PT2015758E - Compostos e métodos para modular a expressão da proteína apob - Google Patents

Compostos e métodos para modular a expressão da proteína apob Download PDF

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Publication number
PT2015758E
PT2015758E PT78118734T PT07811873T PT2015758E PT 2015758 E PT2015758 E PT 2015758E PT 78118734 T PT78118734 T PT 78118734T PT 07811873 T PT07811873 T PT 07811873T PT 2015758 E PT2015758 E PT 2015758E
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PT
Portugal
Prior art keywords
certain embodiments
short antisense
quot
antisense compound
nucleotides
Prior art date
Application number
PT78118734T
Other languages
English (en)
Portuguese (pt)
Inventor
Eric E Swayze
Richard S Geary
Sanjay Bhanot
Robert Mckay
Brett P Monia
Punit P Seth
Andrew M Siwkowsk
Edward Wancewicz
Original Assignee
Isis Pharmaceuticals Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40134111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2015758(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2007/061183 external-priority patent/WO2007090071A2/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of PT2015758E publication Critical patent/PT2015758E/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/0102—Diacylglycerol O-acyltransferase (2.3.1.20)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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PT78118734T 2006-05-05 2007-05-07 Compostos e métodos para modular a expressão da proteína apob PT2015758E (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74663106P 2006-05-05 2006-05-05
US74705906P 2006-05-11 2006-05-11
US80566006P 2006-06-23 2006-06-23
US86455406P 2006-11-06 2006-11-06
PCT/US2007/061183 WO2007090071A2 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs

Publications (1)

Publication Number Publication Date
PT2015758E true PT2015758E (pt) 2014-06-25

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ID=40134111

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Application Number Title Priority Date Filing Date
PT78118734T PT2015758E (pt) 2006-05-05 2007-05-07 Compostos e métodos para modular a expressão da proteína apob

Country Status (15)

Country Link
US (14) US20090326042A1 (cg-RX-API-DMAC7.html)
EP (10) EP2015758B1 (cg-RX-API-DMAC7.html)
JP (7) JP5825754B2 (cg-RX-API-DMAC7.html)
KR (1) KR101441700B1 (cg-RX-API-DMAC7.html)
CN (1) CN103554205A (cg-RX-API-DMAC7.html)
AT (2) ATE514777T1 (cg-RX-API-DMAC7.html)
AU (4) AU2007258117B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0711429A2 (cg-RX-API-DMAC7.html)
CA (3) CA2651309C (cg-RX-API-DMAC7.html)
DK (5) DK2458006T3 (cg-RX-API-DMAC7.html)
ES (2) ES2471978T3 (cg-RX-API-DMAC7.html)
MX (1) MX2008014100A (cg-RX-API-DMAC7.html)
NO (1) NO20084738L (cg-RX-API-DMAC7.html)
PT (1) PT2015758E (cg-RX-API-DMAC7.html)
WO (9) WO2007136989A2 (cg-RX-API-DMAC7.html)

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