DK388384A - Monoklone antistoffer med specifitet for membran-associerede antigener, deres fremstilling og anvendelse - Google Patents

Monoklone antistoffer med specifitet for membran-associerede antigener, deres fremstilling og anvendelse Download PDF

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Publication number
DK388384A
DK388384A DK388384A DK388384A DK388384A DK 388384 A DK388384 A DK 388384A DK 388384 A DK388384 A DK 388384A DK 388384 A DK388384 A DK 388384A DK 388384 A DK388384 A DK 388384A
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DK
Denmark
Prior art keywords
membrane
specificity
associated antigens
preparation
monoclone antibodies
Prior art date
Application number
DK388384A
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English (en)
Other versions
DK167936B1 (da
DK388384D0 (da
Inventor
Klaus Bosslet
Roland Kurrle
Hans-Harald Sedlacek
Ernst-Juergen Kanzy
Takako Katoh
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of DK388384D0 publication Critical patent/DK388384D0/da
Publication of DK388384A publication Critical patent/DK388384A/da
Application granted granted Critical
Publication of DK167936B1 publication Critical patent/DK167936B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK388384A 1983-08-12 1984-08-10 Monoklonale antistoffer mod antigener fra humane carcinomaceller, deres fremstilling og anvendelse samt antigener fra carcinomaceller fra humant epitel DK167936B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3329184 1983-08-12
DE19833329184 DE3329184A1 (de) 1983-08-12 1983-08-12 Monoklonale antikoerper mit spezifitaet fuer membran-assoziierte antigene

Publications (3)

Publication Number Publication Date
DK388384D0 DK388384D0 (da) 1984-08-10
DK388384A true DK388384A (da) 1985-02-13
DK167936B1 DK167936B1 (da) 1994-01-03

Family

ID=6206422

Family Applications (1)

Application Number Title Priority Date Filing Date
DK388384A DK167936B1 (da) 1983-08-12 1984-08-10 Monoklonale antistoffer mod antigener fra humane carcinomaceller, deres fremstilling og anvendelse samt antigener fra carcinomaceller fra humant epitel

Country Status (7)

Country Link
EP (1) EP0141079B1 (da)
JP (1) JPS6089500A (da)
AT (1) ATE71411T1 (da)
CA (1) CA1277612C (da)
DE (2) DE3329184A1 (da)
DK (1) DK167936B1 (da)
ZA (1) ZA846214B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531301A1 (de) * 1985-09-02 1987-03-05 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte glykoproteine, verfahren zu ihrer herstellung sowie ihre verwendung
DE3629640A1 (de) * 1986-08-30 1988-03-03 Behringwerke Ag Verwendung monoklonaler antikoerper zur therapie von tumoren
US6294172B1 (en) * 1983-08-12 2001-09-25 Dade Behring Marburg Gmbh Monoclonal antibodies with specificity for membrane-associated antigens
DE3416774A1 (de) * 1984-05-07 1985-11-14 Behringwerke Ag, 3550 Marburg Monoklonale antikoerper, verfahren zu ihrer herstellung sowie ihre verwendung
DE3432714A1 (de) * 1984-09-06 1986-04-24 Behringwerke Ag, 3550 Marburg Tumortherapeutikum und verfahren zu seiner herstellung
US4701408A (en) * 1984-01-30 1987-10-20 Smithkline Beckman Corporation Monoclonal antibody to activated macrophages
JPS61103837A (ja) * 1984-10-26 1986-05-22 Wakunaga Seiyaku Kk 抗ヒト癌モノクロ−ナル抗体
JPS61104783A (ja) * 1985-09-10 1986-05-23 Wakunaga Seiyaku Kk 抗ヒト癌モノクロ−ナル抗体生産性ハイブリド−マ
US4851332A (en) * 1985-04-01 1989-07-25 Sloan-Kettering Institute For Cancer Research Choriocarcinoma monoclonal antibodies and antibody panels
ATE92081T1 (de) * 1986-04-17 1993-08-15 Hybritech Inc Tumorassoziiertes antigen.
FR2606034B1 (fr) * 1986-10-31 1989-06-02 Cird Nouvelle proteine de surface des cellules basales de l'epiderme, anticorps capables de reconnaitre cette proteine, et leur utilisation, et lignees cellulaires hybrides capables de secreter de tels anticorps
FR2606033B1 (fr) * 1986-10-31 1988-12-16 Cird Proteine cytoplasmique des cellules suprabasales de l'epiderme, anticorps capables de reconnaitre cette proteine, et lignees cellulaires hybrides capables de secreter de tels anticorps
DE3854821T2 (de) * 1987-02-19 1996-05-23 Scripps Clinic Res Zellenoberflachenmarker für humanen Pankreaskrebszellen
US5320942A (en) * 1987-02-19 1994-06-14 Vito Quaranta Method of diagnosing the presence of abnormal epithelial tissue using monoclonal antibodies to the A6 B4 cell surface protein
US5344919A (en) * 1987-02-19 1994-09-06 The Scripps Research Institute Integrin from human epithelial cells
DE3825615A1 (de) * 1988-07-28 1990-02-01 Behringwerke Ag Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung
DE3909799A1 (de) * 1989-03-24 1990-09-27 Behringwerke Ag Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung
CA2015862A1 (en) * 1989-05-04 1990-11-04 Gajanan Nilaver Cell surface antigen that binds with l6 monoclonal antibody
DE3920358A1 (de) * 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
DE3935016A1 (de) * 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
DE4133791A1 (de) * 1991-10-11 1993-04-15 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte antigene, verfahren zu ihrer herstellung und ihre verwendung
US6030797A (en) * 1992-10-08 2000-02-29 Dade Behring Marburg Gmbh Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349528A (en) * 1979-11-21 1982-09-14 The Wistar Institute Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen
US4579827A (en) * 1983-03-11 1986-04-01 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies
US4569788A (en) * 1983-05-18 1986-02-11 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies against non small cell lung cancer

Also Published As

Publication number Publication date
DE3329184A1 (de) 1985-02-21
ATE71411T1 (de) 1992-01-15
EP0141079A3 (en) 1987-09-23
EP0141079B1 (de) 1992-01-08
JPS6089500A (ja) 1985-05-20
DK167936B1 (da) 1994-01-03
ZA846214B (en) 1985-03-27
EP0141079A2 (de) 1985-05-15
DK388384D0 (da) 1984-08-10
CA1277612C (en) 1990-12-11
DE3485432D1 (de) 1992-02-20
JPH0542267B2 (da) 1993-06-28

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Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired