SK282443B6 - Chinazolínové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie - Google Patents

Chinazolínové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie Download PDF

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Publication number
SK282443B6
SK282443B6 SK828-98A SK82898A SK282443B6 SK 282443 B6 SK282443 B6 SK 282443B6 SK 82898 A SK82898 A SK 82898A SK 282443 B6 SK282443 B6 SK 282443B6
Authority
SK
Slovakia
Prior art keywords
methoxy
quinazoline
chloro
hydroxy
group
Prior art date
Application number
SK828-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK82898A3 (en
Inventor
Jean-Jacques Marcel Lohmann
Laurent Francois Andre Hennequin
Andrew Peter Thomas
Original Assignee
Zeneca Limited
Zeneca-Pharma S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26140602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK282443(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zeneca Limited, Zeneca-Pharma S. A. filed Critical Zeneca Limited
Publication of SK82898A3 publication Critical patent/SK82898A3/sk
Publication of SK282443B6 publication Critical patent/SK282443B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicinal Preparation (AREA)
SK828-98A 1995-12-18 1996-12-13 Chinazolínové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie SK282443B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95402846 1995-12-18
EP96402190 1996-10-15
PCT/GB1996/003075 WO1997022596A1 (en) 1995-12-18 1996-12-13 Quinazoline derivatives

Publications (2)

Publication Number Publication Date
SK82898A3 SK82898A3 (en) 1998-11-04
SK282443B6 true SK282443B6 (sk) 2002-02-05

Family

ID=26140602

Family Applications (1)

Application Number Title Priority Date Filing Date
SK828-98A SK282443B6 (sk) 1995-12-18 1996-12-13 Chinazolínové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie

Country Status (29)

Country Link
US (4) US5962458A (ko)
EP (1) EP0873319B1 (ko)
JP (1) JP4291413B2 (ko)
KR (1) KR100530311B1 (ko)
CN (1) CN1133625C (ko)
AT (1) ATE203524T1 (ko)
AU (1) AU712370B2 (ko)
BR (1) BR9612043A (ko)
CA (1) CA2237005C (ko)
CZ (1) CZ291100B6 (ko)
DE (1) DE69614147T2 (ko)
DK (1) DK0873319T3 (ko)
ES (1) ES2162656T3 (ko)
GB (1) GB9624482D0 (ko)
GR (1) GR3036954T3 (ko)
HU (1) HUP9901243A3 (ko)
IL (1) IL124925A0 (ko)
MX (1) MX9804247A (ko)
MY (1) MY132405A (ko)
NO (1) NO311358B1 (ko)
NZ (1) NZ324007A (ko)
PL (1) PL192309B1 (ko)
PT (1) PT873319E (ko)
RU (1) RU2194701C2 (ko)
SI (1) SI0873319T1 (ko)
SK (1) SK282443B6 (ko)
TR (1) TR199801115T2 (ko)
TW (1) TW411274B (ko)
WO (1) WO1997022596A1 (ko)

Families Citing this family (545)

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DE69614147T2 (de) 2002-03-21
JP2000515114A (ja) 2000-11-14
TR199801115T2 (xx) 1998-08-21
IL124925A0 (en) 1999-01-26
KR100530311B1 (ko) 2006-03-09
SI0873319T1 (en) 2002-02-28
KR20000064455A (ko) 2000-11-06
WO1997022596A1 (en) 1997-06-26
CA2237005A1 (en) 1997-06-26
CN1133625C (zh) 2004-01-07
ATE203524T1 (de) 2001-08-15
AU712370B2 (en) 1999-11-04
GR3036954T3 (en) 2002-01-31
CN1205694A (zh) 1999-01-20
DE69614147D1 (de) 2001-08-30
GB9624482D0 (en) 1997-01-15
JP4291413B2 (ja) 2009-07-08
US6362336B1 (en) 2002-03-26

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Effective date: 20131213