US4450150A
(en)
|
1973-05-17 |
1984-05-22 |
Arthur D. Little, Inc. |
Biodegradable, implantable drug delivery depots, and method for preparing and using the same
|
US4275152A
(en)
|
1977-02-03 |
1981-06-23 |
Eastman Kodak Company |
Hydrolysis of protein-bound cholesterol esters
|
PT83613B
(en)
|
1985-10-28 |
1988-11-21 |
Lilly Co Eli |
Process for the selective chemical removal of a protein amino-terminal residue
|
EP0272253A4
(en)
|
1986-03-07 |
1990-02-05 |
Massachusetts Inst Technology |
METHOD FOR IMPROVING GLYCOPROTE INSTABILITY.
|
IN165717B
(es)
|
1986-08-07 |
1989-12-23 |
Battelle Memorial Institute |
|
JPH04504416A
(ja)
|
1989-02-17 |
1992-08-06 |
コセルコ・ミモトープス・ピィ・ティ・ワイ.エル・ティ・ディ. |
ペプチドの使用方法と合成方法
|
EP0512042B1
(en)
|
1990-01-24 |
1998-04-08 |
BUCKLEY, Douglas I. |
Glp-1 analogs useful for diabetes treatment
|
CA2024855C
(en)
|
1990-09-07 |
1997-12-09 |
Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee |
Process and intermediates for producing glucagon
|
JPH04145099A
(ja)
|
1990-10-05 |
1992-05-19 |
Sanwa Kagaku Kenkyusho Co Ltd |
Gip様活性を有するポリペプチド誘導体及びその用途
|
US5510459A
(en)
|
1991-01-17 |
1996-04-23 |
Zymogenetics, Inc. |
Glucagon antagonists
|
JP3266311B2
(ja)
|
1991-05-02 |
2002-03-18 |
生化学工業株式会社 |
新規ポリペプチドおよびこれを用いる抗hiv剤
|
US5359030A
(en)
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
US5480867A
(en)
|
1993-12-29 |
1996-01-02 |
The Rockefeller University |
Glucagon analogs with serine replacements
|
US5512549A
(en)
|
1994-10-18 |
1996-04-30 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
|
US5869602A
(en)
|
1995-03-17 |
1999-02-09 |
Novo Nordisk A/S |
Peptide derivatives
|
DE19530865A1
(de)
|
1995-08-22 |
1997-02-27 |
Michael Dr Med Nauck |
Wirkstoff sowie Mittel zur parenteralen Ernährung
|
AU2263197A
(en)
|
1996-02-06 |
1997-08-28 |
Eli Lilly And Company |
Diabetes therapy
|
KR100600457B1
(ko)
|
1996-06-05 |
2006-07-13 |
로셰 디아그노스틱스 게엠베하 |
엑센딘 유사체, 이의 제조방법 및 이를 함유한 약제
|
JP2001505872A
(ja)
|
1996-09-09 |
2001-05-08 |
ジーランド ファーマシューティカルズ アクティーゼルスカブ |
α―ヒドロキシ酸リンカーを含むペプチドプロドラッグ
|
UA65549C2
(uk)
|
1996-11-05 |
2004-04-15 |
Елі Ліллі Енд Компані |
Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
|
WO1998024464A1
(en)
|
1996-12-03 |
1998-06-11 |
Trustees Of Boston University |
Specific antagonists for glucose-dependent insulinotropic polypeptide (gip)
|
CN1296417A
(zh)
|
1998-02-10 |
2001-05-23 |
卫福有限公司 |
控释制剂
|
CA2321026A1
(en)
|
1998-03-09 |
1999-09-16 |
Zealand Pharmaceuticals A/S |
Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
|
DE19828113A1
(de)
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
US20030236190A1
(en)
|
1998-09-02 |
2003-12-25 |
Renuka Pillutla |
Isulin and IGF-1 receptor agonists and antagonists
|
WO2000020592A1
(en)
|
1998-10-07 |
2000-04-13 |
Medical College Of Georgia Research Institute, Inc. |
Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
|
GB2344287A
(en)
|
1998-12-03 |
2000-06-07 |
Ferring Bv |
Controlled release pharmaceutical formulation
