CL2011002442A1 - Un compuesto n-(4-(4-(3-(3-terc-butil-1-p-tolil-1h-pirazol-5-il)ureido)naftalen-1-iloxi)piridin-2-il)-2-metoxiacetamida o una sal, estereoisomeros y tautomeros del mismo; composicion farmaceutica; y su uso para tratar o prevenir una afeccion seleccionada de epoc, asma e inhibicion del crecimiento y metastasis de tumores, entre otras. - Google Patents
Un compuesto n-(4-(4-(3-(3-terc-butil-1-p-tolil-1h-pirazol-5-il)ureido)naftalen-1-iloxi)piridin-2-il)-2-metoxiacetamida o una sal, estereoisomeros y tautomeros del mismo; composicion farmaceutica; y su uso para tratar o prevenir una afeccion seleccionada de epoc, asma e inhibicion del crecimiento y metastasis de tumores, entre otras.Info
- Publication number
- CL2011002442A1 CL2011002442A1 CL2011002442A CL2011002442A CL2011002442A1 CL 2011002442 A1 CL2011002442 A1 CL 2011002442A1 CL 2011002442 A CL2011002442 A CL 2011002442A CL 2011002442 A CL2011002442 A CL 2011002442A CL 2011002442 A1 CL2011002442 A1 CL 2011002442A1
- Authority
- CL
- Chile
- Prior art keywords
- epoc
- methoxyacetamide
- naphthalen
- ureido
- yloxy
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto n-(4-(4-(3-(3-terc-butil-1-p-tolil-1h-pirazol-5-il)ureido)naftalen-1-iloxi)piridin-2-il)-2-metoxiacetamidao una sal, estereoisómeros y tautómeros del mismo; composición farmacéutica; y su uso para tratar o prevenir una afección seleccionada de epoc, asma e inhibición del crecimiento y metástasis de tumores, entre otras.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16659409P | 2009-04-03 | 2009-04-03 | |
GBGB0905955.1A GB0905955D0 (en) | 2009-04-06 | 2009-04-06 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2011002442A1 true CL2011002442A1 (es) | 2012-04-09 |
Family
ID=40750191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011002442A CL2011002442A1 (es) | 2009-04-03 | 2011-09-30 | Un compuesto n-(4-(4-(3-(3-terc-butil-1-p-tolil-1h-pirazol-5-il)ureido)naftalen-1-iloxi)piridin-2-il)-2-metoxiacetamida o una sal, estereoisomeros y tautomeros del mismo; composicion farmaceutica; y su uso para tratar o prevenir una afeccion seleccionada de epoc, asma e inhibicion del crecimiento y metastasis de tumores, entre otras. |
Country Status (19)
Country | Link |
---|---|
US (2) | US8642773B2 (es) |
EP (1) | EP2414347B1 (es) |
JP (1) | JP5751640B2 (es) |
KR (1) | KR20120006033A (es) |
CN (1) | CN102395575B (es) |
AU (1) | AU2010231120B2 (es) |
CA (1) | CA2754609A1 (es) |
CL (1) | CL2011002442A1 (es) |
CO (1) | CO6501168A2 (es) |
EA (1) | EA201171213A1 (es) |
EC (1) | ECSP11011371A (es) |
GB (1) | GB0905955D0 (es) |
IL (1) | IL214799A0 (es) |
MX (1) | MX2011010366A (es) |
NI (1) | NI201100173A (es) |
PE (1) | PE20120516A1 (es) |
SG (1) | SG174139A1 (es) |
WO (1) | WO2010112936A1 (es) |
ZA (1) | ZA201108048B (es) |
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US8299074B2 (en) * | 2008-12-11 | 2012-10-30 | Respivert Ltd. | P38 MAP kinase inhibitors |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
GB0921730D0 (en) * | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
US8855064B2 (en) | 2010-01-12 | 2014-10-07 | Qualcomm Incorporated | Bundled frequency division multiplexing structure in wireless communications |
DK2531502T3 (da) | 2010-02-01 | 2014-05-19 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi |
GB201005589D0 (en) | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
JP5787976B2 (ja) | 2010-04-08 | 2015-09-30 | レスピバート・リミテツド | P38mapキナーゼ阻害剤としてのピラゾリルウレア |
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GB201010193D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
GB201010196D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Methods |
