|
US5472693A
(en)
*
|
1993-02-16 |
1995-12-05 |
The Dow Chemical Company |
Family of anti-carcinoembryonic antigen chimeric antibodies
|
|
TW458985B
(en)
*
|
1993-05-31 |
2001-10-11 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human antibody against human interleukin-6
|
|
CA2170034C
(en)
*
|
1993-08-24 |
2005-03-15 |
Joseph William Harris |
Recombinant humanized anti-human immunodeficiency virus antibody
|
|
US5914110A
(en)
*
|
1993-09-07 |
1999-06-22 |
Smithkline Beecham Corporation |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
|
EP0729976A1
(en)
*
|
1993-11-19 |
1996-09-04 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human medulloblastomatous cell
|
|
WO1995029690A1
(en)
*
|
1994-04-29 |
1995-11-09 |
The Trustees Of The University Of Pennsylvania |
Biologically active peptides and methods of identifying the same
|
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
CZ296919B6
(cs)
|
1994-10-07 |
2006-07-12 |
Chugai Seiyaku Kabushiki Kaisha |
Farmaceutický prípravek pro lécení chronické revmatické artritidy
|
|
PL182089B1
(en)
*
|
1994-10-21 |
2001-11-30 |
Chugai Pharmaceutical Co Ltd |
Pharmaceutic compositions for treating diseases caused by production of il-6
|
|
WO1996025174A1
(en)
*
|
1995-02-13 |
1996-08-22 |
Chugai Seiyaku Kabushiki Kaisha |
Muscle protein decomposition inhibitor containing il-6 receptor antibody
|
|
DK0923941T3
(da)
|
1996-06-27 |
2006-09-18 |
Chugai Pharmaceutical Co Ltd |
Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler
|
|
CA2266332C
(en)
|
1996-09-26 |
2012-01-03 |
Chugai Seiyaku Kabushiki Kaisha |
Antibodies against human parathyroid hormone related protein
|
|
UA76934C2
(en)
*
|
1996-10-04 |
2006-10-16 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
|
|
AU724133B2
(en)
|
1997-02-12 |
2000-09-14 |
Chugai Seiyaku Kabushiki Kaisha |
Remedies for lymphocytic tumors
|
|
ATE407696T1
(de)
|
1997-03-21 |
2008-09-15 |
Chugai Pharmaceutical Co Ltd |
Vorbeugende- oder heilmittel zur behandlung von multipler sklerose, mit antagonistischen anti-il6-rezeptor antikörpern als wirkstoff
|
|
KR100508338B1
(ko)
|
1997-05-15 |
2005-08-17 |
츄가이 세이야꾸 가부시키가이샤 |
악액질 치료제
|
|
KR20010022846A
(ko)
|
1997-08-15 |
2001-03-26 |
나가야마 오사무 |
항 인터루킨-6 수용체 항체를 유효성분으로서 함유하는 전신성 홍반성 낭창의 예방 및/또는 치료제
|
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
RU2195960C2
(ru)
|
1998-03-17 |
2003-01-10 |
Тугаи Сейяку Кабусики Кайся |
Профилактический или терапевтический агент для лечения воспалительных заболеваний кишечника, содержащий в качестве активного ингредиента антагонист il-6
|
|
BR9909382A
(pt)
|
1998-04-03 |
2000-12-05 |
Chugai Pharmaceutical Co Ltd |
Anticorpo humanizado contra o fator tissular humano (tf) e processo de produção de anticorpo humanizado
|
|
US8440196B1
(en)
|
1998-08-24 |
2013-05-14 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment for pancreatitis using IL-6 receptor antagonist antibodies
|
|
MX343200B
(es)
|
1998-11-27 |
2016-10-19 |
Ucb Pharma Sa |
Composiciones y metodos para aumentar la mineralizacion ósea.
|
|
US7696325B2
(en)
|
1999-03-10 |
2010-04-13 |
Chugai Seiyaku Kabushiki Kaisha |
Polypeptide inducing apoptosis
|
|
AU7078200A
(en)
*
|
1999-08-27 |
2001-03-26 |
United States Of America, Represented By The Secretary, Department Of Health And Human Services, The |
Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use
|
|
US8062638B1
(en)
|
1999-10-01 |
2011-11-22 |
Chugai Seiyaku Kabushiki Kaisha |
Prevention and treatment of diseases associated with blood coagulation
|
|
GB0002666D0
(en)
|
2000-02-04 |
2000-03-29 |
Univ London |
Blockade of voltage dependent sodium channels
|
|
AU2001252618A1
(en)
|
2000-04-28 |
2001-11-12 |
Chugai Seiyaku Kabushiki Kaisha |
Cell proliferation inhibitors
|
|
EP1314437B1
(en)
|
2000-08-11 |
2014-06-25 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilized antibody-containing preparations
|
|
AU2002224417A1
(en)
*
|
2000-10-18 |
2002-04-29 |
Immunex Corporation |
Methods for treating il-18 mediated disorders
|
|
CA2424371A1
(en)
|
2000-10-20 |
2003-04-01 |
Chugai Seiyaku Kabushiki Kaisha |
Agonistic monoclonal antibody fragments
|
|
DE60133479T2
(de)
|
2000-10-20 |
2009-04-16 |
Chugai Seiyaku K.K. |
Modifizierter tpo-agonisten antikörper
|
|
US20040242847A1
(en)
|
2000-10-20 |
2004-12-02 |
Naoshi Fukushima |
Degraded agonist antibody
|
|
KR100824824B1
(ko)
|
2000-10-25 |
2008-04-23 |
추가이 세이야쿠 가부시키가이샤 |
아이엘-6 안타고니스트를 유효 성분으로서 함유하는건선의 예방 또는 치료제
|
|
AU2000279624A1
(en)
*
|
2000-10-27 |
2002-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient
|
|
AU2000279625A1
(en)
*
|
2000-10-27 |
2002-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient
|
|
WO2002064159A1
(fr)
|
2001-02-07 |
2002-08-22 |
Chugai Seiyaku Kabushiki Kaisha |
Remedes contre les tumeurs affectant les organes hematopoietiques
|
|
US20030044406A1
(en)
*
|
2001-03-02 |
2003-03-06 |
Christine Dingivan |
Methods of preventing or treating inflammatory or autoimmune disorders by administering CD2 antagonists in combination with other prophylactic or therapeutic agents
|
|
US7332289B2
(en)
|
2001-03-09 |
2008-02-19 |
Chugai Seiyaku Kabushiki Kaisha |
Method of purifying protein
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
EP1382964A4
(en)
|
2001-04-17 |
2009-06-10 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR TENSID QUANTIFICATION
|
|
PT2163256E
(pt)
*
|
2001-05-11 |
2015-11-20 |
Ludwig Inst For Cancer Res Ltd |
Proteínas de ligação específica e suas utilizações
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
NZ534542A
(en)
*
|
2002-02-14 |
2006-08-31 |
Chugai Pharmaceutical Co Ltd |
Antibody-containing solutions in which the formation of degradation products and insoluble particles during storage and freeze/thaw cycles is inhibited by adding a sugar and surfactant respectively
|
|
GB0208041D0
(en)
*
|
