|
US5472693A
(en)
*
|
1993-02-16 |
1995-12-05 |
The Dow Chemical Company |
Family of anti-carcinoembryonic antigen chimeric antibodies
|
|
TW458985B
(en)
*
|
1993-05-31 |
2001-10-11 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human antibody against human interleukin-6
|
|
JP3741221B2
(ja)
*
|
1993-08-24 |
2006-02-01 |
エスアールディー ファーマシューティカルズ，インコーポレイテッド |
組換えヒト型化抗ヒト免疫不全ウィルス抗体
|
|
US5914110A
(en)
*
|
1993-09-07 |
1999-06-22 |
Smithkline Beecham Corporation |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
|
AU7949394A
(en)
|
1993-11-19 |
1995-06-06 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human medulloblastomatous cell
|
|
WO1995029690A1
(en)
*
|
1994-04-29 |
1995-11-09 |
The Trustees Of The University Of Pennsylvania |
Biologically active peptides and methods of identifying the same
|
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
AU700819B2
(en)
*
|
1994-10-07 |
1999-01-14 |
Chugai Seiyaku Kabushiki Kaisha |
Rheumatoid arthritis remedy containing IL-6 antagonist as effective component
|
|
PL182089B1
(en)
*
|
1994-10-21 |
2001-11-30 |
Chugai Pharmaceutical Co Ltd |
Pharmaceutic compositions for treating diseases caused by production of il-6
|
|
US6261560B1
(en)
*
|
1995-02-13 |
2001-07-17 |
Chugai Seiyaku Kabushiki Kaisha |
Method for inhibiting muscle protein proteolysis with antibodies to interleukin-6 receptor
|
|
DK0923941T3
(da)
*
|
1996-06-27 |
2006-09-18 |
Chugai Pharmaceutical Co Ltd |
Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler
|
|
CZ106299A3
(cs)
|
1996-09-26 |
1999-08-11 |
Chugai Seiyaku Kabushiki Kaisha |
Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
|
|
UA76934C2
(en)
|
1996-10-04 |
2006-10-16 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
|
|
KR20000070989A
(ko)
*
|
1997-02-12 |
2000-11-25 |
나가야마 오사무 |
임파구계 종양의 치료제
|
|
AU736282B2
(en)
|
1997-03-21 |
2001-07-26 |
Chugai Seiyaku Kabushiki Kaisha |
A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient
|
|
WO1998051329A1
(en)
|
1997-05-15 |
1998-11-19 |
Chugai Seiyaku Kabushiki Kaisha |
Cachexia remedy
|
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
KR20040024561A
(ko)
|
1997-08-15 |
2004-03-20 |
츄가이 세이야꾸 가부시키가이샤 |
항 인터루킨-6 수용체 항체를 유효성분으로서 함유하는전신성 홍반성 낭창의 예방 및/또는 치료제
|
|
ATE383875T1
(de)
|
1998-03-17 |
2008-02-15 |
Chugai Pharmaceutical Co Ltd |
Prophylaktische oder therapeutische mittel gegen entzündliche erkrankungen des verdauungstraktes enthaltend antagonistische il-6 rezeptor antikörper
|
|
SK14812000A3
(sk)
|
1998-04-03 |
2001-08-06 |
Chugai Seiyaku Kabushiki Kaisha |
Chimérny reťazec protilátky, chimérna protilátka, v oblasť, humanizovaný reťazec protilátky, humanizovaná protilátka, dna, expresný vektor, hostiteľ, spôsob prípravy a liečivo
|
|
CA2341239C
(en)
*
|
1998-08-24 |
2011-01-04 |
Chugai Seiyaku Kabushiki Kaisha |
A preventive or therapeutic agent for pancreatitis comprising il-6 antagonist as an active ingredient
|
|
ES2639020T3
(es)
|
1998-11-27 |
2017-10-25 |
Ucb Pharma S.A. |
Composiciones y métodos para incrementar la mineralización de la substancia ósea
|
|
US7696325B2
(en)
|
1999-03-10 |
2010-04-13 |
Chugai Seiyaku Kabushiki Kaisha |
Polypeptide inducing apoptosis
|
|
WO2001016166A2
(en)
*
|
1999-08-27 |
2001-03-08 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use
|
|
IL148980A0
(en)
|
1999-10-01 |
2002-11-10 |
Chugai Pharmaceutical Co Ltd |
An antibody to human tissue factor and experimental animals having inserted cells with the gene encoding human tissue factor
|
|
GB0002666D0
(en)
|
2000-02-04 |
2000-03-29 |
Univ London |
Blockade of voltage dependent sodium channels
|
|
WO2001082968A1
(fr)
|
2000-04-28 |
2001-11-08 |
Chugai Seiyaku Kabushiki Kaisha |
Inhibiteurs de proliferation cellulaire
|
|
US8632778B2
(en)
|
2000-08-11 |
2014-01-21 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilized anti-interleukin-6 antibody-containing preparations
|
|
WO2002032374A2
(en)
*
|
2000-10-18 |
2002-04-25 |
Immunex Corporation |
Methods for treating il-18 mediated disorders
|
|
EP1327681A4
(en)
|
2000-10-20 |
2004-09-01 |
Chugai Pharmaceutical Co Ltd |
Degraded agonist antibodies
|
|
CN1308447C
(zh)
|
2000-10-20 |
2007-04-04 |
中外制药株式会社 |
低分子化的激动剂抗体
|
|
RU2287534C2
(ru)
|
2000-10-20 |
2006-11-20 |
Тугаи Сейяку Кабусики Кайся |
Деградированное антитело, являющееся агонистом tpo
|
|
AU1095202A
(en)
|
2000-10-25 |
2002-05-06 |
Chugai Pharmaceutical Co Ltd |
Preventives or remedies for psoriasis containing as the active ingredient il-6 antagonist
|
|
WO2002036164A1
(en)
*
|
2000-10-27 |
2002-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient
|
|
JP4889187B2
(ja)
*
|
2000-10-27 |
2012-03-07 |
中外製薬株式会社 |
Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤
|
|
JP3986439B2
(ja)
|
2001-02-07 |
2007-10-03 |
中外製薬株式会社 |
造血器腫瘍の治療剤
|
|
US20030044406A1
(en)
*
|
2001-03-02 |
2003-03-06 |
Christine Dingivan |
Methods of preventing or treating inflammatory or autoimmune disorders by administering CD2 antagonists in combination with other prophylactic or therapeutic agents
|
|
ES2869895T3
(es)
|
2001-03-09 |
2021-10-26 |
Chugai Pharmaceutical Co Ltd |
Método de purificación de proteínas
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
EP1382964A4
(en)
|
2001-04-17 |
2009-06-10 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR TENSID QUANTIFICATION
|
|
US20100056762A1
(en)
*
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
DK1392359T4
(da)
*
|
2001-05-11 |
2013-06-10 |
Ludwig Inst For Cancer Res Ltd |
Specifikke bindingsproteiner og deres anvendelser.
|
|
WO2003068260A1
(fr)
|
2002-02-14 |
2003-08-21 |
Chugai Seiyaku Kabushiki Kaisha |
Produits pharmaceutiques en solution contenant des anticorps
|
|
GB0208041D0
(en)
*
|
2002-04-08 |
2002-05-22 |
Lonza Biologics Plc |
Method of culturing animal cells
|
|
WO2004022597A1
(ja)
|
2002-09-04 |
2004-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
Gpc3の血中可溶化ｎ端ﾍﾟﾌﾟﾁﾄﾞに対する抗体
|
|
EP1498137A1
(en)
*
|
2002-04-25 |
2005-01-19 |
Chugai Seiyaku Kabushiki Kaisha |
Remedy for lung cancer
|
|
EP1513879B1
(en)
*
|
2002-06-03 |
2018-08-22 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
WO2004019966A1
(ja)
|
2002-08-27 |
2004-03-11 |
Chugai Seiyaku Kabushiki Kaisha |
タンパク質溶液製剤の安定化方法
|
|
CN100522989C
(zh)
|
2002-09-11 |
2009-08-05 |
中外制药株式会社 |
纯化蛋白质的方法
|
|
EP1607100A4
(en)
*
|
2003-02-24 |
2007-06-13 |
Chugai Pharmaceutical Co Ltd |
MEDICAMENT WITH AN INTERLEUKIN-6 ANTAGONIST FOR BACK-MARGIN INJURIES
|
|
JP2004279086A
(ja)
|
2003-03-13 |
2004-10-07 |
Konica Minolta Holdings Inc |
放射線画像変換パネル及び放射線画像変換パネルの製造方法
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
CN1835974A
(zh)
*
|
2003-06-16 |
2006-09-20 |
细胞技术研究与发展公司 |
对硬化素特异的抗体和用于增加骨矿化的方法
|
|
EP2204190A1
(en)
|
2003-07-15 |
2010-07-07 |
Chugai Seiyaku Kabushiki Kaisha |
IgM production by transformed cells and methods for quantifying said IgM production
|
|
MXPA06003768A
(es)
|
2003-10-17 |
2006-06-23 |
Chugai Pharmaceutical Co Ltd |
Agente terapeutico para el mesotelioma.
|
|
CA2548185A1
(en)
|
2003-12-03 |
2005-06-16 |
Chugai Seiyaku Kabushiki Kaisha |
Expression systems using mammalian .beta.-actin promoter
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
CA2555688C
(en)
*
|
2004-02-11 |
2011-11-08 |
Warner-Lambert Company Llc |
Methods of treating osteoarthritis with anti-il-6 or anti-il6 receptor antibodies
|
|
AU2005214988A1
(en)
*
|
2004-02-17 |
2005-09-01 |
Absalus, Inc. |
Super-humanized antibodies against respiratory syncytial virus
|
|
US7767792B2
(en)
*
|
2004-02-20 |
2010-08-03 |
Ludwig Institute For Cancer Research Ltd. |
Antibodies to EGF receptor epitope peptides
|
|
EP3269738A1
(en)
|
2004-03-24 |
2018-01-17 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleukin-6 receptor
|
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
GB0410627D0
(en)
*
|
2004-05-12 |
2004-06-16 |
Scancell Ltd |
Specific binding members
|
|
JPWO2006046661A1
(ja)
*
|
2004-10-28 |
2008-05-22 |
国立大学法人大阪大学 |
インターロイキン−６阻害剤
|
|
US9714410B2
(en)
|
2005-01-05 |
2017-07-25 |
Chugai Seiyaku Kabushiki Kaisha |
Cell culture method and utilization of the same
|
|
PL1859793T3
(pl)
*
|
2005-02-28 |
2011-09-30 |
Eisai R&D Man Co Ltd |
Nowe połączone zastosowanie związku sulfonamidowego w leczeniu choroby nowotworowej
|
|
JP5057967B2
(ja)
|
2005-03-31 |
2012-10-24 |
中外製薬株式会社 |
ｓｃ（Ｆｖ）２構造異性体
|
|
KR101374454B1
(ko)
*
|
2005-03-31 |
2014-03-17 |
추가이 세이야쿠 가부시키가이샤 |
회합제어에 의한 폴리펩티드 제조방법
|
|
PA8672101A1
(es)
|
2005-04-29 |
2006-12-07 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, métodos y usos
|
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
|
JP5085322B2
(ja)
|
2005-06-10 |
2012-11-28 |
中外製薬株式会社 |
ｓｃ（Ｆｖ）２を含有する医薬組成物
|
|
CN101237890A
(zh)
|
2005-06-10 |
2008-08-06 |
中外制药株式会社 |
含有葡甲胺的蛋白质制剂的稳定剂及其利用
|
|
DK2594591T3
(en)
*
|
2005-08-11 |
2018-07-30 |
Matossian Rogers Arpi |
TCR-V-BETA RELATED PEPTIDES FOR TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASE
|
|
US8470316B2
(en)
|
2005-10-14 |
2013-06-25 |
Chugai Seiyaku Kabushiki Kaisha |
Agents for suppressing damage to transplanted islets after islet transplantation
|
|
RU2450830C2
(ru)
|
2005-10-21 |
2012-05-20 |
Чугаи Сейяку Кабусики Кайся |
Средства для лечения кардиопатии
|
|
EP1957531B1
(en)
|
2005-11-07 |
2016-04-13 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
|
|
WO2007055378A1
(ja)
|
2005-11-14 |
2007-05-18 |
Cell Signals Inc. |
調節性ｔ細胞の機能異常に基づく疾患の治療方法及び予防方法
|
|
AR057582A1
(es)
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
WO2007061029A1
(ja)
|
2005-11-25 |
2007-05-31 |
Keio University |
前立腺癌治療剤
|
|
JP5231810B2
(ja)
|
2005-12-28 |
2013-07-10 |
中外製薬株式会社 |
抗体含有安定化製剤
|
|
JP5033643B2
(ja)
|
2006-01-27 |
2012-09-26 |
学校法人慶應義塾 |
脈絡膜血管新生を伴う疾患の治療剤
|
|
WO2007108505A1
(ja)
|
2006-03-22 |
2007-09-27 |
Chugai Seiyaku Kabushiki Kaisha |
エリスロポエチン溶液製剤
|
|
EP4793360A2
(en)
|
2006-03-31 |
2026-08-19 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
JP5144499B2
(ja)
|
2006-03-31 |
2013-02-13 |
中外製薬株式会社 |
二重特異性抗体を精製するための抗体改変方法
|
|
JP5754875B2
(ja)
*
|
2006-04-07 |
2015-07-29 |
国立大学法人大阪大学 |
筋再生促進剤
|
|
US8741643B2
(en)
|
2006-04-28 |
2014-06-03 |
Lifescan, Inc. |
Differentiation of pluripotent stem cells to definitive endoderm lineage
|
|
MX2008014842A
(es)
*
|
2006-05-25 |
2009-02-17 |
Glaxo Group Ltd |
Anticuerpos humanizados contra interleuquina-18 modificados.
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
ATE537190T1
(de)
|
2006-06-02 |
2011-12-15 |
Regeneron Pharma |
Hochaffine antikörper gegen den humanen il-6- rezeptor
|
|
US7919092B2
(en)
|
2006-06-13 |
2011-04-05 |
Oncomed Pharmaceuticals, Inc. |
Antibodies to notch receptors
|
|
US8221751B2
(en)
|
2006-06-21 |
2012-07-17 |
Oncotherapy Science, Inc. |
Tumor-targeting monoclonal antibodies to FZD10 and uses thereof
|
|
JP2010500876A
(ja)
|
2006-08-18 |
2010-01-14 |
アブリンクス エン．ヴェー． |
Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド
|
|
US20080081041A1
(en)
*
|
2006-09-29 |
2008-04-03 |
Jeffrey Nemeth |
Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer
|
|
MX2009007830A
(es)
|
2007-01-23 |
2009-10-07 |
Univ Shinshu |
Inhibidor de rechazo cronico.
|
|
WO2008091641A2
(en)
|
2007-01-24 |
2008-07-31 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
|
US9090693B2
(en)
|
2007-01-25 |
2015-07-28 |
Dana-Farber Cancer Institute |
Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
|
|
CL2008000719A1
(es)
|
2007-03-12 |
2008-09-05 |
Univ Tokushima Chugai Seiyaku |
Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
|
|
US8404235B2
(en)
|
2007-05-21 |
2013-03-26 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US20090238825A1
(en)
*
|
2007-05-21 |
2009-09-24 |
Kovacevich Brian R |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
NZ601583A
(en)
*
|
2007-05-21 |
2013-08-30 |
Bristol Myers Squibb Co |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
DK2164514T3
(en)
*
|
2007-05-21 |
2017-02-27 |
Alderbio Holdings Llc |
Antibodies to IL-6 and its use
|
|
US9701747B2
(en)
|
2007-05-21 |
2017-07-11 |
Alderbio Holdings Llc |
Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
|
|
US8062864B2
(en)
|
2007-05-21 |
2011-11-22 |
Alderbio Holdings Llc |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
|
|
US8178101B2
(en)
|
2007-05-21 |
2012-05-15 |
Alderbio Holdings Inc. |
Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
|
|
US8252286B2
(en)
|
2007-05-21 |
2012-08-28 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US7906117B2
(en)
|
2007-05-21 |
2011-03-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
|
|
JP5142265B2
(ja)
|
2007-05-28 |
2013-02-13 |
独立行政法人産業技術総合研究所 |
抗モータリン抗体のパラトープ及びエピトープ
|
|
US9080145B2
(en)
|
2007-07-01 |
2015-07-14 |
Lifescan Corporation |
Single pluripotent stem cell culture
|
|
EP2174667B1
(en)
|
2007-07-26 |
2017-01-04 |
Osaka University |
Agent for treatment of ophthalmia containing interleukin-6 receptor inhibitor as active ingredient
|
|
RU2473685C2
(ru)
|
2007-07-31 |
2013-01-27 |
Лайфскен, Инк. |
Дифференцировка человеческих эмбриональных стволовых клеток
|
|
JP5532486B2
(ja)
|
2007-08-14 |
2014-06-25 |
ルードヴィッヒ インスティテュート フォー キャンサー リサーチ |
Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途
|
|
CL2008002775A1
(es)
|
2007-09-17 |
2008-11-07 |
Amgen Inc |
Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
|
|
ES2687808T3
(es)
|
2007-09-26 |
2018-10-29 |
Chugai Seiyaku Kabushiki Kaisha |
Región constante de anticuerpo modificado
|
|
RU2505603C2
(ru)
|
2007-09-26 |
2014-01-27 |
Чугаи Сейяку Кабусики Кайся |
Антитело против рецептора il-6
|
|
EP3127921A1
(en)
|
2007-09-26 |
2017-02-08 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substition in cdr
|
|
BRPI0817482B8
(pt)
|
2007-10-02 |
2021-05-25 |
Chugai Pharmaceutical Co Ltd |
uso de um anticorpo do receptor da interleucina-6 (il-6) no tratamento da doença do enxerto versus hospedeiro (gvhd)
|
|
PL2202307T5
(pl)
†
|
2007-10-15 |
2021-10-04 |
Chugai Seiyaku Kabushiki Kaisha |
Sposób wytwarzania przeciwciała
|
|
CN107574142B
(zh)
|
2007-11-27 |
2021-07-06 |
生命扫描有限公司 |
人胚胎干细胞的分化
|
|
TWI548418B
(zh)
|
2007-12-05 |
2016-09-11 |
中外製藥股份有限公司 |
Anti-NR10 / IL-31RA antibody and its use
|
|
WO2009075344A1
(ja)
|
2007-12-12 |
2009-06-18 |
Japan As Represented By Director General Of Agency Of National Cancer Center |
M-csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
WO2009095489A2
(en)
*
|
2008-02-01 |
2009-08-06 |
Ablynx N.V. |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
BRPI0908033A2
(pt)
|
2008-02-21 |
2015-08-04 |
Centocor Ortho Biotech Inc |
Método placas de superfície modificada e composições para adesão, cultura e desprendimento de célula
