-05-04 2017-04-25 Jacques Seguin Apparatus and methods for treating cardiac valve regurgitation
GB2538072B (en) 2015-05-05 2017-11-15 Strait Access Tech Holdings (Pty) Ltd A non-occlusive dilation and deployment catheter device
DE102015107242B4 (de) 2015-05-08 2022-11-03 Highlife Sas System zum Implantieren eines Implantats um eine umfängliche Gewebestruktur in einem Herz und Verfahren zum Anordnen und Vorbringen eines Implantats auf einem Führungsdraht eines solchen Systems
JP6595210B2 (ja) 2015-05-08 2019-10-23 株式会社日本医療機器開発機構 大動脈弁再建術トレーニングキット
EP4074285A1 (en) 2015-05-12 2022-10-19 Ancora Heart, Inc. Device for releasing catheters from cardiac structures
CN110433010A (zh) 2015-05-14 2019-11-12 爱德华兹生命科学公司 心脏瓣膜密封装置及其递送装置
GB2538749B (en) 2015-05-27 2017-08-02 Univ Dublin City Inflatable balloon
US10123892B2 (en) 2015-05-28 2018-11-13 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve having a leaflet restraining member
JP6816889B2 (ja) 2015-05-28 2021-01-20 ４テック インコーポレイテッド 引張り部材を有する偏心組織アンカー
EP3539509B1 (en) 2015-06-01 2021-07-07 Edwards Lifesciences Corporation Cardiac valve repair devices configured for percutaneous delivery
CN108135694B (zh) 2015-06-04 2021-01-19 爱普贡公司 具有原生小叶抓握和保持机构的房室瓣膜支架
CA2987441A1 (en) * 2015-06-05 2016-12-08 Tendyne Holdings, Inc. Apical control of transvascular delivery of prosthetic mitral valve
WO2016200993A1 (en) 2015-06-08 2016-12-15 Mccarthy Patrick M Annuloplasty ring for receiving a replacement valve
US10314707B2 (en) 2015-06-09 2019-06-11 Edwards Lifesciences, Llc Asymmetric mitral annuloplasty band
GB2539444A (en) 2015-06-16 2016-12-21 Ucl Business Plc Prosthetic heart valve
WO2017004360A1 (en) 2015-06-30 2017-01-05 Snyders Robert V Lifetime regenerative heart valve
WO2017004369A1 (en) 2015-07-02 2017-01-05 Edwards Lifesciences Corporation Hybrid heart valves adapted for post-implant expansion
EP3316823B1 (en) 2015-07-02 2020-04-08 Edwards Lifesciences Corporation Integrated hybrid heart valves
US10716671B2 (en) 2015-07-02 2020-07-21 Boston Scientific Scimed, Inc. Prosthetic heart valve composed of composite fibers
JP6778737B2 (ja) 2015-07-03 2020-11-04 ボストン サイエンティフィック リミテッド 人工弁用バルーンカテーテル
DE102015212699A1 (de) 2015-07-07 2017-01-12 AdjuCor GmbH Implantierbare Vorrichtung zur ortsgenauen Zuführung und Applikation von Substanzen in das Perikard oder auf die Herzoberfläche
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
US10639149B2 (en) 2015-07-16 2020-05-05 St. Jude Medical, Cardiology Division, Inc. Sutureless prosthetic heart valve
ITUB20152409A1 (it) 2015-07-22 2017-01-22 Sorin Group Italia Srl Manicotto valvolare per protesi valvolari e corrispondente dispositivo
EP3328318B1 (en) 2015-07-28 2019-08-21 Boston Scientific Scimed, Inc. Valve delivery system with pinless release mechanism
US10492938B2 (en) 2015-08-11 2019-12-03 Terumo Corporation System and method for implant delivery
US10925726B2 (en) 2015-08-12 2021-02-23 Boston Scientific Scimed, Inc. Everting leaflet delivery system with pivoting
EP3334380B1 (en) 2015-08-12 2022-03-16 St. Jude Medical, Cardiology Division, Inc. Collapsible heart valve including stents with tapered struts
US10179041B2 (en) 2015-08-12 2019-01-15 Boston Scientific Scimed Icn. Pinless release mechanism
US10709553B2 (en) 2015-08-12 2020-07-14 Boston Scientific Scimed, Inc. V-Clip post with pivoting
US10179046B2 (en) 2015-08-14 2019-01-15 Edwards Lifesciences Corporation Gripping and pushing device for medical instrument
EP3334382B1 (en) 2015-08-14 2020-12-16 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9895222B2 (en) 2015-08-17 2018-02-20 Venus Medtech (Hangzhou) Inc. Aortic replacement valve