2002-04-08 |
2002-05-22 |
Lonza Biologics Plc |
Method of culturing animal cells
|
|
WO2004022597A1
(ja)
|
2002-09-04 |
2004-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
Gpc3の血中可溶化n端ペプチドに対する抗体
|
|
US20050255103A1
(en)
*
|
2002-04-25 |
2005-11-17 |
Chugai Seiyaku Kabushiki Kaisha |
Remedy for lung cancer
|
|
JP4753578B2
(ja)
*
|
2002-06-03 |
2011-08-24 |
ジェネンテック, インコーポレイテッド |
合成抗体ファージライブラリー
|
|
JP4489591B2
(ja)
|
2002-08-27 |
2010-06-23 |
中外製薬株式会社 |
タンパク質溶液製剤の安定化方法
|
|
EP2261230B1
(en)
|
2002-09-11 |
2017-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Protein purification method
|
|
NZ541928A
(en)
*
|
2003-02-24 |
2009-06-26 |
Chugai Pharmaceutical Co Ltd |
Remedy for spinal injury containing interleukin-6 antagonist
|
|
JP2004279086A
(ja)
|
2003-03-13 |
2004-10-07 |
Konica Minolta Holdings Inc |
放射線画像変換パネル及び放射線画像変換パネルの製造方法
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
EP1636270B1
(en)
*
|
2003-06-16 |
2016-07-20 |
UCB Pharma S.A. |
Antibodies specific for sclerostin and methods for increasing bone mineralization
|
|
EP2204190A1
(en)
|
2003-07-15 |
2010-07-07 |
Chugai Seiyaku Kabushiki Kaisha |
IgM production by transformed cells and methods for quantifying said IgM production
|
|
PL1690550T3
(pl)
|
2003-10-17 |
2013-01-31 |
Chugai Pharmaceutical Co Ltd |
Środek do leczenia międzybłoniaka
|
|
ATE512232T1
(de)
*
|
2003-12-03 |
2011-06-15 |
Chugai Pharmaceutical Co Ltd |
Expressionssystem mit einem säuger-beta-actin- promotor
|
|
AR048210A1
(es)
*
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
US8617550B2
(en)
|
2003-12-19 |
2013-12-31 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment of vasculitis with IL-6 antagonist
|
|
BRPI0506679A
(pt)
*
|
2004-02-11 |
2007-05-15 |
Warner Lambert Co |
métodos de tratar osteoartrite com antagonistas de il-6
|
|
AU2005214988A1
(en)
*
|
2004-02-17 |
2005-09-01 |
Absalus, Inc. |
Super-humanized antibodies against respiratory syncytial virus
|
|
US7767792B2
(en)
*
|
2004-02-20 |
2010-08-03 |
Ludwig Institute For Cancer Research Ltd. |
Antibodies to EGF receptor epitope peptides
|
|
EP3269738A1
(en)
*
|
2004-03-24 |
2018-01-17 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleukin-6 receptor
|
|
AR048335A1
(es)
*
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
GB0410627D0
(en)
*
|
2004-05-12 |
2004-06-16 |
Scancell Ltd |
Specific binding members
|
|
JPWO2006046661A1
(ja)
*
|
2004-10-28 |
2008-05-22 |
国立大学法人大阪大学 |
インターロイキン−6阻害剤
|
|
CA2593521C
(en)
|
2005-01-05 |
2016-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Cell culture method and utilization of the same
|
|
DE602006021401D1
(de)
*
|
2005-02-28 |
2011-06-01 |
Eisai R&D Man Co Ltd |
Neue kombinierte anwendung einer sulfonamid-verbindung zur behandlung von krebs
|
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
|
EP1870458B1
(en)
|
2005-03-31 |
2018-05-09 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2 STRUCTURAL ISOMERS
|
|
PE20061324A1
(es)
|
2005-04-29 |
2007-01-15 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, metodos y usos
|
|
US7592429B2
(en)
*
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
|
JP5068167B2
(ja)
|
2005-06-10 |
2012-11-07 |
中外製薬株式会社 |
メグルミンを含有するタンパク質製剤の安定化剤、およびその利用
|
|
CN101262885B
(zh)
|
2005-06-10 |
2015-04-01 |
中外制药株式会社 |
含有sc(Fv)2的药物组合物
|
|
BRPI0614366A2
(pt)
*
|
2005-08-11 |
2009-10-06 |
Arpi Matossian Rogers |
peptìdeo, anticorpo ou fragmento de anticorpo, anticorpo ou ligante funcionalmente equivalente, molécula de ácido nucleico, vetor, célula hospedeira, métodos para expressar um peptìdeo, um anticorpo ou fragmento de anticorpo, um anticorpo ou ligante equivalente e para tratar uma doença em um paciente, composição farmacêutica, composição de vacina, métodos de vacinação de um indivìduo contra uma doença ou um distúrbio e de diagnose de um indivìduo para a presença de anticorpos autoimunes, e, arranjo de peptìdeos
|
|
BRPI0617378B8
(pt)
|
2005-10-14 |
2022-09-20 |
Chugai Pharmaceutical Co Ltd |
Uso de um inibidor de il-6 para produzir uma composição farmacêutica para suprimir dano a um ilhota transplantada depois do transplante de ilhota; e aperfeiçoar a viabilidade de uma ilhota em um transplante de ilhota
|
|
BRPI0617664B8
(pt)
|
2005-10-21 |
2021-05-25 |
Chugai Pharmaceutical Co Ltd |
uso de um anticorpo que reconhece a il-6 para a produção de uma composição farmacêutica para tratar o enfarte do miocárdio ou suprimir a remodelagem ventricular esquerda depois do enfarte do miocárdio
|
|
ES2577292T3
(es)
|
2005-11-07 |
2016-07-14 |
Genentech, Inc. |
Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso
|
|
US8128934B2
(en)
|
2005-11-14 |
2012-03-06 |
Ribomic, Inc. |
Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
|
|
AR057582A1
(es)
*
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
WO2007061029A1
(ja)
|
2005-11-25 |
2007-05-31 |
Keio University |
前立腺癌治療剤
|
|
EP1977763A4
(en)
|
2005-12-28 |
2010-06-02 |
Chugai Pharmaceutical Co Ltd |
STABILIZER PREPARATION CONTAINING ANTIBODIES
|
|
JP5033643B2
(ja)
|
2006-01-27 |
2012-09-26 |
学校法人慶應義塾 |
脈絡膜血管新生を伴う疾患の治療剤
|
|
WO2007108505A1
(ja)
|
2006-03-22 |
2007-09-27 |
Chugai Seiyaku Kabushiki Kaisha |
エリスロポエチン溶液製剤
|
|
ES2654040T3
(es)
|
2006-03-31 |
2018-02-12 |
Chugai Seiyaku Kabushiki Kaisha |
Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos
|
|
IN2014DN10515A
(enExample)
|
2006-03-31 |
2015-08-21 |
Chugai Pharmaceutical Co Ltd |
|
|
WO2007116962A1
(ja)
|
2006-04-07 |
2007-10-18 |
Osaka University |
筋再生促進剤
|
|
US8741643B2
(en)
|
2006-04-28 |
2014-06-03 |
Lifescan, Inc. |
Differentiation of pluripotent stem cells to definitive endoderm lineage
|
|
BRPI0711908B8
(pt)
*
|
2006-05-25 |
2021-05-25 |
Glaxo Group Ltd |
anticorpo anti-interleucina-18 humanizado, composição farmacêutica, uso de um anticorpo anti-interleucina 18, e, método de produção de um anticorpo.
