|
NZ250844A
(en)
|
1993-04-07 |
1996-03-26 |
Pfizer |
Treatment of non-insulin dependant diabetes with peptides; composition
|
|
US6284727B1
(en)
|
1993-04-07 |
2001-09-04 |
Scios, Inc. |
Prolonged delivery of peptides
|
|
US5424286A
(en)
|
1993-05-24 |
1995-06-13 |
Eng; John |
Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
|
|
US5641757A
(en)
|
1994-12-21 |
1997-06-24 |
Ortho Pharmaceutical Corporation |
Stable 2-chloro-2'-deoxyadenosine formulations
|
|
DE69739172D1
(de)
|
1996-08-08 |
2009-01-29 |
Amylin Pharmaceuticals Inc |
Regulation gastrointestinaler beweglichkeit
|
|
US6458924B2
(en)
|
1996-08-30 |
2002-10-01 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
CA2468374C
(en)
|
1996-08-30 |
2010-12-21 |
Novo-Nordisk A/S |
Glp-1 derivatives
|
|
WO1998030231A1
(en)
|
1997-01-07 |
1998-07-16 |
Amylin Pharmaceuticals, Inc. |
Use of exendins and agonists thereof for the reduction of food intake
|
|
US7312196B2
(en)
|
1997-01-08 |
2007-12-25 |
Amylin Pharmaceuticals, Inc. |
Formulations for amylin agonist peptides
|
|
US6410511B2
(en)
|
1997-01-08 |
2002-06-25 |
Amylin Pharmaceuticals, Inc. |
Formulations for amylin agonist peptides
|
|
US6723530B1
(en)
|
1997-02-05 |
2004-04-20 |
Amylin Pharmaceuticals, Inc. |
Polynucleotides encoding proexendin, and methods and uses thereof
|
|
US7157555B1
(en)
|
1997-08-08 |
2007-01-02 |
Amylin Pharmaceuticals, Inc. |
Exendin agonist compounds
|
|
NZ502592A
(en)
|
1997-08-08 |
2002-03-28 |
Amylin Pharmaceuticals Inc |
Exendin agonist peptides and their use in the treatment of type I and II diabetes
|
|
US7223725B1
(en)
|
1997-11-14 |
2007-05-29 |
Amylin Pharmaceuticals, Inc. |
Exendin agonist compounds
|
|
JP2001523688A
(ja)
|
1997-11-14 |
2001-11-27 |
アミリン・ファーマシューティカルズ，インコーポレイテッド |
新規エキセンジン・アゴニスト化合物
|
|
US7220721B1
(en)
|
1997-11-14 |
2007-05-22 |
Amylin Pharmaceuticals, Inc. |
Exendin agonist peptides
|
|
ES2294822T3
(es)
|
1997-11-14 |
2008-04-01 |
Amylin Pharmaceuticals, Inc. |
Compuestos novedosos de agonistas de exendina.
|
|
CA2365742C
(en)
|
1998-01-09 |
2013-04-30 |
Amylin Pharmaceuticals, Inc. |
Formulations for amylin agonist peptides
|
|
US6703359B1
(en)
|
1998-02-13 |
2004-03-09 |
Amylin Pharmaceuticals, Inc. |
Inotropic and diuretic effects of exendin and GLP-1
|
|
JP2003522099A
(ja)
|
1998-02-27 |
2003-07-22 |
ノボ ノルディスク アクティーゼルスカブ |
遅延作用プロファイルを有するｇｌｐ−１のｇｌｐ−１誘導体及びエキセンジン
|
|
EP1950224A3
(en)
|
1998-03-09 |
2008-12-17 |
Zealand Pharma A/S |
Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
|
|
JP4072319B2
(ja)
|
1998-03-13 |
2008-04-09 |
ノヴォ ノルディスク アクティーゼルスカブ |
安定化水溶性ペプチド溶液
|
|
US6998387B1
(en)
|
1998-03-19 |
2006-02-14 |
Amylin Pharmaceuticals, Inc. |
Human appetite control by glucagon-like peptide receptor binding compounds
|
|
DE69918691T2
(de)
|
1998-06-12 |
2005-07-21 |
Amylin Pharmaceuticals, Inc., San Diego |
Glucagonähnliches peptid 1 (glp-1) verbessert die beta zellen antwort auf glukose in patienten mit verminderter glukosetoleranz
|
|
EP1105460B1
(en)
|
1998-08-10 |
2009-10-07 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof
|
|
JP2002524514A
(ja)
|
1998-09-17 |
2002-08-06 |
イーライ・リリー・アンド・カンパニー |
タンパク質製剤
|
|
US6429197B1
(en)
|
1998-10-08 |
2002-08-06 |
Bionebraska, Inc. |
Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
|
|
US7259136B2
(en)
|
1999-04-30 |
2007-08-21 |
Amylin Pharmaceuticals, Inc. |
Compositions and methods for treating peripheral vascular disease
|
|
US6284725B1
(en)
|
1998-10-08 |
2001-09-04 |
Bionebraska, Inc. |
Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
|
|
ATE307603T1
(de)
|
1998-12-22 |
2005-11-15 |
Lilly Co Eli |
Lagerstabile flüssige zusammensetzungen von glucagon-ähnlichem peptid-1
|
|
US20030087820A1
(en)
|
1999-01-14 |
2003-05-08 |
Young Andrew A. |
Novel exendin agonist formulations and methods of administration thereof
|
|
US6872700B1
(en)
|
1999-01-14 |
2005-03-29 |
Amylin Pharmaceuticals, Inc. |
Methods for glucagon suppression
|
|
PT1140145E
(pt)
|
1999-01-14 |
2005-11-30 |
Amylin Pharmaceuticals Inc |
Formulacoes novas de agonistas de exendina e metodos para a sua administracao
|
|
US7399489B2
(en)
|
1999-01-14 |
2008-07-15 |
Amylin Pharmaceuticals, Inc. |
Exendin analog formulations
|
|
US6451974B1
(en)
|
1999-03-17 |
2002-09-17 |
Novo Nordisk A/S |
Method of acylating peptides and novel acylating agents
|
|
RU2001128068A
(ru)
|
1999-03-17 |
2004-02-20 |
Ново Нордиск А/С (DK) |
Способ ацилирования пептидов и новые ацилирующие агенты
|
|
US6924264B1
(en)
|
1999-04-30 |
2005-08-02 |
Amylin Pharmaceuticals, Inc. |
Modified exendins and exendin agonists
|
|
CN1372570A
(zh)
|
1999-04-30 |
2002-10-02 |
安米林药品公司 |
修饰的exendin和exendin激动剂
|
|
US6887470B1
(en)
|
1999-09-10 |
2005-05-03 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
|
US6849714B1
(en)
|
1999-05-17 |
2005-02-01 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
|
US6514500B1
(en)
|
1999-10-15 |
2003-02-04 |
Conjuchem, Inc. |
Long lasting synthetic glucagon like peptide {GLP-!}
|
|
ES2209885T3
(es)
|
1999-05-17 |
2004-07-01 |
Conjuchem, Inc. |
Peptidos insulinotropicos de larga duracion.
|
|
US6482799B1
(en)
|
1999-05-25 |
2002-11-19 |
The Regents Of The University Of California |
Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial
|
|
US6506724B1
(en)
|
1999-06-01 |
2003-01-14 |
Amylin Pharmaceuticals, Inc. |
Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus
|
|
US6344180B1
(en)
|
1999-06-15 |
2002-02-05 |
Bionebraska, Inc. |
GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes
|
|
US6528486B1
(en)
|
1999-07-12 |
2003-03-04 |
Zealand Pharma A/S |
Peptide agonists of GLP-1 activity
|
|
US6972319B1
(en)
|
1999-09-28 |
2005-12-06 |
Bayer Pharmaceuticals Corporation |
Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
|
|
GB9930882D0
(en)
|
1999-12-30 |
2000-02-23 |
Nps Allelix Corp |
GLP-2 formulations
|
|
CA2396157A1
(en)
|
2000-01-10 |
2001-07-19 |
Amylin Pharmaceuticals, Inc. |
Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia
|
|
JP2003526671A
(ja)
|
2000-03-14 |
2003-09-09 |
レストラゲン，インコーポレイテッド |
幽門洞−十二指腸運動性に対するグルカゴン様ペプチド‐１（７−３６）の作用
|
|
US20020061838A1
(en)
|
2000-05-17 |
2002-05-23 |
Barton Holmquist |
Peptide pharmaceutical formulations
|
|
ES2307619T3
(es)
|
2000-05-19 |
2008-12-01 |
Amylin Pharmaceuticals, Inc. |
Tratamiento del sindrome coronario agudo con glp-1.
