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Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.
Piperidine derived compounds; pharmaceutical composition; and its use as acetyl-coa carboxylase inhibitors for the treatment of metabolic disorders, such as obesity and diabetes.