|
|
TW201920257A
(zh)
|
2008-04-11 |
2019-06-01 |
日商中外製藥股份有限公司 |
重複結合複數個抗原的抗原結合分子
|
|
US8623648B2
(en)
|
2008-04-24 |
2014-01-07 |
Janssen Biotech, Inc. |
Treatment of pluripotent cells
|
|
EP2282769A4
(en)
*
|
2008-04-29 |
2012-04-25 |
Abbott Lab |
DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES
|
|
JP2011520898A
(ja)
|
2008-05-13 |
2011-07-21 |
ノビミューン エスアー |
抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法
|
|
EP2297209A4
(en)
|
2008-06-03 |
2012-08-01 |
Abbott Lab |
IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF
|
|
KR20110016959A
(ko)
|
2008-06-03 |
2011-02-18 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
TW201503898A
(zh)
|
2008-06-05 |
2015-02-01 |
Chugai Pharmaceutical Co Ltd |
神經浸潤抑制劑
|
|
US8188235B2
(en)
*
|
2008-06-18 |
2012-05-29 |
Pfizer Inc. |
Antibodies to IL-6 and their uses
|
|
CA2729121C
(en)
|
2008-06-30 |
2019-04-09 |
Centocor Ortho Biotech Inc. |
Differentiation of pluripotent stem cells
|
|
US8822645B2
(en)
|
2008-07-08 |
2014-09-02 |
Abbvie Inc. |
Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
|
|
CN102112490B
(zh)
|
2008-07-08 |
2014-10-22 |
昂考梅德药品有限公司 |
Notch1受体结合剂和其使用方法
|
|
US9132189B2
(en)
|
2008-07-08 |
2015-09-15 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
TWI440469B
(zh)
*
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
EP2346988B1
(en)
|
2008-10-31 |
2017-05-31 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
|
|
CA2744227C
(en)
|
2008-11-20 |
2018-10-02 |
Centocor Ortho Biotech Inc. |
Methods and compositions for cell attachment and cultivation on planar substrates
|
|
MX2011005288A
(es)
|
2008-11-20 |
2011-06-01 |
Centocor Ortho Biotech Inc |
Celulas madre pluripotentes en microportadores.
|
|
US8323649B2
(en)
*
|
2008-11-25 |
2012-12-04 |
Alderbio Holdings Llc |
Antibodies to IL-6 and use thereof
|
|
US8992920B2
(en)
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
US9212223B2
(en)
|
2008-11-25 |
2015-12-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US8337847B2
(en)
|
2008-11-25 |
2012-12-25 |
Alderbio Holdings Llc |
Methods of treating anemia using anti-IL-6 antibodies
|
|
US9452227B2
(en)
|
2008-11-25 |
2016-09-27 |
Alderbio Holdings Llc |
Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
|
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
|
TWI544077B
(zh)
|
2009-03-19 |
2016-08-01 |
中外製藥股份有限公司 |
Antibody constant region change body
|
|
JP5717624B2
(ja)
|
2009-03-19 |
2015-05-13 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
MX2011010681A
(es)
|
2009-04-10 |
2012-01-20 |
Ablynx Nv |
Secuencias mejoradas de aminoacidos dirigidas contra il-6r y polipeptidos que comprenden el mismo para el tratamiento de enfermedades y trastornos relacionados con il-6r.
|
|
WO2010115995A2
(en)
|
2009-04-10 |
2010-10-14 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
BRPI1012195A2
(en)
*
|
2009-05-01 |
2018-04-24 |
Abbott Laboratories |
double variable domain immunoglobulins and their uses
|
|
CN102459344A
(zh)
|
2009-05-15 |
2012-05-16 |
中外制药株式会社 |
抗axl抗体
|
|
EP2456862A4
(en)
|
2009-07-20 |
2013-02-27 |
Janssen Biotech Inc |
DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
|
|
SG178190A1
(en)
|
2009-07-31 |
2012-03-29 |
Shin Maeda |
Cancer metastasis inhibitor
|
|
US10150808B2
(en)
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
|
TW201118166A
(en)
|
2009-09-24 |
2011-06-01 |
Chugai Pharmaceutical Co Ltd |
HLA class I-recognizing antibodies
|
|
AR078651A1
(es)
*
|
2009-10-15 |
2011-11-23 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
US20110117087A1
(en)
|
2009-10-26 |
2011-05-19 |
Reinhard Franze |
Method for the production of a glycosylated immunoglobulin
|
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
US9775921B2
(en)
|
2009-11-24 |
2017-10-03 |
Alderbio Holdings Llc |
Subcutaneously administrable composition containing anti-IL-6 antibody
|
|
EP2504032A4
(en)
|
2009-11-24 |
2013-06-19 |
Alderbio Holdings Llc |
IL-6 ANTAGONISTS FOR PREVENTING OR TREATING THROMBOSIS
|
|
CN102781964B
(zh)
|
2009-12-28 |
2015-11-25 |
肿瘤疗法科学股份有限公司 |
抗cdh3抗体及其用途
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
MX2012008085A
(es)
|
2010-01-13 |
2012-09-12 |
Oncomed Pharm Inc |
Agentes de union notch1 y metodos de uso de los mismos.