EP3365349B1 (en) 2015-08-18 2022-06-15 University of Pittsburgh- Of the Commonwealth System of Higher Education Viologen-functionalized porphyrins for reducing biofouling on surfaces
US11357499B2 (en) 2015-08-18 2022-06-14 Lsi Solutions, Inc. Apparatus for mitral valve repair and methods thereof
US11026788B2 (en) 2015-08-20 2021-06-08 Edwards Lifesciences Corporation Loader and retriever for transcatheter heart valve, and methods of crimping transcatheter heart valve
US10631977B2 (en) 2015-08-24 2020-04-28 Edwards Lifesciences Corporation Covering and assembly method for transcatheter valve
MA44837A (fr) 2015-08-25 2018-07-04 Innovein Inc Prothèse de valvule veineuse
CA2996166A1 (en) 2015-08-26 2017-03-09 Edwards Lifesciences Corporation Controlled balloon deployment
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
CN108135592B (zh) 2015-09-02 2021-05-14 爱德华兹生命科学公司 用于固定经导管瓣膜至生物假体心脏结构的间隔件
EP3344189B1 (en) 2015-09-03 2019-07-31 St. Jude Medical, Cardiology Division, Inc. Introducer sheath having expandable portions
US11051853B2 (en) 2015-09-04 2021-07-06 The Trustees Of The University Of Pennsylvania Systems and methods for percutaneous removal of objects from an internal body space
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
WO2017042627A1 (en) 2015-09-11 2017-03-16 S.M. Scienzia Machinale S.R.L. Apparatus and method for producing a biocompatible three-dimensional object
US10195023B2 (en) 2015-09-15 2019-02-05 Boston Scientific Scimed, Inc. Prosthetic heart valves including pre-stressed fibers
US10478288B2 (en) 2015-09-30 2019-11-19 Clover Life Sciences Inc. Trileaflet mechanical prosthetic heart valve
ES2554296B1 (es) 2015-10-02 2017-01-18 Jose Ignacio ARAMENDI GALLARDO Anillo subaórtico reabsorbible
US10195024B2 (en) 2015-10-07 2019-02-05 Boston Scientific Scimed, Inc. Porcine small intestine submucosa leaflet material
US9872765B2 (en) 2015-10-12 2018-01-23 Venus Medtech (Hangzhou) Inc Mitral valve assembly
EP3361991B1 (en) 2015-10-14 2023-07-05 Heart Repair Technologies, Inc. Transvalvular intraannular band for mitral valve repair
US10350067B2 (en) 2015-10-26 2019-07-16 Edwards Lifesciences Corporation Implant delivery capsule
WO2017072262A1 (en) 2015-10-28 2017-05-04 Koninklijke Philips N.V. Signaling of an aortic valve state
US10266657B2 (en) 2015-10-29 2019-04-23 Commonwealth Scientific And Industrial Research Organisation Polyurethane/urea compositions
EP3370649B1 (en) 2015-11-02 2023-03-15 Edwards Lifesciences Corporation Devices for reducing cardiac valve regurgitation
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US10321996B2 (en) 2015-11-11 2019-06-18 Edwards Lifesciences Corporation Prosthetic valve delivery apparatus having clutch mechanism
CN108289737B (zh) 2015-11-17 2020-03-31 魅尔皮德股份有限公司 用于使心脏瓣环重新定形的可植入装置和输送系统
US10143554B2 (en) 2015-12-03 2018-12-04 Medtronic Vascular, Inc. Venous valve prostheses
DE102015121501A1 (de) 2015-12-10 2017-06-14 Biotronik Ag Einführkatheter und Katheteranordnung
JP7002451B2 (ja) 2015-12-15 2022-01-20 ニオバスク ティアラ インコーポレイテッド 経中隔送達システム
US11008676B2 (en) 2015-12-16 2021-05-18 Edwards Lifesciences Corporation Textured woven fabric for use in implantable bioprostheses
EP3184081B1 (en) 2015-12-22 2021-03-24 Medira Ag Prosthetic mitral valve coaptation enhancement device
EP3184082B1 (en) 2015-12-23 2022-08-17 P+F Products + Features Vertriebs GmbH Stent for a surgical valve
WO2017117109A1 (en) 2015-12-28 2017-07-06 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
