MX2018012275A - Inhibidores de quinasa. - Google Patents

Inhibidores de quinasa.

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Publication number
MX2018012275A
MX2018012275A MX2018012275A MX2018012275A MX2018012275A MX 2018012275 A MX2018012275 A MX 2018012275A MX 2018012275 A MX2018012275 A MX 2018012275A MX 2018012275 A MX2018012275 A MX 2018012275A MX 2018012275 A MX2018012275 A MX 2018012275A
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MX
Mexico
Prior art keywords
members
inflammatory diseases
kinase inhibitors
family
compounds
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Application number
MX2018012275A
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English (en)
Inventor
Colin Thor Fyfe Matthew
Malcolm Thom Stephen
Original Assignee
Topivert Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Topivert Pharma Ltd filed Critical Topivert Pharma Ltd
Publication of MX2018012275A publication Critical patent/MX2018012275A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan compuestos de formula I, (ver formula I)donde T, A, Q, Z, G, R4, R5a, R5b y n tienen el significado dado en la descripción, donde los compuestos tienen actividad anti-inflamatoria (por ejemplo mediante la inhibición de uno o más de los miembros de: la familia de enzimas de proteína quinasa activada por mitogeno p38; Syk quinasa; y los miembros de la familia Src de tirosina quinasas) y tienen uso en la terapia, incluyendo en combinaciones farmacéuticas, especialmente en el tratamiento de enfermedades inflamatorias, incluyendo las enfermedades inflamatorias del pulmón, ojo y los intestinos.
MX2018012275A 2016-04-06 2017-04-06 Inhibidores de quinasa. MX2018012275A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201605844 2016-04-06
PCT/GB2017/050970 WO2017174995A1 (en) 2016-04-06 2017-04-06 Kinase inhibitors

Publications (1)

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MX2018012275A true MX2018012275A (es) 2019-05-23

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US (2) US10072034B2 (es)
EP (1) EP3440073B1 (es)
JP (1) JP6995774B2 (es)
KR (1) KR102387073B1 (es)
CN (1) CN109071505B (es)
AU (1) AU2017245888B2 (es)
BR (1) BR112018067552A2 (es)
CA (1) CA3015978A1 (es)
EA (1) EA201892213A1 (es)
MA (1) MA44607A (es)
MX (1) MX2018012275A (es)
WO (1) WO2017174995A1 (es)

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CN105246884B (zh) * 2013-04-02 2018-05-22 瑞斯比维特有限公司 用作激酶抑制剂的脲衍生物
KR102387073B1 (ko) * 2016-04-06 2022-04-15 옥슬러 액퀴지션즈 리미티드 키나제 저해제
JPWO2021200975A1 (es) * 2020-03-31 2021-10-07

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