DE3783754T2 - Prolin-derivate. - Google Patents
Prolin-derivate.Info
- Publication number
- DE3783754T2 DE3783754T2 DE8787118566T DE3783754T DE3783754T2 DE 3783754 T2 DE3783754 T2 DE 3783754T2 DE 8787118566 T DE8787118566 T DE 8787118566T DE 3783754 T DE3783754 T DE 3783754T DE 3783754 T2 DE3783754 T2 DE 3783754T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- chem
- general formula
- carbon atoms
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31015186 | 1986-12-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3783754D1 DE3783754D1 (de) | 1993-03-04 |
DE3783754T2 true DE3783754T2 (de) | 1993-08-05 |
Family
ID=18001775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787118566T Expired - Fee Related DE3783754T2 (de) | 1986-12-29 | 1987-12-15 | Prolin-derivate. |
Country Status (6)
Country | Link |
---|---|
US (2) | US4983624A (de) |
EP (1) | EP0275482B1 (de) |
KR (1) | KR950009359B1 (de) |
AT (1) | ATE84787T1 (de) |
DE (1) | DE3783754T2 (de) |
ES (1) | ES2046195T3 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE87306T1 (de) * | 1987-02-04 | 1993-04-15 | Ono Pharmaceutical Co | Prolinalderivate. |
US5212191A (en) * | 1988-04-08 | 1993-05-18 | Ono Pharmaceutical Co., Ltd. | Heterocyclic compounds |
EP0419683A4 (en) * | 1989-04-13 | 1992-03-11 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
JP4806628B2 (ja) | 2003-05-05 | 2011-11-02 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤 |
JP2007509898A (ja) | 2003-11-03 | 2007-04-19 | プロビオドルグ エージー | 神経障害治療に有用な組合せ |
EP1713780B1 (de) | 2004-02-05 | 2012-01-18 | Probiodrug AG | Neue inhibitoren von glutaminylcyclase |
JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体 |
US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
US8524654B2 (en) * | 2007-05-21 | 2013-09-03 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
CN102791704B (zh) | 2010-03-10 | 2015-11-25 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂 |
EP2560953B1 (de) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Hemmer der glutaminylzyklase |
JP6050264B2 (ja) | 2011-03-16 | 2016-12-21 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
DE3684633D1 (de) * | 1985-04-16 | 1992-05-07 | Suntory Ltd | Dipeptid-derivate von fettsaeure, verfahren zu ihrer herstellung, heilmittel, das sie enthaelt und anwendung. |
JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するn−アシルピロリジン誘導体及びその製法並びに用途 |
DE3786229T2 (de) * | 1986-11-20 | 1993-10-07 | Ono Pharmaceutical Co | Prolinalderivate. |
-
1987
- 1987-12-15 ES ES198787118566T patent/ES2046195T3/es not_active Expired - Lifetime
- 1987-12-15 AT AT87118566T patent/ATE84787T1/de not_active IP Right Cessation
- 1987-12-15 DE DE8787118566T patent/DE3783754T2/de not_active Expired - Fee Related
- 1987-12-15 EP EP87118566A patent/EP0275482B1/de not_active Expired - Lifetime
- 1987-12-28 KR KR1019870015052A patent/KR950009359B1/ko not_active IP Right Cessation
- 1987-12-29 US US07/139,231 patent/US4983624A/en not_active Expired - Lifetime
-
1990
- 1990-06-12 US US07/536,830 patent/US5112847A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0275482B1 (de) | 1993-01-20 |
EP0275482A3 (en) | 1988-12-28 |
ATE84787T1 (de) | 1993-02-15 |
DE3783754D1 (de) | 1993-03-04 |
KR880007457A (ko) | 1988-08-27 |
US5112847A (en) | 1992-05-12 |
KR950009359B1 (ko) | 1995-08-21 |
EP0275482A2 (de) | 1988-07-27 |
ES2046195T3 (es) | 1994-02-01 |
US4983624A (en) | 1991-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |