AU2007257094B2 - Compounds and methods for modulating expression of SGLT2 - Google Patents

Compounds and methods for modulating expression of SGLT2 Download PDF

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Publication number
AU2007257094B2
AU2007257094B2 AU2007257094A AU2007257094A AU2007257094B2 AU 2007257094 B2 AU2007257094 B2 AU 2007257094B2 AU 2007257094 A AU2007257094 A AU 2007257094A AU 2007257094 A AU2007257094 A AU 2007257094A AU 2007257094 B2 AU2007257094 B2 AU 2007257094B2
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Australia
Prior art keywords
short antisense
certain embodiments
monomers
moe
certain
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Ceased
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AU2007257094A
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AU2007257094A1 (en
Inventor
Sanjay Bhanot
Richard S. Geary
Robert Mckay
Brett P. Monia
Punit P. Seth
Andrew M. Siwkowski
Eric E. Swayze
Edward Wancewicz
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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Priority claimed from PCT/US2007/061183 external-priority patent/WO2007090071A2/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of AU2007257094A1 publication Critical patent/AU2007257094A1/en
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Publication of AU2007257094B2 publication Critical patent/AU2007257094B2/en
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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AU2007257094A 2006-05-05 2007-05-07 Compounds and methods for modulating expression of SGLT2 Ceased AU2007257094B2 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US74663106P 2006-05-05 2006-05-05
US60/746,631 2006-05-05
US74705906P 2006-05-11 2006-05-11
US60/747,059 2006-05-11
US80566006P 2006-06-23 2006-06-23
US60/805,660 2006-06-23
US86455406P 2006-11-06 2006-11-06
US60/864,554 2006-11-06
AUPCT/US2007/061183 2007-01-27
PCT/US2007/061183 WO2007090071A2 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs
PCT/US2007/068406 WO2007143316A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2

Publications (2)

Publication Number Publication Date
AU2007257094A1 AU2007257094A1 (en) 2007-12-13
AU2007257094B2 true AU2007257094B2 (en) 2012-10-25

Family

ID=40134111

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2007257094A Ceased AU2007257094B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of SGLT2
AU2007253909A Ceased AU2007253909B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCCR
AU2007258117A Active AU2007258117B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
AU2007257093A Abandoned AU2007257093A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PCSK9

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2007253909A Ceased AU2007253909B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCCR
AU2007258117A Active AU2007258117B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
AU2007257093A Abandoned AU2007257093A1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of PCSK9

Country Status (15)

Country Link
US (14) US20090292006A1 (cg-RX-API-DMAC7.html)
EP (10) EP2015758B1 (cg-RX-API-DMAC7.html)
JP (7) JP2009536039A (cg-RX-API-DMAC7.html)
KR (1) KR101441700B1 (cg-RX-API-DMAC7.html)
CN (1) CN103554205A (cg-RX-API-DMAC7.html)
AT (2) ATE514777T1 (cg-RX-API-DMAC7.html)
AU (4) AU2007257094B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0711429A2 (cg-RX-API-DMAC7.html)
CA (3) CA2651309C (cg-RX-API-DMAC7.html)
DK (5) DK2015758T3 (cg-RX-API-DMAC7.html)
ES (2) ES2471978T3 (cg-RX-API-DMAC7.html)
MX (1) MX2008014100A (cg-RX-API-DMAC7.html)
NO (1) NO20084738L (cg-RX-API-DMAC7.html)
PT (1) PT2015758E (cg-RX-API-DMAC7.html)
WO (9) WO2007146511A2 (cg-RX-API-DMAC7.html)

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