|
WO1995006119A1
(en)
*
|
1993-08-24 |
1995-03-02 |
Scotgen Limited |
Recombinant humanized anti-human immunodeficiency virus antibody
|
|
US5472693A
(en)
*
|
1993-02-16 |
1995-12-05 |
The Dow Chemical Company |
Family of anti-carcinoembryonic antigen chimeric antibodies
|
|
AU6808194A
(en)
*
|
1993-05-31 |
1994-12-20 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstructed human antibody against human interleukin-6
|
|
US5914110A
(en)
*
|
1993-09-07 |
1999-06-22 |
Smithkline Beecham Corporation |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
|
EP0729976A1
(en)
*
|
1993-11-19 |
1996-09-04 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human medulloblastomatous cell
|
|
WO1995029690A1
(en)
*
|
1994-04-29 |
1995-11-09 |
The Trustees Of The University Of Pennsylvania |
Biologically active peptides and methods of identifying the same
|
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
EP0783893B1
(en)
|
1994-10-07 |
2012-04-04 |
Chugai Seiyaku Kabushiki Kaisha |
Inhibition of abnormal growth of synovial cells using il-6 antagonist as active ingredient
|
|
WO1996012503A1
(en)
*
|
1994-10-21 |
1996-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Remedy for diseases caused by il-6 production
|
|
CA2211578C
(en)
*
|
1995-02-13 |
2010-09-21 |
Chugai Seiyaku Kabushiki Kaisha |
Muscle protein proteolysis inhibiting agent containing il-6 receptor antibody
|
|
DE69735888T2
(de)
*
|
1996-06-27 |
2006-11-02 |
Chugai Seiyaku K.K. |
Mittel gegen myelome, welches zusammen mit antitumorwirkstoffen auf der basis von stickstoffsenfgasen verwendet werden kann
|
|
SK40599A3
(en)
|
1996-09-26 |
2000-06-12 |
Chugai Pharmaceutical Co Ltd |
Antibody against human parathormone related peptides
|
|
UA76934C2
(en)
*
|
1996-10-04 |
2006-10-16 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
|
|
KR100655979B1
(ko)
|
1997-02-12 |
2006-12-08 |
츄가이 세이야꾸 가부시키가이샤 |
임파구계 종양의 치료제
|
|
AU736282B2
(en)
|
1997-03-21 |
2001-07-26 |
Chugai Seiyaku Kabushiki Kaisha |
A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient
|
|
TR199902800T2
(xx)
|
1997-05-15 |
2000-04-21 |
Chugai Seiyaku Kabushiki Kaisha |
Ka�eksiyi tedavi edici madde.
|
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
PT1004315E
(pt)
|
1997-08-15 |
2008-07-09 |
Chugai Pharmaceutical Co Ltd |
Profilácticos e/ou medicamentos contendo anticorpos neutralizantes anti-receptor de il-6 para reduzir a excreção de proteínas urinárias no lúpus eritematoso sistémico
|
|
HU225539B1
(en)
|
1998-03-17 |
2007-02-28 |
Chugai Pharmaceutical Co Ltd |
Preventives or remedies for inflammatory intestinal diseases containing as the active ingredient antibody against il-6 receptor
|
|
AU752730B2
(en)
|
1998-04-03 |
2002-09-26 |
Chugai Seiyaku Kabushiki Kaisha |
Humanized antibody against human tissue factor (TF) and process for constructing humanized antibody
|
|
WO2000010607A1
(en)
*
|
1998-08-24 |
2000-03-02 |
Chugai Seiyaku Kabushiki Kaisha |
Preventives or remedies for pancreatitis containing il-6 antagonists as the active ingredient
|
|
DE69942782D1
(de)
|
1998-11-27 |
2010-10-28 |
Ucb Sa |
Zusammensetzungen und Verfahren zur Erhöhung der Knochenmineralisierung
|
|
US7696325B2
(en)
|
1999-03-10 |
2010-04-13 |
Chugai Seiyaku Kabushiki Kaisha |
Polypeptide inducing apoptosis
|
|
AU7078200A
(en)
*
|
1999-08-27 |
2001-03-26 |
United States Of America, Represented By The Secretary, Department Of Health And Human Services, The |
Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use
|
|
HUP0203486A2
(hu)
|
1999-10-01 |
2003-02-28 |
Chugai Seiyaku Kabushiki Kaisha |
Véralvadással összefüggő betegségek megelőzése és kezelése
|
|
GB0002666D0
(en)
|
2000-02-04 |
2000-03-29 |
Univ London |
Blockade of voltage dependent sodium channels
|
|
AU2001252618A1
(en)
|
2000-04-28 |
2001-11-12 |
Chugai Seiyaku Kabushiki Kaisha |
Cell proliferation inhibitors
|
|
US8632778B2
(en)
|
2000-08-11 |
2014-01-21 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilized anti-interleukin-6 antibody-containing preparations
|
|
WO2002032374A2
(en)
*
|
2000-10-18 |
2002-04-25 |
Immunex Corporation |
Methods for treating il-18 mediated disorders
|
|
US8034903B2
(en)
|
2000-10-20 |
2011-10-11 |
Chugai Seiyaku Kabushiki Kaisha |
Degraded TPO agonist antibody
|
|
EP1327681A4
(en)
|
2000-10-20 |
2004-09-01 |
Chugai Pharmaceutical Co Ltd |
Degraded agonist antibodies
|
|
US20040242847A1
(en)
|
2000-10-20 |
2004-12-02 |
Naoshi Fukushima |
Degraded agonist antibody
|
|
AU2002210952B2
(en)
|
2000-10-25 |
2007-01-11 |
Chugai Seiyaku Kabushiki Kaisha |
Preventives or remedies for psoriasis containing as the active ingredient IL-6 antagonist
|
|
JP4889187B2
(ja)
*
|
2000-10-27 |
2012-03-07 |
中外製薬株式会社 |
Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤
|
|
AU2000279624A1
(en)
*
|
2000-10-27 |