US10426619B2 (en) 2015-12-30 2019-10-01 Avvie Gmbh Implant and method for improving coaptation of an atrioventricular valve
WO2017117388A1 (en) 2015-12-30 2017-07-06 Caisson Interventional, LLC Systems and methods for heart valve therapy
AU2017207775A1 (en) 2016-01-14 2018-07-26 Cardiatis S.A. Implantable prosthesis for thoracic aortic disease involving aortic valve dysfunction
JP7220338B2 (ja) 2016-01-22 2023-02-10 メドテンティア・インターナショナル・リミテッド・オサケユキチュア 弁輪形成インプラント
JP6658773B2 (ja) 2016-01-25 2020-03-04 株式会社リコー 立体造形物、立体造形物の製造方法、立体造形物の製造装置、立体造形用材料セット、及びハイドロゲル前駆体液
US20170209268A1 (en) 2016-01-27 2017-07-27 Medtronic, Inc. Systems and methods for repositioning a fully deployed valve assembly
US10342660B2 (en) 2016-02-02 2019-07-09 Boston Scientific Inc. Tensioned sheathing aids
JP2019503813A (ja) 2016-02-04 2019-02-14 ミリピード， インコーポレイテッドＭｉｌｌｉｐｅｄｅ， Ｉｎｃ． 僧帽弁反転プロテーゼ
US10363130B2 (en) 2016-02-05 2019-07-30 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
AU2017218708B2 (en) 2016-02-08 2022-02-03 Innoventric Ltd. Treatment of tricuspid insufficiency
US10376681B2 (en) 2016-02-29 2019-08-13 Edwards Lifesciences Corporation Vacuum-based compliance restoration
DE102016103843A1 (de) 2016-03-03 2017-09-07 Biotronik Ag Reduktion von paravalvulärer Leckage durch kontrollierten Thrombusaufbau
EP3213714A1 (de) 2016-03-03 2017-09-06 Biotronik AG Einführkatheter und katheteranordnung
US10779941B2 (en) 2016-03-08 2020-09-22 Edwards Lifesciences Corporation Delivery cylinder for prosthetic implant
US10398549B2 (en) 2016-03-15 2019-09-03 Abbott Cardiovascular Systems Inc. System and method for transcatheter heart valve platform
EP3432832A1 (en) 2016-03-22 2019-01-30 Assistance Publique - Hôpitaux de Paris Vascular valved prosthesis and manufacturing method
US10512757B2 (en) 2016-03-25 2019-12-24 Project Moray, Inc. Fluid-actuated sheath displacement and articulation behavior improving systems, devices, and methods for catheters, continuum manipulators, and other uses
GB2548891B (en) 2016-03-31 2018-07-04 I Birdi Ltd A prosthetic device for mitral valve repair
DE102016106575A1 (de) 2016-04-11 2017-10-12 Biotronik Ag Herzklappenprothese
US10159569B2 (en) 2016-04-12 2018-12-25 Lars Erickson Minimally invasive atrio-ventricular valve treatment by chordae adjustment
CN105852916B (zh) 2016-04-14 2018-02-06 上海甲悦医疗器械有限公司 一种经心尖植入的二尖瓣柔性闭合板阻塞体及植入方法
US10485658B2 (en) 2016-04-22 2019-11-26 Backbeat Medical, Inc. Methods and systems for controlling blood pressure
US10624743B2 (en) 2016-04-22 2020-04-21 Edwards Lifesciences Corporation Beating-heart mitral valve chordae replacement
US10405974B2 (en) 2016-04-26 2019-09-10 Boston Scientific Scimed, Inc. Replacement heart valve with improved stitching
WO2017190161A1 (en) 2016-04-27 2017-11-02 Strait Access Technologies Holdings (Pty) Ltd Expandable stent and methods of crimping and expanding such stent
US10406011B2 (en) 2016-04-28 2019-09-10 Medtronic Vascular, Inc. Implantable medical device delivery system
US10231829B2 (en) 2016-05-04 2019-03-19 Boston Scientific Scimed Inc. Leaflet stitching backer
US10172710B2 (en) 2016-05-10 2019-01-08 William Joseph Drasler Two component mitral valve
EP3454794B1 (en) 2016-05-13 2021-04-14 St. Jude Medical, Cardiology Division, Inc. Systems for device implantation
EP3454795B1 (en) 2016-05-13 2023-01-11 JenaValve Technology, Inc. Heart valve prosthesis delivery system for delivery of heart valve prosthesis with introducer sheath and loading system
US10583005B2 (en) 2016-05-13 2020-03-10 Boston Scientific Scimed, Inc. Medical device handle
EP3454785B1 (en) 2016-05-13 2021-11-17 St. Jude Medical, Cardiology Division, Inc. Heart valve with stent having varying cell densities