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GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
EP2890460B1 (en) | 2012-08-29 | 2017-02-22 | Respivert Limited | Kinase inhibitors |
EP2890695A2 (en) | 2012-08-29 | 2015-07-08 | Respivert Limited | Kinase inhibitors |
EP2890701B1 (en) | 2012-08-29 | 2017-03-29 | Respivert Limited | Kinase inhibitors |
GB201215357D0 (en) * | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
EP2925742B1 (en) | 2012-11-16 | 2016-10-26 | Respivert Limited | Kinase inhibitors |
US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
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GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
US9890185B2 (en) | 2013-12-20 | 2018-02-13 | Respivert Limited | Urea derivatives useful as kinase inhibitors |
JP6630280B2 (ja) | 2014-02-14 | 2020-01-15 | レスピバート・リミテツド | 抗炎症化合物としての芳香族複素環化合物 |
MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
KR102387073B1 (ko) | 2016-04-06 | 2022-04-15 | 옥슬러 액퀴지션즈 리미티드 | 키나제 저해제 |
US11407771B2 (en) | 2018-05-30 | 2022-08-09 | Washington University | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof |
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-
2009
- 2009-04-06 GB GBGB0905955.1A patent/GB0905955D0/en not_active Ceased
-
2010
- 2010-04-01 EA EA201171213A patent/EA201171213A1/ru unknown
- 2010-04-01 JP JP2012502808A patent/JP5751640B2/ja not_active Expired - Fee Related
- 2010-04-01 KR KR1020117026060A patent/KR20120006033A/ko not_active Application Discontinuation
- 2010-04-01 PE PE2011001744A patent/PE20120516A1/es not_active Application Discontinuation
- 2010-04-01 SG SG2011060316A patent/SG174139A1/en unknown
- 2010-04-01 AU AU2010231120A patent/AU2010231120B2/en not_active Ceased
- 2010-04-01 US US13/262,266 patent/US8642773B2/en active Active
- 2010-04-01 CN CN201080015800.0A patent/CN102395575B/zh not_active Expired - Fee Related
- 2010-04-01 WO PCT/GB2010/050575 patent/WO2010112936A1/en active Application Filing
- 2010-04-01 EP EP10711930.7A patent/EP2414347B1/en active Active
- 2010-04-01 CA CA2754609A patent/CA2754609A1/en not_active Abandoned
- 2010-04-01 MX MX2011010366A patent/MX2011010366A/es unknown
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2011
- 2011-08-23 IL IL214799A patent/IL214799A0/en unknown
- 2011-09-30 NI NI201100173A patent/NI201100173A/es unknown
- 2011-09-30 CL CL2011002442A patent/CL2011002442A1/es unknown
- 2011-09-30 CO CO11129260A patent/CO6501168A2/es not_active Application Discontinuation
- 2011-10-03 EC EC2011011371A patent/ECSP11011371A/es unknown
- 2011-11-02 ZA ZA2011/08048A patent/ZA201108048B/en unknown
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2014
- 2014-02-03 US US14/171,198 patent/US9242960B2/en active Active
Also Published As
Publication number | Publication date |
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CO6501168A2 (es) | 2012-08-15 |
ZA201108048B (en) | 2013-04-24 |
IL214799A0 (en) | 2011-11-30 |
CN102395575A (zh) | 2012-03-28 |
US8642773B2 (en) | 2014-02-04 |
MX2011010366A (es) | 2011-10-17 |
EP2414347A1 (en) | 2012-02-08 |
SG174139A1 (en) | 2011-10-28 |
WO2010112936A1 (en) | 2010-10-07 |
ECSP11011371A (es) | 2011-11-30 |
PE20120516A1 (es) | 2012-05-09 |
US20140228410A1 (en) | 2014-08-14 |
EA201171213A1 (ru) | 2012-03-30 |
JP2012522760A (ja) | 2012-09-27 |
KR20120006033A (ko) | 2012-01-17 |
AU2010231120A1 (en) | 2011-09-08 |
EP2414347B1 (en) | 2016-03-30 |
JP5751640B2 (ja) | 2015-07-22 |
AU2010231120B2 (en) | 2014-01-30 |
CA2754609A1 (en) | 2010-10-07 |
NI201100173A (es) | 2012-02-21 |
US9242960B2 (en) | 2016-01-26 |
CN102395575B (zh) | 2014-11-12 |
US20120136031A1 (en) | 2012-05-31 |
GB0905955D0 (en) | 2009-05-20 |
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