2002-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient
|
|
EP1364657B1
(en)
|
2001-02-07 |
2016-12-28 |
Chugai Seiyaku Kabushiki Kaisha |
Remedies for myelocytic leukemia
|
|
AU2002322478A1
(en)
*
|
2001-03-02 |
2002-12-16 |
Medimmune, Inc. |
Methods of administering/dosing cd2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders
|
|
EP3088412B1
(en)
|
2001-03-09 |
2021-05-05 |
Chugai Seiyaku Kabushiki Kaisha |
Protein purification method
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
JP4236934B2
(ja)
|
2001-04-17 |
2009-03-11 |
中外製薬株式会社 |
界面活性剤の定量方法
|
|
US20100056762A1
(en)
*
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
DE60234094D1
(de)
*
|
2001-05-11 |
2009-12-03 |
Ludwig Inst For Cancer Res Ltd |
Spezifische bindungsproteine und ihre verwendung
|
|
WO2003068260A1
(fr)
*
|
2002-02-14 |
2003-08-21 |
Chugai Seiyaku Kabushiki Kaisha |
Produits pharmaceutiques en solution contenant des anticorps
|
|
GB0208041D0
(en)
*
|
2002-04-08 |
2002-05-22 |
Lonza Biologics Plc |
Method of culturing animal cells
|
|
WO2004022597A1
(ja)
|
2002-09-04 |
2004-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
Gpc3の血中可溶化ｎ端ﾍﾟﾌﾟﾁﾄﾞに対する抗体
|
|
EP1498137A1
(en)
*
|
2002-04-25 |
2005-01-19 |
Chugai Seiyaku Kabushiki Kaisha |
Remedy for lung cancer
|
|
JP4753578B2
(ja)
*
|
2002-06-03 |
2011-08-24 |
ジェネンテック， インコーポレイテッド |
合成抗体ファージライブラリー
|
|
AU2003257536A1
(en)
|
2002-08-27 |
2004-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Method of stabilizing protein solution preparation
|
|
EP2261230B1
(en)
|
2002-09-11 |
2017-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Protein purification method
|
|
MXPA05008713A
(es)
*
|
2003-02-24 |
2005-09-20 |
Chugai Pharmaceutical Co Ltd |
Agente terapeutico para dano de medula espinal que comprende antagonista de interluceina-6.
|
|
JP2004279086A
(ja)
|
2003-03-13 |
2004-10-07 |
Konica Minolta Holdings Inc |
放射線画像変換パネル及び放射線画像変換パネルの製造方法
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
EP1636270B1
(en)
|
2003-06-16 |
2016-07-20 |
UCB Pharma S.A. |
Antibodies specific for sclerostin and methods for increasing bone mineralization
|
|
TW200510532A
(en)
|
2003-07-15 |
2005-03-16 |
Chugai Pharmaceutical Co Ltd |
IgM production by transformed cell and method of quantifying the same
|
|
US20070134242A1
(en)
|
2003-10-17 |
2007-06-14 |
Chugai Seiyaku Kabushiki Kaisha |
Mesothelioma therapeutic agent
|
|
EP2270152A1
(en)
*
|
2003-12-03 |
2011-01-05 |
Chugai Seiyaku Kabushiki Kaisha |
Expression system using mammalian beta-actin promoter
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
US8617550B2
(en)
|
2003-12-19 |
2013-12-31 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment of vasculitis with IL-6 antagonist
|
|
WO2005080429A2
(en)
*
|
2004-02-11 |
2005-09-01 |
Warner-Lambert Company Llc |
Methods of treating osteoarthritis with anti-il-6 or anti-il6 receptor antibodies
|
|
WO2005079479A2
(en)
*
|
2004-02-17 |
2005-09-01 |
Absalus, Inc. |
Super-humanized antibodies against respiratory syncytial virus
|
|
US7767792B2
(en)
*
|
2004-02-20 |
2010-08-03 |
Ludwig Institute For Cancer Research Ltd. |
Antibodies to EGF receptor epitope peptides
|
|
JPWO2005090405A1
(ja)
|
2004-03-24 |
2008-04-17 |
中外製薬株式会社 |
インターロイキン−６受容体に対するヒト型化抗体のサブタイプ
|
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
GB0410627D0
(en)
*
|
2004-05-12 |
2004-06-16 |
Scancell Ltd |
Specific binding members
|
|
WO2006046661A1
(ja)
*
|
2004-10-28 |
2006-05-04 |
Osaka University |
インターロイキン－６阻害剤
|
|
DK1835022T3
(en)
|
2005-01-05 |
2015-02-23 |
Chugai Pharmaceutical Co Ltd |
CELL CULTIVATION PROCEDURE AND UTILIZATION OF THIS
|
|
US20090047278A1
(en)
*
|
2005-02-28 |
2009-02-19 |
Eisai R & D Management Co., Ltd. |
Novel Combinational Use of Sulfonamide Compound
|
|
EP1870458B1
(en)
|
2005-03-31 |
2018-05-09 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2 STRUCTURAL ISOMERS
|
|
TWI671403B
(zh)
*
|
2005-03-31 |
2019-09-11 |
中外製藥股份有限公司 |
控制組裝之多肽的製造方法
|
|
PA8672101A1
(es)
|
2005-04-29 |
2006-12-07 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, métodos y usos
|
|
US7592429B2
(en)
*
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
|
CN101262885B
(zh)
|
2005-06-10 |
2015-04-01 |
中外制药株式会社 |
含有sc(Fv)2的药物组合物
|
|
CA2610987C
(en)
|
2005-06-10 |
2013-09-10 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
|
CA2618796C
(en)
*
|
2005-08-11 |
2018-01-02 |
Arpi Matossian-Rogers |
Peptides for treatment and diagnosis of autoimmune disease
|
|
RU2446826C2
(ru)
|
2005-10-14 |
2012-04-10 |
Фукуока Юниверсити |
Агенты для подавления повреждения трансплантированных островков после трансплантации островков
|
|
JP5191235B2
(ja)
|
2005-10-21 |
2013-05-08 |
中外製薬株式会社 |
心疾患治療剤
|
|
EP1957531B1
(en)
|
2005-11-07 |
2016-04-13 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
|
|
EP1964574B1
(en)
|
2005-11-14 |
2016-09-07 |
Cellmid Limited |
Method for treatment or prevention of disease associated with functional disorder of regulatory t cell
|
|
AR057582A1
(es)
*
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
AR057941A1
(es)
|
2005-11-25 |
2007-12-26 |
Univ Keio |
Agentes terapeuticos para el cancer de prostata
|
|
EP1977763A4
(en)
|
2005-12-28 |
2010-06-02 |
Chugai Pharmaceutical Co Ltd |
ANTIBODY-CONTAINING STABILIZING PREPARATION
|
|
AR059213A1
(es)
|
2006-01-27 |
2008-03-19 |
Univ Keio |
Agentes terapeuticos para enfermedades que involucran neovascularizacion coroidal
|
|
WO2007108505A1
(ja)
|
2006-03-22 |
2007-09-27 |
Chugai Seiyaku Kabushiki Kaisha |
エリスロポエチン溶液製剤
|
|
IN2014DN10515A
(enExample)
|
2006-03-31 |
2015-08-21 |
Chugai Pharmaceutical Co Ltd |
|
|
WO2007114325A1
(ja)
|
2006-03-31 |
2007-10-11 |
Chugai Seiyaku Kabushiki Kaisha |
二重特異性抗体を精製するための抗体改変方法
|
|
CA2648644C
(en)
|
2006-04-07 |
2016-01-05 |
Osaka University |
Muscle regeneration promoter
|
|
US8741643B2
(en)
|
2006-04-28 |
2014-06-03 |
Lifescan, Inc. |
Differentiation of pluripotent stem cells to definitive endoderm lineage
|
|
EP2027157B1
(en)
*
|
2006-05-25 |
2014-08-06 |
Glaxo Group Limited |
Modified humanised anti-interleukin-18 antibodies
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
RS52176B
(sr)
*
|
2006-06-02 |
2012-08-31 |
Regeneron Pharmaceuticals Inc. |
Antitela visokog afiniteta prema humanom il-6 receptoru
|
|
PL2032166T3
(pl)
|
2006-06-13 |
2013-09-30 |
Oncomed Pharm Inc |
Kompozycje i sposoby diagnozowania i leczenia nowotworów
|
|
CN101573383B
(zh)
|
2006-06-21 |
2015-05-13 |
肿瘤疗法科学股份有限公司 |
靶向肿瘤的针对卷曲同源物10的单克隆抗体及其用途
|
|
AU2007285695B2
(en)
|
2006-08-18 |
2012-05-24 |
Ablynx N.V. |
Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling
|
|
US20080081041A1
(en)
*
|
2006-09-29 |
2008-04-03 |
Jeffrey Nemeth |
Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer
|
|
KR101508019B1
(ko)
|
2007-01-23 |
2015-04-06 |
고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 |
만성 거부반응 억제제
|
|
US8088617B2
(en)
|
2007-01-24 |
2012-01-03 |
Oncomed Pharmaceuticals, Inc. |
Antibodies that bind the glutamate ligand binding region of Notch1
|
|
CA2676244C
(en)
|
2007-01-25 |
2017-01-17 |
Kwok-Kin Wong |
Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
|
|
CL2008000719A1
(es)
|
2007-03-12 |
2008-09-05 |
Univ Tokushima Chugai Seiyaku |
Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
|
|
US8252286B2
(en)
*
|
2007-05-21 |
2012-08-28 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US7906117B2
(en)
*
|
2007-05-21 |
2011-03-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
|
|
KR101741731B1
(ko)
|
2007-05-21 |
2017-05-30 |
앨더바이오 홀딩스 엘엘씨 |
Ｉｌ-６에 대한 항체 및 이의 용도
|
|
US8062864B2
(en)
|
2007-05-21 |
2011-11-22 |
Alderbio Holdings Llc |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
|
|
US9701747B2
(en)
|
2007-05-21 |
2017-07-11 |
Alderbio Holdings Llc |
Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
|
|
KR20170036814A
(ko)
*
|
2007-05-21 |
2017-04-03 |
앨더바이오 홀딩스 엘엘씨 |
신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
|
|
US20090238825A1
(en)
*
|
2007-05-21 |
2009-09-24 |
Kovacevich Brian R |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
US8404235B2
(en)
|
2007-05-21 |
2013-03-26 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US8178101B2
(en)
*
|
2007-05-21 |
2012-05-15 |
Alderbio Holdings Inc. |
Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
|
|
JP5142265B2
(ja)
*
|
2007-05-28 |
2013-02-13 |
独立行政法人産業技術総合研究所 |
抗モータリン抗体のパラトープ及びエピトープ
|
|
US9080145B2
(en)
|
2007-07-01 |
2015-07-14 |
Lifescan Corporation |
Single pluripotent stem cell culture
|
|
WO2009014263A1
(ja)
|
2007-07-26 |
2009-01-29 |
Osaka University |
インターロイキン６受容体阻害剤を有効成分とする眼炎症疾患治療剤
|
|
KR101617243B1
(ko)
|
2007-07-31 |
2016-05-02 |
라이프스캔, 인코포레이티드 |
인간 배아 줄기 세포의 분화
|
|
CA2696360C
(en)
|
2007-08-14 |
2018-11-20 |
Ludwig Institute For Cancer Research |
Monoclonal antibody targeting the egfr receptor and uses thereof
|
|
CL2008002775A1
(es)
|
2007-09-17 |
2008-11-07 |
Amgen Inc |
Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
|
|
MX336725B
(es)
|
2007-09-26 |
2016-01-28 |
Chugai Pharmaceutical Co Ltd |
Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
|
|
WO2009041621A1
(ja)
|
2007-09-26 |
2009-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
抗il-6レセプター抗体
|
|
DK3059246T3
(en)
*
|
2007-09-26 |
2018-10-01 |
Chugai Pharmaceutical Co Ltd |
Modified constant region of an antibody
|
|
JP5264752B2
(ja)
|
2007-10-02 |
2013-08-14 |
中外製薬株式会社 |
インターロイキン６受容体阻害剤を有効成分とする移植片対宿主病治療剤
|
|
BRPI0818674B1
(pt)
|
2007-10-15 |
2023-01-17 |
Chugai Seiyaku Kabushiki Kaisha |
Métodos para produção de um anticorpo inteiro ou de um fragmento do mesmo e para preparação de fármacos, bem como vetor recombinante
|
|
CA3123528C
(en)
|
2007-11-27 |