US20170325952A1 (en) 2016-05-13 2017-11-16 Boston Scientific Scimed, Inc. Implant release system
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
AU2017267441A1 (en) 2016-05-16 2018-11-01 Valve Medical Ltd. Inverting temporary valve sheath
US11116630B2 (en) 2016-05-16 2021-09-14 Boston Scientific Scimed, Inc. Sheathing aid
CN113143536B (zh) 2016-05-16 2022-08-30 万能医药公司 撑开支架
EP3457990B1 (en) 2016-05-17 2022-11-30 Boston Scientific Scimed, Inc. Replacement heart valve implant with inflow stitching
WO2017200920A1 (en) 2016-05-19 2017-11-23 Boston Scientific Scimed, Inc. Prosthetic valves, valve leaflets and related methods
CN111759368A (zh) 2016-06-02 2020-10-13 美敦力瓦斯科尔勒公司 具有隔膜孔闭合末端组件的经导管瓣膜递送系统
WO2017210656A1 (en) 2016-06-03 2017-12-07 Intervene, Inc. Devices for manipulating blood vessel walls and associated systems and methods of use
EP3471662B1 (en) 2016-06-15 2022-08-03 Corcym S.r.l. Two-part mitral valve
DE102016111323A1 (de) 2016-06-21 2017-12-21 Biotronik Ag Einführkatheter und Katheteranordnung
US10639147B2 (en) 2016-06-24 2020-05-05 Edwards Lifesciences Corporation System and method for crimping a prosthetic valve
EP3478224B1 (en) 2016-06-30 2022-11-02 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus for delivery of same
CN107550524B (zh) 2016-07-01 2020-01-03 先健科技(深圳)有限公司 输送装置
WO2018009685A1 (en) 2016-07-06 2018-01-11 The Methodist Hospital Prosthetic mitral valve comprising an annular-ventricular coupling mechanism
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
US10973638B2 (en) 2016-07-07 2021-04-13 Edwards Lifesciences Corporation Device and method for treating vascular insufficiency
US10828150B2 (en) 2016-07-08 2020-11-10 Edwards Lifesciences Corporation Docking station for heart valve prosthesis
GB201611910D0 (en) 2016-07-08 2016-08-24 Valtech Cardio Ltd Adjustable annuloplasty device with alternating peaks and troughs
CN109414326B (zh) 2016-07-12 2021-02-26 美敦力股份有限公司 用于管控流体流动的人工瓣膜
GB201612180D0 (en) 2016-07-13 2016-08-24 Ucl Business Plc Bioprosthetic heart valve
US10058426B2 (en) 2016-07-20 2018-08-28 Abbott Cardiovascular Systems Inc. System for tricuspid valve repair
US10478304B2 (en) 2016-07-20 2019-11-19 Abbott Cardiovascular Systems Inc. Independent system for tricuspid valve repair
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US10561423B2 (en) 2016-07-25 2020-02-18 Virender K. Sharma Cardiac shunt device and delivery system
CN106175986B (zh) 2016-07-26 2017-12-01 复旦大学附属中山医院 一种瓣膜夹合器
WO2018022862A1 (en) 2016-07-27 2018-02-01 Sainath Intellectual Properties, Llc Stent with one-way sock valve
US10974027B2 (en) 2016-07-29 2021-04-13 Cephea Valve Technologies, Inc. Combination steerable catheter and systems
US11324495B2 (en) 2016-07-29 2022-05-10 Cephea Valve Technologies, Inc. Systems and methods for delivering an intravascular device to the mitral annulus
US10646689B2 (en) 2016-07-29 2020-05-12 Cephea Valve Technologies, Inc. Mechanical interlock for catheters
US11096781B2 (en) 2016-08-01 2021-08-24 Edwards Lifesciences Corporation Prosthetic heart valve
CN109789018B (zh) 2016-08-10 2022-04-26 卡迪尔维尔福股份有限公司 具有同轴框架的人工瓣膜
US10828152B2 (en) 2016-08-11 2020-11-10 4C Medical Technologies, Inc. Heart chamber prosthetic valve implant with base, spring and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function
EP3432806B1 (en) 2016-08-18 2019-10-02 4Tech Inc. Tissue anchors with flexible tips for insertion into the pericardial cavity
CR20190069A (es) 2016-08-26 2019-05-14 Edwards Lifesciences Corp Valvulas y sistemas de acoplamiento de valvulas corazon
