ES2613761T3 - Sistema protésico para el reemplazo de la válvula cardíaca - Google Patents

Sistema protésico para el reemplazo de la válvula cardíaca Download PDF

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Publication number
ES2613761T3
ES2613761T3 ES13812152.0T ES13812152T ES2613761T3 ES 2613761 T3 ES2613761 T3 ES 2613761T3 ES 13812152 T ES13812152 T ES 13812152T ES 2613761 T3 ES2613761 T3 ES 2613761T3
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ES
Spain
Prior art keywords
segments
ring
prosthetic
valve
heart valve
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Active
Application number
ES13812152.0T
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English (en)
Inventor
Giovanni Righini
Sarah Zanon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovheart SRL
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Innovheart SRL
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Filing date
Publication date
Priority claimed from IT000636A external-priority patent/ITBO20120636A1/it
Application filed by Innovheart SRL filed Critical Innovheart SRL
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Publication of ES2613761T3 publication Critical patent/ES2613761T3/es
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427Devices for manipulating or deploying heart valves during implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445Annuloplasty rings in direct contact with the valve annulus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457Chordae tendineae prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466Delivery devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238Type of minimally invasive operation
    • A61B2017/00243Type of minimally invasive operation cardiac
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00358Snares for grasping
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00778Operations on blood vessels
    • A61B2017/00783Valvuloplasty
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22031Gripping instruments, e.g. forceps, for removing or smashing calculi
    • A61B2017/22035Gripping instruments, e.g. forceps, for removing or smashing calculi for retrieving or repositioning foreign objects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0033Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/006Additional features; Implant or prostheses properties not otherwise provided for modular

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Prostheses (AREA)

Abstract

Un sistema protésico (70) para reemplazar una válvula cardíaca, comprende un cuerpo de válvula protésico (72) y una estructura de soporte anular (60) dentro de los cuales el cuerpo de válvula protésico puede expandirse hasta que encuentre oposición, el soporte anular se proporciona en dos o más segmentos del anillos (61, 62) que tienen medios de conexión terminales (63) para formar, en la condición de uso del sistema protésico, una estructura anular estable y duradera continua capaz de resistir la oposición ejercida por el cuerpo de válvula protésico, caracterizado porque cada uno de los dos o más segmentos del anillos puede insertarse de manera separada en una cámara cardíaca y puede interconectarse por medio de un sistema de conexión que comprende pasadores (55) y se adapta para acoplarse en agujeros correspondientes (56), en donde la estructura anular formada por la conexión de dos o más segmentos del anillos tiene formas y dimensiones predeterminadas, que coinciden sustancialmente con la anatomía del anillo de la válvula cardíaca, para que sea capaz de rodear la válvula de una manera continua, y en donde cada uno de los dos o más segmentos del anillos es hueco internamente para permitir el paso de al menos un alambre guía (46), los alambres guías emergen de los extremos de cada uno de los dos o más segmentos del anillos, sustancialmente en las posiciones del sistema de conexión.

Description

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Claims (1)

  1. imagen1
ES13812152.0T 2012-11-20 2013-11-19 Sistema protésico para el reemplazo de la válvula cardíaca Active ES2613761T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000636A ITBO20120636A1 (it) 2012-11-20 2012-11-20 Sistema protesico sostitutivo per valvola cardiaca
ITBO20120636 2012-11-20
PCT/IB2013/060250 WO2014080339A1 (en) 2012-11-20 2013-11-19 Prosthetic system for heart valve replacement

Publications (1)

Publication Number Publication Date
ES2613761T3 true ES2613761T3 (es) 2017-05-25

Family

ID=53547733

Family Applications (2)

Application Number Title Priority Date Filing Date
ES13812152.0T Active ES2613761T3 (es) 2012-11-20 2013-11-19 Sistema protésico para el reemplazo de la válvula cardíaca
ES16198837T Active ES2939616T3 (es) 2012-11-20 2013-11-19 Sistema protésico para el reemplazo de la válvula cardíaca

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES16198837T Active ES2939616T3 (es) 2012-11-20 2013-11-19 Sistema protésico para el reemplazo de la válvula cardíaca

Country Status (9)

