PT3153514T - Quinazolinonas como inibidoras da fosfatidilinositol 3-quinase delta humana - Google Patents

Quinazolinonas como inibidoras da fosfatidilinositol 3-quinase delta humana

Info

Publication number
PT3153514T
PT3153514T PT161852132T PT16185213T PT3153514T PT 3153514 T PT3153514 T PT 3153514T PT 161852132 T PT161852132 T PT 161852132T PT 16185213 T PT16185213 T PT 16185213T PT 3153514 T PT3153514 T PT 3153514T
Authority
PT
Portugal
Prior art keywords
quinazolinones
phosphatidylinositol
kinase
inhibitors
human delta
Prior art date
Application number
PT161852132T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3153514(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corp filed Critical Icos Corp
Publication of PT3153514T publication Critical patent/PT3153514T/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Dermatology (AREA)
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PT161852132T 2004-05-13 2005-05-12 Quinazolinonas como inibidoras da fosfatidilinositol 3-quinase delta humana PT3153514T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57078404P 2004-05-13 2004-05-13

Publications (1)

Publication Number Publication Date
PT3153514T true PT3153514T (pt) 2021-06-25

Family

ID=34969603

Family Applications (3)

Application Number Title Priority Date Filing Date
PT131501108T PT2612862T (pt) 2004-05-13 2005-05-12 Quinazolinonas como inibidores de fosfatidilinositol 3-quinase delta humana
PT57521221T PT1761540T (pt) 2004-05-13 2005-05-12 Quinazolinonas como inibidores de fosfatidilinositol-3-cinase delta humana
PT161852132T PT3153514T (pt) 2004-05-13 2005-05-12 Quinazolinonas como inibidoras da fosfatidilinositol 3-quinase delta humana

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT131501108T PT2612862T (pt) 2004-05-13 2005-05-12 Quinazolinonas como inibidores de fosfatidilinositol 3-quinase delta humana
PT57521221T PT1761540T (pt) 2004-05-13 2005-05-12 Quinazolinonas como inibidores de fosfatidilinositol-3-cinase delta humana

Country Status (23)

Country Link
US (14) USRE44638E1 (OSRAM)
EP (4) EP3943494A1 (OSRAM)
JP (1) JP2007537291A (OSRAM)
CN (2) CN101031569B (OSRAM)
AU (2) AU2005245875C1 (OSRAM)
BE (1) BE2017C002I2 (OSRAM)
CA (1) CA2566609C (OSRAM)
CY (3) CY2016046I2 (OSRAM)
DK (2) DK2612862T3 (OSRAM)
ES (3) ES2605792T3 (OSRAM)
FR (1) FR17C1007I2 (OSRAM)
HR (2) HRP20161751T1 (OSRAM)
HU (3) HUE030950T2 (OSRAM)
IL (4) IL179176A (OSRAM)
LT (3) LT2612862T (OSRAM)
LU (1) LUC00005I2 (OSRAM)
ME (2) ME02695B (OSRAM)
NL (1) NL300867I2 (OSRAM)
PL (3) PL3153514T3 (OSRAM)
PT (3) PT2612862T (OSRAM)
RS (2) RS55546B1 (OSRAM)
SI (2) SI3153514T1 (OSRAM)
WO (2) WO2005113556A1 (OSRAM)

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WO2005016348A1 (en) * 2003-08-14 2005-02-24 Icos Corporation Method of inhibiting immune responses stimulated by an endogenous factor
CA2730540A1 (en) * 2004-05-13 2005-12-01 Vanderbilt University Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis
DK2612862T3 (en) 2004-05-13 2016-12-05 Icos Corp Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
WO2006068760A2 (en) * 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
EP1885356A2 (en) * 2005-02-17 2008-02-13 Icos Corporation Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
GB2431156A (en) * 2005-10-11 2007-04-18 Piramed Ltd 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase
CA2647391C (en) * 2006-04-04 2015-12-29 The Regents Of The University Of California Kinase antagonists
SG178786A1 (en) * 2006-11-13 2012-03-29 Lilly Co Eli Thienopyrimidinones for treatment of inflammatory disorders and cancers
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US20110123486A1 (en) * 2007-06-25 2011-05-26 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
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IL241732A0 (en) 2015-11-30
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PT1761540T (pt) 2016-12-07
EP3153514B1 (en) 2021-04-21
US20100256168A1 (en) 2010-10-07
DK2612862T3 (en) 2016-12-05
US8586597B2 (en) 2013-11-19
US20120015964A1 (en) 2012-01-19
US20200017503A1 (en) 2020-01-16
SI3153514T1 (sl) 2022-02-28
ME02688B (me) 2017-10-20
RS55551B1 (sr) 2017-05-31
EP1761540A1 (en) 2007-03-14
ES2607804T3 (es) 2017-04-04
ES2605792T3 (es) 2017-03-16
WO2005113556A1 (en) 2005-12-01
IL179176A (en) 2015-10-29
NL300867I2 (OSRAM) 2017-05-09
AU2005245875A1 (en) 2005-12-01
RS55546B1 (sr) 2017-05-31
EP3943494A1 (en) 2022-01-26
PL3153514T3 (pl) 2022-01-10
LTC1761540I2 (lt) 2019-04-10
PL1761540T3 (pl) 2017-06-30
US20140121224A1 (en) 2014-05-01
US20080275067A1 (en) 2008-11-06
AU2009230739A1 (en) 2009-11-12
CA2566609C (en) 2012-06-26
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US8980901B2 (en) 2015-03-17
US10906907B2 (en) 2021-02-02
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US10336756B2 (en) 2019-07-02
EP2612862B1 (en) 2016-09-14
ES2873875T3 (es) 2021-11-04
IL179176A0 (en) 2007-03-08
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CY2016046I1 (el) 2017-11-14
USRE44599E1 (en) 2013-11-12
US20130231356A1 (en) 2013-09-05
US20100256167A1 (en) 2010-10-07
US8207153B2 (en) 2012-06-26
US20140378479A1 (en) 2014-12-25
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US8779131B2 (en) 2014-07-15
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EP1761540B1 (en) 2016-09-28
JP2007537291A (ja) 2007-12-20
LUC00005I1 (OSRAM) 2017-02-21
CY1118516T1 (el) 2017-07-12
US8993583B2 (en) 2015-03-31
HUE030950T2 (en) 2017-06-28
CN101031569B (zh) 2011-06-22
AU2005245875B2 (en) 2009-07-30
HUE030839T2 (en) 2017-06-28
FR17C1007I2 (fr) 2018-03-23
EP3153514A1 (en) 2017-04-12
CY2016046I2 (el) 2017-11-14
US20130116266A1 (en) 2013-05-09
HUS1700006I1 (hu) 2017-03-28
IL241732B (en) 2019-10-31
WO2005113554A2 (en) 2005-12-01
EP2612862A3 (en) 2014-01-08
LT2612862T (lt) 2017-01-25
LT1761540T (lt) 2017-02-27
US20210332047A1 (en) 2021-10-28
USRE44638E1 (en) 2013-12-10
US20160075705A1 (en) 2016-03-17
ME02695B (me) 2017-10-20
FR17C1007I1 (fr) 2017-04-21
US20140121223A1 (en) 2014-05-01
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AU2005245875C1 (en) 2017-08-31
US7932260B2 (en) 2011-04-26

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