US10548722B2 (en) 2016-08-26 2020-02-04 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
EP3503848B1 (en) 2016-08-26 2021-09-22 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
US10751485B2 (en) 2016-08-29 2020-08-25 Cephea Valve Technologies, Inc. Methods, systems, and devices for sealing and flushing a delivery system
US10575946B2 (en) 2016-09-01 2020-03-03 Medtronic Vascular, Inc. Heart valve prosthesis and separate support flange for attachment thereto
EP3512465B1 (en) 2016-09-15 2021-09-01 Cardiac Implants LLC An apparatus for delivering a cardiac annulus ring
WO2018052927A1 (en) 2016-09-15 2018-03-22 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
US10052201B2 (en) 2016-09-21 2018-08-21 Peijia Medical Co., Ltd. Valved stent for mitral and tricuspid heart valve replacement
US10575944B2 (en) 2016-09-22 2020-03-03 Edwards Lifesciences Corporation Prosthetic heart valve with reduced stitching
US10874512B2 (en) 2016-10-05 2020-12-29 Cephea Valve Technologies, Inc. System and methods for delivering and deploying an artificial heart valve within the mitral annulus
JP7073355B2 (ja) 2016-10-07 2022-05-23 エレクトロデューサー 心臓弁を置換するためのアセンブリまたは冠動脈形成アセンブリ
FR3057154B1 (fr) 2016-10-07 2018-10-19 Electroducer Electrode transcutanee pour ensemble de remplacement d'une valve cardiaque ou ensemble d'angioplastie coronaire comprenant un catheter de delivrance ou un introducteur
EP3311774B1 (en) 2016-10-19 2022-05-11 P+F Products + Features Vertriebs GmbH Self-expandable atrioventricular valve and system of cardiac valves
CN107374782B (zh) 2016-10-20 2023-04-18 上海微创心通医疗科技有限公司 植入体输送装置
DE202016105963U1 (de) 2016-10-24 2018-01-25 Nvt Ag Intraluminale Gefäßprothese zur Implantation in das Herz oder Herzgefäße eines Patienten
CA3042021A1 (en) 2016-10-31 2018-05-03 Cardiac Implants Llc Flexible radio-opaque protrusions for revealing the position of a constricting cord or annulus ring prior to installation onto a cardiac valve annulus
US10722356B2 (en) 2016-11-03 2020-07-28 Edwards Lifesciences Corporation Prosthetic mitral valve holders
US11376121B2 (en) 2016-11-04 2022-07-05 Highlife Sas Transcatheter valve prosthesis
US9999502B2 (en) 2016-11-04 2018-06-19 Highlife Sas Transcather valve prosthesis
US10653862B2 (en) 2016-11-07 2020-05-19 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
US10869991B2 (en) 2016-11-09 2020-12-22 Medtronic Vascular, Inc. Telescoping catheter
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
DE102016013480A1 (de) 2016-11-11 2018-05-17 Peter Osypka Stiftung Vorrichtung zur Ballondilatation einer verengten Herzklappe
FR3058631B1 (fr) 2016-11-14 2019-01-25 Laboratoires Invalv Implant de traitement d'une valve biologique
FR3058632B1 (fr) 2016-11-14 2019-01-25 Laboratoires Invalv Dispositif de traitement d'une valve biologique avec organe de poussee de la valve
US20180133006A1 (en) 2016-11-15 2018-05-17 Medtronic Vascular, Inc. Stabilization and advancement system for direct aortic transcatheter aortic valve implantation
US10959841B2 (en) 2016-11-15 2021-03-30 Hancock Jaffe Laboratories, Inc. Implantable vein frame
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
US11026716B2 (en) 2016-11-22 2021-06-08 Boston Scientific Scimed, Inc. Medical device shaft resistant to compression and/or tension
US11013588B2 (en) 2016-11-23 2021-05-25 St. Jude Medical, Cardiology Division, Inc. Tissue heart valve (THV) humidor packaging system
US10548614B2 (en) 2016-11-29 2020-02-04 Evalve, Inc. Tricuspid valve repair system
WO2018102694A1 (en) 2016-12-01 2018-06-07 Boston Scientific Scimed, Inc. Heart valve remodeling device
