US20110111406A1 - Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly - Google Patents

Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly Download PDF

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Publication number
US20110111406A1
US20110111406A1 US12/936,587 US93658709A US2011111406A1 US 20110111406 A1 US20110111406 A1 US 20110111406A1 US 93658709 A US93658709 A US 93658709A US 2011111406 A1 US2011111406 A1 US 2011111406A1
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United States
Prior art keywords
antigen
binding molecule
binding
antibody
histidine
Prior art date
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Abandoned
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US12/936,587
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English (en)
Inventor
Tomoyuki Igawa
Shinya Ishii
Atsuhiko Maeda
Takashi Nakai
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41161956&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20110111406(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Assigned to CHUGAI SEIYAKU KABUSHIKI KAISHA reassignment CHUGAI SEIYAKU KABUSHIKI KAISHA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: IGAWA, TOMOYUKI, ISHII, SHINYA, MAEDA, ATSUHIKO, NAKAI, TAKASHI
Publication of US20110111406A1 publication Critical patent/US20110111406A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/544—Mucosal route to the airways
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20071—Demonstrated in vivo effect
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • General Chemical & Material Sciences (AREA)
US12/936,587 2008-04-11 2009-04-10 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly Abandoned US20110111406A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2008-1041472008 2008-04-11
JP2008104147 2008-04-11
JP2008-2477132008 2008-09-26
JP2008247713 2008-09-26
JP2009068744 2009-03-19
JP2009-0687442009 2009-03-19
PCT/JP2009/057309 WO2009125825A1 (ja) 2008-04-11 2009-04-10 複数分子の抗原に繰り返し結合する抗原結合分子

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/057309 A-371-Of-International WO2009125825A1 (ja) 2008-04-11 2009-04-10 複数分子の抗原に繰り返し結合する抗原結合分子

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/595,139 Continuation US20130011866A1 (en) 2008-04-11 2012-08-27 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly

Publications (1)

Publication Number Publication Date
US20110111406A1 true US20110111406A1 (en) 2011-05-12

Family

ID=41161956

Family Applications (10)

Application Number Title Priority Date Filing Date
US12/936,587 Abandoned US20110111406A1 (en) 2008-04-11 2009-04-10 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US13/595,139 Granted US20130011866A1 (en) 2008-04-11 2012-08-27 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US13/889,512 Active 2029-11-02 US9890377B2 (en) 2008-04-11 2013-05-08 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US13/889,484 Active 2029-04-12 US9868948B2 (en) 2008-04-11 2013-05-08 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US15/952,945 Active US10472623B2 (en) 2008-04-11 2018-04-13 Antigen-binding molecule capable of binding two or more antigen molecules repeatedly
US15/952,951 Abandoned US20180282719A1 (en) 2008-04-11 2018-04-13 Antigen-binding molecule capable of binding two or more antigen molecules repeatedly
US16/361,498 Abandoned US20200048627A1 (en) 2008-04-11 2019-03-22 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US17/020,543 Active US11371039B2 (en) 2008-04-11 2020-09-14 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US17/020,497 Active US11359194B2 (en) 2008-04-11 2020-09-14 Antigen-binding molecule capable of binding two or more antigen molecules repeatedly
US18/156,138 Pending US20240002836A1 (en) 2008-04-11 2023-01-18 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly

Family Applications After (9)

Application Number Title Priority Date Filing Date
US13/595,139 Granted US20130011866A1 (en) 2008-04-11 2012-08-27 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US13/889,512 Active 2029-11-02 US9890377B2 (en) 2008-04-11 2013-05-08 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US13/889,484 Active 2029-04-12 US9868948B2 (en) 2008-04-11 2013-05-08 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US15/952,945 Active US10472623B2 (en) 2008-04-11 2018-04-13 Antigen-binding molecule capable of binding two or more antigen molecules repeatedly
US15/952,951 Abandoned US20180282719A1 (en) 2008-04-11 2018-04-13 Antigen-binding molecule capable of binding two or more antigen molecules repeatedly
US16/361,498 Abandoned US20200048627A1 (en) 2008-04-11 2019-03-22 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US17/020,543 Active US11371039B2 (en) 2008-04-11 2020-09-14 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US17/020,497 Active US11359194B2 (en) 2008-04-11 2020-09-14 Antigen-binding molecule capable of binding two or more antigen molecules repeatedly
US18/156,138 Pending US20240002836A1 (en) 2008-04-11 2023-01-18 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly

Country Status (33)