|
|
AR080428A1
(es)
|
2010-01-20 |
2012-04-11 |
Chugai Pharmaceutical Co Ltd |
Formulaciones liquidas estabilizadas contentivas de anticuerpos
|
|
AU2011223900A1
(en)
|
2010-03-01 |
2012-09-13 |
Janssen Biotech, Inc. |
Methods for purifying cells derived from pluripotent stem cells
|
|
EP2543730B1
(en)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
EP2543388A4
(en)
|
2010-03-04 |
2013-11-27 |
Dainippon Sumitomo Pharma Co |
MEDICINAL PRODUCT FOR INFLAMMATORY ENDURANCE
|
|
EP4450523A3
(en)
|
2010-04-02 |
2025-03-12 |
Amunix Pharmaceuticals, Inc. |
Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
|
|
WO2011128096A1
(en)
|
2010-04-16 |
2011-10-20 |
Roche Diagnostics Gmbh |
Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
AU2011250912A1
(en)
|
2010-05-12 |
2012-11-22 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells
|
|
SMT202000095T1
(it)
|
2010-05-14 |
2020-03-13 |
Amgen Inc |
Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
|
|
RS63800B1
(sr)
|
2010-05-28 |
2022-12-30 |
Chugai Pharmaceutical Co Ltd |
Poboljšanje antitumorskog odgovora t ćelije
|
|
JP5904552B2
(ja)
|
2010-05-28 |
2016-04-13 |
国立研究開発法人国立がん研究センター |
膵癌治療剤
|
|
EP2578232A4
(en)
|
2010-06-02 |
2013-11-20 |
Dainippon Sumitomo Pharma Co |
TREATMENT FOR AUTOIMMUN DISEASES AND ALLERGIC DISEASES
|
|
WO2011154139A2
(en)
|
2010-06-07 |
2011-12-15 |
Roche Diagnostics Gmbh |
Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
JO3330B1
(ar)
*
|
2010-06-10 |
2019-03-13 |
Lilly Co Eli |
الأجسام المضادة cgrp
|
|
KR20130100118A
(ko)
|
2010-08-03 |
2013-09-09 |
아비에 인코포레이티드 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
US9046513B2
(en)
|
2010-08-26 |
2015-06-02 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
CN103221536B
(zh)
|
2010-08-31 |
2016-08-31 |
詹森生物科技公司 |
人胚胎干细胞的分化
|
|
EP2857499A1
(en)
|
2010-10-01 |
2015-04-08 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
CA2815277A1
(en)
|
2010-10-29 |
2012-05-03 |
Immunogen, Inc. |
Novel egfr-binding molecules and immunoconjugates thereof
|
|
JP5828902B2
(ja)
|
2010-10-29 |
2015-12-09 |
イミュノジェン， インコーポレイテッド |
非拮抗性ｅｇｆｒ結合分子およびその免疫複合体
|
|
KR101933197B1
(ko)
|
2010-11-08 |
2018-12-27 |
제넨테크, 인크. |
피하 투여용 항―ｉｌ―6 수용체 항체
|
|
CN105859889B
(zh)
|
2010-11-17 |
2020-01-07 |
中外制药株式会社 |
具有代替凝血因子viii的功能的功能的多特异性抗原结合分子
|
|
US8992908B2
(en)
|
2010-11-23 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of oral mucositis
|
|
TWI654203B
(zh)
|
2010-11-30 |
2019-03-21 |
Chugai Seiyaku Kabushiki Kaisha |
具有鈣依存性的抗原結合能力之抗體
|
|
CA2825778A1
(en)
|
2011-01-28 |
2012-08-02 |
Sanofi |
Pharmaceutical compositions comprising human antibodies to pcsk9
|
|
SG10201609665PA
(en)
|
2011-02-25 |
2017-01-27 |
Chugai Pharmaceutical Co Ltd |
FcɣRIIb-SPECIFIC Fc ANTIBODY
|
|
JP2014509588A
(ja)
|
2011-03-01 |
2014-04-21 |
アムジエン・インコーポレーテツド |
二特異性結合剤
|
|
US9145457B2
(en)
|
2011-03-25 |
2015-09-29 |
Amgen Inc. |
Sclerostin antibody crystals and formulations thereof
|
|
CA2831613A1
(en)
|
2011-03-31 |
2012-10-04 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
DK3150632T3
(en)
|
2011-06-10 |
2020-04-27 |
Canada Minister Nat Defence |
ANTI-RICIN ANTIBODIES AND APPLICATIONS THEREOF
|
|
US10400029B2
(en)
|
2011-06-28 |
2019-09-03 |
Inhibrx, Lp |
Serpin fusion polypeptides and methods of use thereof
|
|
SMT201900520T1
(it)
|
2011-06-28 |
2019-11-13 |
Inhibrx Lp |
Polipeptidi di fusione serpinici e relativi metodi d'uso
|
|
JP6176849B2
(ja)
|
2011-07-19 |
2017-08-09 |
中外製薬株式会社 |
アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
|
|
AR087305A1
(es)
|
2011-07-28 |
2014-03-12 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
|
|
WO2013017656A1
(en)
|
2011-08-02 |
2013-02-07 |
Medizinische Universität Wien |
Antagonists of ribonucleases for treating obesity
|
|
WO2013017691A1
(en)
|
2011-08-04 |
2013-02-07 |
Medizinische Universität Innsbruck |
Cahgt1p inhibitors for use in the treatment of candidiasis
|
|
ES2667554T3
(es)
|
2011-08-04 |
2018-05-11 |
Amgen Inc. |
Método para el tratamiento de los defectos de espacio óseo
|
|
CN103889555B
(zh)
|
2011-09-01 |
2018-10-26 |
中外制药株式会社 |
通过超滤制备包含高度浓缩的抗体的组合物的方法
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2013041722A1
(en)
|
2011-09-23 |
2013-03-28 |
Ablynx Nv |
Prolonged inhibition of interleukin-6 mediated signaling
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
DE102011083811A1
(de)
*
|
2011-09-30 |
2013-04-04 |
Airbus Operations Gmbh |
Sitzvorrichtung für ein Luft- oder Raumfahrzeug
|
|
TW201817745A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
|
|
PT3682905T
(pt)
|
2011-10-03 |
2022-04-07 |
Modernatx Inc |
Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
WO2013059548A1
(en)
|
2011-10-19 |
2013-04-25 |
Sanofi |
Compositions and methods for treating cancer using jak2 inhibitor
|
|
CN104203982B
(zh)
|
2011-10-28 |
2018-08-31 |
特瓦制药澳大利亚私人有限公司 |
多肽构建体及其用途
|
|
JO3370B1
(ar)
|
2011-11-10 |
2019-03-13 |
Regeneron Pharma |
طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
|
|
JP2014533954A
(ja)
|
2011-11-21 |
2014-12-18 |
イミュノジェン， インコーポレイテッド |
Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法
|
|
CA2857298A1
(en)
*
|
2011-11-30 |
2013-06-06 |
Abbvie Biotherapeutics Inc. |
Vectors and host cells comprising a modified sv40 promoter for protein expression
|
|
EP3272364B1
(en)
*
|
2011-12-13 |
2020-07-29 |
Nordic Nanovector ASA |
Chimeric therapeutic anti-cd37 antibodie hh1
|
|
ES2923757T3
(es)
|
2011-12-16 |
2022-09-30 |
Modernatx Inc |
Composiciones de ARNm modificado
|
|
RU2705001C2
(ru)
|
2011-12-22 |
2019-11-01 |
Янссен Байотек, Инк. |
Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки
|
|
KR20190120401A
(ko)
|
2011-12-28 |
2019-10-23 |
암젠 인크 |
항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법
|
|
AR089529A1
(es)
|
2011-12-30 |
2014-08-27 |
Abbvie Inc |
Proteinas de union especificas duales dirigidas contra il-13 y/o il-17
|
|
WO2013151664A1
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins
|
|
JO3787B1
(ar)
|
2012-03-15 |
2021-01-31 |
Janssen Biotech Inc |
أجسام مضادة بشرية ضد cd27 و طرق و استخداماتها
|
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
JP6224077B2
(ja)
|
2012-04-17 |
2017-11-01 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
改変された核酸を用いてポリペプチドを発現させるための方法
|
|
KR101510831B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
항 ｉｌ-６ｒ 및 ｔｎｆｒ２을 포함하는 이중특이적 단백질을 발현하는 미니서클 벡터를 포함하는 줄기세포 치료제
|
|
KR101510830B1
(ko)
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
생리활성 단백질을 발현하는 미니서클을 이용하여 형질전환된 줄기세포를 통한 치료법
|
|
KR101510302B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제
|
|
CN104334719B
(zh)
|
2012-06-08 |
2018-02-13 |
詹森生物科技公司 |
人胚胎干细胞向胰腺内分泌细胞的分化
|
|
JP6770312B2
(ja)
|
2012-07-05 |
2020-10-14 |
ユセベ ファルマ ソシエテ アノニム |
骨疾患の治療
|
|
EP2896291B1
(en)
|
2012-09-13 |
2019-03-20 |
Chugai Seiyaku Kabushiki Kaisha |
Gene knock-in non-human animal
|
|
US9487590B2
(en)
|
2012-09-25 |
2016-11-08 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
|
PE20151179A1
(es)
|
2012-11-01 |
2015-09-12 |
Abbvie Inc |
Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
PT2922554T
(pt)
|
2012-11-26 |
2022-06-28 |
Modernatx Inc |
Arn modificado nas porções terminais
|
|
DK2938722T3
(da)
|
2012-12-31 |
2022-02-14 |
Janssen Biotech Inc |
Suspension og klyngedannelse af humane pluripotente celler til differentiering til endokrine pankreasceller
|
|
US10370644B2
(en)
|
2012-12-31 |
2019-08-06 |
Janssen Biotech, Inc. |
Method for making human pluripotent suspension cultures and cells derived therefrom
|
|
KR102084561B1
(ko)
|
2012-12-31 |
2020-03-04 |
얀센 바이오테크 인코포레이티드 |
췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양
|
|
MX2015008578A
(es)
|
2012-12-31 |
2015-09-07 |
Janssen Biotech Inc |
Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9.
|
|
AU2014227732A1
(en)
|
2013-03-15 |
2015-09-17 |
Abbvie Inc. |
Dual specific binding proteins directed against IL-1 beta and IL-17
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
US9963515B2
(en)
|
2013-04-29 |
2018-05-08 |
Teva Pharmaceuticals Australia Pty Ltd. |
Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
|
|
EP3009518B1
(en)
*
|
2013-06-11 |
2020-08-12 |
National Center of Neurology and Psychiatry |
Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
|
|
JP6563910B2
(ja)
|
2013-07-04 |
2019-08-21 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ
|
|
CA2925256C
(en)
|
2013-09-27 |
2023-08-15 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide heteromultimer
|
|
US10023626B2
(en)
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
KR20160067219A
(ko)
|
2013-10-03 |
2016-06-13 |
모더나 세라퓨틱스, 인코포레이티드 |
저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
|
|
US10428157B2
(en)
|
2013-11-12 |
2019-10-01 |
Sanofi Biotechnology |
Dosing regimens for use with PCSK9 inhibitors
|
|
US9017678B1
(en)
|
2014-07-15 |
2015-04-28 |
Kymab Limited |
Method of treating rheumatoid arthritis using antibody to IL6R
|
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
|
HUE064292T2
(hu)
|
2013-12-26 |
2024-03-28 |
Mitsubishi Tanabe Pharma Corp |
Humán anti-IL-33 semlegesítõ monoklonális antitest
|
|
US10654933B2
(en)
|
2013-12-27 |
2020-05-19 |
Chugai Seiyaku Kabushiki Kaisha |
Method for purifying antibody having low isoelectric point
|
|
EP2898896A1
(en)
|
2014-01-22 |
2015-07-29 |
Université Pierre et Marie Curie (Paris 6) |
Agents for use in the treatment of retinal inflammation
|
|
WO2015116852A1
(en)
|
2014-01-29 |
2015-08-06 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating rheumatoid arthritis by administering an il-6r antibody
|
|
TWI731535B
(zh)
|
2014-03-21 |
2021-06-21 |
美商艾伯維有限公司 |
抗-egfr抗體及抗體藥物結合物
|
|
UA119352C2
(uk)
|
2014-05-01 |
2019-06-10 |
Тева Фармасьютикалз Острейліа Пті Лтд |
Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
|
|
SG11201609473XA
(en)
|
2014-05-16 |
2016-12-29 |
Janssen Biotech Inc |
Use of small molecules to enhance mafa expression in pancreatic endocrine cells
|
|
EP3185004A4
(en)
|
2014-08-20 |
2018-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Method for measuring viscosity of protein solution
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
CA2963712A1
(en)
|
2014-10-21 |
2016-04-28 |
Ablynx Nv |
Treatment of il-6r related diseases
|
|
PE20170908A1
(es)
|
2014-10-29 |
2017-07-12 |
Teva Pharmaceuticals Australia Pty Ltd |
VARIANTES DE INTERFERON a2b
|
|
US10093733B2
(en)
|
2014-12-11 |
2018-10-09 |
Abbvie Inc. |
LRP-8 binding dual variable domain immunoglobulin proteins
|
|
MA41142A
(fr)
|
2014-12-12 |
2017-10-17 |
Amgen Inc |
Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
|
|
EP3234120B1
(en)
|
2014-12-15 |
2025-09-03 |
The Regents of the University of California |
Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
|
|
WO2016100232A1
(en)
|
2014-12-15 |
2016-06-23 |
The Regents Of The University Of California |
Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
|
|
EA201791366A1
(ru)
|
2014-12-19 |
2018-02-28 |
Чугаи Сейяку Кабусики Кайся |
Антитела к c5 и способы их применения
|
|
MX2017005774A
(es)
|
2014-12-19 |
2017-07-28 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso.