FR3060292B1 (fr) 2016-12-15 2019-01-25 Cmi'nov Dispositif pour realiser ou preparer une annuloplastie mitrale par voie transfemorale
HUE061376T2 (hu) 2016-12-16 2023-06-28 Edwards Lifesciences Corp Behelyezõ rendszerek és mûszerek rögzítõeszköz bejuttatására egy billentyûprotézishez
SG10202109534TA (en) 2016-12-20 2021-10-28 Edwards Lifesciences Corp Systems and mechanisms for deploying a docking device for a replacement heart valve
EP3342355B1 (en) 2016-12-29 2020-04-22 Medtentia International Ltd Oy Medical securing device for securing an object with a securing member
US10463517B2 (en) 2017-01-16 2019-11-05 Cook Medical Technologies Llc Controlled expansion stent graft delivery system
US11185406B2 (en) 2017-01-23 2021-11-30 Edwards Lifesciences Corporation Covered prosthetic heart valve
JP7046078B2 (ja) 2017-01-23 2022-04-01 セフィア・バルブ・テクノロジーズ，インコーポレイテッド 置換僧帽弁
ES2886225T3 (es) 2017-02-02 2021-12-16 Valfix Medical Ltd Reparación y sustitución de válvulas percutáneas
JP6718189B2 (ja) 2017-02-08 2020-07-08 ４テック インコーポレイテッド 心臓埋め込みにおける埋め込み後の張力付与
DE102017202159A1 (de) 2017-02-10 2018-08-16 Tribio Gmbh Biologische Transkatheterklappe
US10492779B2 (en) 2017-02-20 2019-12-03 Edwards Lifesciences Corporation Suturing devices for heart valve surgery
EP3372198B1 (en) 2017-03-06 2019-06-19 AVVie GmbH Implant for improving coaptation of an atrioventricular valve
US10631968B2 (en) 2017-03-06 2020-04-28 Edwards Lifesciences Corporation Humidity-management packaging systems and methods
EP3592289B1 (en) 2017-03-09 2021-07-07 Medtronic Vascular Inc. Tension management devices for stented prosthesis delivery device
US10799685B2 (en) 2017-03-09 2020-10-13 Edwards Lifesciences Corporation Expandable sheath with longitudinally extending reinforcing members
FR3063631B1 (fr) 2017-03-13 2019-03-22 Cmi'nov Dispositif de reparation des cordages de la valve mitrale d'un cœur par voie transfemorale
EP3595588B1 (en) 2017-03-14 2022-06-08 Shape Memory Medical, Inc. Shape memory polymer foams to seal space around valves
WO2018175619A1 (en) 2017-03-22 2018-09-27 Edwards Lifesciences Corporation System and method for implanting and securing a bioprosthetic device to wet tissue
WO2018178966A1 (en) 2017-03-27 2018-10-04 Truleaf Medical Ltd. Docking elements
DE102017002974A1 (de) 2017-03-28 2018-10-04 Immanuel Diakonie Gmbh Herzklappen-Implantat, geeignet für den Einsatz in der minimal-invasiven Chirurgie zur Reparatur einer Herzklappe und/oder eines Herzklappensegels am schlagenden Herzen
AU2018248410B2 (en) 2017-04-05 2020-07-09 Opus Medical Therapies, LLC Transcatheter atrial sealing skirt, anchor, and tether and methods of implantation
EP3606472B1 (en) 2017-04-06 2021-09-15 Harpoon Medical, Inc. Distal anchor apparatus and method of manufacturing a distal anchor
US11224511B2 (en) 2017-04-18 2022-01-18 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
PT3682854T (pt) 2017-04-18 2022-01-27 Edwards Lifesciences Corp Dispositivos de vedação de válvulas cardíacas e respetivos dispositivos de entrega
CN110603205B (zh) 2017-05-02 2022-08-09 美敦力瓦斯科尔勒公司 用于干组织假体心脏瓣膜的包装
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
DK4035629T3 (da) 2017-05-31 2023-11-13 Edwards Lifesciences Corp Tætningselement til en hjerteklapprotese
WO2018227048A1 (en) 2017-06-08 2018-12-13 4Tech Inc. Tissue anchor with tether stop
EP3417831B2 (en) 2017-06-19 2023-05-24 HVR Cardio Oy Delivery device for an annuloplasty implant
EP3645065B1 (en) 2017-06-29 2022-09-28 St. Jude Medical, Cardiology Division, Inc. Method of preparing calcification-resistant bioprosthetic tissue