2026-01-13 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells to pancreatic cells
|
|
BRPI0821110B8
(pt)
|
2007-12-05 |
2021-05-25 |
Chugai Pharmaceutical Co Ltd |
anticorpo de neutralização de anti-nr10/il31ra, composição farmacêutica compreendendo o referido anticorpo e uso do mesmo
|
|
EP2241333A1
(en)
|
2007-12-12 |
2010-10-20 |
National Cancer Center |
Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
|
|
PE20091174A1
(es)
*
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
WO2009095489A2
(en)
*
|
2008-02-01 |
2009-08-06 |
Ablynx N.V. |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
BR122017025207B1
(pt)
|
2008-02-21 |
2021-03-16 |
Centocor Ortho Biotech Inc |
superfície que faz parte de um recipiente ou matriz destinada para uso em uma cultura de células ou análises, desprovida de uma camada de células alimentadoras e desprovida de uma camada adsorvente
|
|
TWI700293B
(zh)
|
2008-04-11 |
2020-08-01 |
日商中外製藥股份有限公司 |
重複結合複數個抗原的抗體
|
|
US8623648B2
(en)
|
2008-04-24 |
2014-01-07 |
Janssen Biotech, Inc. |
Treatment of pluripotent cells
|
|
JP5646457B2
(ja)
*
|
2008-04-29 |
2014-12-24 |
アッヴィ・インコーポレイテッド |
二重可変ドメイン免疫グロブリン及びその使用
|
|
AU2009246430B2
(en)
|
2008-05-13 |
2015-07-02 |
Novimmune S.A. |
Anti-IL-6/IL-6R antibodies and methods of use thereof
|
|
JP2011523853A
(ja)
|
2008-06-03 |
2011-08-25 |
アボット・ラボラトリーズ |
二重可変ドメイン免疫グロブリン及びその使用
|
|
AR072000A1
(es)
|
2008-06-03 |
2010-07-28 |
Abbott Lab |
Proteinas de union multivalentes con capacidad de unir dos o mas antigenos y usos de la misma
|
|
US10717781B2
(en)
*
|
2008-06-05 |
2020-07-21 |
National Cancer Center |
Neuroinvasion inhibitor
|
|
US8188235B2
(en)
|
2008-06-18 |
2012-05-29 |
Pfizer Inc. |
Antibodies to IL-6 and their uses
|
|
US20100015711A1
(en)
|
2008-06-30 |
2010-01-21 |
Janet Davis |
Differentiation of Pluripotent Stem Cells
|
|
BRPI0915448A2
(pt)
|
2008-07-08 |
2015-11-10 |
Abbott Lab |
imunoglobulinas de domínio variável duplo para prostaglandina e2 e usos das mesmas
|
|
EP2307051B1
(en)
|
2008-07-08 |
2015-02-11 |
OncoMed Pharmaceuticals, Inc. |
Notch-binding agents and antagonists and methods of use thereof
|
|
US9132189B2
(en)
|
2008-07-08 |
2015-09-15 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
BRPI0919885A2
(pt)
|
2008-10-31 |
2015-08-11 |
Centocor Ortho Biotech Inc |
Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática
|
|
US20100124781A1
(en)
|
2008-11-20 |
2010-05-20 |
Shelley Nelson |
Pluripotent Stem Cell Culture on Micro-Carriers
|
|
AU2009316583B2
(en)
|
2008-11-20 |
2016-04-21 |
Janssen Biotech, Inc. |
Methods and compositions for cell attachment and cultivation on planar substrates
|
|
US8323649B2
(en)
|
2008-11-25 |
2012-12-04 |
Alderbio Holdings Llc |
Antibodies to IL-6 and use thereof
|
|
US8337847B2
(en)
|
2008-11-25 |
2012-12-25 |
Alderbio Holdings Llc |
Methods of treating anemia using anti-IL-6 antibodies
|
|
US8992920B2
(en)
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
US9452227B2
(en)
*
|
2008-11-25 |
2016-09-27 |
Alderbio Holdings Llc |
Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
|
|
US9212223B2
(en)
|
2008-11-25 |
2015-12-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
|
EP2409991B1
(en)
|
2009-03-19 |
2017-05-03 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
JP5787446B2
(ja)
|
2009-03-19 |
2015-09-30 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
WO2010115995A2
(en)
|
2009-04-10 |
2010-10-14 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
AU2010233658B2
(en)
|
2009-04-10 |
2013-11-28 |
Ablynx Nv |
Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders
|
|
AU2010242840B2
(en)
*
|
2009-05-01 |
2014-04-17 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
CN102459344A
(zh)
|
2009-05-15 |
2012-05-16 |
中外制药株式会社 |
抗axl抗体
|
|
BR112012001480A2
(pt)
|
2009-07-20 |
2015-09-01 |
Janssen Biotech Inc |
Diferenciação de células-tronco embriônicas humanas
|
|
TWI523661B
(zh)
*
|
2009-07-31 |
2016-03-01 |
前田慎 |
Anti-IL-6 receptor antibody in the manufacture of inhibitors of metastatic inhibition of lung cancer metastasis to the liver
|
|
TW201118166A
(en)
|
2009-09-24 |
2011-06-01 |
Chugai Pharmaceutical Co Ltd |
HLA class I-recognizing antibodies
|
|
US10150808B2
(en)
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
|
TW201119676A
(en)
*
|
2009-10-15 |
2011-06-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
EP4406615A3
(en)
|
2009-10-26 |
2024-12-11 |
F. Hoffmann-La Roche AG |
Method for the production of a glycosylated immunoglobulin
|
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
US9775921B2
(en)
|
2009-11-24 |
2017-10-03 |
Alderbio Holdings Llc |
Subcutaneously administrable composition containing anti-IL-6 antibody
|
|
CN102740888B
(zh)
|
2009-11-24 |
2016-10-12 |
奥尔德生物制药公司 |
Il-6抗体及其用途
|
|
JP5728718B2
(ja)
|
2009-12-28 |
2015-06-03 |
オンコセラピー・サイエンス株式会社 |
抗ｃｄｈ３抗体およびその使用