|
|
EP1317412A1
(en)
|
2000-08-18 |
2003-06-11 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
|
US7507714B2
(en)
|
2000-09-27 |
2009-03-24 |
Bayer Corporation |
Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
|
|
CA2395165C
(en)
|
2000-10-20 |
2012-05-22 |
Mario Ehlers |
Treatment of hibernating myocardium and diabetic cardiomyopathy with a glp-1 peptide
|
|
ATE437891T1
(de)
|
2000-12-07 |
2009-08-15 |
Lilly Co Eli |
Glp-1 fusionsproteine
|
|
CA2431173A1
(en)
|
2000-12-13 |
2002-06-20 |
Eli Lilly And Company |
Chronic treatment regimen using glucagon-like insulinotropic peptides
|
|
GB2371227A
(en)
|
2001-01-10 |
2002-07-24 |
Grandis Biotech Gmbh |
Crystallisation - resistant aqueous growth hormone formulations
|
|
US6573237B2
(en)
|
2001-03-16 |
2003-06-03 |
Eli Lilly And Company |
Protein formulations
|
|
CN1162446C
(zh)
|
2001-05-10 |
2004-08-18 |
上海华谊生物技术有限公司 |
促胰岛素分泌肽衍生物
|
|
WO2002098348A2
(en)
|
2001-06-01 |
2002-12-12 |
Eli Lilly And Company |
Glp-1 formulations with protracted time action
|
|
DK1412384T3
(da)
|
2001-06-28 |
2008-04-28 |
Novo Nordisk As |
Stabil formulering af modificeret GLP-1
|
|
EP2053406A3
(en)
|
2001-07-16 |
2009-06-24 |
caprotec bioanalytics GmbH |
Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
|
|
CA2455963C
(en)
|
2001-07-31 |
2017-07-04 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Glp-1, exendin-4, peptide analogs and uses thereof
|
|
CA2452044A1
(en)
|
2001-08-28 |
2003-03-13 |
Eli Lilly And Company |
Pre-mixes of glp-1 and basal insulin
|
|
EP1448222A4
(en)
|
2001-10-19 |
2006-05-17 |
Lilly Co Eli |
BIPHASIC MIXTURES OF GLP-1 AND INSULIN
|
|
WO2003060071A2
(en)
|
2001-12-21 |
2003-07-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
WO2003059934A2
(en)
|
2001-12-21 |
2003-07-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US7105489B2
(en)
|
2002-01-22 |
2006-09-12 |
Amylin Pharmaceuticals, Inc. |
Methods and compositions for treating polycystic ovary syndrome
|
|
EP1478233B1
(en)
|
2002-02-20 |
2016-11-09 |
Emisphere Technologies, Inc. |
Method for administering glp-1 molecules
|
|
PT1946776T
(pt)
|
2002-02-27 |
2017-03-17 |
Immunex Corp |
Composição de tnfr-fc estabilizada compreendendo arginina
|
|
WO2003077851A2
(en)
|
2002-03-11 |
2003-09-25 |
Hk Pharmaceuticals, Inc. |
Compounds and methods for analyzing the proteome
|
|
US7141240B2
(en)
|
2002-03-12 |
2006-11-28 |
Cedars-Sinai Medical Center |
Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
|
|
JP2005535569A
(ja)
|
2002-04-04 |
2005-11-24 |
ノボ・ノルデイスク・エー／エス |
Ｇｌｐ−１アゴニスト及び心臓血管合併症
|
|
EA200401345A1
(ru)
|
2002-04-10 |
2005-08-25 |
Эли Лилли Энд Компани |
Лечение гастропареза
|
|
US6861236B2
(en)
|
2002-05-24 |
2005-03-01 |
Applied Nanosystems B.V. |
Export and modification of (poly)peptides in the lantibiotic way
|
|
US20040037826A1
(en)
|
2002-06-14 |
2004-02-26 |
Michelsen Birgitte Koch |
Combined use of a modulator of CD3 and a GLP-1 compound
|
|
EP1515749B1
(en)
|
2002-06-14 |
2012-08-15 |
Novo Nordisk A/S |
Combined use of a modulator of cd3 and a glp-1 compound
|
|
DE10227232A1
(de)
|
2002-06-18 |
2004-01-15 |
Aventis Pharma Deutschland Gmbh |
Saure Insulinzubereitungen mit verbesserter Stabilität
|
|
DK1525219T3
(da)
|
2002-07-04 |
2009-09-07 |
Zealand Pharma As |
GLP-1 og fremgangsm der til behandling af diabetes
|
|
US20070065469A1
(en)
|
2002-07-09 |
2007-03-22 |
Michael Betz |
Liquid formulations with high concentration of human growth hormone (high) comprising glycine
|
|
AR040529A1
(es)
|
2002-07-09 |
2005-04-13 |
Grandis Biotech Gmbh |
Formulaciones de hgh en alta concentracion que contienen 1,2-propilenglicol
|
|
US20080260838A1
(en)
|
2003-08-01 |
2008-10-23 |
Mannkind Corporation |
Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
|
|
US20040038865A1
(en)
|
2002-08-01 |
2004-02-26 |
Mannkind Corporation |
Cell transport compositions and uses thereof
|
|
US8372804B2
(en)
|
2007-10-24 |
2013-02-12 |
Mannkind Corporation |
Delivery of active agents
|
|
AU2003257156B2
(en)
|
2002-08-01 |
2007-08-30 |
Mannkind Corporation |
Cell transport compositions and uses thereof
|
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
|
DE50312295D1
(de)
|
2002-08-21 |
2010-02-11 |
Boehringer Ingelheim Pharma |
8-ä3-amino-piperidin-1-ylü -xanthine, deren herstellung und deren verwendung als arzneimittel
|
|
BR0314996A
(pt)
|
2002-10-02 |
2005-08-09 |
Zealand Pharma As |
Composição, composição farmaceuticamente aceitável, método para produzir a composição, métodos para estabilizar a exendina-4 (1-39) ou uma sua variante, derivado ou análogo contra a degradação, antes, durante ou após o uso pretendido, para tratar doenças, para tratar de estados de doenças associados com nìveis elevados de glicose do sangue, para a regulação dos nìveis de glicose do sangue, para a regulação do esvaziamento gástrico, para estimular a liberação de insulina em um mamìfero para reduzir o nìvel de glicose do sangue em um mamìfero, para reduzir o nìvel de lipìdeos plasmáticos em um mamìfero, para reduzir a mortalidade e a morbidez após o infarto miocárdico em um mamìfero, para estimular a liberação de insulina em um mamìfero, e para produzir uma exendina (1-39) estabilizada, e, exendina (1-39) estabilizada
|
|
DK1583541T3
(da)
|
2002-11-20 |
2011-04-11 |
Neuronova Ab |
Forbindelser og fremgangsmåder til at øge neurogenese
|
|
US20050209142A1
(en)
|
2002-11-20 |
2005-09-22 |
Goran Bertilsson |
Compounds and methods for increasing neurogenesis
|
|
US6969702B2
(en)
|
2002-11-20 |
2005-11-29 |
Neuronova Ab |
Compounds and methods for increasing neurogenesis
|
|
WO2004056313A2
(en)
|
2002-12-17 |
2004-07-08 |
Amylin Pharmaceuticals, Inc. |
Prevention and treatment of cardiac arrhythmias
|
|
US20040209803A1
(en)
|
2002-12-19 |
2004-10-21 |
Alain Baron |
Compositions for the treatment and prevention of nephropathy
|
|
US7790681B2
(en)
|
2002-12-17 |
2010-09-07 |
Amylin Pharmaceuticals, Inc. |
Treatment of cardiac arrhythmias with GLP-1 receptor ligands
|
|
GB0300571D0
(en)
|
2003-01-10 |
2003-02-12 |
Imp College Innovations Ltd |
Modification of feeding behaviour
|
|
CA2521784C
(en)
|
2003-04-08 |
2012-03-27 |
Yeda Research And Development Co. Ltd. |
Reversible pegylated drugs
|
|
WO2004089985A1
(en)
|
2003-04-11 |
2004-10-21 |
Novo Nordisk A/S |
Stable pharmaceutical compositions
|
|
EP1633384B1
(en)
|
2003-05-15 |
2012-03-14 |
Trustees Of Tufts College |
Stable analogs of glp-1
|
|
US7947261B2
(en)
|
2003-05-23 |
2011-05-24 |
Nektar Therapeutics |
Conjugates formed from polymer derivatives having particular atom arrangements