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
WO2007143168A2
(en)
*
|
2006-06-02 |
2007-12-13 |
Regeneron Pharmaceuticals, Inc. |
High affinity antibodies to human il-6 receptor
|
|
ES2413087T3
(es)
|
2006-06-13 |
2013-07-15 |
Oncomed Pharmaceuticals, Inc. |
Composiciones y métodos para el diagnóstico y tratamiento del cáncer
|
|
EP2386577A3
(en)
|
2006-06-21 |
2012-05-02 |
Oncotherapy Science, Inc. |
Tumor-targeting monoclonal antibodies to FZD10 and uses thereof
|
|
AU2007285695B2
(en)
|
2006-08-18 |
2012-05-24 |
Ablynx N.V. |
Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling
|
|
WO2008042611A2
(en)
*
|
2006-09-29 |
2008-04-10 |
Centocor, Inc. |
Method of using il6 antagonists with mitoxantrone for prostate cancer
|
|
TWI438208B
(zh)
|
2007-01-23 |
2014-05-21 |
Chugai Pharmaceutical Co Ltd |
抑制慢性排斥反應之藥劑
|
|
JP5618544B2
(ja)
|
2007-01-24 |
2014-11-05 |
オンコメッドファーマシューティカルズ インコーポレイテッド |
癌の診断および処置のための組成物および方法
|
|
ES2609094T3
(es)
|
2007-01-25 |
2017-04-18 |
Dana-Farber Cancer Institute, Inc. |
Uso de anticuerpos anti-EGFR en el tratamiento de enfermedades mediadas por un EGFR mutante
|
|
CL2008000719A1
(es)
|
2007-03-12 |
2008-09-05 |
Univ Tokushima Chugai Seiyaku |
Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
|
|
CA2993715A1
(en)
*
|
2007-05-21 |
2008-11-27 |
Alderbio Holdings Llc |
Antibodies to il-6 and use thereof
|
|
US7906117B2
(en)
|
2007-05-21 |
2011-03-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
|
|
US20090238825A1
(en)
*
|
2007-05-21 |
2009-09-24 |
Kovacevich Brian R |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
US8062864B2
(en)
|
2007-05-21 |
2011-11-22 |
Alderbio Holdings Llc |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
|
|
US8404235B2
(en)
|
2007-05-21 |
2013-03-26 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US8178101B2
(en)
|
2007-05-21 |
2012-05-15 |
Alderbio Holdings Inc. |
Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
|
|
US8252286B2
(en)
|
2007-05-21 |
2012-08-28 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US9701747B2
(en)
|
2007-05-21 |
2017-07-11 |
Alderbio Holdings Llc |
Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
|
|
NZ581418A
(en)
*
|
2007-05-21 |
2012-08-31 |
Alderbio Holdings Llc |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
JP5142265B2
(ja)
*
|
2007-05-28 |
2013-02-13 |
独立行政法人産業技術総合研究所 |
抗モータリン抗体のパラトープ及びエピトープ
|
|
US9080145B2
(en)
|
2007-07-01 |
2015-07-14 |
Lifescan Corporation |
Single pluripotent stem cell culture
|
|
JP5424330B2
(ja)
*
|
2007-07-26 |
2014-02-26 |
国立大学法人大阪大学 |
インターロイキン6受容体阻害剤を有効成分とする眼炎症疾患治療剤
|
|
JP5769965B2
(ja)
|
2007-07-31 |
2015-08-26 |
ライフスキャン・インコーポレイテッドLifescan,Inc. |
ヒト胚性幹細胞の分化
|
|
EP2188311B1
(en)
|
2007-08-14 |
2016-10-05 |
Ludwig Institute for Cancer Research Ltd. |
Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof
|
|
CL2008002775A1
(es)
|
2007-09-17 |
2008-11-07 |
Amgen Inc |
Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
|
|
AU2008304756B8
(en)
|
2007-09-26 |
2015-02-12 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-IL-6 receptor antibody
|
|
ES2687808T3
(es)
|
2007-09-26 |
2018-10-29 |
Chugai Seiyaku Kabushiki Kaisha |
Región constante de anticuerpo modificado
|
|
MX369784B
(es)
|
2007-09-26 |
2019-11-21 |
Chugai Pharmaceutical Co Ltd |
Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
|
|
WO2009044774A1
(ja)
|
2007-10-02 |
2009-04-09 |
Chugai Seiyaku Kabushiki Kaisha |
インターロイキン6受容体阻害剤を有効成分とする移植片対宿主病治療剤
|
|
WO2009051108A1
(ja)
†
|
2007-10-15 |
2009-04-23 |
Chugai Seiyaku Kabushiki Kaisha |
抗体の製造方法
|
|
CN101878298B
(zh)
|
2007-11-27 |
2017-08-15 |
生命扫描有限公司 |
人胚胎干细胞的分化
|
|
KR20160074019A
(ko)
*
|
2007-12-05 |
2016-06-27 |
추가이 세이야쿠 가부시키가이샤 |
항nr10 항체 및 그의 이용
|
|
JPWO2009075344A1
(ja)
|
2007-12-12 |
2011-04-28 |
独立行政法人国立がん研究センター |
M−csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
WO2009095489A2
(en)
*
|
2008-02-01 |
2009-08-06 |
Ablynx N.V. |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
KR101597731B1
(ko)
|
2008-02-21 |
2016-02-26 |
센토코 오르토 바이오테크 인코포레이티드 |
세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
|
|
PT2708559T
(pt)
|
2008-04-11 |
2018-05-16 |
Chugai Pharmaceutical Co Ltd |
Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio
|
|
US8623648B2
(en)
|
2008-04-24 |
2014-01-07 |
Janssen Biotech, Inc. |
Treatment of pluripotent cells
|
|
AU2009241589B2
(en)
*
|
2008-04-29 |
2013-10-10 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
ES2564635T3
(es)
|
2008-05-13 |
2016-03-28 |
Novimmune Sa |
Anticuerpos anti-IL-6/IL-6R y métodos de uso de los mismos
|
|
EP2297208A4
(en)
|
2008-06-03 |
2012-07-11 |
Abbott Lab |
DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES
|
|
NZ589434A
(en)
|
2008-06-03 |
2012-11-30 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
CA2728243C
(en)
|
2008-06-05 |
2020-03-10 |
National Cancer Center |
Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer
|
|
US8188235B2
(en)
|
2008-06-18 |
2012-05-29 |
Pfizer Inc. |
Antibodies to IL-6 and their uses
|
|
AU2009267137A1
(en)
|
2008-06-30 |
2010-01-07 |
Centocor Ortho Biotech Inc. |
Differentiation of pluripotent stem cells
|
|
US9132189B2
(en)
|
2008-07-08 |
2015-09-15 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
ME02069B
(me)
|
2008-07-08 |
2015-05-20 |
Oncomed Pharm Inc |
Vezujuci agensi notch1 receptora i postupci njihove primene
|
|
MX2010014574A
(es)
|
2008-07-08 |
2011-04-27 |
Abbott Lab |
Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
|
|
BRPI0919885A2
(pt)
|
2008-10-31 |
2015-08-11 |
Centocor Ortho Biotech Inc |
Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática
|
|
JP2012509085A
(ja)
|
2008-11-20 |
2012-04-19 |
ヤンセン バイオテツク,インコーポレーテツド |
マイクロキャリア上での多能性幹細胞の培養
|
|
PL2366022T3
(pl)
|
2008-11-20 |
2016-11-30 |
|
Sposoby i kompozycje do przyłączania i hodowli komórek na podłożach planarnych
|
|
US8992920B2
(en)
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
US9452227B2
(en)
|
2008-11-25 |
2016-09-27 |
Alderbio Holdings Llc |
Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
|
|
US9212223B2
(en)
|
2008-11-25 |
2015-12-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US8337847B2
(en)
|
2008-11-25 |
2012-12-25 |
Alderbio Holdings Llc |
Methods of treating anemia using anti-IL-6 antibodies
|
|
US8323649B2
(en)
|
2008-11-25 |
2012-12-04 |
Alderbio Holdings Llc |
Antibodies to IL-6 and use thereof
|
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
|
US20120071634A1
(en)
|
2009-03-19 |
2012-03-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody Constant Region Variant
|
|
JP5717624B2
(ja)
|
2009-03-19 |
2015-05-13 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
CN105399828B
(zh)
|
2009-04-10 |
2021-01-15 |
埃博灵克斯股份有限公司 |
用于治疗il-6r相关疾病和病症的改进的针对il-6r的氨基酸序列和包含其的多肽
|
|
WO2010115995A2
(en)
|
2009-04-10 |
2010-10-14 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
KR20140014382A
(ko)
*
|
2009-05-01 |
2014-02-06 |
애브비 인코포레이티드 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
PE20120562A1
(es)
|
2009-05-15 |
2012-06-06 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti-axl
|
|
AU2010276438B2
(en)
|
2009-07-20 |
2015-06-11 |
Janssen Biotech Inc. |
Differentiation of human embryonic stem cells
|
|
MY161541A
(en)
|
2009-07-31 |
2017-04-28 |
Shin Maeda |
Cancer metastasis inhibitor
|
|
TW201118166A
(en)
|
2009-09-24 |
2011-06-01 |
Chugai Pharmaceutical Co Ltd |
HLA class I-recognizing antibodies
|
|
JP5837821B2
(ja)
|
2009-09-24 |
2015-12-24 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
PH12012500691A1
(en)
*
|
2009-10-15 |
2012-11-12 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
HUE033758T2
(en)
|
2009-10-26 |
2017-12-28 |
Hoffmann La Roche |
A method for producing glycosylated immunoglobulin
|
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
EP2504031A4
(en)
|
2009-11-24 |
2013-06-26 |
Alderbio Holdings Llc |
ANTI-IL-6 ANTIBODIES AND THEIR USE
|
|
US9775921B2
(en)
|
2009-11-24 |
2017-10-03 |
Alderbio Holdings Llc |
Subcutaneously administrable composition containing anti-IL-6 antibody
|
|
ES2701626T3
(es)
|
2009-12-28 |
2019-02-25 |
Oncotherapy Science Inc |
Anticuerpos anti-CDH3 y sus usos
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
MX2012008085A
(es)
|
2010-01-13 |
2012-09-12 |
Oncomed Pharm Inc |
Agentes de union notch1 y metodos de uso de los mismos.