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
WO2011088215A2
(en)
*
|
2010-01-13 |
2011-07-21 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
TWI505838B
(zh)
|
2010-01-20 |
2015-11-01 |
中外製藥股份有限公司 |
Stabilized antibody solution containing
|
|
WO2011109279A2
(en)
|
2010-03-01 |
2011-09-09 |
Centocor Ortho Biotech Inc. |
Methods for purifying cells derived from pluripotent stem cells
|
|
WO2011108638A1
(ja)
|
2010-03-04 |
2011-09-09 |
大日本住友製薬株式会社 |
炎症性腸疾患用薬剤
|
|
EP2543730B1
(en)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
EP3372617B1
(en)
|
2010-04-02 |
2024-07-24 |
Amunix Pharmaceuticals, Inc. |
Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
|
|
WO2011128096A1
(en)
|
2010-04-16 |
2011-10-20 |
Roche Diagnostics Gmbh |
Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
US9752125B2
(en)
|
2010-05-12 |
2017-09-05 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells
|
|
SMT202000095T1
(it)
|
2010-05-14 |
2020-03-13 |
Amgen Inc |
Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
|
|
JP5904552B2
(ja)
|
2010-05-28 |
2016-04-13 |
国立研究開発法人国立がん研究センター |
膵癌治療剤
|
|
EP4115906A1
(en)
|
2010-05-28 |
2023-01-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antitumor t cell response enhancer
|
|
US8858944B2
(en)
|
2010-06-02 |
2014-10-14 |
Sumitomo Dainippon Pharma Co., Ltd. |
Treatment drug for autoimmune diseases and allergic diseases
|
|
EP2576824A2
(en)
|
2010-06-07 |
2013-04-10 |
Roche Diagnostics GmbH |
Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
AR081434A1
(es)
*
|
2010-06-10 |
2012-08-29 |
Lilly Co Eli |
Anticuerpo del peptido relacionado con el gen calcitonina (cgrp), composicion farmaceutica que lo comprende, uso de dicho anticuerpo para preparar un medicamento util para tratar dolor de osteoartritis o migranas y fragmento de union a antigeno de dicho anticuerpo
|
|
EP3252072A3
(en)
|
2010-08-03 |
2018-03-14 |
AbbVie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
US8822663B2
(en)
|
2010-08-06 |
2014-09-02 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
SG187938A1
(en)
|
2010-08-26 |
2013-04-30 |
Abbvie Inc |
Dual variable domain immunoglobulins and uses thereof
|
|
CA2809300A1
(en)
|
2010-08-31 |
2012-03-08 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells
|
|
DK4108671T3
(da)
|
2010-10-01 |
2025-01-06 |
Modernatx Inc |
Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf
|
|
US8790649B2
(en)
*
|
2010-10-29 |
2014-07-29 |
Immunogen, Inc. |
EGFR-binding molecules and immunoconjugates thereof
|
|
AU2011320318B9
(en)
|
2010-10-29 |
2015-11-19 |
Immunogen, Inc. |
Non-antagonistic EGFR-binding molecules and immunoconjugates thereof
|
|
EP2638067A2
(en)
|
2010-11-08 |
2013-09-18 |
Genentech, Inc. |
Subcutaneously administered anti-il-6 receptor antibody
|
|
JP6013915B2
(ja)
|
2010-11-17 |
2016-10-25 |
中外製薬株式会社 |
血液凝固第ｖｉｉｉ因子の機能を代替する機能を有する多重特異性抗原結合分子
|
|
US8992908B2
(en)
|
2010-11-23 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of oral mucositis
|
|
KR102568454B1
(ko)
|
2010-11-30 |
2023-08-18 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복해서 결합하는 항원 결합 분자
|
|
BR112013018740A2
(pt)
|
2011-01-28 |
2019-01-08 |
Sanofi Sa |
anticorpos humanos para pcsk9 para uso em métodos de tratamento de grupos específicos de indivíduos
|
|
EP3604330A1
(en)
|
2011-02-25 |
2020-02-05 |
Chugai Seiyaku Kabushiki Kaisha |
Fcgammariib-specific fc antibody
|
|
US9133272B2
(en)
|
2011-03-01 |
2015-09-15 |
Amgen Inc. |
Bispecific binding agents
|
|
JP2014511842A
(ja)
|
2011-03-25 |
2014-05-19 |
アムジエン・インコーポレーテツド |
抗スクレロスチン抗体結晶およびその製剤
|
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
|
DK3006464T3
(en)
|
2011-06-10 |
2018-09-17 |
Canada Minister Nat Defence |
ANTIRICIN ANTIBODIES AND APPLICATIONS THEREOF
|
|
US10400029B2
(en)
|
2011-06-28 |
2019-09-03 |
Inhibrx, Lp |
Serpin fusion polypeptides and methods of use thereof
|
|
IL312872A
(en)
|
2011-06-28 |
2024-07-01 |
Inhibrx Inc |
Methods for purifying fusion proteins containing serphin
|
|
WO2013012022A1
(ja)
|
2011-07-19 |
2013-01-24 |
中外製薬株式会社 |
アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
|
|
AR087305A1
(es)
|
2011-07-28 |
2014-03-12 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
|
|
WO2013017656A1
(en)
|
2011-08-02 |
2013-02-07 |
Medizinische Universität Wien |
Antagonists of ribonucleases for treating obesity
|
|
DK2739311T3
(en)
|
2011-08-04 |
2018-04-23 |
Amgen Inc |
Method of treating bone slit defects
|
|
WO2013017691A1
(en)
|
2011-08-04 |
2013-02-07 |
Medizinische Universität Innsbruck |
Cahgt1p inhibitors for use in the treatment of candidiasis
|
|
CA2847302C
(en)
|
2011-09-01 |
2021-02-16 |
Chugai Seiyaku Kabushiki Kaisha |
Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
US10138302B2
(en)
|
2011-09-23 |
2018-11-27 |
Ablynx N.V. |
Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