|
WO2000042026A1
(en)
|
1999-01-15 |
2000-07-20 |
Novo Nordisk A/S |
Non-peptide glp-1 agonists
|
PT1171465E
(pt)
|
1999-03-29 |
2004-12-31 |
Uutech Ltd |
Analogos de petido inibidor gastrico e sua utilizacao para o tratamento de diabetes
|
GB0404124D0
(en)
|
2004-02-25 |
2004-03-31 |
Univ Ulster |
Antagonists of GIP
|
WO2000069911A1
(en)
|
1999-05-17 |
2000-11-23 |
Conjuchem, Inc. |
Long lasting insulinotropic peptides
|
AU2001257278A1
(en)
|
2000-04-27 |
2001-11-07 |
Bionebraska, Inc. |
Gastric inhibitory polypeptide diagnostic test for detecting susceptibility to type-2 diabetes, impaired glucose tolerance, or impaired fasting glucose
|
US6677136B2
(en)
|
2000-05-03 |
2004-01-13 |
Amgen Inc. |
Glucagon antagonists
|
AU2001269833A1
(en)
|
2000-06-14 |
2001-12-24 |
Cytovax Biotechnologies, Inc. |
Use of coiled-coil structural scaffold to generate structure-specific peptides
|
KR100847615B1
(ko)
|
2000-06-16 |
2008-07-21 |
일라이 릴리 앤드 캄파니 |
글루카곤-유사 펩티드-1 유사체
|
EP1305338A2
(en)
|
2000-08-02 |
2003-05-02 |
Theratechnologies Inc. |
Modified peptides with increased potency
|
US20020045572A1
(en)
|
2000-08-15 |
2002-04-18 |
Cpd, Llc |
Method of treating the syndrome of type 2 diabetes in humans
|
US6262062B1
(en)
|
2000-08-15 |
2001-07-17 |
Cpd, Llc |
Method of treating the syndrome of coronary heart disease risk factors in humans
|
US6846831B2
(en)
|
2000-08-15 |
2005-01-25 |
Cpd, Llc |
Method of treating the syndrome of lipodystrophy
|
US6528520B2
(en)
|
2000-08-15 |
2003-03-04 |
Cpd, Llc |
Method of treating the syndrome of coronary heart disease risk factors in humans
|
EP1324779B1
(en)
|
2000-09-29 |
2011-07-20 |
Schering Corporation |
Pegylated interleukin-10
|
WO2002048192A2
(en)
|
2000-12-13 |
2002-06-20 |
Eli Lilly And Company |
Amidated glucagon-like peptide-1
|
ATE408414T1
(de)
|
2001-07-31 |
2008-10-15 |
Us Gov Health & Human Serv |
Glp 1 exendin 4 peptidanaloga und deren verwendungen
|
EP1572885A2
(en)
|
2001-08-08 |
2005-09-14 |
Genzyme Corporation |
Methods for treating diabetes and other blood sugar disorders
|
WO2003020201A2
(en)
|
2001-08-28 |
2003-03-13 |
Eli Lilly And Company |
Pre-mixes of glp-1 and basal insulin
|
GB0121709D0
(en)
|
2001-09-07 |
2001-10-31 |
Imp College Innovations Ltd |
Food inhibition agent
|
US7041646B2
(en)
|
2001-10-05 |
2006-05-09 |
Bayer Pharmaceuticals Corporation |
Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists
|
AR036711A1
(es)
|
2001-10-05 |
2004-09-29 |
Bayer Corp |
Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
|
BR0213377A
(pt)
|
2001-10-18 |
2006-05-23 |
Bristol Myers Squibb Co |
mìmico de peptìdeo semelhante ao glucagon 1 humano e seu uso no tratamento de diabetes e condições relacionadas
|
CA2463803A1
(en)
|
2001-10-19 |
2003-05-01 |
Eli Lilly And Company |
Biphasic mixtures of glp-1 and insulin
|
EP1461069A2
(en)
|
2001-12-29 |
2004-09-29 |
Novo Nordisk A/S |
Combined use of a glp-1 compound and another drug for treating dyslipidemia
