|
WO1995006119A1
(en)
*
|
1993-08-24 |
1995-03-02 |
Scotgen Limited |
Recombinant humanized anti-human immunodeficiency virus antibody
|
|
US5472693A
(en)
*
|
1993-02-16 |
1995-12-05 |
The Dow Chemical Company |
Family of anti-carcinoembryonic antigen chimeric antibodies
|
|
TW458985B
(en)
*
|
1993-05-31 |
2001-10-11 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human antibody against human interleukin-6
|
|
US5914110A
(en)
*
|
1993-09-07 |
1999-06-22 |
Smithkline Beecham Corporation |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
|
US6214973B1
(en)
|
1993-11-19 |
2001-04-10 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human antibody to human medulloblastoma cells
|
|
WO1995029690A1
(en)
*
|
1994-04-29 |
1995-11-09 |
The Trustees Of The University Of Pennsylvania |
Biologically active peptides and methods of identifying the same
|
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
AU700819B2
(en)
|
1994-10-07 |
1999-01-14 |
Chugai Seiyaku Kabushiki Kaisha |
Rheumatoid arthritis remedy containing IL-6 antagonist as effective component
|
|
PL182089B1
(en)
*
|
1994-10-21 |
2001-11-30 |
Chugai Pharmaceutical Co Ltd |
Pharmaceutic compositions for treating diseases caused by production of il-6
|
|
EP0811384B1
(en)
*
|
1995-02-13 |
2006-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Muscle protein decomposition inhibitor containing il-6 receptor antibody
|
|
ES2263178T3
(es)
|
1996-06-27 |
2006-12-01 |
Chugai Seiyaku Kabushiki Kaisha |
Remedios para mieloma para ser utilizados junto con agentes antitumorales de mostaza nitrogenada.
|
|
AU744146B2
(en)
|
1996-09-26 |
2002-02-14 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody against human parathormone related peptides
|
|
UA76934C2
(en)
|
1996-10-04 |
2006-10-16 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
|
|
ES2241114T3
(es)
*
|
1997-02-12 |
2005-10-16 |
Chugai Seiyaku Kabushiki Kaisha |
Anticuerpos como remedios para tumores linfociticos (excepto mieloma).
|
|
EP0983767B1
(en)
|
1997-03-21 |
2008-09-10 |
Chugai Seiyaku Kabushiki Kaisha |
Preventives or remedies for the treatment of multiple sclerosis containing antagonist anti-IL-6-receptor antibodies
|
|
EP1004313B1
(en)
|
1997-05-15 |
2007-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Cachexia remedy
|
|
AU747883B2
(en)
*
|
1997-08-15 |
2002-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Preventives and/or remedies for systemic lupus erythematosus containing anti-IL-6 receptor antibody as the active ingredient
|
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
ATE383875T1
(de)
|
1998-03-17 |
2008-02-15 |
Chugai Pharmaceutical Co Ltd |
Prophylaktische oder therapeutische mittel gegen entzündliche erkrankungen des verdauungstraktes enthaltend antagonistische il-6 rezeptor antikörper
|
|
BR9909382A
(pt)
|
1998-04-03 |
2000-12-05 |
Chugai Pharmaceutical Co Ltd |
Anticorpo humanizado contra o fator tissular humano (tf) e processo de produção de anticorpo humanizado
|
|
US8440196B1
(en)
|
1998-08-24 |
2013-05-14 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment for pancreatitis using IL-6 receptor antagonist antibodies
|
|
ES2350454T3
(es)
|
1998-11-27 |
2011-01-24 |
Ucb Pharma S.A. |
Composiciones y métodos para incrementar la mineralización de la sustancia ósea.
|
|
US7696325B2
(en)
|
1999-03-10 |
2010-04-13 |
Chugai Seiyaku Kabushiki Kaisha |
Polypeptide inducing apoptosis
|
|
WO2001016166A2
(en)
*
|
1999-08-27 |
2001-03-08 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use
|
|
WO2001024626A1
(fr)
|
1999-10-01 |
2001-04-12 |
Chugai Seiyaku Kabushiki Kaisha |
Prevention et traitement de maladies associees a la coagulation sanguine
|
|
GB0002666D0
(en)
|
2000-02-04 |
2000-03-29 |
Univ London |
Blockade of voltage dependent sodium channels
|
|
EP1283057B2
(en)
|
2000-04-28 |
2012-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Cell proliferation inhibitors
|
|
ES2644275T3
(es)
|
2000-08-11 |
2017-11-28 |
Chugai Seiyaku Kabushiki Kaisha |
Preparaciones estabilizadas que contienen anticuerpos
|
|
WO2002032374A2
(en)
*
|
2000-10-18 |
2002-04-25 |
Immunex Corporation |
Methods for treating il-18 mediated disorders
|
|
RU2287534C2
(ru)
|
2000-10-20 |
2006-11-20 |
Тугаи Сейяку Кабусики Кайся |
Деградированное антитело, являющееся агонистом tpo
|
|
CN1308447C
(zh)
|
2000-10-20 |
2007-04-04 |
中外制药株式会社 |
低分子化的激动剂抗体
|
|
CA2424371A1
(en)
|
2000-10-20 |
2003-04-01 |
Chugai Seiyaku Kabushiki Kaisha |
Agonistic monoclonal antibody fragments
|
|
WO2002034292A1
(fr)
|
2000-10-25 |
2002-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Agents preventifs ou therapeutiques contre le psoriasis renfermant l'antagoniste de l'il-6 comme substance active
|
|
WO2002036165A1
(fr)
*
|
2000-10-27 |
2002-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Agent à base d'antagoniste d'il-6, faisant baisser le niveau des mmp-3 dans le sang
|
|
WO2002036164A1
(fr)
*
|
2000-10-27 |
2002-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Agent abaissant le taux sanguin de vegf contenant un antagoniste de il-6 en tant que principe actif
|
|
JP3986439B2
(ja)
|
2001-02-07 |
2007-10-03 |
中外製薬株式会社 |
造血器腫瘍の治療剤
|
|
US20030068320A1
(en)
*
|
2001-03-02 |
2003-04-10 |
Christine Dingivan |
Methods of administering/dosing CD2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders
|
|
ES2869895T3
(es)
|
2001-03-09 |
2021-10-26 |
Chugai Pharmaceutical Co Ltd |
Método de purificación de proteínas
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
EP1382964A4
(en)
|
2001-04-17 |
2009-06-10 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR TENSID QUANTIFICATION
|
|
EP2335728A1
(en)
|
2001-05-11 |
2011-06-22 |
Ludwig Institute for Cancer Research Ltd. |
Specific binding proteins and uses thereof
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
EP3578168A1
(en)
|
2002-02-14 |
2019-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Formulation of antibody-containing solutions comprising a sugar as a stabilizer
|
|
GB0208041D0
(en)
*
|
2002-04-08 |
2002-05-22 |
Lonza Biologics Plc |
Method of culturing animal cells
|
|
WO2004022597A1
(ja)
|
2002-09-04 |
2004-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
Gpc3の血中可溶化ｎ端ﾍﾟﾌﾟﾁﾄﾞに対する抗体
|
|
AU2003235948A1
(en)
*
|
2002-04-25 |
2003-11-10 |
Chugai Seiyaku Kabushiki Kaisha |
Remedy for lung cancer
|
|
WO2003102157A2
(en)
*
|
2002-06-03 |
2003-12-11 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
AU2003257536A1
(en)
|
2002-08-27 |
2004-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Method of stabilizing protein solution preparation
|
|
CA2497364C
(en)
*
|
2002-09-11 |
2013-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Protein purification method
|
|
CN100340294C
(zh)
*
|
2003-02-24 |
2007-10-03 |
中外制药株式会社 |
含有白介素6拮抗剂的脊髓损伤治疗剂
|
|
JP2004279086A
(ja)
|
2003-03-13 |
2004-10-07 |
Konica Minolta Holdings Inc |
放射線画像変換パネル及び放射線画像変換パネルの製造方法
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
US7381409B2
(en)
|
2003-06-16 |
2008-06-03 |
Celltech R&D, Inc. |
Antibodies specific for sclerostin and methods of screening and use therefor
|
|
TW200510532A
(en)
|
2003-07-15 |
2005-03-16 |
Chugai Pharmaceutical Co Ltd |
IgM production by transformed cell and method of quantifying the same
|
|
US20070134242A1
(en)
|
2003-10-17 |
2007-06-14 |
Chugai Seiyaku Kabushiki Kaisha |
Mesothelioma therapeutic agent
|
|
AU2004295590B2
(en)
|
2003-12-03 |
2010-04-29 |
Chugai Seiyaku Kabushiki Kaisha |
Expression systems using mammalian beta-actin promoter
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
US8617550B2
(en)
|
2003-12-19 |
2013-12-31 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment of vasculitis with IL-6 antagonist
|
|
ATE464908T1
(de)
*
|
2004-02-11 |
2010-05-15 |
Warner Lambert Co |
Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern
|
|
WO2005079479A2
(en)
*
|
2004-02-17 |
2005-09-01 |
Absalus, Inc. |
Super-humanized antibodies against respiratory syncytial virus
|
|
US7767792B2
(en)
*
|
2004-02-20 |
2010-08-03 |
Ludwig Institute For Cancer Research Ltd. |
Antibodies to EGF receptor epitope peptides
|
|
EP3269738A1
(en)
*
|
2004-03-24 |
2018-01-17 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleukin-6 receptor
|
|
AR048335A1
(es)
*
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
GB0410627D0
(en)
*
|
2004-05-12 |
2004-06-16 |
Scancell Ltd |
Specific binding members
|
|
JPWO2006046661A1
(ja)
*
|
2004-10-28 |
2008-05-22 |
国立大学法人大阪大学 |
インターロイキン−６阻害剤
|
|
CN101061215A
(zh)
|
2005-01-05 |
2007-10-24 |
中外制药株式会社 |
细胞的培养方法及其应用
|
|
PT1859793E
(pt)
*
|
2005-02-28 |
2011-07-05 |
Eisai R&D Man Co Ltd |
Uso combinado inovador de um composto de sulfonamida no tratamento oncológico
|
|
EP1870458B1
(en)
|
2005-03-31 |
2018-05-09 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2 STRUCTURAL ISOMERS
|
|
DK3050963T3
(da)
|
2005-03-31 |
2019-12-09 |
Chugai Pharmaceutical Co Ltd |
Fremgangsmåde til fremstilling af polypeptid ved regulering af arrangement
|
|
PE20061324A1
(es)
|
2005-04-29 |
2007-01-15 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, metodos y usos
|
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
|
PT1888123E
(pt)
|
2005-06-08 |
2013-03-13 |
Janssen Biotech Inc |