TW201817745A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
|
|
DE102011083811A1
(de)
*
|
2011-09-30 |
2013-04-04 |
Airbus Operations Gmbh |
Sitzvorrichtung für ein Luft- oder Raumfahrzeug
|
|
JP6113737B2
(ja)
|
2011-10-03 |
2017-04-12 |
モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． |
修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
WO2013059548A1
(en)
|
2011-10-19 |
2013-04-25 |
Sanofi |
Compositions and methods for treating cancer using jak2 inhibitor
|
|
EP3559049B1
(en)
|
2011-10-28 |
2025-06-11 |
Teva Pharmaceuticals Australia Pty Ltd |
Polypeptide constructs and uses thereof
|
|
JO3370B1
(ar)
|
2011-11-10 |
2019-03-13 |
Regeneron Pharma |
طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
|
|
KR20140105765A
(ko)
|
2011-11-21 |
2014-09-02 |
이뮤노젠 아이엔씨 |
EGfr 항체 세포독성제 접합체에 의한 EGfr 치료에 내성을 나타내는 종양의 치료 방법
|
|
AU2011382454B2
(en)
|
2011-11-30 |
2017-02-23 |
Abbvie Biotechnology Ltd |
Vectors and host cells comprising a modified SV40 promoter for protein expression
|
|
WO2013088363A1
(en)
*
|
2011-12-13 |
2013-06-20 |
Nordic Nanovector As |
Chimeric therapeutic anti - cd37 antibodie hh1
|
|
KR20140102759A
(ko)
|
2011-12-16 |
2014-08-22 |
모더나 세라퓨틱스, 인코포레이티드 |
변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
|
|
KR102203056B1
(ko)
|
2011-12-22 |
2021-01-14 |
얀센 바이오테크 인코포레이티드 |
인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화
|
|
EA036740B1
(ru)
|
2011-12-28 |
2020-12-15 |
Эмджен Инк. |
Способ увеличения высоты альвеолярного отростка посредством применения антител к склеростину
|
|
CN104159920A
(zh)
|
2011-12-30 |
2014-11-19 |
艾伯维公司 |
针对il-13和/或il-17的双重可变结构域免疫球蛋白
|
|
NZ629697A
(en)
|
2012-03-15 |
2017-01-27 |
Janssen Biotech Inc |
Human anti-cd27 antibodies, methods and uses
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
EP2834259A4
(en)
|
2012-04-02 |
2016-08-24 |
Moderna Therapeutics Inc |
MODIFIED POLYNUCLEOTIDES
|
|
BR112014025693B1
(pt)
|
2012-04-17 |
2021-12-07 |
F. Hoffmann-La Roche Ag |
Método de produção recombinante de um polipeptídeo em uma célula bacteriana
|
|
KR101510302B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제
|
|
KR101510830B1
(ko)
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
생리활성 단백질을 발현하는 미니서클을 이용하여 형질전환된 줄기세포를 통한 치료법
|
|
KR101510831B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
항 ｉｌ-６ｒ 및 ｔｎｆｒ２을 포함하는 이중특이적 단백질을 발현하는 미니서클 벡터를 포함하는 줄기세포 치료제
|
|
KR102667288B1
(ko)
|
2012-06-08 |
2024-05-17 |
얀센 바이오테크 인코포레이티드 |
인간 배아 줄기 세포의 췌장 내분비 세포로의 분화
|
|
WO2014006100A1
(en)
|
2012-07-05 |
2014-01-09 |
Ucb Pharma S.A. |
Treatment for bone diseases
|
|
WO2014042251A1
(ja)
|
2012-09-13 |
2014-03-20 |
中外製薬株式会社 |
遺伝子ノックイン非ヒト動物
|
|
US9487590B2
(en)
|
2012-09-25 |
2016-11-08 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
|
MY171664A
(en)
|
2012-11-01 |
2019-10-22 |
Abbvie Inc |
Anti-dll4/vegf dual variable domain immunoglobulins and uses thereof
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
US9597380B2
(en)
|
2012-11-26 |
2017-03-21 |
Modernatx, Inc. |
Terminally modified RNA
|
|
RU2768963C2
(ru)
|
2012-12-31 |
2022-03-25 |
Янссен Байотек, Инк. |
Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки
|
|
US10370644B2
(en)
|
2012-12-31 |
2019-08-06 |
Janssen Biotech, Inc. |
Method for making human pluripotent suspension cultures and cells derived therefrom
|
|
WO2014105546A1
(en)
|
2012-12-31 |
2014-07-03 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
|
|
WO2014106141A1
(en)
|
2012-12-31 |
2014-07-03 |
Janssen Biotech, Inc. |
Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
|
|
JP2016522793A
(ja)
|
2013-03-15 |
2016-08-04 |
アッヴィ・インコーポレイテッド |
ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
FI3677591T3
(fi)
|
2013-04-29 |
2023-04-03 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-cd38-vasta-aineet ja fuusiot heikennetylle interferonille alfa-2b
|
|
US11117975B2
(en)
|
2013-04-29 |
2021-09-14 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
|
|
WO2014200018A1
(ja)
|
2013-06-11 |
2014-12-18 |
独立行政法人 国立精神・神経医療研究センター |
再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法
|
|
KR102248581B1
(ko)
|
2013-07-04 |
2021-05-06 |
에프. 호프만-라 로슈 아게 |
혈청 샘플 중 항-약물 항체를 검출하기 위한 간섭-억제된 면역분석
|
|
SG10201803449VA
(en)
|
2013-09-27 |
2018-05-30 |
Chugai Pharmaceutical Co Ltd |
Method for producing polypeptide heteromultimer
|
|
US10023626B2
(en)
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
EP3052521A1
(en)
|
2013-10-03 |
2016-08-10 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
|
US9017678B1
(en)
|
2014-07-15 |
2015-04-28 |
Kymab Limited |
Method of treating rheumatoid arthritis using antibody to IL6R
|
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
|
US9758578B2
(en)
|
2013-12-26 |
2017-09-12 |
Mitsubishi Tanabe Pharma Corporation |
Human anti-IL-33 neutralizing monoclonal antibody
|
|
EP4671270A3
(en)
|
2013-12-27 |
