HRP20181678T1 - Glukagon/glp-1 agonisti za liječenje pretilosti - Google Patents
Glukagon/glp-1 agonisti za liječenje pretilostiInfo
- Publication number
- HRP20181678T1 HRP20181678T1 HRP20181678TT HRP20181678T HRP20181678T1 HR P20181678 T1 HRP20181678 T1 HR P20181678T1 HR P20181678T T HRP20181678T T HR P20181678TT HR P20181678 T HRP20181678 T HR P20181678T HR P20181678 T1 HRP20181678 T1 HR P20181678T1
- Authority
- HR
- Croatia
- Prior art keywords
- glp
- glucagon
- obesity
- agonists
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261735823P | 2012-12-11 | 2012-12-11 | |
EP13849992.6A EP2931745B1 (en) | 2012-12-11 | 2013-12-10 | Glucagon/glp-1 agonists for the treatment of obesity |
PCT/IB2013/003191 WO2014091316A2 (en) | 2012-12-11 | 2013-12-10 | Glucagon/glp-1 agonists for the treatment of obesity |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20181678T1 true HRP20181678T1 (hr) | 2019-03-08 |
Family
ID=50588751
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220734TT HRP20220734T1 (hr) | 2012-12-11 | 2013-12-10 | Koagonisti glukagona i glp-1 za liječenje pretilosti |
HRP20181678TT HRP20181678T1 (hr) | 2012-12-11 | 2018-10-15 | Glukagon/glp-1 agonisti za liječenje pretilosti |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220734TT HRP20220734T1 (hr) | 2012-12-11 | 2013-12-10 | Koagonisti glukagona i glp-1 za liječenje pretilosti |
Country Status (26)
Country | Link |
---|---|
US (4) | US9765130B2 (hr) |
EP (2) | EP2931745B1 (hr) |
JP (1) | JP6490011B2 (hr) |
KR (1) | KR102080366B1 (hr) |
CN (2) | CN104822699B (hr) |
AR (1) | AR093903A1 (hr) |
AU (3) | AU2013356934C1 (hr) |
BR (1) | BR112015012238B1 (hr) |
CA (1) | CA2893445C (hr) |
CY (1) | CY1121114T1 (hr) |
DK (2) | DK3495380T3 (hr) |
ES (2) | ES2698329T3 (hr) |
HK (1) | HK1216179A1 (hr) |
HR (2) | HRP20220734T1 (hr) |
HU (1) | HUE039952T2 (hr) |
LT (2) | LT3495380T (hr) |
MX (2) | MX365458B (hr) |
PL (2) | PL3495380T3 (hr) |
PT (2) | PT3495380T (hr) |
RS (2) | RS63305B1 (hr) |
RU (2) | RU2671088C2 (hr) |
SG (2) | SG11201503230XA (hr) |
SI (2) | SI2931745T1 (hr) |
TR (1) | TR201815172T4 (hr) |
TW (2) | TWI674270B (hr) |
WO (1) | WO2014091316A2 (hr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
TWI674270B (zh) * | 2012-12-11 | 2019-10-11 | 英商梅迪繆思有限公司 | 用於治療肥胖之升糖素與glp-1共促效劑 |
EP2934569A1 (en) | 2012-12-21 | 2015-10-28 | Sanofi | Exendin-4 derivatives |
JP2016512213A (ja) * | 2013-03-14 | 2016-04-25 | メディミューン リミテッド | 肥満の治療のためのペグ化グルカゴン及びglp−1コアゴニスト |
WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/gip受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
CN104926934B (zh) * | 2014-09-23 | 2016-11-09 | 蒋先兴 | 胃泌酸调节素类似物 |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
TWI622596B (zh) * | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
CN113546159B (zh) | 2015-12-29 | 2023-09-08 | 派格生物医药(苏州)股份有限公司 | 包含glp-1受体激动剂和胰高血糖素受体激动剂的组合物及其用途 |
EA201891946A1 (ru) * | 2016-03-10 | 2019-04-30 | Медиммун Лимитед | Коагонисты глюкагона и glp-1 для лечения ожирения |
EP3463423A4 (en) * | 2016-06-02 | 2019-05-08 | Indiana University Research & Technology Corporation | GLUCAGON-T3 CONJUGATES |
