ES2103287T3 - Nuevos derivados de tiazolidina. - Google Patents

Nuevos derivados de tiazolidina.

Info

Publication number
ES2103287T3
ES2103287T3 ES91111866T ES91111866T ES2103287T3 ES 2103287 T3 ES2103287 T3 ES 2103287T3 ES 91111866 T ES91111866 T ES 91111866T ES 91111866 T ES91111866 T ES 91111866T ES 2103287 T3 ES2103287 T3 ES 2103287T3
Authority
ES
Spain
Prior art keywords
group
carbon atom
general formula
atom
single bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91111866T
Other languages
English (en)
Inventor
Masaaki Toda
Shuichi Shinbayashida Ohuchida
Hiroyuki Ohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2103287T3 publication Critical patent/ES2103287T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Abstract

UN NUEVO DERIVADO DE TIAZOLIDINA DE LA FORMULA GENERAL: DONDE R REPRESENTA UN GRUPO DE LA FORMULA GENERAL: G-E-D-B-ADONDE A REPRESENTA UN GRUPO ALCALINO DE UNION SIMPLE DE 1 A 6 ATOMO(S) DE CARBONO, UN GRUPO ALKENILENO DE 2 A 6 ATOMOS DE CARBONO, UN GRUPO DE LA FORMULA GENERAL: O DE ANILLO DE HIDROCARBURO SATURADO DE 4 A 7 ATOMOS DE CARBONO O DE UN ANILLO HETEROCICLICO MONOAROMATICO QUE CONTIENE DE 4 A 7 MIEMBROS DE ANILLO QUE INCLUYEN UN ATOMO DE NITROGENO Y/O UN ATOMO DE AZUFRE QUE PUEDEN SER TOTAL O PARCIALMENTE SATURADOS, Y REPRESENTA UN GRUPO ALKILENO DE 1 A 4 ATOMO(S) DE CARBONO O UN GRUPO ALKENILENO DE 2 A 4 ATOMOS DE CARBONO, B REPRESENTA UN GRUPO ALCALINO DE UNION SIMPLE DE 1 A 6 ATOMO(S) DE CARBONO, D REPRESENTA UN ATOMO DE OXIGENO DE UNION SIMPLE, UN GRUPO CARBONILO U OTRO DE LA FORMULA GENERAL: R ELEVADO 1 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALCALINO DE 1 A 4 ATOMO(S) DE CARBONO, UN GRUPO FENILO O BENCILO, E REPRESENTA UN GRUPO ALCALINO DE UNION SIMPLE DE 1 A 8 ATOMO(S) DE CARBONO O UN GRUPO ALCALINO DE 1 A 8 ATOMO(S) DE CARBONO SUSTITUIDOS POR UN GRUPO FENILO O BENCILO, G REPRESENTA ANILLO(S) CARBONCICLICOS MONO, BI O TRIAROMATICOS QUE CONTIENEN NO MAS DE 15 ATOMOS DE CARBONO QUE PUEDEN SER PARCIAL O COMPLETAMENTE SATURADOS, O G REPRESENTA ANILLO(S) HETEROCICLICOS MONO, BI O TRIAROMATICOS QUE CONTIENEN NO MAS DE 15 MIEMBROS DE ANILLOS QUE INCLUYEN UN ATOMO DE NITROGENO QUE PUEDE SER PARCIAL O COMPLETAMENTE SATURADO DONDE DICHO ANILLO CARBOCICLICO O HETEROCICLICO REPRESENTADO POR G PUEDE SUSTITUIRSE O NO, POR UNO A TRES GRUPOS ALCALINOS DE 1 A 6 ATOMO(S) DE CARBONO, POR UN GRUPO ALKOXI DE 1 A 6 ATOMO(S) DE CARBONO, POR ATOMO HALOGENO, POR UN GRUPO TRIFLUOROMETILO O NITRO, CON LA CONDICION DE QUE A Y B NO REPRESENTEN UNIONES SIMPLES AL MISMO TIEMPO POSEE ACTIVIDAD INHIBITORIA EN LA PROLIL ENDOPEPTIDASA Y, POR LO TANTO, ES UTIL COMO AGENTE PARA EL TRATAMIENTO Y/O PREVENCION DE LA AMNESIA.
ES91111866T 1987-02-23 1988-02-16 Nuevos derivados de tiazolidina. Expired - Lifetime ES2103287T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3784487 1987-02-23

