AU2010294214B2 - Heterocylcic derivatives as inhibitors of glutaminyl cyclase - Google Patents

Heterocylcic derivatives as inhibitors of glutaminyl cyclase Download PDF

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AU2010294214B2
AU2010294214B2 AU2010294214A AU2010294214A AU2010294214B2 AU 2010294214 B2 AU2010294214 B2 AU 2010294214B2 AU 2010294214 A AU2010294214 A AU 2010294214A AU 2010294214 A AU2010294214 A AU 2010294214A AU 2010294214 B2 AU2010294214 B2 AU 2010294214B2
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benzo
imidazol
phenyl
imidazolidin
val
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AU2010294214A1 (en
Inventor
Livia Boehme
Hans-Ulrich Demuth
Ulrich Heiser
Torsten Hoffmann
Antje Meyer
Daniel Ramsbeck
Robert Sommer
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Vivoryon Therapeutics NV
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Vivoryon Therapeutics NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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AU2010294214A 2009-09-11 2010-09-13 Heterocylcic derivatives as inhibitors of glutaminyl cyclase Active AU2010294214B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24143209P 2009-09-11 2009-09-11
US61/241,432 2009-09-11
PCT/EP2010/063341 WO2011029920A1 (fr) 2009-09-11 2010-09-13 Dérivés hétérocycliques en tant qu'inhibiteurs de glutaminyle cyclase

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AU2010294214A1 AU2010294214A1 (en) 2012-03-29
AU2010294214B2 true AU2010294214B2 (en) 2015-05-07

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US (3) US8486940B2 (fr)
EP (1) EP2475428B1 (fr)
JP (1) JP5934645B2 (fr)
KR (1) KR101755737B1 (fr)
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