2026-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
Method for purifying antibody having low isoelectric point
|
|
EP2898896A1
(en)
|
2014-01-22 |
2015-07-29 |
Université Pierre et Marie Curie (Paris 6) |
Agents for use in the treatment of retinal inflammation
|
|
WO2015116852A1
(en)
|
2014-01-29 |
2015-08-06 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating rheumatoid arthritis by administering an il-6r antibody
|
|
TWI731535B
(zh)
|
2014-03-21 |
2021-06-21 |
美商艾伯維有限公司 |
抗-egfr抗體及抗體藥物結合物
|
|
UA119352C2
(uk)
|
2014-05-01 |
2019-06-10 |
Тева Фармасьютикалз Острейліа Пті Лтд |
Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
|
|
EP3954759A1
(en)
|
2014-05-16 |
2022-02-16 |
Janssen Biotech, Inc. |
Use of small molecules to enhance mafa expression in pancreatic endocrine cells
|
|
EP3185004A4
(en)
|
2014-08-20 |
2018-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Method for measuring viscosity of protein solution
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
CA2963712A1
(en)
|
2014-10-21 |
2016-04-28 |
Ablynx Nv |
Treatment of il-6r related diseases
|
|
EA037749B1
(ru)
|
2014-10-29 |
2021-05-18 |
Тева Фармасьютикалз Острэйлиа Пти Лтд |
ВАРИАНТЫ ИНТЕРФЕРОНА 2b
|
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|
|
MA41142A
(fr)
|
2014-12-12 |
2017-10-17 |
Amgen Inc |
Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
|
|
US11384350B2
(en)
|
2014-12-15 |
2022-07-12 |
The Regents Of The University Of California |
Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing
|
|
WO2016100232A1
(en)
|
2014-12-15 |
2016-06-23 |
The Regents Of The University Of California |
Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
|
|
TWI656133B
(zh)
|
2014-12-19 |
2019-04-11 |
日商中外製藥股份有限公司 |
抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法
|
|
KR101838645B1
(ko)
|
2014-12-19 |
2018-03-14 |
추가이 세이야쿠 가부시키가이샤 |
항-c5 항체 및 그의 사용 방법
|
|
WO2016125495A1
(en)
|
2015-02-05 |
2016-08-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
|
|
EP3263132B1
(en)
|
2015-02-27 |
2023-12-06 |
Chugai Seiyaku Kabushiki Kaisha |
Composition for treating il-6-related diseases
|
|
AR104050A1
(es)
|
2015-03-26 |
2017-06-21 |
Chugai Pharmaceutical Co Ltd |
Proceso de producción con iones de cobre controlados
|
|
JP7082484B2
(ja)
|
2015-04-01 |
2022-06-08 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
US10697883B2
(en)
|
2015-05-19 |
2020-06-30 |
National Center Of Neurology And Psychiatry |
Method for determining application of therapy to multiple sclerosis (MS) patient
|
|
EP3305325B1
(en)
|
2015-06-04 |
2025-07-30 |
National Center of Neurology and Psychiatry |
Mental illness therapeutic agent having il-6 inhibitor as active ingredient
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
|
|
JP2018523684A
(ja)
|
2015-08-18 |
2018-08-23 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
リポタンパク質アフェレーシスを受けている高脂血症の患者を治療するための抗ｐｃｓｋ９阻害抗体
|
|
EP3371224A1
(en)
|
2015-11-03 |
2018-09-12 |
Sanofi Biotechnology |
Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same
|
|
WO2017110981A1
(en)
|
2015-12-25 |
2017-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies and methods of use
|
|
CA3004288C
(en)
|
2015-12-28 |
2025-05-27 |
Chugai Seiyaku Kabushiki Kaisha |
METHOD FOR PROMOTING THE CLEARANCE EFFICIENCY OF A POLYPEPTIDE CONTAINING THE FC REGION
|
|
WO2017147169A1
(en)
|
2016-02-22 |
2017-08-31 |
Ohio State Innovation Foundation |
Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin a analogues or metabolites, and estradiol metabolites
|
|
GB201604124D0
(en)
|
2016-03-10 |
2016-04-27 |
Ucb Biopharma Sprl |
Pharmaceutical formulation
|
|
TW202214700A
(zh)
|
2016-03-14 |
2022-04-16 |
日商中外製藥股份有限公司 |
用於癌之治療的細胞傷害誘導治療劑
|
|
CA3020905A1
(en)
|
2016-04-14 |
2017-10-19 |
Janssen Biotech, Inc. |
Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
|
|
AU2017255077B2
(en)
|
2016-04-28 |
2024-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody-containing preparation
|
|
CN109689099B
(zh)
|
2016-08-05 |
2023-02-28 |
中外制药株式会社 |
用于预防或治疗il-8相关疾病的组合物
|
|
KR20190057308A
(ko)
|
2016-09-02 |
2019-05-28 |
더 리전츠 오브 더 유니버시티 오브 캘리포니아 |
인터류킨-6 수용체 알파-결합 단일 사슬 가변 단편을 포함하는 방법 및 조성물
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
KR102546471B1
(ko)
|
2016-09-27 |
2023-06-21 |
프레제니우스 카비 도이치란트 게엠베하 |
액상의 약학 조성물
|
|
KR102051177B1
(ko)
*
|
2016-10-19 |
2019-12-17 |
주식회사 엘지화학 |
전압 분배를 이용한 스위치 진단 장치 및 방법
|
|
EP3964197A1
(en)
|
2016-10-31 |
2022-03-09 |
Fresenius Kabi Deutschland GmbH |
Liquid pharmaceutical composition
|
|
US10093731B2
(en)
|
2017-02-24 |
2018-10-09 |
Kindred Biosciences, Inc. |
Anti-IL31 antibodies for veterinary use
|
|
EP3596175A4
(en)
|
2017-03-17 |
2021-01-13 |
The Ohio State Innovation Foundation |
NANOPARTICLES FOR THE ADMINISTRATION OF CHEMOPREVENTIVE AGENTS
|
|
EP3620531A4
(en)
|
2017-05-02 |
2021-03-17 |