|
|
DK2644206T3
(da)
|
2003-05-23 |
2019-06-11 |
Nektar Therapeutics |
PEG-derivater indeholdende to PEG-kæder
|
|
WO2005000222A2
(en)
|
2003-05-30 |
2005-01-06 |
Amylin Pharmaceuticals, Inc. |
Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins
|
|
JP2007524592A
(ja)
|
2003-06-03 |
2007-08-30 |
ノボ・ノルデイスク・エー／エス |
安定化された薬学的ペプチド組成物
|
|
EP2292253A3
(en)
|
2003-06-03 |
2011-12-14 |
Novo Nordisk A/S |
Stabilized pharmaceutical peptide compositions
|
|
EP1633390B1
(en)
|
2003-06-03 |
2012-01-18 |
Novo Nordisk A/S |
Stabilized pharmaceutical glp-1 peptide compositions
|
|
BRPI0410972C1
(pt)
|
2003-06-03 |
2021-05-25 |
Novo Nordisk As |
método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia
|
|
US8921311B2
(en)
|
2003-08-01 |
2014-12-30 |
Mannkind Corporation |
Method for treating hyperglycemia
|
|
CA2531988C
(en)
|
2003-08-05 |
2016-06-28 |
Novo Nordisk A/S |
Novel insulin derivatives
|
|
JP5622998B2
(ja)
|
2003-08-21 |
2014-11-12 |
ノヴォ ノルディスク アー／エス |
ラセミ化されたアミノ酸を含むポリペプチドの分離
|
|
EP1663295A2
(en)
|
2003-09-01 |
2006-06-07 |
Novo Nordisk A/S |
Stable formulations of peptides
|
|
US20060247167A1
(en)
|
2003-09-01 |
2006-11-02 |
Novo Nordisk A/S |
Stable formulations of peptides
|
|
EP1667724A2
(en)
|
2003-09-19 |
2006-06-14 |
Novo Nordisk A/S |
Albumin-binding derivatives of therapeutic peptides
|
|
US20060287221A1
(en)
|
2003-11-13 |
2006-12-21 |
Novo Nordisk A/S |
Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia
|
|
ATE525083T1
(de)
|
2003-11-13 |
2011-10-15 |
Novo Nordisk As |
Pharmazeutische zusammensetzung umfassend eine insulinotrope glp-1(7-37) analoge, asp(b28)- insulin, und eine oberflächenaktive verbindung
|
|
US20050281879A1
(en)
|
2003-11-14 |
2005-12-22 |
Guohua Chen |
Excipients in drug delivery vehicles
|
|
US20050106214A1
(en)
|
2003-11-14 |
2005-05-19 |
Guohua Chen |
Excipients in drug delivery vehicles
|
|
EP1750752A2
(en)
|
2003-11-20 |
2007-02-14 |
Neuronova AB |
Compounds and methods for increasing neurogenesis
|
|
WO2005049061A2
(en)
|
2003-11-20 |
2005-06-02 |
Novo Nordisk A/S |
Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices
|
|
CN1902226A
(zh)
|
2003-12-03 |
2007-01-24 |
诺和诺德公司 |
单链胰岛素
|
|
US9539337B2
(en)
|
2003-12-10 |
2017-01-10 |
Nektar Therapeutics |
Compositions comprising two different populations of polymer-active agent conjugates
|
|
US20060210614A1
(en)
|
2003-12-26 |
2006-09-21 |
Nastech Pharmaceutical Company Inc. |
Method of treatment of a metabolic disease using intranasal administration of exendin peptide
|
|
US20050143303A1
(en)
|
2003-12-26 |
2005-06-30 |
Nastech Pharmaceutical Company Inc. |
Intranasal administration of glucose-regulating peptides
|
|
CN1938334A
(zh)
*
|
2004-01-30 |
2007-03-28 |
瓦拉塔药品公司 |
Glp－1激动剂和胃泌素化合物的联合使用
|
|
EP2233497A3
(en)
|
2004-02-11 |
2011-01-12 |
Amylin Pharmaceuticals, Inc. |
Amylin family peptides and methods for making and using them
|
|
EP2335716A3
(en)
|
2004-02-11 |
2011-10-19 |
Amylin Pharmaceuticals Inc. |
Pancreatic polypeptide family motifs and polypeptides comprising the same
|
|
AU2005211755B2
(en)
|
2004-02-11 |
2012-03-15 |
Amylin Pharmaceuticals, Llc |
Hybrid polypeptides with selectable properties
|
|
US8076288B2
(en)
|
2004-02-11 |
2011-12-13 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides having glucose lowering activity
|
|
US7399744B2
(en)
|
2004-03-04 |
2008-07-15 |
Amylin Pharmaceuticals, Inc. |
Methods for affecting body composition
|
|
US20060110423A1
(en)
|
2004-04-15 |
2006-05-25 |
Wright Steven G |
Polymer-based sustained release device
|
|
KR20100129799A
(ko)
|
2004-04-15 |
2010-12-09 |
알케르메스,인코포레이티드 |
중합체 기재 지속적 방출 방법
|
|
US7456254B2
(en)
|
2004-04-15 |
2008-11-25 |
Alkermes, Inc. |
Polymer-based sustained release device
|
|
US20090069226A1
(en)
|
2004-05-28 |
2009-03-12 |
Amylin Pharmaceuticals, Inc. |
Transmucosal delivery of peptides and proteins
|
|
WO2005117584A2
(en)
|
2004-05-28 |
2005-12-15 |
Amylin Pharmaceuticals, Inc |
Improved transmucosal delivery of peptides and proteins
|
|
EP2316446A1
(en)
|
2004-06-11 |
2011-05-04 |
Novo Nordisk A/S |
Counteracting drug-induced obesity using GLP-1 agonists
|
|
KR101276754B1
(ko)
|
2004-07-19 |
2013-06-19 |
바이오콘 리미티드 |
인슐린―올리고머 접합체，제형 및 이들의 용도
|
|
JP2008507280A
(ja)
|
2004-07-21 |
2008-03-13 |
アンブレツクス・インコーポレイテツド |
非天然コードアミノ酸を用いた生合成ポリペプチド
|
|
RU2007107808A
(ru)
|
2004-08-03 |
2008-09-10 |
Байорексис Фармасьютикал Корпорейшн (Us) |
Комбинированное лечение с применением слитых белков трансферрина, содержащих glp-1
|
|
BRPI0515188A
(pt)
|
2004-08-16 |
2008-07-08 |
Water Un Ltd |
aparelho e método para resfriamento de ar
|
|
PL1789434T3
(pl)
|
2004-08-31 |
2014-07-31 |
Novo Nordisk As |
Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek
|
|
DE102004043153B4
(de)
|
2004-09-03 |
2013-11-21 |
Philipps-Universität Marburg |
Erfindung betreffend GLP-1 und Exendin
|
|
TW200612991A
(en)
|
2004-09-07 |
2006-05-01 |
Chugai Pharmaceutical Co Ltd |
Process for producing water-soluble hyaluronic acid modification
|
|
WO2006029634A2
(en)
|
2004-09-17 |
2006-03-23 |
Novo Nordisk A/S |
Pharmaceutical compositions containing insulin and insulinotropic peptide
|
|
KR101341359B1
(ko)
|
2004-10-01 |
2013-12-13 |
램스코르 인코포레이티드 |
편리하게 이식가능한 서방형 약물 조성물
|
|
WO2006037811A2
(en)
|
2004-10-07 |
2006-04-13 |
Novo Nordisk A/S |
Protracted exendin-4 compounds
|
|
US7595294B2
(en)
|
2004-10-08 |
2009-09-29 |
Transition Therapeutics, Inc. |
Vasoactive intestinal polypeptide pharmaceuticals
|
|
US20090036355A1
(en)
|
2004-10-13 |
2009-02-05 |
Sanjay Bhanot |
Antisense Modulation of PTP1B Expression
|
|
US7442682B2
(en)
|
2004-10-19 |
2008-10-28 |
Nitto Denko Corporation |
Transepithelial delivery of peptides with incretin hormone activities
|
|
CA2586771A1
(en)
|
2004-11-12 |
2006-05-18 |
Novo Nordisk A/S |
Stable formulations of insulinotropic peptides
|
|
CN112618700A
(zh)
|
2004-11-12 |
2021-04-09 |
诺和诺德公司 |
促胰岛素肽的稳定制剂
|
|
EP1814581B1
(en)
|
2004-11-12 |
2016-03-16 |
Novo Nordisk A/S |
Stable formulations of peptides comprising an acylated glp-1 analogue and a basal insuline
|
|
KR20070094909A
(ko)
|
2004-12-02 |
2007-09-27 |
도만티스 리미티드 |
혈청 알부민 및 ｇｌｐ-1 또는 ｐｙｙ를 표적으로 삼는이중특이성 도메인을 갖는 항체
|
|
NZ555533A
(en)
|
2004-12-13 |
2010-03-26 |
Amylin Pharmaceuticals Inc |
Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
|
|
KR101320936B1
(ko)
|
2004-12-21 |
2013-10-23 |
넥타르 테라퓨틱스 |
안정화된 중합체성 티올 시약
|
|
ES2326906T3
(es)
|
2004-12-22 |
2009-10-21 |
Eli Lilly And Company |
Formulaciones de proteinas de fusion analogas al glp-1.
