ATE84787T1 - Prolin-derivate. - Google Patents

Prolin-derivate.

Info

Publication number
ATE84787T1
ATE84787T1 AT87118566T AT87118566T ATE84787T1 AT E84787 T1 ATE84787 T1 AT E84787T1 AT 87118566 T AT87118566 T AT 87118566T AT 87118566 T AT87118566 T AT 87118566T AT E84787 T1 ATE84787 T1 AT E84787T1
Authority
AT
Austria
Prior art keywords
group
chem
general formula
carbon atoms
alkyl
Prior art date
Application number
AT87118566T
Other languages
English (en)
Inventor
Masaaki Toda
Shuichi Shinbayashida Ohuchida
Hiroyuki Ohno
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Application granted granted Critical
Publication of ATE84787T1 publication Critical patent/ATE84787T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT87118566T 1986-12-29 1987-12-15 Prolin-derivate. ATE84787T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31015186 1986-12-29
EP87118566A EP0275482B1 (de) 1986-12-29 1987-12-15 Prolin-Derivate

Publications (1)

Publication Number Publication Date
ATE84787T1 true ATE84787T1 (de) 1993-02-15

Family

ID=18001775

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87118566T ATE84787T1 (de) 1986-12-29 1987-12-15 Prolin-derivate.

Country Status (6)

Country Link
US (2) US4983624A (de)
EP (1) EP0275482B1 (de)
KR (1) KR950009359B1 (de)
AT (1) ATE84787T1 (de)
DE (1) DE3783754T2 (de)
ES (1) ES2046195T3 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE87306T1 (de) * 1987-02-04 1993-04-15 Ono Pharmaceutical Co Prolinalderivate.
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
WO1990012005A1 (fr) * 1989-04-13 1990-10-18 Japan Tobacco Inc. Nouveaux derives aminoacides possedant une activite d'inhibiteur de la prolylendopeptidase
ATE462432T1 (de) 2003-05-05 2010-04-15 Probiodrug Ag Glutaminylcyclase-hemmer
JP2007509898A (ja) 2003-11-03 2007-04-19 プロビオドルグ エージー 神経障害治療に有用な組合せ
KR101099206B1 (ko) 2004-02-05 2011-12-27 프로비오드룩 아게 신규한 글루타미닐 시클라제 저해제
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (de) 2006-11-30 2012-04-18 Probiodrug AG Neue inhibitoren von glutaminylcyclase
CA2679446C (en) 2007-03-01 2016-05-17 Probiodrug Ag New use of glutaminyl cyclase inhibitors
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
BR112012008346B1 (pt) 2009-09-11 2021-12-21 Vivoryon Therapeutics N.V. Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
EP0201743B1 (de) * 1985-04-16 1992-04-01 Suntory Limited Dipeptid-Derivate von Fettsäure, Verfahren zu ihrer Herstellung, Heilmittel, das sie enthält und Anwendung
DE3786229T2 (de) * 1986-11-20 1993-10-07 Ono Pharmaceutical Co Prolinalderivate.

Also Published As

Publication number Publication date
KR950009359B1 (ko) 1995-08-21
EP0275482B1 (de) 1993-01-20
EP0275482A3 (en) 1988-12-28
US4983624A (en) 1991-01-08
DE3783754T2 (de) 1993-08-05
DE3783754D1 (de) 1993-03-04
US5112847A (en) 1992-05-12
EP0275482A2 (de) 1988-07-27
ES2046195T3 (es) 1994-02-01
KR880007457A (ko) 1988-08-27

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Legal Events

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