ATE84787T1 - Prolin-derivate. - Google Patents

Prolin-derivate.

Info

Publication number
ATE84787T1
ATE84787T1 AT87118566T AT87118566T ATE84787T1 AT E84787 T1 ATE84787 T1 AT E84787T1 AT 87118566 T AT87118566 T AT 87118566T AT 87118566 T AT87118566 T AT 87118566T AT E84787 T1 ATE84787 T1 AT E84787T1
Authority
AT
Austria
Prior art keywords
group
chem
general formula
carbon atoms
alkyl
Prior art date
Application number
AT87118566T
Other languages
English (en)
Inventor
Masaaki Toda
Shuichi Shinbayashida Ohuchida
Hiroyuki Ohno
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Application granted granted Critical
Publication of ATE84787T1 publication Critical patent/ATE84787T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT87118566T 1986-12-29 1987-12-15 Prolin-derivate. ATE84787T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31015186 1986-12-29
EP87118566A EP0275482B1 (de) 1986-12-29 1987-12-15 Prolin-Derivate

Publications (1)

Publication Number Publication Date
ATE84787T1 true ATE84787T1 (de) 1993-02-15

Family

ID=18001775

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87118566T ATE84787T1 (de) 1986-12-29 1987-12-15 Prolin-derivate.

Country Status (6)

Country Link
US (2) US4983624A (de)
EP (1) EP0275482B1 (de)
KR (1) KR950009359B1 (de)
AT (1) ATE84787T1 (de)
DE (1) DE3783754T2 (de)
ES (1) ES2046195T3 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277588B1 (de) * 1987-02-04 1993-03-24 Ono Pharmaceutical Co., Ltd. Prolinalderivate
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
US5118811A (en) * 1989-04-13 1992-06-02 Japan Tobacco Inc. Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities
WO2004098591A2 (en) 2003-05-05 2004-11-18 Probiodrug Ag Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
AU2004290499C1 (en) 2003-11-03 2011-02-24 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1713780B1 (de) 2004-02-05 2012-01-18 Probiodrug AG Neue inhibitoren von glutaminylcyclase
EP2089383B1 (de) 2006-11-09 2015-09-16 Probiodrug AG 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
EP2481408A3 (de) 2007-03-01 2013-01-09 Probiodrug AG Neue Verwendung von Inhibitoren der Glutaminyl Cyclase
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
EP2686313B1 (de) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazolderivate als glutaminylcyclase-hemmer
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
CA1298033C (en) * 1985-04-16 1992-03-24 Takaharu Tanaka Dipeptide derivative of fatty acid
DE3786229T2 (de) * 1986-11-20 1993-10-07 Ono Pharmaceutical Co Prolinalderivate.

Also Published As

Publication number Publication date
DE3783754T2 (de) 1993-08-05
EP0275482A2 (de) 1988-07-27
KR950009359B1 (ko) 1995-08-21
US4983624A (en) 1991-01-08
DE3783754D1 (de) 1993-03-04
EP0275482B1 (de) 1993-01-20
ES2046195T3 (es) 1994-02-01
US5112847A (en) 1992-05-12
EP0275482A3 (en) 1988-12-28
KR880007457A (ko) 1988-08-27

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Legal Events

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