|
|
EP1838336A2
(en)
|
2004-12-24 |
2007-10-03 |
Amylin Pharmaceuticals, Inc. |
Use of glp-1 and agonists thereof to prevent cardiac myocyte apoptosis
|
|
ES2541633T3
(es)
|
2005-01-14 |
2015-07-22 |
Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. |
Exendinas modificadas y usos de las mismas
|
|
US8716221B2
(en)
|
2005-01-14 |
2014-05-06 |
Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. |
Modified exendins and uses thereof
|
|
EP1848541A4
(en)
|
2005-02-07 |
2013-01-16 |
Pharmalight Inc |
METHOD AND DEVICE FOR THE OPHTHALMIC ADMINISTRATION OF PHARMACEUTICAL ACTIVE SUBSTANCES
|
|
EP2390264A1
(en)
|
2005-02-11 |
2011-11-30 |
Amylin Pharmaceuticals Inc. |
GIP analog and hybrid polypeptides with selectable propperties
|
|
US8263545B2
(en)
|
2005-02-11 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
|
WO2006097535A2
(en)
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Peptide agonists of the glucagon family with secretin like activity
|
|
WO2006110887A2
(en)
|
2005-04-11 |
2006-10-19 |
Amylin Pharmaceuticals, Inc |
Use of glp-1, exendin and agonists thereof to delay or prevent cardiac remodeling
|
|
CN101163514B
(zh)
|
2005-04-24 |
2012-01-25 |
诺和诺德公司 |
注射装置
|
|
JP5235661B2
(ja)
|
2005-05-25 |
2013-07-10 |
ノボ・ノルデイスク・エー／エス |
安定化ポリペプチド製剤
|
|
TW200716679A
(en)
|
2005-05-26 |
2007-05-01 |
Bristol Myers Squibb Co |
N-terminally modified GLP-1 receptor modulators
|
|
CN101217940B
(zh)
|
2005-06-06 |
2013-03-27 |
卡穆鲁斯公司 |
Glp-1类似物制剂
|
|
EP2351776A1
(en)
|
2005-06-13 |
2011-08-03 |
Imperial Innovations Limited |
Oxyntomodulin analogues and their effects on feeding behaviour
|
|
GB0511986D0
(en)
|
2005-06-13 |
2005-07-20 |
Imp College Innovations Ltd |
Novel compounds and their effects on feeding behaviour
|
|
ES2536450T3
(es)
|
2005-06-16 |
2015-05-25 |
Nektar Therapeutics |
Conjugados que tienen una unión degradable y reactivos poliméricos útiles en la preparación de tales conjugados
|
|
KR20080033439A
(ko)
|
2005-08-04 |
2008-04-16 |
넥타르 테라퓨틱스 에이엘, 코포레이션 |
Ｇ-ｃｓｆ 부분 및 중합체의 컨주게이트
|
|
EP1924293A4
(en)
|
2005-08-06 |
2008-12-24 |
Qinghua Wang |
COMPOSITION AND METHOD FOR THE PREVENTION AND TREATMENT OF DIABETES TYPE I
|
|
AU2006279680B2
(en)
|
2005-08-11 |
2012-12-06 |
Amylin Pharmaceuticals, Llc |
Hybrid polypeptides with selectable properties
|
|
LT2347762T
(lt)
|
2005-08-19 |
2019-08-26 |
Amylin Pharmaceuticals, Llc |
Eksendinas, skirtas diabeto gydymui ir kūno svorio mažinimui
|
|
DK2656836T3
(en)
|
2005-09-14 |
2017-10-23 |
Mannkind Corp |
Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
|
|
CA2622579C
(en)
|
2005-09-20 |
2013-12-31 |
Novartis Ag |
Use of a dpp-iv inhibitor to reduce hypoglycemic events
|
|
WO2007047834A2
(en)
|
2005-10-18 |
2007-04-26 |
Biocon Limited |
Oral peptide conjugates for metabolic diseases
|
|
WO2007047997A2
(en)
|
2005-10-19 |
2007-04-26 |
Smartcells, Inc. |
Methods for reducing the mitogenicity of lectin compositions
|
|
CN101534846B
(zh)
|
2005-11-07 |
2014-11-05 |
印第安纳大学研究及科技有限公司 |
显示生理学溶解性和稳定性的胰高血糖素类似物
|
|
WO2007053946A1
(en)
|
2005-11-09 |
2007-05-18 |
Conjuchem Biotechnologies Inc. |
Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin
|
|
EP1965828A2
(en)
|
2005-12-02 |
2008-09-10 |
Nastech Pharmaceutical Company Inc. |
Pharmaceutical formulation for increased epithelial permeability of glucose-regulating peptide
|
|
EP1968607B1
(en)
|
2005-12-02 |
2014-01-15 |
Nabil Habib Lab |
Treatment of cancer and other diseases
|
|
US20080318861A1
(en)
|
2005-12-08 |
2008-12-25 |
Nastech Pharmaceutical Company Inc. |
Mucosal Delivery of Stabilized Formulations of Exendin
|
|
JP5096363B2
(ja)
|
2005-12-16 |
2012-12-12 |
ネクター セラピューティックス |
Ｇｌｐ−１のポリマ複合体
|
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US8841255B2
(en)
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
|
US8334257B2
(en)
|
2005-12-20 |
2012-12-18 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
CN101400363B
(zh)
|
2006-01-18 |
2012-08-29 |
昌达生物科技公司 |
具有增强的稳定性的药物组合物
|
|
US20080071063A1
(en)
|
2006-02-03 |
2008-03-20 |
Medimmune, Inc. |
Protein Formulations
|
|
US7704953B2
(en)
|
2006-02-17 |
2010-04-27 |
Mdrna, Inc. |
Phage displayed cell binding peptides
|
|
WO2007109354A2
(en)
|
2006-03-21 |
2007-09-27 |
Amylin Pharmaceuticals, Inc. |
Peptide-peptidase inhibitor conjugates and methods of using same
|
|
CA2648440A1
(en)
|
2006-04-13 |
2007-10-25 |
Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. . |
Pharmaceutical compositions of hglp-1, exendin-4 and analogs thereof
|
|
KR101438839B1
(ko)
|
2006-04-14 |
2014-10-02 |
맨카인드 코포레이션 |
글루카곤 유사 펩타이드 1 （ｇｌｐ-1） 약제학적 제제
|
|
PE20110235A1
(es)
|
2006-05-04 |
2011-04-14 |
Boehringer Ingelheim Int |
Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
|
|
WO2007133778A2
(en)
|
2006-05-12 |
2007-11-22 |
Amylin Pharmaceuticals, Inc. |
Methods to restore glycemic control
|
|
EP2021014A1
(en)
|
2006-05-26 |
2009-02-11 |
Brystol-Myers Squibb Company |
Sustained release glp-1 receptor modulators
|
|
MX2008015107A
(es)
|
2006-05-26 |
2008-12-09 |
Amylin Pharmaceuticals Inc |
Composicion y metodos para el tratamiento de insuficiecia cardiaca congestiva.
|
|
WO2007148345A2
(en)
|
2006-06-21 |
2007-12-27 |
Biocon Limited |
A method of producing biologically active polypeptide having insulinotropic activity
|
|
PL2494959T3
(pl)
|
2006-07-05 |
2015-06-30 |
Foamix Pharmaceuticals Ltd |
Nośnik ze spienialnego kwasu dikarboksylowego oraz kompozycje farmaceutyczne z nośnikiem
|
|
ES2371495T3
(es)
|
2006-07-24 |
2012-01-03 |
Biorexis Pharmaceutical Corporation |
Proteínas de fusión de exendina.
|
|
US7928186B2
(en)
|
2006-08-02 |
2011-04-19 |
Phoenix Pharmaceuticals, Inc. |
Cell permeable bioactive peptide conjugates
|
|
AU2007281433A1
(en)
|
2006-08-04 |
2008-02-07 |
Nastech Pharmaceutical Company Inc. |
Compositions for intranasal delivery of human insulin and uses thereof
|
|
PT2359808E
(pt)
|
2006-08-09 |
2013-08-28 |
Intarcia Therapeutics Inc |
Sistemas de entrega osmótica e montagens de pistão
|
|
AU2007284365A1
(en)
|
2006-08-17 |
2008-02-21 |
Amylin Pharmaceuticals, Inc. |
DPP-IV resistant GIP hybrid polypeptides with selectable properties
|
|
US8497240B2
(en)
|
2006-08-17 |
2013-07-30 |
Amylin Pharmaceuticals, Llc |
DPP-IV resistant GIP hybrid polypeptides with selectable properties
|
|
US20090318353A1
(en)
*
|
2006-08-25 |
2009-12-24 |
Novo Nordisk A/S |
Acylated Exendin-4 Compounds
|
|
CN102827284B
(zh)
|
2006-11-14 |
2015-07-29 |
上海仁会生物制药股份有限公司 |