CN107281471A (zh) * | 2017-06-26 | 2017-10-24 | 中国药科大学 | 一种改构的胰高血糖素样肽-1及其修饰物的应用 |
WO2019085772A1 (zh) * | 2017-11-06 | 2019-05-09 | 深圳市图微安创科技开发有限公司 | 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗胆汁性肝硬化 |
TWI770085B (zh) * | 2017-11-21 | 2022-07-11 | 日商武田藥品工業股份有限公司 | 胜肽化合物 |
DK3774862T3 (da) | 2018-04-05 | 2022-09-05 | Sun Pharmaceutical Ind Ltd | Nye GLP-1-analoger |
JP7350851B2 (ja) * | 2018-11-12 | 2023-09-26 | 天津薬物研究院有限公司 | グルカゴン由来ペプチド及びその用途 |
EP3972630A1 (en) | 2019-05-21 | 2022-03-30 | MedImmune Limited | Cyclodextrin based injectable coformulations of sglt2 inhibitors and incretin peptides |
EP3993823A1 (en) | 2019-07-01 | 2022-05-11 | MedImmune Limited | Pharmaceutical compositions for glucagon and glp-1 co-agonist peptides |
TW202140061A (zh) | 2020-01-10 | 2021-11-01 | 英商梅迪繆思有限公司 | 用於治療2型糖尿病中的慢性腎病和糖尿病性腎病的升糖素及glp-1協同促效劑 |
CN113493503B (zh) * | 2020-04-08 | 2022-08-05 | 浙江道尔生物科技有限公司 | 一种肠促胰岛素类似物及其制备方法和用途 |
CN115484972A (zh) | 2020-04-24 | 2022-12-16 | 勃林格殷格翰国际有限公司 | 作为长效glp-1/升糖素受体激动剂以治疗脂肪肝疾病及脂肪肝炎的升糖素类似物 |
TW202313974A (zh) | 2021-06-08 | 2023-04-01 | 瑞典商阿斯特捷利康公司 | 用於治療肝病之組合療法 |
KR20240043778A (ko) | 2021-07-30 | 2024-04-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 장시간-작용하는 glp1/글루카곤 수용체 작용제를 위한 용량 용법 |
TW202346323A (zh) | 2022-02-07 | 2023-12-01 | 英商梅迪繆思有限公司 | 具有改善的生物穩定性的glp—1及升糖素雙重激動肽 |
CN115975057B (zh) * | 2023-03-16 | 2023-05-16 | 杭州信海医药科技有限公司 | 一种可妥度肽的固相合成方法 |
Family Cites Families (13)
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US30326A (en) * | 1860-10-09 | Steam-g-eneratob | ||
EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
EP1539210A4 (en) * | 2002-09-06 | 2006-06-07 | Bayer Pharmaceuticals Corp | GLP-1 RECEPTOR MODIFIED AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE |
CN1938334A (zh) * | 2004-01-30 | 2007-03-28 | 瓦拉塔药品公司 | Glp-1激动剂和胃泌素化合物的联合使用 |
DE102004043153B4 (de) * | 2004-09-03 | 2013-11-21 | Philipps-Universität Marburg | Erfindung betreffend GLP-1 und Exendin |
MX2008002028A (es) * | 2005-08-11 | 2008-03-27 | Amylin Pharmaceuticals Inc | Polipeptidos hibridos con propiedades de seleccion. |
CN1935846A (zh) * | 2005-09-14 | 2007-03-28 | 王庆华 | 一种用于治疗糖尿病的融合蛋白及其制备方法和应用 |
PL2173890T3 (pl) | 2007-06-21 | 2011-07-29 | Univ Muenchen Tech | Białka czynne biologicznie o zwiększonej stabilności in vivo i (lub) in vitro |
CA2702289A1 (en) * | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Compounds exhibiting glucagon antagonist and glp-1 agonist activity |
CN102459325B (zh) | 2009-06-16 | 2015-03-25 | 印第安纳大学科技研究有限公司 | 胃抑胜肽受体活化的胰高血糖素化合物 |
EP2569000B1 (en) * | 2010-05-13 | 2017-09-27 | Indiana University Research and Technology Corporation | Glucagon superfamily peptides exhibiting nuclear hormone receptor activity |
TWI674270B (zh) * | 2012-12-11 | 2019-10-11 | 英商梅迪繆思有限公司 | 用於治療肥胖之升糖素與glp-1共促效劑 |
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2013
- 2013-12-05 TW TW107102837A patent/TWI674270B/zh active
- 2013-12-05 TW TW102144692A patent/TWI617574B/zh active
- 2013-12-10 WO PCT/IB2013/003191 patent/WO2014091316A2/en active Application Filing