National Center of Neurology and Psychiatry |
METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
|
|
CN107098969B
(zh)
*
|
2017-06-28 |
2018-10-12 |
武汉波睿达生物科技有限公司 |
一种治疗hiv感染的嵌合抗原受体的重组基因构建及其应用
|
|
CN115920032A
(zh)
|
2017-08-31 |
2023-04-07 |
田边三菱制药株式会社 |
含有il-33拮抗剂的子宫内膜异位症治疗剂
|
|
CN111051343B
(zh)
|
2017-09-13 |
2022-11-22 |
江苏恒瑞医药股份有限公司 |
Il-6r抗体、其抗原结合片段及医药用途
|
|
US11692037B2
(en)
|
2017-10-20 |
2023-07-04 |
Hyogo College Of Medicine |
Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
|
|
BR112020008393A2
(pt)
|
2017-11-01 |
2020-11-03 |
Chugai Seiyaku Kabushiki Kaisha |
variante e isoforma de anticorpos com atividade biológica reduzida
|
|
TWI822728B
(zh)
|
2018-01-31 |
2023-11-21 |
加藤元一 |
含有il-6抑制劑的哮喘治療劑
|
|
IL277375B2
(en)
|
2018-03-15 |
2025-08-01 |
Chugai Pharmaceutical Co Ltd |
Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
|
|
CN119241705A
(zh)
|
2018-03-30 |
2025-01-03 |
安姆根有限公司 |
C末端抗体变体
|
|
CN112512480B
(zh)
|
2018-05-21 |
2024-10-01 |
中外制药株式会社 |
被封入玻璃容器的冷冻干燥制剂
|
|
EP3805112A4
(en)
|
2018-05-28 |
2022-03-09 |
Chugai Seiyaku Kabushiki Kaisha |
FILLING NOZZLE
|
|
CN112955222A
(zh)
|
2018-08-29 |
2021-06-11 |
里珍纳龙药品有限公司 |
用于治疗患有类风湿性关节炎的个体的方法和组合物
|
|
US20220096548A1
(en)
*
|
2019-01-07 |
2022-03-31 |
Hunan Siweikang Therapeutics Co. Ltd. |
Modified immune cells co-expressing chimeric antigen receptor and il-6 antagonist for reducing toxicity and uses thereof in adoptive cell therapy
|
|
TW202521583A
(zh)
|
2019-01-31 |
2025-06-01 |
法商賽諾菲生物技術公司 |
用於治療幼年原發性關節炎之組成物及方法
|
|
MX2021011464A
(es)
|
2019-03-29 |
2021-10-22 |
Chugai Pharmaceutical Co Ltd |
Inhibidor que contiene anticuerpo del receptor anti-interleucina 6 (il-6) para inhibir el deterioro de la funcion de la barrera hemato-encefalica (bbb).
|
|
WO2020201362A2
(en)
|
2019-04-02 |
2020-10-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of predicting and preventing cancer in patients having premalignant lesions
|
|
JP7583411B2
(ja)
|
2019-04-10 |
2024-11-14 |
中外製薬株式会社 |
Ｆｃ領域改変抗体の精製方法
|
|
MX2021012163A
(es)
|
2019-04-17 |
2022-01-31 |
Univ Hiroshima |
Agente terapeutico para cancer urologico que se caracteriza por ser administrado con un inhibidor de il-6 y un inhibidor de ccr2 en combinacion.
|
|
MA55760A
(fr)
|
2019-04-24 |
2022-03-02 |
Regeneron Pharma |
Procédés de diagnostic et de traitement de la polyarthrite rhumatoïde
|
|
WO2020243479A1
(en)
|
2019-05-31 |
2020-12-03 |
The Johns Hopkins University |
Bispecific binding agents
|
|
JP2022534794A
(ja)
|
2019-06-04 |
2022-08-03 |
サノフィ・バイオテクノロジー |
関節リウマチを有する対象における疼痛を治療するための組成物および方法
|
|
US20200405883A1
(en)
|
2019-06-20 |
2020-12-31 |
Baxalta Incorporated |
Method of treatment with viral-based gene therapy
|
|
CN110483640B
(zh)
*
|
2019-07-16 |
2020-05-01 |
北京汇智和源生物技术有限公司 |
白介素-6r的人源化单克隆抗体、其编码基因及应用
|
|
BR112022017574A2
(pt)
|
2020-03-03 |
2022-11-16 |
Twentyeight Seven Inc |
Compostos que têm como alvo proteínas de ligação ao rna ou proteínas modificadoras de rna
|
|
US20230125415A1
(en)
|
2020-03-23 |
2023-04-27 |
Genentech, Inc. |
Biomarkers for predicting response to il-6 antagonist in covid-19 pneumonia
|
|
US20230174656A1
(en)
|
2020-03-23 |
2023-06-08 |
Genentech, Inc. |
Tocilizumab and remdesivir combination therapy for covid-19 pneumonia
|
|
JP2023518815A
(ja)
|
2020-03-23 |
2023-05-08 |
ジェネンテック， インコーポレイテッド |
Ｉｌ６アンタゴニストによるｃｏｖｉｄ－１９肺炎を含む肺炎の治療方法
|
|
WO2021211006A1
(en)
|
2020-04-13 |
2021-10-21 |
Federal State Budgetary Institution Center Of Biomedical Technologies Of Federal Medical And Biological Agency |
Inhaled hexapeptide for treating interleukin-6 related respiratory diseases
|
|
WO2021228917A1
(en)
|
2020-05-15 |
2021-11-18 |
F. Hoffmann-La Roche Ag |
Prevention of visible particle formation in parenteral protein solutions
|
|
CN115667297B
(zh)
*
|
2020-05-18 |
2026-02-03 |
博奥信生物技术（南京）有限公司 |
结合il6r的抗体及其用途
|
|
CN115697404A
(zh)
|
2020-05-29 |
2023-02-03 |
中外制药株式会社 |
含有抗体的制剂
|
|
WO2022005321A1
(en)
|
2020-06-29 |
2022-01-06 |
Federal State Budgetary Institution Scientific center of biomedical technologies of Federal Medical and Biological Agency |
Inhaled tocilizumab for treating interleukin-6 related respiratory diseases
|
|
KR20220028972A
(ko)
|
2020-08-31 |
2022-03-08 |
(주)셀트리온 |
안정한 약제학적 제제
|
|
CN116685351A
(zh)
|
2020-09-17 |
2023-09-01 |
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|
|
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|
|
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|
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|
|
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|
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|
|
|
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|
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|
|
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|
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