PE20142355A1 - 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il)ureas como inhibidores de proteinas cinasas activadas por mitogeno p38 - Google Patents

1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il)ureas como inhibidores de proteinas cinasas activadas por mitogeno p38

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Publication number
PE20142355A1
PE20142355A1 PE2014000468A PE2014000468A PE20142355A1 PE 20142355 A1 PE20142355 A1 PE 20142355A1 PE 2014000468 A PE2014000468 A PE 2014000468A PE 2014000468 A PE2014000468 A PE 2014000468A PE 20142355 A1 PE20142355 A1 PE 20142355A1
Authority
PE
Peru
Prior art keywords
mitogen
pirazolil
anilinopyrimidin
kines
oxi
Prior art date
Application number
PE2014000468A
Other languages
English (en)
Inventor
Kazuhiro Ito
John King-Underwood
Stuart Thomas Onions
Alistair Ian Longshaw
Rudy Broeckx
Walter Filliers
Alex Copmans
Catherine Elisabeth Charron
Original Assignee
Respivert Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47018247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142355(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP11183688.8A external-priority patent/EP2578582A1/en
Application filed by Respivert Ltd filed Critical Respivert Ltd
Publication of PE20142355A1 publication Critical patent/PE20142355A1/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/415—1,2-Diazoles
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

REFERIDA AL COMPUESTO 1-(3-TERC-BUTIL-1-p-TOLIL-1H-PIRAZOL-5-IL)-3-(4-(2-(FENILAMINO)PIRIMIDIN-4-ILOXI)NAFTALEN-1-IL)UREA DE FORMULA (I), COMO BASE LIBRE ANHIDRA EN FORMA CRISTALINA QUE PRESENTA UN PATRON DE PICOS DE DIFRACCION DE POLVOS DE RAYOS X SELECCIONADO DE 10,3, 15,2, 17,5, 23,1, 24,6, 26,7 Y 27,4 GRADOS 2-THETA. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA FAMILIA DE ENZIMAS CINASAS DE LA PROTEINA ACTIVADA POR EL MITOGENO p38 Y ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, INCLUYENDO ENFERMEDADES INFLAMATORIAS DEL PULMON TALES COMO ASMA Y COPD
PE2014000468A 2011-10-03 2012-10-03 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il)ureas como inhibidores de proteinas cinasas activadas por mitogeno p38 PE20142355A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11183682 2011-10-03
EP11183688.8A EP2578582A1 (en) 2011-10-03 2011-10-03 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
EP12168396 2012-05-16
EP12168395 2012-05-16

Publications (1)

Publication Number Publication Date
PE20142355A1 true PE20142355A1 (es) 2015-01-10

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PE2014000468A PE20142355A1 (es) 2011-10-03 2012-10-03 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il)ureas como inhibidores de proteinas cinasas activadas por mitogeno p38

Country Status (25)

Country Link
US (5) US9108950B2 (es)
EP (1) EP2763984B1 (es)
JP (2) JP2014528404A (es)
KR (2) KR102057058B1 (es)
CN (1) CN103917536B (es)
AU (1) AU2012320300C1 (es)
BR (1) BR112014007694B1 (es)
CA (1) CA2846222C (es)
CL (1) CL2014000813A1 (es)
CO (1) CO6910202A2 (es)
EA (1) EA023650B1 (es)
EC (1) ECSP14013282A (es)
ES (1) ES2583853T3 (es)
GT (1) GT201400054A (es)
HK (1) HK1199642A1 (es)
IL (1) IL231025A (es)
MX (1) MX342168B (es)
MY (1) MY167798A (es)
NI (1) NI201400027A (es)
PE (1) PE20142355A1 (es)
PL (1) PL2763984T3 (es)
PT (1) PT2763984T (es)
SG (1) SG11201400226UA (es)
WO (1) WO2013050757A1 (es)
ZA (1) ZA201403204B (es)

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DK3357919T3 (da) 2014-02-14 2020-02-17 Respivert Ltd Aromatiske heterocykliske forbindelser som antiinflammatoriske forbindelser
MA40775A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38
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