JP7143340B2 (ja) 2017-06-30 2022-09-28 ギオラ ウェイズ， 体内空間内での多次元ナビゲーション
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
EP3648709B1 (en) 2017-07-06 2022-05-11 Edwards Lifesciences Corporation Steerable rail delivery system
WO2019027956A1 (en) 2017-07-31 2019-02-07 Boston Scientific Scimed, Inc. INTRODUCTION SYSTEM WITH EXTENSION CAPABILITIES
DE202017104793U1 (de) 2017-08-09 2018-11-14 Nvt Ag Ladesystem für Herzklappenprothesen
US10973628B2 (en) 2017-08-18 2021-04-13 Edwards Lifesciences Corporation Pericardial sealing member for prosthetic heart valve
US10722353B2 (en) 2017-08-21 2020-07-28 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
IL254099B (en) 2017-08-22 2021-02-28 Geonovation Medical Tech Ltd Collapsible one-way valve bushing
EP3672532B1 (en) 2017-08-26 2022-08-03 Transmural Systems LLC Implantable cardiac pacing system
EP3681439B1 (en) 2017-09-12 2021-07-28 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation
US11786375B2 (en) 2017-09-13 2023-10-17 Mayo Foundation For Medical Education And Research Methods and devices for securing epicardial devices
US10856982B2 (en) 2017-09-19 2020-12-08 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve delivery system
EP3668450B1 (en) 2017-09-22 2021-07-14 Boston Scientific Scimed, Inc. Dome structure for improved left ventricle function
US20190091013A1 (en) 2017-09-22 2019-03-28 St. Jude Medical, Cardiology Division, Inc. Prosthetic Heart Valve with Atraumatic Aortic Portion
FR3071716B1 (fr) 2017-10-04 2023-02-24 Mdb Texinov Insert textile a finalite medicale et son procede de fabrication
FR3072013B1 (fr) 2017-10-09 2019-09-27 Cmi'nov Dispositif de suture d'une prothese valvulaire cardiaque
EP3470105B1 (de) 2017-10-13 2020-04-22 BIOTRONIK SE & Co. KG Einführelement für eine medizinische einführeinrichtung
US10426473B2 (en) 2017-10-19 2019-10-01 Abbott Cardiovascular Systems Inc. System and method for plicating a heart valve
ES2907379T3 (es) 2017-10-19 2022-04-25 Shanghai Hanyu Medical Tech Co Ltd Dispositivo de sujeción de válvulas
US9895226B1 (en) 2017-10-19 2018-02-20 Mitral Tech Ltd. Techniques for use with prosthetic valve leaflets
EP3697346B1 (en) 2017-10-20 2022-01-19 Boston Scientific Scimed, Inc. Heart valve repair implant for treating tricuspid regurgitation
EP3476366B1 (en) 2017-10-27 2020-12-16 Medtentia International Ltd Oy Annuloplasty implant
US10912664B2 (en) 2017-11-21 2021-02-09 Cook Medical Technologies, LLC Stent with induction responsive muscles that facilitate implantation adjustments
KR102053451B1 (ko) 2017-11-24 2020-01-08 (주) 타우피엔유메디칼 서클라지 심방 제세동장치
EP3498223A1 (en) 2017-12-13 2019-06-19 Epygon Crimping device for collapsible valves
CN108065970B (zh) 2017-12-14 2019-06-25 谭雄进 一种可多次调节的人工腱索固定组件
US11547563B2 (en) 2018-01-08 2023-01-10 Medtentia International Ltd. Oy Annuloplasty device
IT201800000671A1 (it) 2018-01-10 2019-07-10 Matteo Montorfano Dispositivo di inserimento di un filo di guida in un vaso sanguigno
BR112020014367A2 (pt) 2018-01-19 2020-12-01 Edwards Lifesciences Corporation válvula cardíaca protética coberta
EP3661429B1 (en) 2018-01-27 2023-07-19 LSI Solutions, Inc. Prosthetic suturing device
DE102018102940B4 (de) 2018-02-09 2019-10-31 Francisco Javier Carrero Gomez Vorrichtung zur Prüfung der Funktion einer Aortenklappe
EP3527170B1 (en) 2018-02-20 2020-11-18 Institut National des Sciences Appliquées de Lyon Device for assisting a practitioner in adjusting the length of an artificial chordae implanted in an atrio-ventricular heart valve
US11439732B2 (en) 2018-02-26 2022-09-13 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