Uma terapêutica celular para a degeneração ocular
|
|
US9241994B2
(en)
|
2005-06-10 |
2016-01-26 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical compositions containing sc(Fv)2
|
|
AU2006256041B2
(en)
|
2005-06-10 |
2012-03-29 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
|
GB2429013C
(en)
*
|
2005-08-11 |
2012-11-28 |
Arpi Matossian-Rogers |
Peptides for treatment and diagnosis of autoimmunedisease
|
|
RU2446826C2
(ru)
|
2005-10-14 |
2012-04-10 |
Фукуока Юниверсити |
Агенты для подавления повреждения трансплантированных островков после трансплантации островков
|
|
EP1941908B1
(en)
*
|
2005-10-21 |
2015-08-19 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agent for heart disease
|
|
ES2577292T3
(es)
|
2005-11-07 |
2016-07-14 |
Genentech, Inc. |
Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso
|
|
WO2007055378A1
(ja)
|
2005-11-14 |
2007-05-18 |
Cell Signals Inc. |
調節性ｔ細胞の機能異常に基づく疾患の治療方法及び予防方法
|
|
AR057582A1
(es)
*
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
WO2007061029A1
(ja)
|
2005-11-25 |
2007-05-31 |
Keio University |
前立腺癌治療剤
|
|
JP5231810B2
(ja)
|
2005-12-28 |
2013-07-10 |
中外製薬株式会社 |
抗体含有安定化製剤
|
|
EP3135298B1
(en)
|
2006-01-27 |
2018-06-06 |
Keio University |
Therapeutic agents for diseases involving choroidal neovascularization
|
|
US8546329B2
(en)
|
2006-03-22 |
2013-10-01 |
Chugai Seiyaku Kabushiki Kaisha |
Erythropoietin solution preparation
|
|
EP3345616A1
(en)
|
2006-03-31 |
2018-07-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
|
US11046784B2
(en)
|
2006-03-31 |
2021-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
EP2025346B1
(en)
|
2006-04-07 |
2016-08-10 |
Osaka University |
Muscle regeneration promoter
|
|
US8741643B2
(en)
|
2006-04-28 |
2014-06-03 |
Lifescan, Inc. |
Differentiation of pluripotent stem cells to definitive endoderm lineage
|
|
PE20080262A1
(es)
*
|
2006-05-25 |
2008-04-30 |
Glaxo Group Ltd |
Anticuerpo humanizado contra interleuquina-18
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
EP2374818B1
(en)
|
2006-06-02 |
2012-12-19 |
Regeneron Pharmaceuticals, Inc. |
High affinity antibodies to human IL-6 receptor
|
|
EP2032166B1
(en)
|
2006-06-13 |
2013-04-10 |
OncoMed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
|
KR101351208B1
(ko)
|
2006-06-21 |
2014-01-14 |
온코세라피 사이언스 가부시키가이샤 |
Ｆｚｄ10에 대한 종양-표적화 모노클로날 항체 및 이의 용도
|
|
CA2666599A1
(en)
|
2006-08-18 |
2008-02-21 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
WO2008042611A2
(en)
*
|
2006-09-29 |
2008-04-10 |
Centocor, Inc. |
Method of using il6 antagonists with mitoxantrone for prostate cancer
|
|
PE20081635A1
(es)
|
2007-01-23 |
2009-01-07 |
Chugai Pharmaceutical Co Ltd |
Agentes para suprimir la reaccion de rechazo cronica
|
|
US8088617B2
(en)
|
2007-01-24 |
2012-01-03 |
Oncomed Pharmaceuticals, Inc. |
Antibodies that bind the glutamate ligand binding region of Notch1
|
|
CN104043123B
(zh)
|
2007-01-25 |
2019-08-13 |
达娜-法勃肿瘤研究所公司 |
抗egfr抗体在治疗egfr突变体介导的疾病中的用途
|
|
CL2008000719A1
(es)
|
2007-03-12 |
2008-09-05 |
Univ Tokushima Chugai Seiyaku |
Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
|
|
NZ597767A
(en)
|
2007-05-21 |
2013-06-28 |
Bristol Myers Squibb Co |
Antibodies to IL-6 and use thereof
|
|
US8404235B2
(en)
|
2007-05-21 |
2013-03-26 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US20090238825A1
(en)
*
|
2007-05-21 |
2009-09-24 |
Kovacevich Brian R |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
US8252286B2
(en)
|
2007-05-21 |
2012-08-28 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US8062864B2
(en)
|
2007-05-21 |
2011-11-22 |
Alderbio Holdings Llc |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
|
|
US7906117B2
(en)
*
|
2007-05-21 |
2011-03-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
|
|
US9701747B2
(en)
|
2007-05-21 |
2017-07-11 |
Alderbio Holdings Llc |
Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
|
|
US8178101B2
(en)
|
2007-05-21 |
2012-05-15 |
Alderbio Holdings Inc. |
Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
|
|
TWI609965B
(zh)
*
|
2007-05-21 |
2018-01-01 |
艾爾德生物控股有限責任公司 |
新穎兔抗體人化方法以及經人化之兔抗體
|
|
JP5142265B2
(ja)
|
2007-05-28 |
2013-02-13 |
独立行政法人産業技術総合研究所 |
抗モータリン抗体のパラトープ及びエピトープ
|
|
US9080145B2
(en)
|
2007-07-01 |
2015-07-14 |
Lifescan Corporation |
Single pluripotent stem cell culture
|
|
EP2174667B1
(en)
|
2007-07-26 |
2017-01-04 |
Osaka University |
Agent for treatment of ophthalmia containing interleukin-6 receptor inhibitor as active ingredient
|
|
BRPI0814894A2
(pt)
|
2007-07-31 |
2014-10-21 |
Lifescan Inc |
Diferenciação de células-tronco embrionárias de ser humano.
|
|
CN101896503B
(zh)
|
2007-08-14 |
2018-05-22 |
路德维格癌症研究所有限公司 |
靶向egf受体的单克隆抗体175及其衍生物和用途
|
|
CL2008002775A1
(es)
|
2007-09-17 |
2008-11-07 |
Amgen Inc |
Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
|
|
CA2700394C
(en)
*
|
2007-09-26 |
2017-10-24 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant region
|
|
WO2009041621A1
(ja)
|
2007-09-26 |
2009-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
抗il-6レセプター抗体
|
|
MX369784B
(es)
|
2007-09-26 |
2019-11-21 |
Chugai Pharmaceutical Co Ltd |
Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
|
|
AU2008308163B2
(en)
|
2007-10-02 |
2013-03-21 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agents for graft-versus-host disease comprising interleukin 6 receptor inhibitor as active ingredient
|
|
CN103540632A
(zh)
*
|
2007-10-15 |
2014-01-29 |
中外制药株式会社 |
抗体的制备方法
|
|
CA2954431C
(en)
|
2007-11-27 |
2021-08-24 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells to pancreatic cells
|
|
AU2008332271C1
(en)
|
2007-12-05 |
2014-04-24 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-NR10 antibody and use thereof
|
|
WO2009075344A1
(ja)
|
2007-12-12 |
2009-06-18 |
Japan As Represented By Director General Of Agency Of National Cancer Center |
M-csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
WO2009095489A2
(en)
*
|
2008-02-01 |
2009-08-06 |
Ablynx N.V. |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
CN105886459A
(zh)
|
2008-02-21 |
2016-08-24 |
詹森生物科技公司 |
用于细胞粘附、培养和分离的方法、表面改性培养板和组合物
|
|
CN107551270A
(zh)
|
2008-04-11 |
2018-01-09 |
中外制药株式会社 |
与多个分子的抗原反复结合的抗原结合分子
|
|
US8623648B2
(en)
|
2008-04-24 |
2014-01-07 |
Janssen Biotech, Inc. |
Treatment of pluripotent cells
|
|
MX2010011955A
(es)
*
|
2008-04-29 |
2011-01-21 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
JP2011520898A
(ja)
*
|
2008-05-13 |
2011-07-21 |
ノビミューン エスアー |
抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法
|
|
NZ589436A
(en)
|
2008-06-03 |
2012-12-21 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
MX2010013239A
(es)
|
2008-06-03 |
2011-02-24 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
TWI528973B
(zh)
|
2008-06-05 |
2016-04-11 |
Chugai Pharmaceutical Co Ltd |
Nerve infiltration inhibitor
|
|
US8188235B2
(en)
*
|
2008-06-18 |
2012-05-29 |
Pfizer Inc. |
Antibodies to IL-6 and their uses
|
|
ES2552240T3
(es)
|
2008-06-30 |
2015-11-26 |
Janssen Biotech, Inc. |
Diferenciación de las células madre pluripotentes
|
|
CN102149825B
(zh)
|
2008-07-08 |
2015-07-22 |
Abbvie公司 |
前列腺素e2双重可变结构域免疫球蛋白及其用途
|
|
US9132189B2
(en)
|
2008-07-08 |
2015-09-15 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
EP2899211A1
(en)
|
2008-07-08 |
2015-07-29 |
OncoMed Pharmaceuticals, Inc. |
Notch1 receptor binding agents and methods of use thereof
|
|
TWI440469B
(zh)
*
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
EP2350265B1
(en)
|
2008-10-31 |
2019-04-17 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
|
|
AU2009308967C1
(en)
|
2008-10-31 |
2017-04-20 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
|
|
MX356756B
(es)
|
2008-11-20 |
2018-06-11 |
Centocor Ortho Biotech Inc |
Células madre pluripotentes en microportadores.
|
|
RU2547925C2
(ru)
|
2008-11-20 |
2015-04-10 |
Сентокор Орто Байотек Инк. |
Способы и композиции для закрепления и культивирования клеток на плоских носителях
|
|
US8992920B2
(en)
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
US8337847B2
(en)
|
2008-11-25 |
2012-12-25 |
Alderbio Holdings Llc |
Methods of treating anemia using anti-IL-6 antibodies
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US9452227B2
(en)
|
2008-11-25 |
2016-09-27 |
Alderbio Holdings Llc |
Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
|
|
US8323649B2
(en)
*
|
2008-11-25 |
2012-12-04 |
Alderbio Holdings Llc |
Antibodies to IL-6 and use thereof
|
|
US9212223B2
(en)
|
2008-11-25 |
2015-12-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
WO2010107110A1
(ja)
|
2009-03-19 |
2010-09-23 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
TWI646193B
(zh)
|
2009-03-19 |
2019-01-01 |
中外製藥股份有限公司 |
抗體恆定區域改變體
|
|
EP2417162A2
(en)
|
2009-04-10 |
2012-02-15 |
Ablynx N.V. |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
NZ595461A
(en)
|
2009-04-10 |
2013-01-25 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
BRPI1012195A2
(pt)
*
|
2009-05-01 |
2018-04-24 |
Abbott Lab |
imunoglobulinas de domínio variável duplo e usos das mesmas
|
|
CA2761891A1
(en)
|
2009-05-15 |
2010-11-18 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-axl antibody
|
|
RU2579278C2
(ru)
|
2009-07-20 |
2016-04-10 |
Янссен Байотек, Инк. |
Популяция панкреатических эндокринных клеток-предшественников для снижения концентрации глюкозы в крови и способ дифференцировки панкреатических эндодермальных клеток
|
|
SG10201404340TA
(en)
|
2009-07-31 |
2014-10-30 |
Shin Maeda |
Cancer metastasis inhibitor
|
|
US10150808B2
(en)
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
|
TW201118166A
(en)
|
2009-09-24 |
2011-06-01 |
Chugai Pharmaceutical Co Ltd |
HLA class I-recognizing antibodies
|
|
JP2013507928A
(ja)
*
|
2009-10-15 |
2013-03-07 |
アボット・ラボラトリーズ |
二重可変ドメイン免疫グロブリンおよびその使用
|
|
DK2493922T3
(en)
|
2009-10-26 |
2017-04-24 |
Hoffmann La Roche |
Process for preparing a glycosylated immunoglobulin
|
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
US9775921B2
(en)
|
2009-11-24 |
2017-10-03 |
Alderbio Holdings Llc |
Subcutaneously administrable composition containing anti-IL-6 antibody
|
|
CN102740888B
(zh)
|
2009-11-24 |
2016-10-12 |
奥尔德生物制药公司 |
Il-6抗体及其用途
|
|
BR112012017761A2
(pt)
|
2009-12-23 |
2015-09-15 |
Centocor Ortho Biotech Inc |
diferenciação das células-tronco embrionárias humanas
|
|
KR101764404B1
(ko)
|
2009-12-23 |
2017-08-03 |
얀센 바이오테크 인코포레이티드 |
인간 배아 줄기 세포의 분화
|
|
EP2519542B1
(en)
|
2009-12-28 |
2018-10-10 |
OncoTherapy Science, Inc. |
Anti-cdh3 antibodies and uses thereof
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
EP2523682B1
(en)
*
|
2010-01-13 |
2015-12-16 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
TWI505838B
(zh)
|
2010-01-20 |
2015-11-01 |
Chugai Pharmaceutical Co Ltd |
Stabilized antibody solution containing
|
|
CA2791476C
(en)
|
2010-03-01 |
2020-06-30 |
Janssen Biotech, Inc. |
Methods for purifying cells derived from pluripotent stem cells
|
|
WO2011108714A1
(ja)
|
2010-03-04 |
2011-09-09 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
WO2011108638A1
(ja)
|
2010-03-04 |
2011-09-09 |
大日本住友製薬株式会社 |
炎症性腸疾患用薬剤
|
|
WO2011128096A1
(en)
|
2010-04-16 |
2011-10-20 |
Roche Diagnostics Gmbh |
Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
MX351515B
(es)
|
2010-05-12 |
2017-10-17 |
Janssen Biotech Inc |
Diferenciacion de celulas madre embrionarias humanas.
|
|
EA202092884A1
(ru)
|
2010-05-14 |
2022-01-31 |
Эмджен Инк. |
Композиции с высокой концентрацией антител
|
|
ES2932398T3
(es)
|
2010-05-28 |
2023-01-18 |
Chugai Pharmaceutical Co Ltd |
Potenciador de la respuesta de las células T antitumorales
|
|
US20130149302A1
(en)
|
2010-05-28 |
2013-06-13 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agents for pancreatic cancer
|
|
CA2801509A1
(en)
|
2010-06-02 |
2011-12-08 |
Dainippon Sumitomo Pharma Co., Ltd. |
Treatment drug for autoimmune diseases and allergic diseases
|
|
CA2801107A1
(en)
|
2010-06-07 |
2011-12-15 |
F. Hoffman-La Roche Ag |
Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
JO3330B1
(ar)
*
|
2010-06-10 |
2019-03-13 |
Lilly Co Eli |
الأجسام المضادة cgrp
|
|
WO2012018790A2
(en)
|
2010-08-03 |
2012-02-09 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
|
EP3578205A1
(en)
|
2010-08-06 |
2019-12-11 |
ModernaTX, Inc. |
A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
|
|
CN103260639A
(zh)
|
2010-08-26 |
2013-08-21 |
Abbvie公司 |
双重可变结构域免疫球蛋白及其用途
|
|
US9506036B2
(en)
|
2010-08-31 |
2016-11-29 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells
|
|
CN104531812A
(zh)
|
2010-10-01 |
2015-04-22 |
现代治疗公司 |
设计核酸及其使用方法
|
|
KR20140008308A
(ko)
*
|
2010-10-29 |
2014-01-21 |
이뮤노젠 아이엔씨 |
신규한 egfr-결합 분자 및 이의 면역컨쥬게이트
|
|
EP2632947A4
(en)
|
2010-10-29 |
2015-03-18 |
Immunogen Inc |
NON-ANTAGONIST MOLECULES BINDING TO THE EGF RECEPTOR AND IMMUNOCONJUGATES THEREOF
|
|
TWI603738B
(zh)
|
2010-11-08 |
2017-11-01 |
建南德克公司 |
皮下投予抗－ｉｌ－６受體抗體
|
|
RU2620071C2
(ru)
|
2010-11-17 |
2017-05-22 |
Чугаи Сеияку Кабушики Каиша |
Мультиспецифическая связывающая антиген молекула, которая обладает альтернативной функцией к функции фактора свертывания крови viii
|
|
ES2847891T3
(es)
|
2010-11-23 |
2021-08-04 |
Vitaeris Inc |
Anticuerpos anti-IL-6 para el tratamiento de la mucositis oral
|
|
RU2658504C9
(ru)
|
2010-11-30 |
2018-08-21 |
Чугаи Сейяку Кабусики Кайся |
Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул
|
|
KR20230005405A
(ko)
|
2011-02-25 |
2023-01-09 |
추가이 세이야쿠 가부시키가이샤 |
ＦｃγＲＩＩｂ 특이적 Ｆｃ 항체
|
|
EP2681242B1
(en)
|
2011-03-01 |
2018-01-24 |
Amgen Inc. |
Sclerostin and dkk-1 bispecific binding agents
|
|
EP2688910B1
(en)
|
2011-03-25 |
2019-05-29 |
Amgen Inc. |
Anti-sclerostin antibody crystals and formulations thereof
|
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
|
WO2012167346A1
(en)
|
2011-06-10 |
2012-12-13 |
Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence |
Anti-ricin antibodies and uses thereof
|
|
ES2746052T3
(es)
|
2011-06-28 |
2020-03-04 |
Inhibrx Lp |
Polipéptidos de fusión de serpina y métodos de uso de los mismos
|
|
US10400029B2
(en)
|
2011-06-28 |
2019-09-03 |
Inhibrx, Lp |
Serpin fusion polypeptides and methods of use thereof
|
|
EP2735315B1
(en)
|
2011-07-19 |
2019-10-02 |
Chugai Seiyaku Kabushiki Kaisha |
Stable protein-containing preparation containing argininamide or valinamide
|
|
AR087305A1
(es)
|
2011-07-28 |
2014-03-12 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
|
|
WO2013017656A1
(en)
|
2011-08-02 |
2013-02-07 |
Medizinische Universität Wien |
Antagonists of ribonucleases for treating obesity
|
|
WO2013017691A1
(en)
|
2011-08-04 |
2013-02-07 |
Medizinische Universität Innsbruck |
Cahgt1p inhibitors for use in the treatment of candidiasis
|
|
PL2739311T3
(pl)
|
2011-08-04 |
2018-08-31 |
Amgen Inc. |
Metoda leczenia szczelinowych uszkodzeń kości
|
|
MY182178A
(en)
|
2011-09-01 |
2021-01-18 |
Chugai Pharmaceutical Co Ltd |
Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2013041722A1
(en)
|
2011-09-23 |
2013-03-28 |
Ablynx Nv |
Prolonged inhibition of interleukin-6 mediated signaling
|
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
|
|
EP2762493B1
(en)
|
2011-09-30 |
2021-06-09 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
|
|
DE102011083811A1
(de)
*
|
2011-09-30 |
2013-04-04 |
Airbus Operations Gmbh |
Sitzvorrichtung für ein Luft- oder Raumfahrzeug
|
|
ES2911677T3
(es)
|
2011-10-03 |
2022-05-20 |
Modernatx Inc |
Nucleósidos, nucleótidos y ácidos nucleicos modificados, y sus usos
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
WO2013059548A1
(en)
|
2011-10-19 |
2013-04-25 |
Sanofi |
Compositions and methods for treating cancer using jak2 inhibitor
|
|
CA2851892C
(en)
|
2011-10-28 |
2021-09-14 |
Teva Pharmaceuticals Australia Pty Ltd |
Polypeptide constructs and uses thereof
|
|
JO3370B1
(ar)
|
2011-11-10 |
2019-03-13 |
Regeneron Pharma |
طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
|
|
MX2014006087A
(es)
|
2011-11-21 |
2014-08-01 |
Immunogen Inc |
Metodo de tratamiento de tumores que son resistentes a terapias contra el receptor del factor de crecimiento epidermico (egfr) con agentes citotoxicos conjugados con anticuerpos dirigidos contra el receptor del factor de crecimiento epidermico.
|
|
CA2857298A1
(en)
|
2011-11-30 |
2013-06-06 |
Abbvie Biotherapeutics Inc. |
Vectors and host cells comprising a modified sv40 promoter for protein expression
|
|
CN109276713A
(zh)
*
|
2011-12-13 |
2019-01-29 |
诺帝克纳诺维科特股份公司 |
嵌合的治疗性抗-cd37抗体hh1
|
|
RS63244B1
(sr)
|
2011-12-16 |
2022-06-30 |
Modernatx Inc |
Kompozicije modifikovane mrna
|
|
MX2014007744A
(es)
|
2011-12-22 |
2015-01-12 |
Janssen Biotech Inc |
Diferenciacion de celulas madre embrionicas humanas en celulas individuales positivas de insulina hormonal.
|
|
SG10201509629QA
(en)
|
2011-12-28 |
2015-12-30 |
Amgen Inc |
Method Of Treating Alveolar Bone Loss Through The Use Of Anti-Sclerostin Antibodies
|
|
BR112014015851A2
(pt)
|
2011-12-30 |
2019-09-24 |
Abbvie Inc |
proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17
|
|
EA030828B1
(ru)
|
2012-03-15 |
2018-10-31 |
Янссен Байотек, Инк. |
Человеческие антитела к cd27, методы и применение
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US20140010861A1
(en)
|
2012-04-02 |
2014-01-09 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins associated with human disease
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9878056B2
(en)
|
2012-04-02 |
2018-01-30 |
Modernatx, Inc. |
Modified polynucleotides for the production of cosmetic proteins and peptides
|
|
BR112014025693B1
(pt)
|
2012-04-17 |
2021-12-07 |
F. Hoffmann-La Roche Ag |
Método de produção recombinante de um polipeptídeo em uma célula bacteriana
|
|
KR101510302B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제
|
|
KR101510830B1
(ko)
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
생리활성 단백질을 발현하는 미니서클을 이용하여 형질전환된 줄기세포를 통한 치료법
|
|
KR101510831B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
항 ｉｌ-６ｒ 및 ｔｎｆｒ２을 포함하는 이중특이적 단백질을 발현하는 미니서클 벡터를 포함하는 줄기세포 치료제
|
|
MX358590B
(es)
|
2012-06-08 |
2018-08-24 |
Janssen Biotech Inc |
Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas.
|
|
EP2869844B2
(en)
|
2012-07-05 |
2023-06-21 |
UCB Pharma S.A. |
Treatment for bone diseases
|
|
CN104797132B
(zh)
|
2012-09-13 |
2017-06-30 |
中外制药株式会社 |
基因敲入非人动物
|
|
US9487590B2
(en)
|
2012-09-25 |
2016-11-08 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
|
KR20210111353A
(ko)
|
2012-11-01 |
2021-09-10 |
애브비 인코포레이티드 |
항-ｖｅｇｆ／ｄｌｌ4 이원 가변 도메인 면역글로불린 및 이의 용도
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
LT2922554T
(lt)
|
2012-11-26 |
2022-06-27 |
Modernatx, Inc. |
Terminaliai modifikuota rnr
|
|
US10370644B2
(en)
|
2012-12-31 |
2019-08-06 |
Janssen Biotech, Inc. |
Method for making human pluripotent suspension cultures and cells derived therefrom
|
|
RU2658488C2
(ru)
|
2012-12-31 |
2018-06-21 |
Янссен Байотек, Инк. |
Способ получения клеток, экспрессирующих маркеры, характерные для панкреатических эндокринных клеток
|
|
CA2896750A1
(en)
|
2012-12-31 |
2014-07-03 |
Janssen Biotech, Inc. |
Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
|
|
KR101942769B1
(ko)
|
2012-12-31 |
2019-01-28 |
얀센 바이오테크 인코포레이티드 |
Hb9 조절제를 사용하는 인간 배아 줄기세포의 췌장 내분비 세포로의 분화
|
|
MX2015013166A
(es)
|
2013-03-15 |
2015-12-11 |
Abbvie Inc |
Proteinas de union especificas duales dirigidas contra il-1 beta y/o il-17.
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
FI3677591T3
(fi)
|
2013-04-29 |
2023-04-03 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-cd38-vasta-aineet ja fuusiot heikennetylle interferonille alfa-2b
|
|
US11117975B2
(en)
|
2013-04-29 |
2021-09-14 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
|
|
WO2014200018A1
(ja)
|
2013-06-11 |
2014-12-18 |
独立行政法人 国立精神・神経医療研究センター |
再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法
|
|
JP6563910B2
(ja)
|
2013-07-04 |
2019-08-21 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ
|
|
US11124576B2
(en)
|
2013-09-27 |
2021-09-21 |
Chungai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide heteromultimer
|
|
US10023626B2
(en)
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
KR20160067219A
(ko)
|
2013-10-03 |
2016-06-13 |
모더나 세라퓨틱스, 인코포레이티드 |
저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
|
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
|
US9017678B1
(en)
|
2014-07-15 |
2015-04-28 |
Kymab Limited |
Method of treating rheumatoid arthritis using antibody to IL6R
|
|
FI3088517T3
(fi)
|
2013-12-26 |
2023-11-30 |
Mitsubishi Tanabe Pharma Corp |
Ihmisen Anti-IL-33 neutraloiva monoklonaalinen vasta-aine
|
|
RU2714967C2
(ru)
|
2013-12-27 |
2020-02-21 |
Чугаи Сейяку Кабусики Кайся |
Способ очистки антител с низкой изоэлектрической точкой
|
|
EP2898896A1
(en)
|
2014-01-22 |
2015-07-29 |
Université Pierre et Marie Curie (Paris 6) |
Agents for use in the treatment of retinal inflammation
|
|
WO2015116852A1
(en)
|
2014-01-29 |
2015-08-06 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating rheumatoid arthritis by administering an il-6r antibody
|
|
IL295906A
(en)
|
2014-03-21 |
2022-10-01 |
Abbvie Inc |
Antibodies against egfr and drug antibody conjugates
|
|
UA119352C2
(uk)
|
2014-05-01 |
2019-06-10 |
Тева Фармасьютикалз Острейліа Пті Лтд |
Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
|
|
MX2016015004A
(es)
|
2014-05-16 |
2017-06-27 |
Janssen Biotech Inc |
Uso de moleculas pequeñas para mejorar la expresion de mafa en celulas endocrinas pancreaticas.