|
CA2468700A1
(en)
|
2002-01-08 |
2003-07-17 |
Eli Lilly And Company |
Extended glucagon-like peptide-1 analogs
|
US20030232761A1
(en)
|
2002-03-28 |
2003-12-18 |
Hinke Simon A. |
Novel analogues of glucose-dependent insulinotropic polypeptide
|
WO2003103572A2
(en)
|
2002-06-04 |
2003-12-18 |
Eli Lilly And Company |
Modified glucagon-like peptide-1 analogs
|
JP2006502100A
(ja)
|
2002-06-11 |
2006-01-19 |
エーザイ株式会社 |
細胞の異常消失に関わる障害の治療のための、および/または、肥満の治療のためのgip活性を有する化合物の使用
|
BR0311843A
(pt)
|
2002-06-15 |
2005-03-15 |
Enteromed Inc |
Métodos para prevenir, inibir, tratar ou reduzir esteatose hepática não- alcoólica em um animal e para prevenir o desenvolvimento e/ou a reversão do processo de nafld em um animal
|
CA2497794A1
(en)
|
2002-09-06 |
2004-03-18 |
Bayer Pharmaceuticals Corporation |
Modified glp-1 receptor agonists and their pharmacological methods of use
|
DE60331455D1
(de)
|
2002-10-04 |
2010-04-08 |
Microchips Inc |
Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
|
US7192922B2
(en)
|
2002-11-19 |
2007-03-20 |
Allegheny-Singer Research Institute |
Method of treating left ventricular dysfunction
|
EP2368578A1
(en)
|
2003-01-09 |
2011-09-28 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
US20050059605A1
(en)
|
2003-01-31 |
2005-03-17 |
Krishna Peri |
Chemically modified metabolites of regulatory peptides and methods of producing and using same
|
WO2004078777A2
(en)
|
2003-03-04 |
2004-09-16 |
Biorexis Pharmaceutical Corporation |
Dipeptidyl-peptidase protected proteins
|
PL1605897T3
(pl)
|
2003-03-19 |
2012-12-31 |
Lilly Co Eli |
Związki będące połączeniem GLP-1 z poli(glikolem etylenowym)
|
CA2843439A1
(en)
|
2003-04-08 |
2004-10-21 |
Yeda Research And Development Co. Ltd |
Reversible pegylated drugs
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
US7259234B2
(en)
|
2003-05-15 |
2007-08-21 |
Trustees Of Tufts College |
Stable analogs of peptide and polypeptide therapeutics
|
JP2007524592A
(ja)
|
2003-06-03 |
2007-08-30 |
ノボ・ノルデイスク・エー/エス |
安定化された薬学的ペプチド組成物
|
CA2527743A1
(en)
|
2003-06-03 |
2004-12-09 |
Novo Nordisk A/S |
Stabilized pharmaceutical peptide compositions
|
PL1641823T3
(pl)
|
2003-06-12 |
2012-02-29 |
Lilly Co Eli |
Białka fuzyjne analogu GLP-1
|
US20050124550A1
(en)
|
2003-06-18 |
2005-06-09 |
Peri Krishna G. |
Compounds that modulate the glucagon response and uses thereof
|
SI2932981T1
(sl)
|
2003-09-19 |
2021-11-30 |
Novo Nordisk A/S |
Albumin-vezavni derivati GLP-1
|
US7364875B2
(en)
|
2003-10-30 |
2008-04-29 |
Cresent Innovations, Inc. |
Method for producing medical and commercial grade poly-gamma-glutamic acid of high molecular weight
|
DE602004026113D1
(de)
|
2003-12-18 |
2010-04-29 |
Novo Nordisk As |
Glp-1-verbindungen
|
US20060286129A1
(en)
|
2003-12-19 |
2006-12-21 |
Emisphere Technologies, Inc. |
Oral GLP-1 formulations
|
US20080318837A1
(en)
|
2003-12-26 |
2008-12-25 |
Nastech Pharmaceutical Company Inc. |
Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