|
|
TWI609698B
(zh)
|
2010-01-20 |
2018-01-01 |
Chugai Pharmaceutical Co Ltd |
穩定化的含抗體溶液製劑
|
|
KR20130025375A
(ko)
|
2010-03-01 |
2013-03-11 |
얀센 바이오테크 인코포레이티드 |
만능 줄기 세포로부터 유래된 세포의 정제 방법
|
|
JP5845171B2
(ja)
|
2010-03-04 |
2016-01-20 |
大日本住友製薬株式会社 |
炎症性腸疾患用薬剤
|
|
WO2011108714A1
(ja)
|
2010-03-04 |
2011-09-09 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
EP2552967A4
(en)
|
2010-04-02 |
2014-10-08 |
Amunix Operating Inc |
BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE
|
|
WO2011128096A1
(en)
|
2010-04-16 |
2011-10-20 |
Roche Diagnostics Gmbh |
Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
WO2011143299A2
(en)
|
2010-05-12 |
2011-11-17 |
Centocor Ortho Biotech Inc. |
Differentiation of human embryonic stem cells
|
|
SMT202000095T1
(it)
|
2010-05-14 |
2020-03-13 |
Amgen Inc |
Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
|
|
ES2932398T3
(es)
|
2010-05-28 |
2023-01-18 |
Chugai Pharmaceutical Co Ltd |
Potenciador de la respuesta de las células T antitumorales
|
|
JP5904552B2
(ja)
|
2010-05-28 |
2016-04-13 |
国立研究開発法人国立がん研究センター |
膵癌治療剤
|
|
JPWO2011152503A1
(ja)
|
2010-06-02 |
2013-08-01 |
大日本住友製薬株式会社 |
自己免疫疾患またはアレルギー疾患の治療剤
|
|
CA2801107A1
(en)
|
2010-06-07 |
2011-12-15 |
F. Hoffman-La Roche Ag |
Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
AR081434A1
(es)
*
|
2010-06-10 |
2012-08-29 |
Lilly Co Eli |
Anticuerpo del peptido relacionado con el gen calcitonina (cgrp), composicion farmaceutica que lo comprende, uso de dicho anticuerpo para preparar un medicamento util para tratar dolor de osteoartritis o migranas y fragmento de union a antigeno de dicho anticuerpo
|
|
AR082461A1
(es)
|
2010-08-03 |
2012-12-12 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
MX2013002270A
(es)
|
2010-08-26 |
2013-05-14 |
Abbvie Inc |
Inmonoglubinas de dominio variable doble y usos de las mismas.
|
|
WO2012030538A2
(en)
|
2010-08-31 |
2012-03-08 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells
|
|
SI3590949T1
(sl)
|
2010-10-01 |
2022-09-30 |
Modernatx, Inc. |
Ribonukleinske kisline, ki vsebujejo N1-metil-psevdouracil, in njihove uporabe
|
|
EP2632947A4
(en)
|
2010-10-29 |
2015-03-18 |
Immunogen Inc |
NON-ANTAGONIST MOLECULES BINDING TO THE EGF RECEPTOR AND IMMUNOCONJUGATES THEREOF
|
|
SG189929A1
(en)
|
2010-10-29 |
2013-06-28 |
Immunogen Inc |
Novel egfr-binding molecules and immunoconjugates thereof
|
|
JP2013541594A
(ja)
|
2010-11-08 |
2013-11-14 |
ジェネンテック, インコーポレイテッド |
皮下投与される抗il−6受容体抗体
|
|
TWI629355B
(zh)
|
2010-11-17 |
2018-07-11 |
中外製藥股份有限公司 |
具有替代血液凝固第viii因子之功能的多重專一性抗原結合分子
|
|
US9304134B2
(en)
|
2010-11-23 |
2016-04-05 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of anemia
|
|
TWI654204B
(zh)
|
2010-11-30 |
2019-03-21 |
中外製藥股份有限公司 |
具有鈣依存性的抗原結合能力之抗體
|
|
BR112013018877A2
(pt)
|
2011-01-28 |
2016-10-04 |
Sanofi Sa |
composições farmacêuticas que compreendem anticorpos humanos para pcsk9
|
|
MX352889B
(es)
|
2011-02-25 |
2017-12-13 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo de fc especifico para fcyriib.
|
|
JP2014509588A
(ja)
|
2011-03-01 |
2014-04-21 |
アムジエン・インコーポレーテツド |
二特異性結合剤
|
|
EP2688910B1
(en)
|
2011-03-25 |
2019-05-29 |
Amgen Inc. |
Anti-sclerostin antibody crystals and formulations thereof
|
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
|
DK3150632T3
(en)
|
2011-06-10 |
2020-04-27 |
Canada Minister Nat Defence |
ANTI-RICIN ANTIBODIES AND APPLICATIONS THEREOF
|
|
US10400029B2
(en)
|
2011-06-28 |
2019-09-03 |
Inhibrx, Lp |
Serpin fusion polypeptides and methods of use thereof
|
|
RU2727452C1
(ru)
|
2011-06-28 |
2020-07-21 |
Инхибркс, Инк. |
Слитые серпиновые полипептиды и способы их применения
|
|
WO2013012022A1
(ja)
|
2011-07-19 |
2013-01-24 |
中外製薬株式会社 |
アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
|
|
AR087305A1
(es)
|
2011-07-28 |
2014-03-12 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
|
|
WO2013017656A1
(en)
|
2011-08-02 |
2013-02-07 |
Medizinische Universität Wien |
Antagonists of ribonucleases for treating obesity
|
|
JP6301832B2
(ja)
|
2011-08-04 |
2018-03-28 |
アムジエン・インコーポレーテツド |
骨間隙欠陥を処置する方法
|
|
EP2739652B1
(en)
|
2011-08-04 |
2017-04-05 |
Medizinische Universität Innsbruck |
Cahgt1p inhibitors for use in the treatment of candidiasis
|
|
EP3235557B1
(en)
|
2011-09-01 |
2025-04-30 |
Chugai Seiyaku Kabushiki Kaisha |
PROCESS FOR PREPARING A COMPOSITION COMPRISING HIGHLY CONCENTRATED ANTIBODIES BY ULTRAFILTRATION
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP3311837A1
(en)
|
2011-09-23 |
2018-04-25 |
Ablynx NV |
Prolonged inhibition of interleukin-6 mediated signaling
|
|
DE102011083811A1
(de)
*
|
2011-09-30 |
2013-04-04 |
Airbus Operations Gmbh |
Sitzvorrichtung für ein Luft- oder Raumfahrzeug
|
|
EP2762493B1
(en)
|
2011-09-30 |
2021-06-09 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
|
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
|
EP2763701B1
(en)
|
2011-10-03 |
2018-12-19 |
Moderna Therapeutics, Inc. |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
WO2013059548A1
(en)
|
2011-10-19 |
2013-04-25 |
Sanofi |
Compositions and methods for treating cancer using jak2 inhibitor
|
|
EA034989B1
(ru)
|
2011-10-28 |
2020-04-15 |
Тева Фармасьютикал Австралия Пти Лтд |
Полипептидная конструкция для применения при лечении рака, включающая аттенуированный альфа-интерферон
|
|
JO3370B1
(ar)
|
2011-11-10 |
2019-03-13 |
Regeneron Pharma |
طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
|
|
RU2014121820A
(ru)
|
2011-11-21 |
2015-12-27 |
Иммьюноджен, Инк. |