|
|
EP4056993A1
(en)
|
2014-08-20 |
2022-09-14 |
Chugai Seiyaku Kabushiki Kaisha |
Method for measuring viscosity of protein solution
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
CN107074954A
(zh)
|
2014-10-21 |
2017-08-18 |
埃博灵克斯股份有限公司 |
Il‑6r相关疾病的治疗
|
|
KR102639037B1
(ko)
|
2014-10-29 |
2024-02-20 |
테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 |
인터페론 α2b 변이체
|
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|
|
MA41142A
(fr)
|
2014-12-12 |
2017-10-17 |
Amgen Inc |
Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
|
|
CA2971186A1
(en)
|
2014-12-15 |
2016-06-23 |
The Regents Of The University Of California |
Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
|
|
TW201809008A
(zh)
|
2014-12-19 |
2018-03-16 |
日商中外製藥股份有限公司 |
抗ｃ５抗體及使用方法
|
|
TWI808330B
(zh)
|
2014-12-19 |
2023-07-11 |
日商中外製藥股份有限公司 |
抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法
|
|
SG10201907215QA
(en)
|
2015-02-05 |
2019-09-27 |
Chugai Pharmaceutical Co Ltd |
Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof
|
|
TWI805046B
(zh)
|
2015-02-27 |
2023-06-11 |
日商中外製藥股份有限公司 |
Il-6受體抗體用於製備醫藥組成物的用途
|
|
AR104050A1
(es)
|
2015-03-26 |
2017-06-21 |
Chugai Pharmaceutical Co Ltd |
Proceso de producción con iones de cobre controlados
|
|
EP3279216A4
(en)
|
2015-04-01 |
2019-06-19 |
Chugai Seiyaku Kabushiki Kaisha |
PROCESS FOR PREPARING POLYPEPTIDE HETERO OLIGOMER
|
|
US10697883B2
(en)
|
2015-05-19 |
2020-06-30 |
National Center Of Neurology And Psychiatry |
Method for determining application of therapy to multiple sclerosis (MS) patient
|
|
US11174317B2
(en)
|
2015-06-04 |
2021-11-16 |
National Center Of Neurology And Psychiatry |
Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
|
|
EA201890519A1
(ru)
|
2015-08-18 |
2018-07-31 |
Ридженерон Фармасьютикалз, Инк. |
Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов
|
|
TWI729022B
(zh)
|
2015-11-03 |
2021-06-01 |
法商賽諾菲生物技術公司 |
用於治療葡萄膜炎及黃斑水腫之包含ｉｌ６ｒ抗體的組合物與其使用方法
|
|
JP7141336B2
(ja)
|
2015-12-25 |
2022-09-22 |
中外製薬株式会社 |
抗ミオスタチン抗体および使用方法
|
|
CA3004288A1
(en)
|
2015-12-28 |
2017-07-06 |
Nobuyuki Tanaka |
Method for promoting efficiency of purification of fc region-containing polypeptide
|
|
US11484591B2
(en)
|
2016-02-22 |
2022-11-01 |
Ohio State Innovation Foundation |
Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites
|
|
GB201604124D0
(en)
|
2016-03-10 |
2016-04-27 |
Ucb Biopharma Sprl |
Pharmaceutical formulation
|
|
CA3016424A1
(en)
|
2016-03-14 |
2017-09-21 |
Chugai Seiyaku Kabushiki Kaisha |
Cell injury inducing therapeutic drug for use in cancer therapy
|
|
MA45479A
(fr)
|
2016-04-14 |
2019-02-20 |
Janssen Biotech Inc |
Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
|
|
SG11201801024XA
(en)
|
2016-08-05 |
2018-05-30 |
Chugai Pharmaceutical Co Ltd |
Therapeutic or preventive compositions for il-8-related diseases
|
|
KR20190057308A
(ko)
|
2016-09-02 |
2019-05-28 |
더 리전츠 오브 더 유니버시티 오브 캘리포니아 |
인터류킨-6 수용체 알파-결합 단일 사슬 가변 단편을 포함하는 방법 및 조성물
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
EP3518891A1
(en)
|
2016-09-27 |
2019-08-07 |
Fresenius Kabi Deutschland GmbH |
Liquid pharmaceutical composition
|
|
KR102051177B1
(ko)
*
|
2016-10-19 |
2019-12-17 |
주식회사 엘지화학 |
전압 분배를 이용한 스위치 진단 장치 및 방법
|
|
MY192532A
(en)
|
2016-10-31 |
2022-08-26 |
Fresenius Kabi Deutschland Gmbh |
Liquid pharmaceutical composition
|
|
WO2018156180A1
(en)
|
2017-02-24 |
2018-08-30 |
Kindred Biosciences, Inc. |
Anti-il31 antibodies for veterinary use
|
|
AU2018234844B2
(en)
|
2017-03-17 |
2024-01-25 |
Ohio State Innovation Foundation |
Nanoparticles for delivery of chemopreventive agents
|
|
US11851486B2
(en)
|
2017-05-02 |
2023-12-26 |
National Center Of Neurology And Psychiatry |
Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
|
|
CN107098969B
(zh)
*
|
2017-06-28 |
2018-10-12 |
武汉波睿达生物科技有限公司 |