带有聚乙二醇基团的Exendin或其类似物及其制剂和用途
|
|
WO2008073448A2
(en)
|
2006-12-12 |
2008-06-19 |
Amylin Pharmaceuticals, Inc. |
Pharmaceutical formulations and methods for making the same
|
|
TWI428346B
(zh)
|
2006-12-13 |
2014-03-01 |
Imp Innovations Ltd |
新穎化合物及其等對進食行為影響
|
|
CN101663317A
(zh)
*
|
2007-01-05 |
2010-03-03 |
CovX科技爱尔兰有限公司 |
胰高血糖素样蛋白-1受体glp-1r激动剂化合物
|
|
RU2432361C2
(ru)
|
2007-01-05 |
2011-10-27 |
КовЭкс Текнолоджиз Айэлэнд Лимитед |
Соединения агонисты рецептора глюкагоноподобного белка-1 (glp-1r)
|
|
US20090098130A1
(en)
*
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
|
CN101578102B
(zh)
|
2007-01-05 |
2013-07-17 |
印第安纳大学研究及科技有限公司 |
在生理性pH缓冲液中显示增强的溶解性的胰高血糖素类似物
|
|
WO2008098212A2
(en)
|
2007-02-08 |
2008-08-14 |
Diobex, Inc. |
Extended release formulations of glucagon and other peptides and proteins
|
|
AU2008216265B2
(en)
|
2007-02-15 |
2014-04-03 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
US8420598B2
(en)
|
2007-04-20 |
2013-04-16 |
B & L Delipharm Corp. |
Mono modified exendin with polyethylene glycol or its derivatives and uses thereof
|
|
IL290847B2
(en)
|
2007-04-23 |
2024-11-01 |
Intarcia Therapeutics Inc |
Suspension formulations of insulinotropic peptides and uses thereof
|
|
WO2008134425A1
(en)
|
2007-04-27 |
2008-11-06 |
Cedars-Sinai Medical Center |
Use of glp-1 receptor agonists for the treatment of gastrointestinal disorders
|
|
US7829664B2
(en)
|
2007-06-01 |
2010-11-09 |
Boehringer Ingelheim International Gmbh |
Modified nucleotide sequence encoding glucagon-like peptide-1 (GLP-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (GLP-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof
|
|
US9353170B2
(en)
|
2007-06-08 |
2016-05-31 |
Sanofi-Aventis Deutschland Gmbh |
Long-acting transient polymer conjugates of exendin
|
|
DK2158214T3
(da)
|
2007-06-15 |
2011-12-05 |
Zealand Pharma As |
Glukagonanaloger
|
|
AU2008275180A1
(en)
|
2007-07-10 |
2009-01-15 |
Eli Lilly And Company |
GLP-1-Fc fusion protein formulation
|
|
ES2646614T3
(es)
|
2007-08-03 |
2017-12-14 |
Eli Lilly And Company |
Uso de un compuesto de FGF 21 y un compuesto de GLP 1 para el tratamiento de la obesidad
|
|
CN101366692A
(zh)
|
2007-08-15 |
2009-02-18 |
江苏豪森药业股份有限公司 |
一种稳定的艾塞那肽制剂
|
|
CN101896499B
(zh)
|
2007-08-30 |
2014-02-12 |
库尔Dm股份有限公司 |
使用前胰岛肽及其类似物的组合物和方法
|
|
ES2532116T3
(es)
|
2007-09-05 |
2015-03-24 |
Novo Nordisk A/S |
Péptidos derivados con A-B-C-D y sus usos terapéuticos
|
|
WO2009035540A2
(en)
|
2007-09-07 |
2009-03-19 |
Ipsen Pharma S.A.S. |
Analogues of exendin-4 and exendin-3
|
|
US8785396B2
(en)
|
2007-10-24 |
2014-07-22 |
Mannkind Corporation |
Method and composition for treating migraines
|
|
ES2547529T3
(es)
|
2007-10-24 |
2015-10-07 |
Mannkind Corporation |
Formulación en polvo seco inhalable que comprende GLP-1 para usar en el tratamiento de la hiperglucemia y diabetes por administración pulmonar
|
|
AU2008318986B2
(en)
|
2007-10-30 |
2014-12-04 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
|
WO2009058734A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity
|
|
EP2597103B1
(en)
|
2007-11-16 |
2016-11-02 |
Novo Nordisk A/S |
Stable pharmaceutical compositions comprising liraglutide and degludec
|
|
WO2009067268A1
(en)
|
2007-11-23 |
2009-05-28 |
Michael Rothkopf |
Methods of enhancing diabetes resolution
|
|
CN101444618B
(zh)
|
2007-11-26 |
2012-06-13 |
杭州九源基因工程有限公司 |
含有艾塞那肽的药物制剂
|
|
US20090186819A1
(en)
|
2007-12-11 |
2009-07-23 |
Marieve Carrier |
Formulation of insulinotropic peptide conjugates
|
|
DK2229407T3
(en)
|
2008-01-09 |
2017-02-27 |
Sanofi Aventis Deutschland |
NEW INSULIN DERIVATIVES WITH EXTREMELY DELAYED TIME / EFFECTS PROFILE
|
|
WO2009099763A1
(en)
|
2008-01-30 |
2009-08-13 |
Indiana University Research And Technology Corporation |
Ester-based peptide prodrugs
|
|
ES2733355T3
(es)
|
2008-02-01 |
2019-11-28 |
Ascendis Pharma As |
Profármaco que comprende un enlazador autoescindible
|
|
RU2595380C2
(ru)
|
2008-02-06 |
2016-08-27 |
Байокон Лимитид |
Ферментационная среда для получения правастатина и способ получения правастатина
|
|
WO2009114959A1
(zh)
|
2008-03-20 |
2009-09-24 |
中国人民解放军军事医学科学院毒物药物研究所 |
可注射用缓释药物制剂及其制备方法
|
|
CA2720864C
(en)
|
2008-04-07 |
2017-07-04 |
National Institute Of Immunology |
Compositions useful for the treatment of diabetes and other chronic disorder
|
|
TW200950799A
(en)
|
2008-05-07 |
2009-12-16 |
Merrion Res Iii Ltd |
Compositions of GnRH related compounds and processes of preparation
|
|
ES2552646T3
(es)
|
2008-05-21 |
2015-12-01 |
Amylin Pharmaceuticals, Inc. |
Exendinas para disminuir el colesterol y los triglicéridos
|
|
WO2009143014A1
(en)
|
2008-05-23 |
2009-11-26 |
Amylin Pharmaceuticals, Inc. |
Glp-1 receptor agonist bioassays
|
|
US8485180B2
(en)
|
2008-06-13 |
2013-07-16 |
Mannkind Corporation |
Dry powder drug delivery system
|
|
ES2570400T3
(es)
|
2008-06-13 |
2016-05-18 |
Mannkind Corp |
Un inhalador de polvo seco y un sistema para el suministro de fármacos
|
|
KR101609005B1
(ko)
|
2008-06-17 |
2016-04-04 |
가부시키가이샤 도우사 고가쿠 겐큐쇼 |
당쇄 부가 ｇｌｐ－１ 펩티드
|
|
HUE028072T2
(en)
|
2008-06-17 |
2016-11-28 |
Univ Indiana Res & Tech Corp |
GIP-based agonists for the treatment of metabolic disease and obesity
|
|
US8450270B2
(en)
|
2008-06-17 |
2013-05-28 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
|
|
ES2579502T3
(es)
|
2008-06-17 |
2016-08-11 |
Indiana University Research And Technology Corporation |
Coagonistas de receptores de glucagón/GLP-1
|
|
EP2926825A1
(en)
|
2008-06-27 |
2015-10-07 |
Duke University |
Therapeutic agents comprising elastin-like peptides
|
|
CA2731236A1
(en)
|
2008-07-21 |
2010-01-28 |
Transpharma Medical Ltd. |
Transdermal system for extended delivery of incretins and incretin mimetic peptides
|
|
WO2010013012A2
(en)
|
2008-08-01 |
2010-02-04 |
Lund University Bioscience Ab |
Novel polypeptides and uses thereof
|
|
CN101670096B
(zh)
|
2008-09-11 |
2013-01-16 |
杭州九源基因工程有限公司 |
含有艾塞那肽的药物制剂
|
|
CN105396126A
(zh)
|
2008-10-17 |
2016-03-16 |
赛诺菲-安万特德国有限公司 |
胰岛素和glp-1激动剂的组合
|
|
HUE031900T2
(en)
|
2008-12-10 |
2017-08-28 |
Glaxosmithkline Llc |
Pharmaceutical compositions containing Albiglutide
|
|
MA32970B1
(fr)
|
2008-12-15 |
2012-01-02 |
Zealand Pharma As |
Analogues du glucagon
|
|
KR20110126591A
(ko)
|
2008-12-15 |
2011-11-23 |
질랜드 파마 에이/에스 |
글루카곤 유사체
|
|
CN102292348B
(zh)
|
2008-12-15 |
2015-07-08 |
西兰制药公司 |
胰高血糖素类似物
|
|
MX2011006314A
(es)
|
2008-12-15 |
2011-09-22 |
Zealand Pharma As |
Analogos de glucagon.