Способ лечения опухолей, устойчивых к анти-egfr терапиям, с помощью конъюгата антитела egfr с цитотоксическим средством
|
|
WO2013081612A1
(en)
*
|
2011-11-30 |
2013-06-06 |
Abbvie Biotherapeutics Inc. |
Vectors and host cells comprising a modified sv40 promoter for protein expression
|
|
US20140348745A1
(en)
*
|
2011-12-13 |
2014-11-27 |
Nordic Nanovector As |
Chimeric therapeutic anti - cd37 antibodie hh1
|
|
RU2649364C2
(ru)
|
2011-12-16 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Составы на основе модифицированного нуклеозида, нуклеотида и нуклеиновой кислоты
|
|
JP6441080B2
(ja)
|
2011-12-22 |
2018-12-19 |
ヤンセン バイオテツク,インコーポレーテツド |
単一ホルモンのインスリン陽性細胞へのヒト胚性幹細胞の分化
|
|
CN107126560A
(zh)
|
2011-12-28 |
2017-09-05 |
安进公司 |
通过使用抗骨硬化蛋白抗体治疗牙槽骨流失的方法
|
|
UY34558A
(es)
|
2011-12-30 |
2013-07-31 |
Abbvie Inc |
Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17
|
|
JO3787B1
(ar)
|
2012-03-15 |
2021-01-31 |
Janssen Biotech Inc |
أجسام مضادة بشرية ضد cd27 و طرق و استخداماتها
|
|
EP3520821A1
(en)
|
2012-04-02 |
2019-08-07 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of biologics and proteins associated with human disease
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US9878056B2
(en)
|
2012-04-02 |
2018-01-30 |
Modernatx, Inc. |
Modified polynucleotides for the production of cosmetic proteins and peptides
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
ES2599386T3
(es)
|
2012-04-17 |
2017-02-01 |
F. Hoffmann-La Roche Ag |
Método para la expresión de polipéptidos usando ácidos nucleicos modificados
|
|
KR101510831B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
항 il-6r 및 tnfr2을 포함하는 이중특이적 단백질을 발현하는 미니서클 벡터를 포함하는 줄기세포 치료제
|
|
KR101510830B1
(ko)
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
생리활성 단백질을 발현하는 미니서클을 이용하여 형질전환된 줄기세포를 통한 치료법
|
|
KR101510302B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
Il-6 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제
|
|
MX358590B
(es)
|
2012-06-08 |
2018-08-24 |
Janssen Biotech Inc |
Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas.
|
|
CN104619342A
(zh)
|
2012-07-05 |
2015-05-13 |
Ucb医药有限公司 |
骨疾病的治疗
|
|
CN104797132B
(zh)
|
2012-09-13 |
2017-06-30 |
中外制药株式会社 |
基因敲入非人动物
|
|
US9487590B2
(en)
|
2012-09-25 |
2016-11-08 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
|
CA2890263C
(en)
|
2012-11-01 |
2020-03-10 |
Abbvie Inc. |
Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
SI2922554T1
(sl)
|
2012-11-26 |
2022-06-30 |
Modernatx, Inc. |
Terminalno modificirana RNA
|
|
EP2938722B1
(en)
|
2012-12-31 |
2021-12-08 |
Janssen Biotech, Inc. |
Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
|
|
US10370644B2
(en)
|
2012-12-31 |
2019-08-06 |
Janssen Biotech, Inc. |
Method for making human pluripotent suspension cultures and cells derived therefrom
|
|
JP6557147B2
(ja)
|
2012-12-31 |
2019-08-07 |
ヤンセン バイオテツク,インコーポレーテツド |
Hb9調節物を用いたヒト胚性幹細胞の膵臓内分泌細胞への分化
|
|
SG10201709338RA
(en)
|
2012-12-31 |
2017-12-28 |
Janssen Biotech Inc |
Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
JP2016522793A
(ja)
|
2013-03-15 |
2016-08-04 |
アッヴィ・インコーポレイテッド |
IL−1βおよび/またはIL−17に対して指向された二重特異的結合タンパク質
|
|
US11117975B2
(en)
|
2013-04-29 |
2021-09-14 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
|
|
WO2014178820A1
(en)
|
2013-04-29 |
2014-11-06 |
Teva Pharmaceuticals Australia Pty Ltd. |
Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b
|
|
EP3009518B1
(en)
*
|
2013-06-11 |
2020-08-12 |
National Center of Neurology and Psychiatry |
Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
|
|
WO2015000865A1
(en)
|
2013-07-04 |
2015-01-08 |
F. Hoffmann-La Roche Ag |
Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples
|
|
KR102441231B1
(ko)
|
2013-09-27 |
2022-09-06 |
추가이 세이야쿠 가부시키가이샤 |
폴리펩티드 이종 다량체의 제조방법
|
|
US10023626B2
(en)
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
KR20160067219A
(ko)
|
2013-10-03 |
2016-06-13 |
모더나 세라퓨틱스, 인코포레이티드 |
저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
|
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
|
US9017678B1
(en)
|
2014-07-15 |
2015-04-28 |
Kymab Limited |
Method of treating rheumatoid arthritis using antibody to IL6R
|
|
EP3088517B1
(en)
|
2013-12-26 |
2023-11-01 |
Mitsubishi Tanabe Pharma Corporation |
Human anti-il-33 neutralizing monoclonal antibody
|
|
IL296754A
(en)
|
2013-12-27 |
2022-11-01 |
Chugai Pharmaceutical Co Ltd |
A method for isolating an antibody with a low isoelectric point
|
|
EP2898896A1
(en)
|
2014-01-22 |
2015-07-29 |
Université Pierre et Marie Curie (Paris 6) |
Agents for use in the treatment of retinal inflammation
|
|
WO2015116852A1
(en)
|
2014-01-29 |
2015-08-06 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating rheumatoid arthritis by administering an il-6r antibody
|
|
CA2942101A1
(en)
|
2014-03-21 |
2015-09-24 |
Abbvie Inc. |
Anti-egfr antibodies and antibody drug conjugates
|
|
UA119352C2
(uk)
|
2014-05-01 |
2019-06-10 |
Тева Фармасьютикалз Острейліа Пті Лтд |
Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
|
|
CN117821369A
(zh)
|
2014-05-16 |
2024-04-05 |
詹森生物科技公司 |
小分子增强胰腺内分泌细胞中的mafa表达的用途
|
|
EP4056993A1
(en)
|
2014-08-20 |
2022-09-14 |
Chugai Seiyaku Kabushiki Kaisha |
Method for measuring viscosity of protein solution
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
WO2016062766A1
(en)
|
2014-10-21 |
2016-04-28 |
Ablynx Nv |
Treatment of il-6r related diseases
|
|
JP6730271B2
(ja)
|
2014-10-29 |
2020-07-29 |
テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド |
インターフェロンα2Bバリアント
|
|
US10093733B2
(en)
|