Country Link
EP (3) EP4147676A1 (es)
JP (2) JP6203859B2 (es)
KR (2) KR102232108B1 (es)
AU (2) AU2013349353B2 (es)
BR (1) BR112015011672B1 (es)
CA (2) CA2922899C (es)
DK (2) DK2922500T3 (es)
ES (2) ES2613761T3 (es)
PL (2) PL3158975T3 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
KR20150026766A (ko) 2013-08-29 2015-03-11 김준홍 승모판막 서클라지 시술용 카테터 및 이를 이용한 유도방법
JP7006940B2 (ja) 2016-01-29 2022-01-24 ニオバスク ティアラ インコーポレイテッド 流出の閉塞を回避するための人工弁
CN113893064A (zh) 2016-11-21 2022-01-07 内奥瓦斯克迪亚拉公司 用于快速收回经导管心脏瓣膜递送系统的方法和系统
JP6985493B2 (ja) * 2017-03-28 2021-12-22 カーディアック・サクセス・リミテッド 心機能を向上させる方法
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. TRANSCATHETER MITRAL VALVULE PROSTHESIS WITH SEQUENTIAL DEPLOYMENT
KR102167091B1 (ko) * 2018-08-21 2020-10-16 (주) 타우피엔유메디칼 스네어 일체형 심근 전기 신호 감지 카테터
JP7260930B2 (ja) 2018-11-08 2023-04-19 ニオバスク ティアラ インコーポレイテッド 経カテーテル僧帽弁人工補綴物の心室展開
US11998447B2 (en) 2019-03-08 2024-06-04 Neovasc Tiara Inc. Retrievable prosthesis delivery system
CN113811265A (zh) 2019-04-01 2021-12-17 内奥瓦斯克迪亚拉公司 能够以可控的方式部署的假体瓣膜
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
CN114025813B (zh) 2019-05-20 2024-05-14 内奥瓦斯克迪亚拉公司 具有止血机构的引入器
KR102207685B1 (ko) * 2019-05-31 2021-01-26 (주) 타우피엔유메디칼 히스 감지 스네어 카테터
JP2022537559A (ja) 2019-06-20 2022-08-26 ニオバスク ティアラ インコーポレイテッド 薄型人工補綴僧帽弁
US11684473B2 (en) 2019-07-25 2023-06-27 Innovheart S.R.L. Device for arranging guidewires around a heart valve
US11517425B2 (en) 2019-07-25 2022-12-06 Innovheart S.R.L. Device for implanting a prosthesis for a heart valve and assembly procedure
IT201900015494A1 (it) * 2019-09-03 2021-03-03 Innovheart S R L Dispositivo per la disposizione di fili guida attorno ad una valvola cardiaca
CN113993572A (zh) * 2019-07-25 2022-01-28 创新心有限公司 用于在心脏瓣膜周围布置导丝的装置
EP4132428A4 (en) * 2020-04-08 2024-05-01 Shifamed Holdings, LLC VALVE DISPENSING SYSTEM

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7927371B2 (en) * 2005-07-15 2011-04-19 The Cleveland Clinic Foundation Apparatus and method for reducing cardiac valve regurgitation
US8449605B2 (en) 2006-06-28 2013-05-28 Kardium Inc. Method for anchoring a mitral valve
EP2217153B1 (en) 2007-10-19 2021-03-03 Ancora Heart, Inc. Systems for cardiac remodeling
US8287591B2 (en) * 2008-09-19 2012-10-16 Edwards Lifesciences Corporation Transformable annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation
EP2542186B1 (en) * 2010-03-05 2019-09-11 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
EP2962664B1 (en) * 2010-07-09 2022-05-11 Highlife SAS Transcatheter atrio-ventricular valve prosthesis
EP2600799B1 (en) * 2010-08-04 2017-05-17 ValCare, Inc. Percutaneous transcatheter repair of heart valves
IT1402571B1 (it) 2010-11-12 2013-09-13 Ht Consultant Di Giovanni Righini Sistema protesico per valvola cardio-vascolare con struttura di ancoraggio separata
JP6010545B2 (ja) * 2010-12-23 2016-10-19 トゥエルヴ, インコーポレイテッド 僧帽弁の修復および置換のためのシステム
US9039713B2 (en) * 2011-05-13 2015-05-26 Merit Medical Systems, Inc. Releasably attached snare loop retrieval device and method of using the same
WO2013123059A1 (en) * 2012-02-13 2013-08-22 Mitraspan, Inc Method and apparatus for repairing a mitral valve
AU2013229583B2 (en) * 2012-03-06 2017-04-13 Highlife Sas Treatment catheter member with encircling function

Also Published As

Publication number Publication date
EP3158975A1 (en) 2017-04-26
BR112015011672B1 (pt) 2021-08-31
AU2018200730A1 (en) 2018-03-08
BR112015011672A2 (pt) 2017-07-11
AU2013349353A1 (en) 2015-07-09
CA2922899C (en) 2021-12-28
JP6434589B2 (ja) 2018-12-05
KR102280752B1 (ko) 2021-07-22
KR102232108B1 (ko) 2021-03-25
AU2013349353B2 (en) 2017-11-09
EP3158975B1 (en) 2023-01-04
PL2922500T3 (pl) 2017-05-31
PL3158975T3 (pl) 2023-05-02
CA3112256A1 (en) 2014-05-30
CA3112256C (en) 2023-09-26
AU2018200730B2 (en) 2019-08-15
KR20150091336A (ko) 2015-08-10
DK3158975T3 (da) 2023-03-13
JP2017221747A (ja) 2017-12-21
EP4147676A1 (en) 2023-03-15
EP2922500A1 (en) 2015-09-30
EP2922500B1 (en) 2016-11-16
ES2939616T3 (es) 2023-04-25
DK2922500T3 (en) 2017-02-06
CA2922899A1 (en) 2014-05-30
JP6203859B2 (ja) 2017-09-27
KR20200134337A (ko) 2020-12-01
JP2016503320A (ja) 2016-02-04

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