|
|
CN102325539A
(zh)
|
2008-12-19 |
2012-01-18 |
印第安纳大学研究及科技有限公司 |
基于酰胺的胰高血糖素超家族肽前药
|
|
CN101538323B
(zh)
|
2009-01-13 |
2012-05-09 |
深圳翰宇药业股份有限公司 |
一种纯化艾塞那肽的方法
|
|
DE102009006602A1
(de)
|
2009-01-29 |
2010-08-05 |
Bayer Schering Pharma Aktiengesellschaft |
Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
|
|
WO2010096052A1
(en)
|
2009-02-19 |
2010-08-26 |
Merck Sharp & Dohme Corp. |
Oxyntomodulin analogs
|
|
JP5624063B2
(ja)
|
2009-03-04 |
2014-11-12 |
マンカインドコーポレイション |
改善された乾燥粉末薬物送達システム
|
|
WO2010100241A1
(en)
|
2009-03-05 |
2010-09-10 |
Sanofi-Aventis Deutschland Gmbh |
Drug delivery device with retractable needle
|
|
WO2010120476A2
(en)
|
2009-04-01 |
2010-10-21 |
Amylin Pharmaceuticals, Inc. |
N-terminus conformationally constrained glp-1 receptor agonist compounds
|
|
US8992886B2
(en)
|
2009-04-06 |
2015-03-31 |
Board Of Regents, The University Of Texas System |
Cyclic peptide analogues for non-invasive imaging of pancreatic beta-cells
|
|
AU2010239861B2
(en)
|
2009-04-22 |
2013-07-11 |
Alteogen, Inc |
In vivo half life increased fusion protein or peptide maintained by sustained in vivo release, and method for increasing in vivo half-life using same
|
|
CN101870728A
(zh)
|
2009-04-23 |
2010-10-27 |
派格生物医药(苏州)有限公司 |
新型Exendin变体及其缀合物
|
|
CN101559041B
(zh)
|
2009-05-19 |
2014-01-15 |
中国科学院过程工程研究所 |
粒径均一的多肽药物缓释微球或微囊制剂及制备方法
|
|
CA2760760A1
(en)
|
2009-05-20 |
2010-11-25 |
Sanofi-Aventis Deutschland Gmbh |
A bung for drug containing cartridges in drug delivery devices
|
|
US9855389B2
(en)
|
2009-05-20 |
2018-01-02 |
Sanofi-Aventis Deutschland Gmbh |
System comprising a drug delivery device and a cartridge provided with a bung and a method of identifying the cartridge
|
|
WO2010138671A1
(en)
|
2009-05-28 |
2010-12-02 |
Amylin Pharmaceuticals, Inc. |
Glp-1 receptor agonist compounds for sleep enhancement
|
|
US20120172298A1
(en)
|
2009-06-11 |
2012-07-05 |
Novo Nordisk A/S |
Glp-1 and fgf21 combinations for treatment of diabetes type 2
|
|
US9150632B2
(en)
|
2009-06-16 |
2015-10-06 |
Indiana University Research And Technology Corporation |
GIP receptor-active glucagon compounds
|
|
EP2448965A4
(en)
|
2009-07-02 |
2015-02-11 |
Angiochem Inc |
MULTIMEPEPTID CONJUGATES AND ITS USES
|
|
AP3329A
(en)
|
2009-07-13 |
2015-06-30 |
Zealand Pharma As |
Acylated glucagon analogues
|
|
CN101601646B
(zh)
|
2009-07-22 |
2011-03-23 |
南京凯瑞尔纳米生物技术有限公司 |
治疗糖尿病的鼻腔滴剂及其制备方法
|
|
WO2011011675A1
(en)
|
2009-07-23 |
2011-01-27 |
Zelos Therapeutics, Inc. |
Pharmaceutically acceptable formulations/compositions for peptidyl drugs
|
|
BR112012002168A2
(pt)
|
2009-07-31 |
2016-05-31 |
Sanofi Aventis Deutschland |
profármacos compreendendo um conjugado ligador de insulina
|
|
WO2011017835A1
(en)
|
2009-08-11 |
2011-02-17 |
Nanjing University |
Preparation method of protein or peptide nanoparticles for in vivo drug delivery by unfolding and refolding
|
|
CN101993485B
(zh)
|
2009-08-20 |
2013-04-17 |
重庆富进生物医药有限公司 |
促胰岛素分泌肽类似物同源二聚体及其用途
|
|
US20120148586A1
(en)
|
2009-08-27 |
2012-06-14 |
Joyce Ching Tsu Chou |
Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
|
|
SG10201406063XA
(en)
|
2009-09-30 |
2014-11-27 |
Glaxo Group Ltd |
Drug fusions and conjugates with extended half life
|
|
DK2490708T3
(da)
|
2009-10-22 |
2013-04-15 |
Biodel Inc |
Stabiliserede glucagon-opløsninger
|
|
US20110097386A1
(en)
|
2009-10-22 |
2011-04-28 |
Biodel, Inc. |
Stabilized glucagon solutions
|
|
US9610329B2
(en)
|
2009-10-22 |
2017-04-04 |
Albireo Pharma, Inc. |
Stabilized glucagon solutions
|
|
WO2011052523A1
(ja)
|
2009-10-30 |
2011-05-05 |
大塚化学株式会社 |
抗原性ｇｌｐ－１アナログの糖鎖付加体
|
|
EP2496583B1
(en)
|
2009-11-02 |
2014-12-10 |
Pfizer Inc |
Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
|
|
EP2496249B1
(en)
|
2009-11-03 |
2016-03-09 |
Amylin Pharmaceuticals, LLC |
Glp-1 receptor agonist for use in treating obstructive sleep apnea
|
|
EP3345593B1
(de)
|
2009-11-13 |
2023-09-06 |
Sanofi-Aventis Deutschland GmbH |
Pharmazeutische zusammensetzung umfassend despro36exendin-4(1-39)-lys6-nh2 und methionin
|
|
US10029011B2
(en)
|
2009-11-13 |
2018-07-24 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
|
|
RU2012129971A
(ru)
|
2009-12-15 |
2014-01-27 |
МЕТАБОЛИК СОЛЮШНЗ ДЕВЕЛОПМЕНТ КОМПАНИ, ЭлЭлСи |
Тиазолидиндионы, не взаимодействующие с ppar, и комбинации для лечения ожирения и нарушений обмена веществ
|
|
AU2010331926B2
(en)
|
2009-12-15 |
2014-03-27 |
Cirius Therapeutics, Inc. |
PPAR-sparing thiazolidinediones and combinations for the treatment of neurodegenerative diseases
|
|
DK2513070T3
(en)
|
2009-12-15 |
2018-01-22 |
Cirius Therapeutics Inc |
PPAR-sparing thiazolidinedione salts for the treatment of metabolic disorders
|
|
CN102753170A
(zh)
|
2009-12-15 |
2012-10-24 |
新陈代谢解决方案开发公司 |
治疗糖尿病及其它代谢性疾病的ppar节制的噻唑烷二酮和组合
|
|
DK2513140T3
(en)
|
2009-12-16 |
2016-01-18 |
Novo Nordisk As |
Double-acylated GLP-1 derivatives
|
|
CN102933200B
(zh)
|
2009-12-18 |
2015-11-25 |
莱迪杜德制药公司 |
包含磷脂的单相凝胶组合物
|
|
EP2512503A4
(en)
|
2009-12-18 |
2013-08-21 |
Univ Indiana Res & Tech Corp |
COAGONISTS OF GLUCAGON / GLP-1 RECEPTOR
|
|
CN101798588B
(zh)
*
|
2009-12-21 |
2015-09-09 |
上海仁会生物制药股份有限公司 |
Glp-1受体激动剂生物学活性测定方法
|
|
JO2976B1
(en)
|
2009-12-22 |
2016-03-15 |
ايلي ليلي اند كومباني |
Axentomodulin polypeptide
|
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
|
MX342409B
(es)
|
2010-01-20 |
2016-09-28 |
Zealand Pharma As |
Tratamiento de enfermedades cardiacas.
|
|
JP2013518115A
(ja)
|
2010-01-27 |
2013-05-20 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション |
代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐ｇｉｐアゴニスト複合体及び組成物
|
|
MY166695A
(en)
|
2010-02-01 |
2018-07-18 |
Sanofi Aventis Deutschland |
Cartridge holder, drug delivery device and method for securing a cartridge in a cartridge holder
|
|
WO2011109784A1
(en)
|
2010-03-05 |
2011-09-09 |
Conjuchem, Llc |
Formulation of insulinotropic peptide conjugates
|
|
WO2011119857A2
(en)
|
2010-03-24 |
2011-09-29 |
Shifamed, Llc |
Intravascular tissue disruption
|
|
AR080592A1
(es)
*
|
2010-03-26 |
2012-04-18 |
Lilly Co Eli |
Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso
|
|
US20130143798A1
(en)
|
2010-03-26 |
2013-06-06 |
Novo Nordisk A/S |
Novel glucagon analogues
|
|
KR20130111923A
(ko)
|
2010-05-13 |
2013-10-11 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
G-단백결합 수용체 활성을 나타내는 글루카곤 슈퍼패밀리 펩티드
|
|
ES2661228T3
(es)
|
2010-05-13 |
2018-03-28 |
Indiana University Research And Technology Corporation |
Péptidos de la superfamilia de glucagón que muestran actividad de receptor nuclear de hormona
|
|
AU2011202239C1
(en)
|
2010-05-19 |
2017-03-16 |
Sanofi |
Long-acting formulations of insulins
|
|
SG185437A1
(en)
|
2010-05-20 |
2012-12-28 |
Glaxo Group Ltd |
Improved anti-serum albumin binding variants
|
|
US8263554B2
(en)
|
2010-06-09 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
Methods of using GLP-1 receptor agonists to treat pancreatitis
|
|
CN101891823B
(zh)
|
2010-06-11 |
2012-10-03 |
北京东方百泰生物科技有限公司 |
一种Exendin-4及其类似物融合蛋白
|
|
US8636711B2
(en)
|
2010-06-14 |
2014-01-28 |
Legacy Emanuel Hospital & Health Center |
Stabilized glucagon solutions and uses therefor
|
|
CA2801936C
(en)
|
2010-06-21 |
2021-06-01 |
Mannkind Corporation |
Dry powder drug delivery system and methods
|
|
UY33462A
(es)
|
2010-06-23 |
2012-01-31 |
Zealand Pharma As |
Analogos de glucagon
|
|
WO2011162830A2
(en)
|
2010-06-24 |
2011-12-29 |
Biousian Biosystems, Inc. |
Glucagon-like peptide-1 glycopeptides
|
|
RU2580317C2
(ru)
|
2010-06-24 |
2016-04-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Пептидные пролекарства, принадлежащие к суперсемейству амид-содержащих глюкагонов
|
|
WO2011163473A1
(en)
|
2010-06-25 |
2011-12-29 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility and stability in physiological ph buffers
|
|
US20130137645A1
(en)
|
2010-07-19 |
2013-05-30 |
Mary S. Rosendahl |
Modified peptides and proteins
|
|
WO2012012460A1
(en)
|
2010-07-19 |
2012-01-26 |
Xeris Pharmaceuticals, Inc. |
Stable glucagon formulations for the treatment of hypoglycemia
|
|
MX2013001131A
(es)
|
2010-07-28 |
2013-10-17 |
Amylin Pharmaceuticals Llc |
Compuestos agonistas del receptor del peptido similar al glucagon tipo 1 que tienen regiones estabilizadas.