2014-12-11 |
2018-10-09 |
Abbvie Inc. |
LRP-8 binding dual variable domain immunoglobulin proteins
|
|
MA41142A
(fr)
|
2014-12-12 |
2017-10-17 |
Amgen Inc |
Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
|
|
US11384350B2
(en)
|
2014-12-15 |
2022-07-12 |
The Regents Of The University Of California |
Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing
|
|
FI3240805T3
(fi)
|
2014-12-15 |
2025-02-17 |
Univ California |
Cd19- ja cd20-vasteellinen bispesifinen tai-veräjän kimeerinen antigeenireseptori
|
|
AR103161A1
(es)
|
2014-12-19 |
2017-04-19 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos antimiostatina y regiones fc variantes así como métodos de uso
|
|
AR103162A1
(es)
|
2014-12-19 |
2017-04-19 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos anti-c5 y métodos para su uso
|
|
EP3816179A3
(en)
|
2015-02-05 |
2021-08-04 |
Chugai Seiyaku Kabushiki Kaisha |
Fc region variant comprising a modified fcrn-binding domain
|
|
CA2972393A1
(en)
|
2015-02-27 |
2016-09-01 |
Chugai Seiyaku Kabushiki Kaisha |
Composition for treating il-6-related diseases
|
|
AR104050A1
(es)
|
2015-03-26 |
2017-06-21 |
Chugai Pharmaceutical Co Ltd |
Proceso de producción con iones de cobre controlados
|
|
US11142587B2
(en)
|
2015-04-01 |
2021-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide hetero-oligomer
|
|
US10697883B2
(en)
|
2015-05-19 |
2020-06-30 |
National Center Of Neurology And Psychiatry |
Method for determining application of therapy to multiple sclerosis (MS) patient
|
|
JP7128460B2
(ja)
|
2015-06-04 |
2022-08-31 |
国立研究開発法人国立精神・神経医療研究センター |
Il-6阻害剤を有効成分とする精神疾患治療剤
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
|
WO2017031151A1
(en)
|
2015-08-18 |
2017-02-23 |
Regeneron Pharmaceuticals, Inc. |
Anti-pcsk9 inhibitory antibodies for treating patients with hyperlipidemia undergoing lipoprotein apheresis
|
|
IL319993A
(en)
|
2015-11-03 |
2025-06-01 |
Sanofi Biotechnology |
Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same
|
|
US11359009B2
(en)
|
2015-12-25 |
2022-06-14 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies and methods of use
|
|
SG11201803989WA
(en)
|
2015-12-28 |
2018-06-28 |
Chugai Pharmaceutical Co Ltd |
Method for promoting efficiency of purification of fc region-containing polypeptide
|
|
US11484591B2
(en)
|
2016-02-22 |
2022-11-01 |
Ohio State Innovation Foundation |
Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites
|
|
GB201604124D0
(en)
|
2016-03-10 |
2016-04-27 |
Ucb Biopharma Sprl |
Pharmaceutical formulation
|
|
RU2746754C2
(ru)
|
2016-03-14 |
2021-04-20 |
Чугаи Сейяку Кабусики Кайся |
Индуцирующее повреждение клеток терапевтическое лекарственное средство, предназначенное для противораковой терапии
|
|
MA45479A
(fr)
|
2016-04-14 |
2019-02-20 |
Janssen Biotech Inc |
Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
|
|
PE20181889A1
(es)
|
2016-04-28 |
2018-12-11 |
Chugai Pharmaceutical Co Ltd |
Preparaciones que contienen anticuerpos
|
|
CN116251182A
(zh)
|
2016-08-05 |
2023-06-13 |
中外制药株式会社 |
用于预防或治疗il-8相关疾病的组合物
|
|
CA3039136A1
(en)
|
2016-09-02 |
2018-03-08 |
The Regents Of The University Of California |
Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
RU2019112680A
(ru)
|
2016-09-27 |
2020-10-29 |
Фрезениус Каби Дойчланд Гмбх |
Жидкая фармацевтическая композиция
|
|
KR102051177B1
(ko)
*
|
2016-10-19 |
2019-12-17 |
주식회사 엘지화학 |
전압 분배를 이용한 스위치 진단 장치 및 방법
|
|
BR112019006853B1
(pt)
|
2016-10-31 |
2021-08-24 |
Fresenius Kabi Deutschland Gmbh |
Composição farmacêutica líquida, seu método de fabricação, seu uso, kit e dispositivo de liberação de fármaco que a compreendem e método de fabricação do dito dispositivo
|
|
WO2018156180A1
(en)
|
2017-02-24 |
2018-08-30 |
Kindred Biosciences, Inc. |
Anti-il31 antibodies for veterinary use
|
|
CN110603057A
(zh)
|
2017-03-17 |
2019-12-20 |
俄亥俄州创新基金会 |
用于递送化学预防剂的纳米颗粒
|
|
JP7185884B2
(ja)
|
2017-05-02 |
2022-12-08 |
国立研究開発法人国立精神・神経医療研究センター |
Il-6及び好中球の関連する疾患の治療効果の予測及び判定方法
|
|
CN107098969B
(zh)
*
|
2017-06-28 |
2018-10-12 |
武汉波睿达生物科技有限公司 |
一种治疗hiv感染的嵌合抗原受体的重组基因构建及其应用
|
|
WO2019045075A1
(ja)
|
2017-08-31 |
2019-03-07 |
田辺三菱製薬株式会社 |
Il-33アンタゴニストを含む子宮内膜症治療剤
|
|
RU2020111737A
(ru)
|
2017-09-13 |
2021-10-13 |
Цзянсу Хэнжуй Медицин Ко., Лтд. |
Антитело против il-6r и его антигенсвязывающий фрагмент и медицинское применение
|
|
KR102771895B1
(ko)
|
2017-10-20 |
2025-02-21 |
가꼬우호우징 효고 이카다이가쿠 |
항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물
|
|
EP3705496A4
(en)
|
2017-11-01 |
2021-12-08 |
Chugai Seiyaku Kabushiki Kaisha |
ANTIBODY VARIANT AND ISOFORM WITH REDUCED BIOLOGICAL ACTIVITY
|
|
US20210363238A1
(en)
|
2018-01-31 |
2021-11-25 |
Motokazu Kato |
Therapeutic agent for asthma containing il-6 inhibitor
|
|
TWI827585B
(zh)
|
2018-03-15 |
2024-01-01 |
日商中外製藥股份有限公司 |
對茲卡病毒具有交叉反應性的抗登革病毒抗體及其使用方法
|
|
JP7405764B2
(ja)
|
2018-03-30 |
2023-12-26 |
アムジエン・インコーポレーテツド |
C末端抗体改変体
|
|
WO2019225568A1
(ja)
|
2018-05-21 |
2019-11-28 |
中外製薬株式会社 |
ガラス容器に封入された凍結乾燥製剤
|
|
CN115649558A
(zh)
|
2018-05-28 |
2023-01-31 |
中外制药株式会社 |
填充喷嘴
|
|
TWI868074B
(zh)
|
2018-08-29 |
2025-01-01 |
美商再生元醫藥公司 |
用來治療患有類風濕性關節炎之個體的方法及組成物
|
|
AU2020205951A1
(en)
*
|
2019-01-07 |
2021-07-22 |
Hunan Siweikang Therapeutics Co. Ltd |
Modified immune cells co-expressing chimeric antigen receptor and il-6 antagonist for reducing toxicity and uses thereof in adoptive cell therapy
|
|
MX2021009242A
(es)
|
2019-01-31 |
2021-10-26 |
Sanofi Biotechnology |
Anticuerpo anti-receptor de il-6 para tratar la artritis juvenil idiopatica.
