KR100249937B1 - 인간 인터루킨-6 수용체에 대한 재구성 인간 항체 - Google Patents
인간 인터루킨-6 수용체에 대한 재구성 인간 항체 Download PDFInfo
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- KR100249937B1 KR100249937B1 KR1019930703229A KR930703229A KR100249937B1 KR 100249937 B1 KR100249937 B1 KR 100249937B1 KR 1019930703229 A KR1019930703229 A KR 1019930703229A KR 930703229 A KR930703229 A KR 930703229A KR 100249937 B1 KR100249937 B1 KR 100249937B1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3095476A JPH05236966A (ja) | 1991-04-25 | 1991-04-25 | ヒトインターロイキン−６レセプターに対するマウスモノクローナル抗体の可変領域をコードするｄｎａ |
| JP95476/1991 | 1991-04-25 | ||
| JP32084/1992 | 1992-02-19 | ||
| JP4032084A JPH05227970A (ja) | 1992-02-19 | 1992-02-19 | ヒトインターロイキン−６受容体に対する再構成ヒト抗体 |
| PCT/JP1992/000544 WO1992019759A1 (fr) | 1991-04-25 | 1992-04-24 | Anticorps humains reconstitues diriges contre un recepteur de l'interleukine 6 humaine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR100249937B1 true KR100249937B1 (ko) | 2000-04-01 |
Family
ID=26370596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930703229A Expired - Lifetime KR100249937B1 (ko) | 1991-04-25 | 1992-04-24 | 인간 인터루킨-6 수용체에 대한 재구성 인간 항체 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US5795965A (enExample) |
| EP (1) | EP0628639B1 (enExample) |
| JP (6) | JP3370324B2 (enExample) |
| KR (1) | KR100249937B1 (enExample) |
| AT (1) | ATE181575T1 (enExample) |
| AU (2) | AU668349B2 (enExample) |
| DE (2) | DE69229482T2 (enExample) |
| DK (1) | DK0628639T3 (enExample) |
| ES (1) | ES2134212T3 (enExample) |
| GR (1) | GR3031174T3 (enExample) |
| HU (1) | HU218140B (enExample) |
| LU (1) | LU91556I2 (enExample) |
| NL (1) | NL300383I2 (enExample) |
| RU (1) | RU2139351C1 (enExample) |
| TW (1) | TW205553B (enExample) |
| WO (1) | WO1992019759A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101510830B1 (ko) | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | 생리활성 단백질을 발현하는 미니서클을 이용하여 형질전환된 줄기세포를 통한 치료법 |
| KR101510831B1 (ko) * | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | 항 ｉｌ-６ｒ 및 ｔｎｆｒ２을 포함하는 이중특이적 단백질을 발현하는 미니서클 벡터를 포함하는 줄기세포 치료제 |
| KR101510302B1 (ko) * | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제 |
Families Citing this family (335)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472693A (en) * | 1993-02-16 | 1995-12-05 | The Dow Chemical Company | Family of anti-carcinoembryonic antigen chimeric antibodies |
| AU6808194A (en) * | 1993-05-31 | 1994-12-20 | Chugai Seiyaku Kabushiki Kaisha | Reconstructed human antibody against human interleukin-6 |
| KR100304333B1 (ko) * | 1993-08-24 | 2001-11-30 | 안도 고끼 | 재조합의사람화된항-사람면역결핍바이러스항체 |
| US5914110A (en) * | 1993-09-07 | 1999-06-22 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
| EP0729976A1 (en) * | 1993-11-19 | 1996-09-04 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human medulloblastomatous cell |
| WO1995029690A1 (en) * | 1994-04-29 | 1995-11-09 | The Trustees Of The University Of Pennsylvania | Biologically active peptides and methods of identifying the same |
| US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| EP0783893B1 (en) | 1994-10-07 | 2012-04-04 | Chugai Seiyaku Kabushiki Kaisha | Inhibition of abnormal growth of synovial cells using il-6 antagonist as active ingredient |
| CA2203182C (en) * | 1994-10-21 | 2009-11-24 | Asao Katsume | Remedy for diseases caused by il-6 production |
| EP0811384B1 (en) * | 1995-02-13 | 2006-06-21 | Chugai Seiyaku Kabushiki Kaisha | Muscle protein decomposition inhibitor containing il-6 receptor antibody |
| AU3276297A (en) * | 1996-06-27 | 1998-01-14 | Chugai Seiyaku Kabushiki Kaisha | Remedies for myeloma to be used together with nitrogen mustard antitumor agents |
| US6903194B1 (en) | 1996-09-26 | 2005-06-07 | Chungai Seiyaku Kabushiki Kaisha | Antibody against human parathormone related peptides |
| UA76934C2 (en) * | 1996-10-04 | 2006-10-16 | Chugai Pharmaceutical Co Ltd | Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody |
| CA2280875C (en) | 1997-02-12 | 2005-07-05 | Chugai Seiyaku Kabushiki Kaisha | Remedies for lymphocytic tumors |
| DK2011514T3 (da) | 1997-03-21 | 2012-03-26 | Chugai Pharmaceutical Co Ltd | Forebyggende eller terapeutisk middel til sensibiliserede-T-celle-medierede sygdomme omfattende IL-6-antagonist som en aktiv bestanddel |
| CN1329080C (zh) | 1997-05-15 | 2007-08-01 | 中外制药株式会社 | 恶病质的治疗剂 |
| PT1004315E (pt) * | 1997-08-15 | 2008-07-09 | Chugai Pharmaceutical Co Ltd | Profilácticos e/ou medicamentos contendo anticorpos neutralizantes anti-receptor de il-6 para reduzir a excreção de proteínas urinárias no lúpus eritematoso sistémico |
| US20020187150A1 (en) * | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
| ES2299241T3 (es) | 1998-03-17 | 2008-05-16 | Chugai Seiyaku Kabushiki Kaisha | Preventivos o remedios para enfermedades intestinales inflamatorias que contienen anticuerpos antagonistas del receptor il-6. |
| ATE512225T1 (de) | 1998-04-03 | 2011-06-15 | Chugai Pharmaceutical Co Ltd | Humanisierter antikörper gegen den menschlichen gewebefaktor (tf) und verfahren für die konstruktion eines solchen humanisierten antikörpers. |
| EP1108435B1 (en) | 1998-08-24 | 2007-01-03 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for pancreatitis containing anti-il-6 receptor antibodies as the active ingredient |
| US6395511B1 (en) | 1998-11-27 | 2002-05-28 | Darwin Discovery, Ltd. | Nucleic acids encoding a novel family of TGF-β binding proteins from humans |
| US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
| AU7078200A (en) | 1999-08-27 | 2001-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use |
| EP2351483A1 (en) | 1999-10-01 | 2011-08-03 | Chugai Seiyaku Kabushiki Kaisha | Prevention and treatment of blood coagulation-related diseases |
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| KR101510830B1 (ko) | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | 생리활성 단백질을 발현하는 미니서클을 이용하여 형질전환된 줄기세포를 통한 치료법 |
| KR101510831B1 (ko) * | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | 항 ｉｌ-６ｒ 및 ｔｎｆｒ２을 포함하는 이중특이적 단백질을 발현하는 미니서클 벡터를 포함하는 줄기세포 치료제 |
| KR101510302B1 (ko) * | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제 |
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