- 2013-12-10 EP EP13849992.6A patent/EP2931745B1/en active Active
- 2013-12-10 CA CA2893445A patent/CA2893445C/en active Active
- 2013-12-10 PL PL18182274.3T patent/PL3495380T3/pl unknown
- 2013-12-10 SG SG11201503230XA patent/SG11201503230XA/en unknown
- 2013-12-10 EP EP18182274.3A patent/EP3495380B1/en active Active
- 2013-12-10 PL PL13849992T patent/PL2931745T3/pl unknown
- 2013-12-10 RS RS20220574A patent/RS63305B1/sr unknown
- 2013-12-10 HU HUE13849992A patent/HUE039952T2/hu unknown
- 2013-12-10 RU RU2015127780A patent/RU2671088C2/ru active
- 2013-12-10 TR TR2018/15172T patent/TR201815172T4/tr unknown
- 2013-12-10 JP JP2015546105A patent/JP6490011B2/ja active Active
- 2013-12-10 CN CN201380062842.3A patent/CN104822699B/zh active Active
- 2013-12-10 DK DK18182274.3T patent/DK3495380T3/da active
- 2013-12-10 CN CN201910117184.2A patent/CN109776670A/zh active Pending
- 2013-12-10 DK DK13849992.6T patent/DK2931745T3/en active
- 2013-12-10 MX MX2015006568A patent/MX365458B/es active IP Right Grant
- 2013-12-10 PT PT181822743T patent/PT3495380T/pt unknown
- 2013-12-10 KR KR1020157015139A patent/KR102080366B1/ko active IP Right Grant
- 2013-12-10 LT LTEP18182274.3T patent/LT3495380T/lt unknown
- 2013-12-10 SG SG10201801159WA patent/SG10201801159WA/en unknown
- 2013-12-10 LT LTEP13849992.6T patent/LT2931745T/lt unknown
- 2013-12-10 HR HRP20220734TT patent/HRP20220734T1/hr unknown
- 2013-12-10 PT PT13849992T patent/PT2931745T/pt unknown
- 2013-12-10 RU RU2018137842A patent/RU2018137842A/ru unknown
- 2013-12-10 BR BR112015012238-8A patent/BR112015012238B1/pt active IP Right Grant
- 2013-12-10 RS RS20181267A patent/RS57899B1/sr unknown
- 2013-12-10 ES ES13849992T patent/ES2698329T3/es active Active
- 2013-12-10 US US14/650,469 patent/US9765130B2/en active Active
- 2013-12-10 SI SI201331220T patent/SI2931745T1/sl unknown
- 2013-12-10 AR ARP130104612A patent/AR093903A1/es unknown
- 2013-12-10 ES ES18182274T patent/ES2926713T3/es active Active
- 2013-12-10 AU AU2013356934A patent/AU2013356934C1/en active Active
- 2013-12-10 SI SI201331995T patent/SI3495380T1/sl unknown
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2015
- 2015-05-25 MX MX2019006260A patent/MX2019006260A/es unknown
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2016
- 2016-04-08 HK HK16104007.5A patent/HK1216179A1/zh unknown
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2017
- 2017-08-10 US US15/673,826 patent/US10556939B2/en active Active
- 2017-11-15 AU AU2017261505A patent/AU2017261505C1/en active Active
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2018
- 2018-10-15 HR HRP20181678TT patent/HRP20181678T1/hr unknown
- 2018-11-21 CY CY181101228T patent/CY1121114T1/el unknown
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2019
- 2019-11-29 AU AU2019272054A patent/AU2019272054A1/en not_active Abandoned
- 2019-12-20 US US16/723,645 patent/US11230584B2/en active Active
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2021
- 2021-12-14 US US17/550,269 patent/US20220098265A1/en not_active Abandoned
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