EP4218669A1 (en) 2018-03-27 2023-08-02 Maduro Discovery, LLC Accessory device to provide neuroprotection during interventional procedures
FR3079404B1 (fr) 2018-03-29 2020-03-06 Electroducer Ensemble de remplacement d’une valve cardiaque avec assistance de stimulation par voie arterielle ou veineuse peripherique
EP3556323B1 (en) 2018-04-18 2023-07-19 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve
CA3097895A1 (en) 2018-04-30 2019-11-07 Edwards Lifesciences Corporation Devices and methods for crimping prosthetic implants
US11026787B2 (en) 2018-04-30 2021-06-08 St. Jude Medical, Cardiology Division, Inc. Heart valve holder
WO2019217364A1 (en) 2018-05-07 2019-11-14 Medtronic Vascular, Inc. Assemblies and methods of sterilizing a wet stored implant
WO2019223975A1 (en) 2018-05-21 2019-11-28 Medtentia International Ltd Oy Annuloplasty device
EP3796876B1 (en) 2018-05-22 2022-07-27 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation
WO2019224581A1 (en) 2018-05-23 2019-11-28 Sorin Group Italia S.R.L. A device for the in-situ delivery of heart valve prostheses
JP7109657B2 (ja) 2018-05-23 2022-07-29 コーシム・ソチエタ・ア・レスポンサビリタ・リミタータ 心臓弁プロテーゼ
EP3581232B1 (en) 2018-06-11 2021-02-17 Dentsply IH AB Urethral stent and bladder control assembly comprising such a urethral stent
EP3833302B1 (en) 2018-08-06 2022-12-14 Thubrikar Aortic Valve, Inc. Apparatus for delivery of a prosthetic valve device
US20210145580A1 (en) 2018-08-07 2021-05-20 4Tech Inc. Post-implantation tensioning in cardiac implants
EP3620133A1 (en) 2018-09-07 2020-03-11 AVVie GmbH Implant for improving coaptation of an artrioventricular valve
FR3085835B1 (fr) 2018-09-13 2020-08-28 Univ Compiegne Tech Implant pour valve cardiaque
US11395738B2 (en) 2018-09-25 2022-07-26 Truleaf Medical Ltd. Docking elements
JP7410940B2 (ja) 2018-10-04 2024-01-10 ストライカー コーポレイション 医療用インプラント送達システム
EP3863567B1 (de) 2018-10-10 2024-04-03 Devie Medical GmbH Implantat zur behandlung und/oder zum ersatz einer entzündeten, thrombosierten oder degenerierten herzklappe
DE102018126828A1 (de) 2018-10-26 2020-04-30 Nvt Ag Herzklappenprothese
AU2019387434A1 (en) 2018-11-29 2021-06-10 Cardiomech As Device for heart repair
WO2020126001A1 (de) 2018-12-20 2020-06-25 Medizinische Universität Wien Stentgraft und vorrichtung zum zuführen und setzen eines solchen stentgrafts in die aorta ascendens
CN111437065A (zh) 2019-01-17 2020-07-24 TauPNU医疗有限公司 位置可调节的三尖瓣返流手术用器械
US10898329B2 (en) 2019-01-25 2021-01-26 Edwards Lifesciences Corporation Testing apparatus for prosthetic device
WO2020174590A1 (ja) 2019-02-26 2020-09-03 株式会社ｉＣｏｒＮｅｔ研究所 心臓サポートネット及び植込み型除細動器
US11452599B2 (en) 2019-05-02 2022-09-27 Twelve, Inc. Fluid diversion devices for hydraulic delivery systems and associated methods
EP3986332A4 (en) 2019-06-20 2023-07-19 Neovasc Tiara Inc. LOW-PROFILE PROSTHETIC MITRAL VALVE
EP4119092A1 (en) 2020-03-17 2023-01-18 Cardiovalve Ltd. Leaflet-grouping system
EP3881801A1 (en) 2020-03-18 2021-09-22 Medtronic Inc. Improvements in or relating to the delivery and unsheathing of prosthetic heart valves
WO2021195823A1 (zh) 2020-03-30 2021-10-07 乐普（北京）医疗器械股份有限公司 心脏瓣膜夹合器
US11318013B2 (en) 2020-04-21 2022-05-03 Medtronic, Inc. Compact prosthetic heart valve device
EP3912595B1 (en) 2020-05-19 2023-01-04 AVVie GmbH Implant for improving coaptation of an atrioventricular valve

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11931254B2 (en) 2019-06-20 2024-03-19 Neovasc Tiara Inc. Low profile prosthetic mitral valve

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US11931254B2 (en) 2024-03-19
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