Country Link
US (10) US20110111406A1 (no)
EP (7) EP2275443B1 (no)
JP (14) JP4954326B2 (no)
KR (6) KR102469853B1 (no)
CN (6) CN103251948A (no)
AR (1) AR071656A1 (no)
BR (2) BRPI0911431B8 (no)
CA (1) CA2721052C (no)
CO (1) CO6311005A2 (no)
CR (3) CR11783A (no)
DK (3) DK2708558T3 (no)
EC (1) ECSP10010600A (no)
ES (3) ES2563483T3 (no)
HK (3) HK1246157A1 (no)
HR (2) HRP20160209T1 (no)
HU (2) HUE028718T2 (no)
IL (3) IL208516A (no)
LT (1) LT2708559T (no)
MA (1) MA32754B1 (no)
MX (2) MX2010011184A (no)
MY (1) MY195714A (no)
NO (1) NO2708559T3 (no)
NZ (4) NZ717429A (no)
PH (2) PH12014502054A1 (no)
PL (3) PL2275443T3 (no)
PT (2) PT2275443E (no)
RU (2) RU2571225C2 (no)
SG (3) SG10201608379YA (no)
SI (2) SI2275443T1 (no)
TR (2) TR201808046T4 (no)
TW (6) TWI564021B (no)
UA (1) UA121453C2 (no)
WO (1) WO2009125825A1 (no)

Cited By (102)

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US20070041978A1 (en) * 2003-10-10 2007-02-22 Kunihiro Hattori Bispecific antibody substituting for functional proteins
US20090220500A1 (en) * 2005-10-21 2009-09-03 Chugai Seiyaku Kabushiki Kaisha Agents for treating cardiopathy
US20090220499A1 (en) * 2005-10-14 2009-09-03 Fukuoka University Agents for Suppressing Damage to Transplanted Islets After Islet Transplantation
US20090263384A1 (en) * 2005-11-15 2009-10-22 National Hospital Organization Agents for Suppressing the Induction of Cytotoxic T Cells
US20090324589A1 (en) * 2006-03-31 2009-12-31 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
US20100008907A1 (en) * 2006-04-07 2010-01-14 Norihiro Nishimoto Muscle regeneration promoter
US20100015133A1 (en) * 2005-03-31 2010-01-21 Chugai Seiyaku Kabushiki Kaisha Methods for Producing Polypeptides by Regulating Polypeptide Association
US20100034811A1 (en) * 2006-01-27 2010-02-11 Chugai Seiyaku Kabushiki Kaisha Therapeutic agents for diseases involving choroidal neovascularization
US20100061986A1 (en) * 2007-01-23 2010-03-11 Shinshu University Chronic Rejection Inhibitor
US20100298542A1 (en) * 2007-09-26 2010-11-25 Chugai Seiyaku Kabushiki Kaisha Modified Antibody Constant Region
US20110076275A1 (en) * 2007-09-26 2011-03-31 Chugai Seiyaku Kabushiki Kaisha Method of Modifying Isoelectric Point of Antibody Via Amino Acid Substitution in CDR
US20110098450A1 (en) * 2008-09-26 2011-04-28 Chugai Seiyaku Kabushiki Kaisha Antibody Molecules
US20110129459A1 (en) * 2007-12-05 2011-06-02 Chugai Seiyaku Kabushiki Kaisha Anti-nr10 antibody and use thereof
US20110150869A1 (en) * 2008-06-05 2011-06-23 National Cancer Center Neuroinvasion Inhibitor
US20110229489A1 (en) * 2010-03-11 2011-09-22 Rinat Neuroscience Corp. Antibodies with pH Dependent Antigen Binding
US20130131319A1 (en) * 2010-03-30 2013-05-23 Chugai Seiyaku Kabushiki Kaisha Antibodies with modified affinity to fcrn that promote antigen clearance
WO2013138680A1 (en) 2012-03-16 2013-09-19 Regeneron Pharmaceuticals, Inc. Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same
US20130247235A1 (en) * 2012-03-16 2013-09-19 Regeneron Pharmaceuticals, Inc. Mice That Produce Antigen-Binding Proteins With pH-Dependent Binding Characteristics
WO2013138712A1 (en) 2012-03-16 2013-09-19 Regeneron Pharmaceuticals, Inc. Non-human animals expressing ph-sensitive immunoglobulin sequences
WO2013177470A1 (en) 2012-05-23 2013-11-28 Genentech, Inc. Selection method for therapeutic agents
US20140105889A1 (en) * 2011-02-25 2014-04-17 Chugai Seiyaku Kabushiki Kaisha Method for altering plasma retention and immunogenicity of antigen-binding molecule
KR20140069074A (ko) * 2011-09-30 2014-06-09 추가이 세이야쿠 가부시키가이샤 이온 농도 의존성 결합 분자 라이브러리
WO2014130690A1 (en) * 2013-02-20 2014-08-28 Regeneron Pharmaceuticals, Inc. Non-human animals with modified immunoglobulin heavy chain sequences
WO2014146575A1 (en) 2013-03-19 2014-09-25 Beijing Shenogen Pharma Group Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
WO2014160958A1 (en) 2013-03-29 2014-10-02 Alexion Pharmaceuticals, Inc. Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
US20140363428A1 (en) * 2011-09-30 2014-12-11 Chugai Seiyaku Kabushiki Kaisha THERAPEUTIC ANTIGEN-BINDING MOLECULE WITH A FcRn-BINDING DOMAIN THAT PROMOTES ANTIGEN CLEARANCE
WO2015042250A1 (en) 2013-09-18 2015-03-26 Regeneron Pharmaceuticals, Inc. Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same
US9056915B2 (en) 2007-08-23 2015-06-16 Amgen Inc. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
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