|
|
CN114773469B
(zh)
|
2015-02-05 |
2025-12-19 |
中外制药株式会社 |
包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
|
|
TWI759261B
(zh)
|
2015-02-27 |
2022-04-01 |
日商中外製藥股份有限公司 |
Ｉｌ－６受體抗體用於製備醫藥組成物的用途
|
|
AR104050A1
(es)
|
2015-03-26 |
2017-06-21 |
Chugai Pharmaceutical Co Ltd |
Proceso de producción con iones de cobre controlados
|
|
JP7082484B2
(ja)
|
2015-04-01 |
2022-06-08 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
JP6875683B2
(ja)
|
2015-05-19 |
2021-05-26 |
国立研究開発法人国立精神・神経医療研究センター |
多発性硬化症（ｍｓ）患者の新規治療適用判断方法
|
|
JP7128460B2
(ja)
|
2015-06-04 |
2022-08-31 |
国立研究開発法人国立精神・神経医療研究センター |
Ｉｌ－６阻害剤を有効成分とする精神疾患治療剤
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
|
|
EA201890519A1
(ru)
|
2015-08-18 |
2018-07-31 |
Ридженерон Фармасьютикалз, Инк. |
Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов
|
|
EP3368571B1
(en)
|
2015-10-30 |
2022-12-07 |
The Regents of The University of California |
Transforming growth factor-beta-responsive polypeptides and their methods for use
|
|
BR112018008900A8
(pt)
|
2015-11-03 |
2019-02-26 |
Regeneron Pharma |
composições compreendendo anticorpos para il6r para o tratamento de uveíte e edema macular e métodos de uso das mesmas
|
|
EP3394098A4
(en)
|
2015-12-25 |
2019-11-13 |
Chugai Seiyaku Kabushiki Kaisha |
ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE
|
|
SG11201803989WA
(en)
|
2015-12-28 |
2018-06-28 |
Chugai Pharmaceutical Co Ltd |
Method for promoting efficiency of purification of fc region-containing polypeptide
|
|
US11484591B2
(en)
|
2016-02-22 |
2022-11-01 |
Ohio State Innovation Foundation |
Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites
|
|
GB201604124D0
(en)
|
2016-03-10 |
2016-04-27 |
Ucb Biopharma Sprl |
Pharmaceutical formulation
|
|
EP3431102A4
(en)
|
2016-03-14 |
2019-09-25 |
Chugai Seiyaku Kabushiki Kaisha |
CELL DAMAGING THERAPEUTIC MEDICAMENT FOR USE IN CANCER THERAPY
|
|
WO2017180361A1
(en)
|
2016-04-14 |
2017-10-19 |
Janssen Biotech, Inc. |
Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
|
|
AU2017255077B2
(en)
|
2016-04-28 |
2024-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody-containing preparation
|
|
CN116271014A
(zh)
|
2016-08-05 |
2023-06-23 |
中外制药株式会社 |
用于预防或治疗il-8相关疾病的组合物
|
|
CA3039136A1
(en)
|
2016-09-02 |
2018-03-08 |
The Regents Of The University Of California |
Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
BR112019005328A2
(pt)
|
2016-09-27 |
2019-06-18 |
Fresenius Kabi Deutschland Gmbh |
composição farmacêutica líquida
|
|
KR102051177B1
(ko)
*
|
2016-10-19 |
2019-12-17 |
주식회사 엘지화학 |
전압 분배를 이용한 스위치 진단 장치 및 방법
|
|
BR112019006853B1
(pt)
|
2016-10-31 |
2021-08-24 |
Fresenius Kabi Deutschland Gmbh |
Composição farmacêutica líquida, seu método de fabricação, seu uso, kit e dispositivo de liberação de fármaco que a compreendem e método de fabricação do dito dispositivo
|
|
US10093731B2
(en)
|
2017-02-24 |
2018-10-09 |
Kindred Biosciences, Inc. |
Anti-IL31 antibodies for veterinary use
|
|
US11033496B2
(en)
|
2017-03-17 |
2021-06-15 |
The Regents Of The University Of Michigan |
Nanoparticles for delivery of chemopreventive agents
|
|
JP7209298B2
(ja)
|
2017-03-31 |
2023-01-20 |
公立大学法人奈良県立医科大学 |
血液凝固第ｖｉｉｉ因子の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第ｉｘ因子異常症の予防および／または治療に用いられる医薬組成物
|
|
EP3620531A4
(en)
|
2017-05-02 |
2021-03-17 |
National Center of Neurology and Psychiatry |
METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
|
|
CN107098969B
(zh)
*
|
2017-06-28 |
2018-10-12 |
武汉波睿达生物科技有限公司 |
一种治疗hiv感染的嵌合抗原受体的重组基因构建及其应用
|
|
WO2019045075A1
(ja)
|
2017-08-31 |
2019-03-07 |
田辺三菱製薬株式会社 |
Ｉｌ－３３アンタゴニストを含む子宮内膜症治療剤
|
|
CN111051343B
(zh)
|
2017-09-13 |
2022-11-22 |
江苏恒瑞医药股份有限公司 |
Il-6r抗体、其抗原结合片段及医药用途
|
|
WO2019078344A1
(ja)
|
2017-10-20 |
2019-04-25 |
学校法人兵庫医科大学 |
抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
|
|
KR20260090008A
(ko)
|
2017-11-01 |
2026-06-16 |
추가이 세이야쿠 가부시키가이샤 |
생물 활성이 저하된 항체 배리언트 및 아이소폼
|
|
TWI822728B
(zh)
|
2018-01-31 |
2023-11-21 |
加藤元一 |
含有il-6抑制劑的哮喘治療劑
|
|
TWI827585B
(zh)
|
2018-03-15 |
2024-01-01 |
日商中外製藥股份有限公司 |
對茲卡病毒具有交叉反應性的抗登革病毒抗體及其使用方法
|
|
EP3774879B1
(en)
|
2018-03-30 |
2026-01-28 |
Amgen Inc. |
C-terminal antibody variants
|
|
JP7549530B2
(ja)
|
2018-05-21 |
2024-09-11 |
中外製薬株式会社 |
ガラス容器に封入された凍結乾燥製剤
|
|
EP3805112A4
(en)
|
2018-05-28 |
2022-03-09 |
Chugai Seiyaku Kabushiki Kaisha |
FILLING NOZZLE
|
|
KR20260109977A
(ko)
|
2018-08-29 |
2026-07-13 |
리제너론 파아마슈티컬스, 인크. |
류마티스성 관절염을 갖는 대상체를 치료하기 위한 방법 및 조성물
|
|
CA3127669A1
(en)
*
|
2019-01-07 |
2020-07-16 |
Hunan Siweikang Therapeutics Co. Ltd |
Modified immune cells co-expressing chimeric antigen receptor and il-6 antagonist for reducing toxicity and uses thereof in adoptive cell therapy