|
US7442682B2
(en)
|
2004-10-19 |
2008-10-28 |
Nitto Denko Corporation |
Transepithelial delivery of peptides with incretin hormone activities
|
EP2392595A1
(en)
|
2005-02-11 |
2011-12-07 |
Amylin Pharmaceuticals Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
EP1863537A2
(en)
|
2005-03-18 |
2007-12-12 |
Novo Nordisk A/S |
Dimeric peptide agonists of the glp-1 receptor
|
WO2006121904A1
(en)
|
2005-05-06 |
2006-11-16 |
Bayer Pharmaceuticals Corporation |
Glucose-dependent insulinotropic polypeptide (gip) receptor agonists and their pharmacological methods of use
|
PL1881850T3
(pl)
|
2005-05-13 |
2011-03-31 |
Lilly Co Eli |
Pegylowane związki GLP-1
|
DK1891105T3
(da)
*
|
2005-06-13 |
2012-07-16 |
Imp Innovations Ltd |
Hidtil ukendte forbindelser og deres påvirkninger på spiseadfærd
|
EP1922336B1
(en)
|
2005-08-11 |
2012-11-21 |
Amylin Pharmaceuticals, LLC |
Hybrid polypeptides with selectable properties
|
WO2007028633A2
(en)
|
2005-09-08 |
2007-03-15 |
Uutech Limited |
Treatment of diabetes related obesity
|
AU2006289259A1
(en)
|
2005-09-08 |
2007-03-15 |
Uutech Limited |
Analogs of gastric inhibitory polypeptide as a treatment for age related decreased pancreatic beta cell function
|
US7846445B2
(en)
|
2005-09-27 |
2010-12-07 |
Amunix Operating, Inc. |
Methods for production of unstructured recombinant polymers and uses thereof
|
ES2507098T3
(es)
|
2005-11-07 |
2014-10-14 |
Indiana University Research And Technology Corporation |
Análogos de glucagón que muestran solubilidad y estabilidad fisiológicas
|
EP1991574B1
(en)
|
2006-02-22 |
2016-10-12 |
Merck Sharp & Dohme Corp. |
Oxyntomodulin derivatives
|
ES2397659T3
(es)
|
2006-03-15 |
2013-03-08 |
Novo Nordisk A/S |
Mezclas de amilina e insulina
|
JP5412273B2
(ja)
|
2006-03-21 |
2014-02-12 |
アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニー |
ペプチド−ぺプチダーゼ阻害剤及びその使用
|
WO2007124461A2
(en)
|
2006-04-20 |
2007-11-01 |
Amgen Inc. |
Glp-1 compounds
|
CA2651283A1
(en)
|
2006-05-15 |
2007-11-22 |
Wisconsin Alumni Research Foundation |
Pulmonary delivery of 1.alpha.,25-dihydroxyvitamin d3 and co-administration of parathyroid hormone or calcitonin
|
FR2902092B1
(fr)
|
2006-06-07 |
2008-09-05 |
Sapelem Soc Par Actions Simpli |
Appareil de manutention de charge
|
WO2008022015A2
(en)
|
2006-08-11 |
2008-02-21 |
Trustees Of Tufts College |
Retro-inverso incretin analogues, and methods of use thereof
|
AU2007284365A1
(en)
|
2006-08-17 |
2008-02-21 |
Amylin Pharmaceuticals, Inc. |
DPP-IV resistant GIP hybrid polypeptides with selectable properties
|
WO2008023050A1
(en)
|
2006-08-25 |
2008-02-28 |
Novo Nordisk A/S |
Acylated exendin-4 compounds
|
EP2615108B1
(en)
|
2006-09-08 |
2016-10-26 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and thier uses
|
US8617531B2
(en)
|
2006-12-14 |
2013-12-31 |
Bolder Biotechnology, Inc. |
Methods of making proteins and peptides containing a single free cysteine
|
AU2008205229B2
(en)
|
2007-01-05 |
2014-03-27 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility in physiological pH buffers
|
CA2677932A1
(en)
|
2007-02-15 |
2008-08-21 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
KR101034888B1
(ko)
|
2007-04-19 |
2011-05-17 |
동아제약주식회사 |
지속제어 방출 양상을 갖는 당조절 펩타이드 함유 생분해성고분자 미립구 및 그 제조방법
|
BRPI0815416A2
(pt)
|
2007-08-15 |
2014-10-21 |
Amunix Inc |
Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos
|
EP2190872B1
(en)
|
2007-09-05 |
2018-03-14 |
Novo Nordisk A/S |
Glucagon-like peptide-1 derivatives and their pharmaceutical use
|
CN101842386A
(zh)
|
2007-09-05 |
2010-09-22 |
诺沃-诺迪斯克有限公司 |
截短的glp-1衍生物和它们的治疗用途
|
EP2650006A1
(en)
|
2007-09-07 |
2013-10-16 |
Ipsen Pharma S.A.S. |
Analogues of exendin-4 and exendin-3
|
EP2036539A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Stable formulations of amylin and its analogues
|
WO2009034117A1
(en)
|
2007-09-11 |
2009-03-19 |
Novo Nordisk A/S |
Mixture comprising an amylin peptide and a protracted insulin
|
EP2036923A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Improved derivates of amylin
|
JP5771005B2
(ja)
|
2007-10-30 |
2015-08-26 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
グルカゴンアンタゴニスト及びglp−1アゴニスト活性を示す化合物
|
CA2707861A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
JP2011511778A
(ja)
|
2008-01-30 |
2011-04-14 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション |
エステルに基づいたペプチドプロドラッグ
|
WO2009095479A2
(en)
|
2008-02-01 |
2009-08-06 |
Ascendis Pharma As |
Prodrug comprising a self-cleavable linker
|
EP2300037B1
(en)
*
|
2008-06-17 |
2016-03-30 |
Indiana University Research and Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
PL2300035T3
(pl)
|
2008-06-17 |
2016-04-29 |
Univ Indiana Res & Tech Corp |
Mieszani agoniści na bazie GIP do leczenia zaburzeń metabolicznych i otyłości
|
MX2010012695A
(es)
|
2008-06-17 |
2011-03-15 |
Univ Indiana Res & Tech Corp |
Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico.
|
JP2012512898A
(ja)
|
2008-12-19 |
2012-06-07 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション |
ジペプチド結合薬用剤
|
SG172291A1
(en)
|
2008-12-19 |
2011-07-28 |
Univ Indiana Res & Tech Corp |
Amide based glucagon superfamily peptide prodrugs
|
WO2010096052A1
(en)
|
2009-02-19 |
2010-08-26 |
Merck Sharp & Dohme Corp. |
Oxyntomodulin analogs
|
KR20120087875A
(ko)
|
2009-06-16 |
2012-08-07 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
Gip 수용체-활성 글루카곤 화합물
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
JO2976B1
(en)
|
2009-12-22 |
2016-03-15 |
ايلي ليلي اند كومباني |
Axentomodulin polypeptide
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
IN2012DN06437A
(es)
|
2010-01-27 |
2015-10-09 |
Univ Indiana Res & Tech Corp |
|
AR080592A1
(es)
|
2010-03-26 |
2012-04-18 |
Lilly Co Eli |
Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso
|
CN103179976A
(zh)
|
2010-05-13 |
2013-06-26 |
印第安纳大学研究及科技有限公司 |
呈现g蛋白偶联受体活性的胰高血糖素超家族肽
|
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