一种治疗hiv感染的嵌合抗原受体的重组基因构建及其应用
|
|
CN115920032A
(zh)
|
2017-08-31 |
2023-04-07 |
田边三菱制药株式会社 |
含有il-33拮抗剂的子宫内膜异位症治疗剂
|
|
US20200369774A1
(en)
|
2017-09-13 |
2020-11-26 |
Jiangsu Hengrui Medicine Co., Ltd. |
Il-6r antibody and antigen binding fragment thereof and medical use
|
|
JP7235249B2
(ja)
|
2017-10-20 |
2023-03-08 |
学校法人兵庫医科大学 |
抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
|
|
JP7458790B2
(ja)
|
2018-01-31 |
2024-04-01 |
元一 加藤 |
Ｉｌ－６阻害剤を含有する喘息の治療剤
|
|
TWI827585B
(zh)
|
2018-03-15 |
2024-01-01 |
日商中外製藥股份有限公司 |
對茲卡病毒具有交叉反應性的抗登革病毒抗體及其使用方法
|
|
CN112166120A
(zh)
|
2018-03-30 |
2021-01-01 |
安姆根有限公司 |
C末端抗体变体
|
|
EP3797752A4
(en)
|
2018-05-21 |
2022-03-02 |
Chugai Seiyaku Kabushiki Kaisha |
FREEZE-DRIED FORMULATION SEALED IN A GLASS VIAL
|
|
CN115636142A
(zh)
|
2018-05-28 |
2023-01-24 |
中外制药株式会社 |
填充喷嘴
|
|
JP7504871B2
(ja)
|
2018-08-29 |
2024-06-24 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
関節リウマチを有する対象を治療するための方法および組成物
|
|
MA54861A
(fr)
|
2019-01-31 |
2021-12-08 |
Regeneron Pharma |
Anticorps anti-récepteur de l'il6 pour traiter l'arthrite idiopathique juvénile
|
|
MX2021011464A
(es)
|
2019-03-29 |
2021-10-22 |
Chugai Pharmaceutical Co Ltd |
Inhibidor que contiene anticuerpo del receptor anti-interleucina 6 (il-6) para inhibir el deterioro de la funcion de la barrera hemato-encefalica (bbb).
|
|
EP3947737A2
(en)
|
2019-04-02 |
2022-02-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of predicting and preventing cancer in patients having premalignant lesions
|
|
WO2020209318A1
(ja)
|
2019-04-10 |
2020-10-15 |
中外製薬株式会社 |
Ｆｃ領域改変抗体の精製方法
|
|
CN114072173A
(zh)
|
2019-04-17 |
2022-02-18 |
国立大学法人广岛大学 |
以联合施用il-6抑制剂和ccr2抑制剂为特征的泌尿系统癌症治疗剂
|
|
CN114375205A
(zh)
|
2019-06-20 |
2022-04-19 |
武田药品工业株式会社 |
用基于病毒的基因疗法进行治疗的方法
|
|
CN110483640B
(zh)
*
|
2019-07-16 |
2020-05-01 |
北京汇智和源生物技术有限公司 |
白介素-6r的人源化单克隆抗体、其编码基因及应用
|
|
MX2022010957A
(es)
|
2020-03-03 |
2023-01-24 |
Twentyeight Seven Inc |
Compuestos que se dirigen a las proteínas de unión al arn o a las proteínas modificadoras del arn.
|
|
CN115916820A
(zh)
|
2020-03-23 |
2023-04-04 |
基因泰克公司 |
用il6拮抗剂治疗包括covid-19肺炎在内的肺炎的方法
|
|
JP2023518812A
(ja)
|
2020-03-23 |
2023-05-08 |
ジェネンテック， インコーポレイテッド |
Ｃｏｖｉｄ１９肺炎を治療するための、トシリズマブとレムデシビルとの組み合わせ
|
|
CN115867577A
(zh)
|
2020-03-23 |
2023-03-28 |
基因泰克公司 |
用于预测covid-19肺炎中对il-6拮抗剂反应的生物标志物
|
|
WO2021211006A1
(en)
|
2020-04-13 |
2021-10-21 |
Federal State Budgetary Institution Center Of Biomedical Technologies Of Federal Medical And Biological Agency |
Inhaled hexapeptide for treating interleukin-6 related respiratory diseases
|
|
CN115605184A
(zh)
|
2020-05-15 |
2023-01-13 |
豪夫迈·罗氏有限公司（Ch） |
防止胃肠外蛋白质溶液中的可见颗粒形成
|
|
WO2022005321A1
(en)
|
2020-06-29 |
2022-01-06 |
Federal State Budgetary Institution Scientific center of biomedical technologies of Federal Medical and Biological Agency |
Inhaled tocilizumab for treating interleukin-6 related respiratory diseases
|
|
KR20220028972A
(ko)
|
2020-08-31 |
2022-03-08 |
(주)셀트리온 |
안정한 약제학적 제제
|
|
US20230357418A1
(en)
|
2020-09-17 |
2023-11-09 |
Genentech, Inc. |
Results of empacta: a randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of tocilizumab in hospitalized patients with covid-19 pneumonia
|
|
UY39610A
(es)
|
2021-01-20 |
2022-08-31 |
Abbvie Inc |
Conjugados anticuerpo-fármaco anti-egfr
|
|
WO2022165419A1
(en)
|
2021-02-01 |
2022-08-04 |
Kyverna Therapeutics, Inc. |
Methods for increasing t-cell function
|
|
KR20230156368A
(ko)
|
2021-03-12 |
2023-11-14 |
추가이 세이야쿠 가부시키가이샤 |
중증 근무력증의 치료 또는 예방용의 의약 조성물
|
|
KR20240019831A
(ko)
|
2021-06-11 |
2024-02-14 |
제넨테크, 인크. |
St2 길항제를 이용하여 만성 폐쇄성 폐질환을 치료하는 방법
|
|
WO2023058723A1
(ja)
|
2021-10-08 |
2023-04-13 |
中外製薬株式会社 |
プレフィルドシリンジ製剤の調製方法
|
|
US20240190978A1
(en)
|
2022-11-15 |
2024-06-13 |
CSBioAsset LLC |
Compositions and methods for immunomodulatory bifunctional fusion molecules
|