|
|
JP7542543B2
(ja)
|
2019-01-31 |
2024-08-30 |
サノフィ・バイオテクノロジー |
若年性特発性関節炎を治療するための抗ｉｌ－６受容体抗体
|
|
JPWO2020202839A1
(enExample)
|
2019-03-29 |
2020-10-08 |
|
|
|
WO2020201362A2
(en)
|
2019-04-02 |
2020-10-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of predicting and preventing cancer in patients having premalignant lesions
|
|
BR112021020204A2
(pt)
|
2019-04-10 |
2021-12-07 |
Chugai Pharmaceutical Co Ltd |
Método para purificar anticorpo com região fc modificada
|
|
AU2020259884A1
(en)
|
2019-04-17 |
2021-10-07 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination
|
|
JP2022545312A
(ja)
|
2019-04-24 |
2022-10-27 |
サノフィ・バイオテクノロジー |
関節リウマチの診断及び処置の方法
|
|
WO2020243479A1
(en)
|
2019-05-31 |
2020-12-03 |
The Johns Hopkins University |
Bispecific binding agents
|
|
CA3142710A1
(en)
|
2019-06-04 |
2020-12-10 |
Sanofi Biotechnology |
Compositions and methods for treating pain in subjects with rheumatoid arthritis
|
|
CN114375205A
(zh)
|
2019-06-20 |
2022-04-19 |
武田药品工业株式会社 |
用基于病毒的基因疗法进行治疗的方法
|
|
CN110483640B
(zh)
*
|
2019-07-16 |
2020-05-01 |
北京汇智和源生物技术有限公司 |
白介素-6r的人源化单克隆抗体、其编码基因及应用
|
|
JP7671275B2
(ja)
|
2019-08-29 |
2025-05-01 |
エランコ・ユーエス・インコーポレイテッド |
動物用の抗ｉｌ３１抗体
|
|
MX2022010957A
(es)
|
2020-03-03 |
2023-01-24 |
Twentyeight Seven Inc |
Compuestos que se dirigen a las proteínas de unión al arn o a las proteínas modificadoras del arn.
|
|
JP2023518814A
(ja)
|
2020-03-23 |
2023-05-08 |
ジェネンテック， インコーポレイテッド |
Ｃｏｖｉｄ－１９肺炎における、ｉｌ－６アンタゴニストに対する応答を予測するためのバイオマーカー
|
|
EP4107186A1
(en)
|
2020-03-23 |
2022-12-28 |
Genentech, Inc. |
Tocilizumab and remdesivir combination therapy for covid-19 pneumonia
|
|
EP4107184A1
(en)
|
2020-03-23 |
2022-12-28 |
Genentech, Inc. |
Method for treating pneumonia, including covid-19 pneumonia, with an il6 antagonist
|
|
WO2021211006A1
(en)
|
2020-04-13 |
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Federal State Budgetary Institution Center Of Biomedical Technologies Of Federal Medical And Biological Agency |
Inhaled hexapeptide for treating interleukin-6 related respiratory diseases
|
|
CN115605184A
(zh)
|
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2023-01-13 |
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防止胃肠外蛋白质溶液中的可见颗粒形成
|
|
JP7525762B2
(ja)
*
|
2020-05-18 |
2024-07-31 |
ビオシオン インコーポレイテッド |
Ｉｌ６ｒに結合する抗体及びその使用
|
|
US12558423B2
(en)
|
2020-05-29 |
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Antibody-containing formulation
|
|
WO2022005321A1
(en)
|
2020-06-29 |
2022-01-06 |
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|
|
KR20220028972A
(ko)
|
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안정한 약제학적 제제
|
|
WO2022060412A1
(en)
|
2020-09-17 |
2022-03-24 |
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Results of empacta: a randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of tocilizumab in hospitalized patients with covid-19 pneumonia
|
|
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(es)
|
2021-01-20 |
2023-04-26 |
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Conjugados anticuerpo-fármaco anti-egfr
|
|
WO2022165419A1
(en)
|
2021-02-01 |
2022-08-04 |
Kyverna Therapeutics, Inc. |
Methods for increasing t-cell function
|
|
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(zh)
|
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2023-12-29 |
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用于治疗或预防重症肌无力的药物组合物
|
|
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(en)
|
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2022-12-15 |
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Method for treating chronic obstructive pulmonary disease with an st2 antagonist
|
|
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(en)
|
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|
|
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(ko)
|
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|
|
US20240190978A1
(en)
|
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CSBioAsset LLC |
Compositions and methods for immunomodulatory bifunctional fusion molecules
|
|
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(zh)
|
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|
|
WO2024214811A1
(ja)
|
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|
|
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(en)
|
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|
|
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(hu)
|
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|
|
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(zh)
*
|
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|