|
|
CN102397558B
(zh)
|
2010-09-09 |
2013-08-14 |
中国人民解放军军事医学科学院毒物药物研究所 |
Exendin-4类似物的定位聚乙二醇化修饰物及其用途
|
|
EP2438930A1
(en)
|
2010-09-17 |
2012-04-11 |
Sanofi-Aventis Deutschland GmbH |
Prodrugs comprising an exendin linker conjugate
|
|
MX345245B
(es)
|
2010-09-28 |
2017-01-23 |
Amylin Pharmaceuticals Llc |
Polipeptidos manipulados que tienen duracion de accion incrementada.
|
|
CA2816114C
(en)
|
2010-11-03 |
2019-02-12 |
Jan Jezek |
Novel composition comprising glucagon
|
|
CA2817337C
(en)
|
2010-11-09 |
2020-04-14 |
Mannkind Corporation |
Composition comprising a serotonin receptor agonist and a diketopiperazine for treating migraines
|
|
EP2460552A1
(en)
|
2010-12-06 |
2012-06-06 |
Sanofi-Aventis Deutschland GmbH |
Drug delivery device with locking arrangement for dose button
|
|
CN102552883B
(zh)
|
2010-12-09 |
2014-02-19 |
天津药物研究院 |
一种多肽复合物、药物组合物、其制备方法和应用
|
|
WO2012080471A1
(en)
|
2010-12-16 |
2012-06-21 |
Novo Nordisk A/S |
Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
|
|
JP2014504588A
(ja)
|
2010-12-22 |
2014-02-24 |
アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー |
膵島細胞移植のためのｇｌｐ−１受容体アゴニスト
|
|
NZ612297A
(en)
|
2010-12-22 |
2015-10-30 |
Univ Indiana Res & Tech Corp |
Glucagon analogs exhibiting gip receptor activity
|
|
CN102532301B
(zh)
|
2010-12-31 |
2014-09-03 |
上海医药工业研究院 |
一类新型的Exendin-4类似物及其制备方法
|
|
US20120208755A1
(en)
|
2011-02-16 |
2012-08-16 |
Intarcia Therapeutics, Inc. |
Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
|
|
CN102100906A
(zh)
|
2011-02-18 |
2011-06-22 |
深圳翰宇药业股份有限公司 |
一种艾塞那肽的药用制剂及其制备方法
|
|
ES2621304T3
(es)
|
2011-03-10 |
2017-07-03 |
Xeris Pharmaceuticals, Inc. |
Formulaciones estables para inyección parenteral de fármacos peptídicos
|
|
CN102718858B
(zh)
|
2011-03-29 |
2014-07-02 |
天津药物研究院 |
胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
|
|
CN102718868A
(zh)
|
2011-03-30 |
2012-10-10 |
上海华谊生物技术有限公司 |
定点单取代聚乙二醇化Exendin类似物及其制备方法
|
|
DK2694095T3
(en)
|
2011-04-05 |
2018-05-28 |
Longevity Biotech Inc |
COMPOSITIONS COMPREHENSIVE GLUCAGON ANALOGS AND METHODS FOR PREPARING AND USING THE SAME
|
|
WO2012140647A2
(en)
|
2011-04-11 |
2012-10-18 |
Yeda Research And Development Co. Ltd |
Albumin binding probes and drug conjugates thereof
|
|
WO2012150503A2
(en)
|
2011-05-03 |
2012-11-08 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
CN102766204B
(zh)
|
2011-05-05 |
2014-10-15 |
天津药物研究院 |
胰高血糖素样肽-1突变体多肽及其制备方法和其应用
|
|
DK2710031T3
(en)
|
2011-05-18 |
2018-01-02 |
Mederis Diabetes Llc |
IMPROVED PEPTID MEDICINALS FOR INSULIN RESISTANCE
|
|
WO2012162547A2
(en)
|
2011-05-25 |
2012-11-29 |
Amylin Pharmaceuticals, Inc. |
Long duration dual hormone conjugates
|
|
UA113626C2
(xx)
|
2011-06-02 |
2017-02-27 |
|
Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
|
|
PL2718318T3
(pl)
|
2011-06-10 |
2019-02-28 |
Hanmi Science Co., Ltd. |
Nowe pochodne oksyntomoduliny i zawierająca je kompozycja farmaceutyczna do leczenia otyłości
|
|
US9453062B2
(en)
|
2011-06-10 |
2016-09-27 |
Beijing Hanmi Pharmaceutical Co., Ltd. |
Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
|
|
ES2566549T3
(es)
|
2011-06-17 |
2016-04-13 |
Halozyme, Inc. |
Formulaciones estables de enzima degradante de hialuronano
|
|
KR101577734B1
(ko)
|
2011-06-17 |
2015-12-29 |
한미사이언스 주식회사 |
옥신토모듈린과 면역글로불린 단편을 포함하는 결합체 및 그의 용도
|
|
MX2013015168A
(es)
|
2011-06-22 |
2014-03-31 |
Univ Indiana Res & Tech Corp |
Co-agonista del receptor de glucagon/glp-1.
|
|
HRP20170890T1
(hr)
|
2011-06-22 |
2017-09-08 |
Indiana University Research And Technology Corporation |
Suagonisti glukagonskog/glp-1 receptora
|
|
WO2012177929A2
(en)
|
2011-06-24 |
2012-12-27 |
Amylin Pharmaceuticals, Inc. |
Methods for treating diabetes with extended release formulations of glp-1 receptor agonists
|
|
KR101357117B1
(ko)
|
2011-06-28 |
2014-02-06 |
비앤엘델리팜 주식회사 |
폴리에틸렌글라이콜 또는 이의 유도체로 페길화된 엑센딘-4 유사체, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨병 예방 또는 치료용 약학적 조성물
|
|
US9944687B2
(en)
|
2011-07-04 |
2018-04-17 |
Imperial Innovations Limited |
Compounds and their effects on feeding behaviour
|
|
EP2729481B1
(en)
|
2011-07-08 |
2018-10-17 |
Amylin Pharmaceuticals, LLC |
Engineered polypeptides having enhanced duration of action with reduced immunogenicity
|
|
RU2578460C2
(ru)
|
2011-08-10 |
2016-03-27 |
Адосиа |
Приемлемый для инъекций раствор по меньшей мере одного базального инсулина
|
|
JP6169079B2
(ja)
|
2011-08-24 |
2017-07-26 |
フェーズバイオ ファーマシューティカルズ，インコーポレイテッド |
徐放のための活性剤の製剤
|
|
WO2013029279A1
(zh)
|
2011-09-03 |
2013-03-07 |
深圳市健元医药科技有限公司 |
新的glp-ⅰ类似物及其制备方法和用途
|
|
JP6352806B2
(ja)
|
2011-09-23 |
2018-07-04 |
ノヴォ ノルディスク アー／エス |
新規のグルカゴン類似体
|
|
RU2014121386A
(ru)
|
2011-10-28 |
2015-12-10 |
Санофи-Авентис Дойчланд Гмбх |
Протокол лечения диабета 2 типа
|
|
CN102363633B
(zh)
|
2011-11-16 |
2013-11-20 |
天津拓飞生物科技有限公司 |
胰高血糖素样肽-1突变体多肽及其制备方法、药物组合物和其应用
|
|
US8859491B2
(en)
|
2011-11-17 |
2014-10-14 |
Indiana University Research And Technology Corporation |
Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
|
|
EP3446692A1
(en)
|
2011-11-29 |
2019-02-27 |
Jurox Pty. Ltd. |
Methods of preserving injectable pharmaceutical compositions comprising a cyclodextrin and a hydrophobic drug
|
|
EP4144378A1
(en)
|
2011-12-16 |
2023-03-08 |
ModernaTX, Inc. |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
|
US9163227B2
(en)
|
2011-12-22 |
2015-10-20 |
Covx Technologies Ireland Limited |
Anti-diabetic compounds
|
|
WO2013092703A2
(en)
|
2011-12-23 |
2013-06-27 |
Zealand Pharma A/S |
Glucagon analogues
|
|
EP2797585A4
(en)
|
2011-12-29 |
2015-10-07 |
Latitude Pharmaceuticals Inc |
STABILIZED GLUCAGONNANOULULSIONS
|
|
WO2013104861A1
(fr)
|
2012-01-09 |
2013-07-18 |
Adocia |
Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide substitue
|
|
US20150133373A1
(en)
|
2012-03-28 |
2015-05-14 |
Amylin Pharmaceuticals, Llc |
Transmucosal delivery of engineered polypeptides
|
|
WO2013148871A1
(en)
|
2012-03-28 |
2013-10-03 |
Amylin Pharmaceuticals, Llc |
Engineered polypeptides
|
|
CA2868996A1
(en)
|
2012-04-02 |
2013-10-10 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
CN108949772A
(zh)
|
2012-04-02 |
2018-12-07 |
现代泰克斯公司 |
用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
|
|
CN102649947A
(zh)
|
2012-04-20 |
2012-08-29 |
无锡和邦生物科技有限公司 |
一种用于测定glp-1及其功能类似物生物活性的细胞株及其应用
|
|
EP2841090A1
(en)
|
2012-04-24 |
2015-03-04 |
Amylin Pharmaceuticals, LLC |
Site-specific enzymatic modification of exendins and analogs thereof
|
|
US20130289241A1
(en)
|
2012-04-26 |
2013-10-31 |
Shanghai Ambiopharm, Inc. |
Method for preparing exenatide
|
|
WO2013182217A1
(en)
|
2012-04-27 |
2013-12-12 |
Sanofi-Aventis Deutschland Gmbh |
Quantification of impurities for release testing of peptide products
|
|
US8901484B2
(en)
|
2012-04-27 |
2014-12-02 |
Sanofi-Aventis Deutschland Gmbh |
Quantification of impurities for release testing of peptide products
|
|
CN104470948B
(zh)
|
2012-05-03 |
2018-06-15 |
西兰制药公司 |
Gip-glp-1双激动剂化合物及方法
|
|
CN104540850B
(zh)
|
2012-05-03 |
2018-05-18 |
西兰制药公司 |
胰高血糖素样肽2(glp-2)类似物
|
|
EP2664374A1
(en)
|
2012-05-15 |
2013-11-20 |
F. Hoffmann-La Roche AG |
Lysin-glutamic acid dipeptide derivatives
|
|
CN103421094A
(zh)
|
2012-05-24 |
2013-12-04 |
上海医药工业研究院 |
一种具有epo类似活性的多肽化合物
|
|
WO2013177565A1
(en)
|
2012-05-25 |
2013-11-28 |
Amylin Pharmaceuticals, Llc |
Insulin-pramlintide compositions and methods for making and using them
|
|
JP2015525226A
(ja)
|
2012-06-14 |
2015-09-03 |
サノフイ |
エキセンディン−４ペプチドアナログ
|
|
MX2014015558A
(es)
|
2012-06-21 |
2015-03-05 |
Univ Indiana Res & Tech Corp |
Analogos de glucagon que exhiben actividad del receptor gip.