Publications (1)

Publication Number Publication Date
ES2103287T3 true ES2103287T3 (es) 1997-09-16

Family

ID=12508841

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91111866T Expired - Lifetime ES2103287T3 (es) 1987-02-23 1988-02-16 Nuevos derivados de tiazolidina.
ES88102243T Expired - Lifetime ES2052619T3 (es) 1987-02-23 1988-02-16 Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES88102243T Expired - Lifetime ES2052619T3 (es) 1987-02-23 1988-02-16 Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.

Country Status (7)

Country Link
US (1) US4857537A (es)
EP (2) EP0461677B1 (es)
KR (1) KR960001205B1 (es)
AT (1) ATE151760T1 (es)
DE (2) DE3855875T2 (es)
ES (2) ES2103287T3 (es)
GR (1) GR3006406T3 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01250370A (ja) * 1987-12-23 1989-10-05 Zeria Pharmaceut Co Ltd 新規アミノ酸イミド誘導体、製法ならびに用途
JP2515568B2 (ja) * 1987-12-25 1996-07-10 株式会社ヤクルト本社 新規なチアゾリジン誘導体
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
US5053414A (en) * 1988-04-08 1991-10-01 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
CA2004028C (en) * 1988-12-08 1998-09-22 Motoki Torizuka Condensed benzene derivative
US5118811A (en) * 1989-04-13 1992-06-02 Japan Tobacco Inc. Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities
US4999349A (en) * 1990-03-22 1991-03-12 Bristol-Myers Squibb Co. BU-4164E - A and B, prolyl endopeptidase inhibitors
US5073549A (en) * 1990-03-22 1991-12-17 Bristol-Myers Squibb Company BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use
CA2084412C (en) * 1990-06-04 2000-05-09 W. Stephen Faraci Pyrrolidine and thiazolidine amides
US5506256A (en) * 1990-07-27 1996-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Proline derivatives possessing prolyl endopeptidase-inhibitory activity
IT1283782B1 (it) * 1996-08-09 1998-04-30 Ct Lab Farm Srl Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
US6419857B1 (en) * 1999-12-06 2002-07-16 Baker Hughes Incorporated Thiazolidines and use thereof for corrosion inhibition
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
JP2007509898A (ja) 2003-11-03 2007-04-19 プロビオドルグ エージー 神経障害治療に有用な組合せ
EP1713780B1 (en) 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP1760076A1 (en) 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitors
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
DK2142514T3 (da) 2007-04-18 2015-03-23 Probiodrug Ag Thioureaderivater som glutaminylcyclase-inhibitorer
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60188317A (ja) * 1984-03-09 1985-09-25 Yakult Honsha Co Ltd 抗健忘症剤
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
EP0201743B1 (en) * 1985-04-16 1992-04-01 Suntory Limited Dipeptide derivatives of fatty acids, process for preparing them, pharmaceutical composition and use
CA1309805C (en) * 1985-04-16 1992-11-03 Naoki Higuchi Dipeptide derivative and synthesis and use thereof

Also Published As

Publication number Publication date
DE3875361T2 (de) 1993-03-25
ES2052619T3 (es) 1994-07-16
KR960001205B1 (ko) 1996-01-24
ATE151760T1 (de) 1997-05-15
GR3006406T3 (es) 1993-06-21
DE3855875D1 (de) 1997-05-22
EP0280956A1 (en) 1988-09-07
US4857537A (en) 1989-08-15
EP0461677A1 (en) 1991-12-18
EP0461677B1 (en) 1997-04-16
DE3875361D1 (de) 1992-11-26
KR880009949A (ko) 1988-10-06
EP0280956B1 (en) 1992-10-21
DE3855875T2 (de) 1997-08-28

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