|
|
EP3949989A4
(en)
|
2019-03-29 |
2022-12-14 |
Chugai Seiyaku Kabushiki Kaisha |
Anti il-6 receptor antibody-containing inhibitor for inhibiting deterioration of bbb function
|
|
EP3947737A2
(en)
|
2019-04-02 |
2022-02-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of predicting and preventing cancer in patients having premalignant lesions
|
|
CA3136398A1
(en)
|
2019-04-10 |
2020-10-15 |
Chugai Seiyaku Kabushiki Kaisha |
Method for purifying fc region-modified antibody
|
|
KR20220019670A
(ko)
|
2019-04-17 |
2022-02-17 |
고쿠리츠다이가쿠호진 히로시마다이가쿠 |
Il-6 저해제 및 ccr2 저해제를 조합하여 투여하는 것을 특징으로 하는 비뇨기암의 치료제
|
|
CN114651010A
(zh)
|
2019-04-24 |
2022-06-21 |
赛诺菲生物技术公司 |
类风湿性关节炎的诊断和治疗方法
|
|
AU2020288561A1
(en)
|
2019-06-04 |
2021-12-23 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for treating pain in subjects with rheumatoid arthritis
|
|
WO2020257586A2
(en)
|
2019-06-20 |
2020-12-24 |
Baxalta Incorporated |
Method of treatment with viral-based gene therapy
|
|
CN110483640B
(zh)
*
|
2019-07-16 |
2020-05-01 |
北京汇智和源生物技术有限公司 |
白介素-6r的人源化单克隆抗体、其编码基因及应用
|
|
MX2022010957A
(es)
|
2020-03-03 |
2023-01-24 |
Twentyeight Seven Inc |
Compuestos que se dirigen a las proteínas de unión al arn o a las proteínas modificadoras del arn.
|
|
US20230174656A1
(en)
|
2020-03-23 |
2023-06-08 |
Genentech, Inc. |
Tocilizumab and remdesivir combination therapy for covid-19 pneumonia
|
|
EP4107184A1
(en)
|
2020-03-23 |
2022-12-28 |
Genentech, Inc. |
Method for treating pneumonia, including covid-19 pneumonia, with an il6 antagonist
|
|
US20230125415A1
(en)
|
2020-03-23 |
2023-04-27 |
Genentech, Inc. |
Biomarkers for predicting response to il-6 antagonist in covid-19 pneumonia
|
|
WO2021211006A1
(en)
|
2020-04-13 |
2021-10-21 |
Federal State Budgetary Institution Center Of Biomedical Technologies Of Federal Medical And Biological Agency |
Inhaled hexapeptide for treating interleukin-6 related respiratory diseases
|
|
WO2021228917A1
(en)
|
2020-05-15 |
2021-11-18 |
F. Hoffmann-La Roche Ag |
Prevention of visible particle formation in parenteral protein solutions
|
|
JP7525762B2
(ja)
*
|
2020-05-18 |
2024-07-31 |
ビオシオン インコーポレイテッド |
Il6rに結合する抗体及びその使用
|
|
WO2022005321A1
(en)
|
2020-06-29 |
2022-01-06 |
Federal State Budgetary Institution Scientific center of biomedical technologies of Federal Medical and Biological Agency |
Inhaled tocilizumab for treating interleukin-6 related respiratory diseases
|
|
KR20220028972A
(ko)
|
2020-08-31 |
2022-03-08 |
(주)셀트리온 |
안정한 약제학적 제제
|
|
JP2023541921A
(ja)
|
2020-09-17 |
2023-10-04 |
ジェネンテック, インコーポレイテッド |
Covid-19肺炎を有する入院患者におけるトシリズマブの有効性及び安全性を評価するためのランダム化二重盲検プラセボ対照多施設試験(empacta)の結果
|
|
UY39610A
(es)
|
2021-01-20 |
2022-08-31 |
Abbvie Inc |
Conjugados anticuerpo-fármaco anti-egfr
|
|
WO2022165419A1
(en)
|
2021-02-01 |
2022-08-04 |
Kyverna Therapeutics, Inc. |
Methods for increasing t-cell function
|
|
US20240158518A1
(en)
|
2021-03-12 |
2024-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition for treatment or prevention of myasthenia gravis
|
|
MX2023014658A
(es)
|
2021-06-11 |
2024-01-12 |
Genentech Inc |
Metodo para tratar la enfermedad pulmonar obstructiva cronica con un antagonista de st2.
|
|
EP4413998A1
(en)
|
2021-10-08 |
2024-08-14 |
Chugai Seiyaku Kabushiki Kaisha |
Method for preparing prefilled syringe formulation
|
|
IL316445A
(en)
|
2022-04-26 |
2024-12-01 |
Chugai Pharmaceutical Co Ltd |
A syringe containing a pharmaceutical preparation equipped with a filter
|
|
WO2024107752A2
(en)
|
2022-11-15 |
2024-05-23 |
Onestone Therapeutics Llc |
Compositions and methods for immunomodulatory bifunctional fusion molecules
|
|
CN121038814A
(zh)
|
2023-04-14 |
2025-11-28 |
中外制药株式会社 |
用于稳定含蛋白质药物制剂的方法
|
|
WO2025198912A1
(en)
|
2024-03-21 |
2025-09-25 |
Hoffmann-La Roche Inc. |
Methods of treating myasthenia gravis
|
|
HUP2400216A1
(hu)
|
2024-04-17 |
2025-10-28 |
Richter Gedeon Nyrt |
N-terminális glutamint tartalmazó immunglobulinok tisztítására szolgáló eljárások
|