|
|
CA2877127A1
(en)
|
2012-06-21 |
2013-12-27 |
Indiana University Research And Technology Corporation |
Analogs of glucagon exhibiting gip receptor activity
|
|
MY176411A
(en)
|
2012-07-12 |
2020-08-06 |
Mannkind Corp |
Dry powder drug delivery system and methods
|
|
JP6534927B2
(ja)
|
2012-07-23 |
2019-06-26 |
ジーランド ファーマ アクティーゼルスカブ |
グルカゴン類似体
|
|
KR101968344B1
(ko)
|
2012-07-25 |
2019-04-12 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
|
|
AR092862A1
(es)
|
2012-07-25 |
2015-05-06 |
Hanmi Pharm Ind Co Ltd |
Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
|
|
AR094821A1
(es)
|
2012-07-25 |
2015-09-02 |
Hanmi Pharm Ind Co Ltd |
Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
|
|
EP2931300A1
(en)
|
2012-08-14 |
2015-10-21 |
Wockhardt Limited |
Pharmaceutical microparticulate compositions of polypeptides
|
|
EP2934562A1
(en)
|
2012-08-14 |
2015-10-28 |
Wockhardt Limited |
Pharmaceutical microparticulate compositions of polypeptides
|
|
CN102816244A
(zh)
|
2012-08-23 |
2012-12-12 |
无锡和邦生物科技有限公司 |
一种Exendin-4肽与人血清白蛋白HSA的融合蛋白及其制备方法
|
|
CN102827270A
(zh)
|
2012-09-13 |
2012-12-19 |
无锡和邦生物科技有限公司 |
一种聚乙二醇化艾塞那肽衍生物及其用途
|
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
|
US9546205B2
(en)
|
2012-09-17 |
2017-01-17 |
Imperial Innovations Limited |
Peptide analogues of glucagon and GLP1
|
|
WO2014049610A2
(en)
|
2012-09-26 |
2014-04-03 |
Cadila Healthcare Limited |
Peptides as gip, glp-1 and glucagon receptors triple-agonist
|
|
UA116217C2
(uk)
|
2012-10-09 |
2018-02-26 |
Санофі |
Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
|
|
PT2916819T
(pt)
|
2012-11-06 |
2019-10-28 |
Hanmi Pharm Ind Co Ltd |
Formulação líquida de conjugado proteico que compreende a oxintomodulina e um fragmento de imunoglobulina.
|
|
KR101993393B1
(ko)
|
2012-11-06 |
2019-10-01 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
|
|
CN118324870A
(zh)
|
2012-11-20 |
2024-07-12 |
梅德瑞斯糖尿病有限责任公司 |
用于胰岛素抗性的改良的肽药物
|
|
TWI617574B
(zh)
|
2012-12-11 |
2018-03-11 |
梅迪繆思有限公司 |
用於治療肥胖之升糖素與ｇｌｐ－１共促效劑
|
|
BR112015014510A2
(pt)
|
2012-12-21 |
2017-11-21 |
Sanofi Sa |
agonistas de glp1/gip duais ou de glp1/gip/glucagon trigonais
|
|
CN103908657A
(zh)
|
2012-12-31 |
2014-07-09 |
复旦大学附属华山医院 |
胰升糖素样肽-1类似物在制备眼科疾病药物中的用途
|
|
EP3238734A1
(en)
|
2013-03-14 |
2017-11-01 |
Medimmune Limited |
Pegylated glucagon and glp-1 co-agonists for the treatment of obesity
|
|
KR20150131213A
(ko)
|
2013-03-14 |
2015-11-24 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
인슐린-인크레틴 접합체들
|
|
WO2014152460A2
(en)
|
2013-03-15 |
2014-09-25 |
Indiana University Research And Technology Corporation |
Prodrugs with prolonged action
|
|
WO2014170496A1
(en)
|
2013-04-18 |
2014-10-23 |
Novo Nordisk A/S |
Stable, protracted glp-1/glucagon receptor co-agonists for medical use
|
|
JP2014227368A
(ja)
|
2013-05-21 |
2014-12-08 |
国立大学法人帯広畜産大学 |
糖尿病および高血糖状態の処置のためのグルカゴンアナログ
|
|
CN103304660B
(zh)
|
2013-07-12 |
2016-08-10 |
上海昂博生物技术有限公司 |
一种利拉鲁肽的合成方法
|
|
CN103405753B
(zh)
|
2013-08-13 |
2016-05-11 |
上海仁会生物制药股份有限公司 |
稳定的促胰岛素分泌肽水针药物组合物
|
|
SG11201602965WA
(en)
|
2013-10-17 |
2016-05-30 |
Zealand Pharma As |
Acylated glucagon analogues
|
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
|
TR201902516T4
(tr)
|
2013-11-06 |
2019-03-21 |
Zealand Pharma As |
Glukagon-glp-1-gıp üçlü agonist bileşikleri.
|
|
EP3080151A1
(en)
|
2013-12-13 |
2016-10-19 |
Sanofi |
Exendin-4 peptide analogues
|
|
EP3080150B1
(en)
|
2013-12-13 |
2018-08-01 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
|
|
EP3080154B1
(en)
|
2013-12-13 |
2018-02-07 |
Sanofi |
Dual glp-1/gip receptor agonists
|
|
WO2015086730A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Non-acylated exendin-4 peptide analogues
|
|
TW201609797A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
雙重ｇｌｐ－１／升糖素受體促效劑
|
|
WO2015086731A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
|
|
CN103665148B
(zh)
|
2013-12-17 |
2016-05-11 |
中国药科大学 |
一种可口服给药的降糖多肽及其制法和用途
|
|
CN103980358B
(zh)
|
2014-01-03 |
2016-08-31 |
杭州阿诺生物医药科技股份有限公司 |
一种制备利拉鲁肽的方法
|
|
CN105960249B
(zh)
|
2014-01-09 |
2021-03-16 |
赛诺菲 |
胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
|
|
KR20160104726A
(ko)
|
2014-01-09 |
2016-09-05 |
사노피 |
인슐린 유사체 및/또는 인슐린 유도체의 안정화된 무글리세롤 약제학적 제형
|
|
GB201404002D0
(en)
|
2014-03-06 |
2014-04-23 |
Imp Innovations Ltd |
Novel compounds
|
|
TW201625668A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
|
|
TW201625669A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
|
|
TW201625670A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
|
|
US9932381B2
(en)
|
2014-06-18 |
2018-04-03 |
Sanofi |
Exendin-4 derivatives as selective glucagon receptor agonists
|
|
CN104926934B
(zh)
|
2014-09-23 |
2016-11-09 |
蒋先兴 |
胃泌酸调节素类似物
|
|
EP3204408B1
(en)
|
2014-10-10 |
2020-05-06 |
Novo Nordisk A/S |
Stable glp-1 based glp-1/glucagon receptor co-agonists
|
|
US20160114000A1
(en)
|
2014-10-24 |
2016-04-28 |
Merck Sharp & Dohme Corp. |
Co-agonists of the glucagon and glp-1 receptors
|
|
WO2016198624A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
|
|
WO2016198604A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Exendin-4 derivatives as dual glp-1 /glucagon receptor agonists
|
|
TW201706291A
(zh)
|
2015-07-10 |
2017-02-16 |
賽諾菲公司 |
作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
|