KR100753304B1 - 치료제로서 사용되는 변이 펩티드를 함유한 화합물로이루어진 조성물 및 이 화합물의 제조방법 - Google Patents
치료제로서 사용되는 변이 펩티드를 함유한 화합물로이루어진 조성물 및 이 화합물의 제조방법 Download PDFInfo
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- KR100753304B1 KR100753304B1 KR1020077006958A KR20077006958A KR100753304B1 KR 100753304 B1 KR100753304 B1 KR 100753304B1 KR 1020077006958 A KR1020077006958 A KR 1020077006958A KR 20077006958 A KR20077006958 A KR 20077006958A KR 100753304 B1 KR100753304 B1 KR 100753304B1
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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Abstract
Description
Claims (12)
- 다음 화학식의 화합물로 이루어진, 빈혈을 치료하기 위한 조성물( X 1 ) a -F 1 -( X 2 ) b이 식에서,F 1 은 SEQ ID NO : 2 의 아미노산 서열로 이루어진 IgG1 Fc 도메인이고 ;X 1 및 X 2 는 각각 독립적으로 -(L1)c-P1 및 -(L1)c-P1-(L2)d-P2 중에서 선택한 것이고 ;P 1 및 P 2 는 각각 독립적으로 하기의 표 5 에서 선택한 EPO-유사 펩티드 서열이고 ;L 1 및 L 2 는 각각 독립적으로 다음 중에서 선택한 링커이고(Gly)4 ;(Gly)5 ;poly(Gly-Ala) ;polyalanines ;(Gly)3Lys(Gly)4 (SEQ ID NO : 333) ;(Gly)3AsnGlySer(Gly)2 (SEQ ID NO : 334) ;(Gly)3Cys(Gly)4 (SEQ ID NO : 335) ;GlyProAsnGlyGly (SEQ ID NO : 336) ; 및-NH-(CH2)S-C(O)-,여기에서, s 는 2-20 이고, 상기 -NH-(CH2)S-C(O)-링커는 저급 C1 -6 알킬, 저급 아실, 할로겐, CN, NH2 및페닐 중에서 선택한 입체 장애를 가지지 않는 기로치환될 수 있고 ;a 및 b 중 적어도 하나가 1 인 경우에, a, b, c 및 d 는 각각 독립적으로 0 또는 1 이며 ;상기 "펩티드" 는 2 내지 40 개의 아미노산으로 이루어진 분자를 나타내며, X1 및 X2 은 둘 다 천연 단백질이 아니다표 5
- 제 1 항에 있어서, 다음 화학식의 화합물로 이루어짐을 특징으로 하는 조성물 : X1-F1 또는 F1-X2.
- 제 1 항에 있어서, 다음 화학식의 화합물로 이루어짐을 특징으로 하는 조성물 : F1-(L1)C-P1.
- 제 1 항에 있어서, 다음 화학식의 화합물로 이루어짐을 특징으로 하는 조성물 : F1-(L1)C-P1-(L2)d-P2.
- SEQ ID NO : 15, 17, 19 및 21 중에서 선택한 누클레오티드 서열로 이루어진, 제 1 항에 기재되어 있는 화합물을 코드하는 DNA.
- 제 5 항의 DNA 를 포함하는 발현 벡터.
- 제 6 항의 발현 벡터를 포함하는 E.coli 세포.
- 다음 단계를 포함하는, EPO-유사 화합물을 제조하는 방법a) 제 1 항에 기재되어 있는 표 5 중에서 선택한 EPO-유사 펩티드서열을 선택하는 단계 ; 및b) 선택한 펩티드 또는 펩티드들의 아미노산 서열과 SEQ ID NO : 2 의아미노산 서열로 이루어진 IgG1 Fc 도메인을 공유결합시킴을포함하는 EPO-유사 화합물을 제조하는 단계.
- 제 8 항에 있어서, 펩티드는 파지 디스플레이 라이브러리, E.coli 디스플레이 라이브러리, 리보솜 라이브러리 또는 화학적 펩티드 라이브러리의 스크리닝을 포함하는 방법으로 선택함을 특징으로 하는 방법.
- 제 8 항에 있어서, 제조된 화합물은 다음 화학식으로 이루어짐을 특징으로 하는 방법( X 1 ) a -F 1 -( X 2 ) b이 식에서,F 1 은 SEQ ID NO : 2 의 아미노산 서열로 이루어진 IgG1 Fc 도메인이고 ;X 1 및 X 2 는 각각 독립적으로 -(L1)c-P1 및 -(L1)c-P1-(L2)d-P2 중에서 선택한 것이고 ;P 1 및 P 2 는 각각 독립적으로 제 1 항에 기재되어 있는 표 5 에서 선택한 EPO-유사 펩티드 서열이고 ;L 1 및 L 2 는 각각 독립적으로 다음 중에서 선택한 링커이며(Gly)4 ;(Gly)5 ;poly(Gly-Ala) ;polyalanines ;(Gly)3Lys(Gly)4 (SEQ ID NO : 333) ;(Gly)3AsnGlySer(Gly)2 (SEQ ID NO : 334) ;(Gly)3Cys(Gly)4 (SEQ ID NO : 335) ;GlyProAsnGlyGly (SEQ ID NO : 336) ; 및-NH-(CH2)S-C(O)-,여기에서, s 는 2-20 이고, 상기 -NH-(CH2)S-C(O)-링커는 저급 C1 -6 알킬, 저급 아실, 할로겐, CN, NH2 및페닐 중에서 선택한 입체 장애를 가지지 않는 기로치환될 수 있고 ;a 및 b 중 적어도 하나가 1 인 경우에, a, b, c 및 d 는 각각 독립적으로 0 또는 1 이다.
- 제 10 항에 있어서, 제조된 화합물은 다음 화학식으로 이루어짐을 특징으로 하는 방법 : X1-F1 또는 F1-X2.
- 제 10 항에 있어서, 제조된 화합물은 다음 화학식으로 이루어짐을 특징으로 하는 방법 : F1-(L1)C-P1 또는 F1-(L1)C-P1-(L2)d-P2.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US10537198P | 1998-10-23 | 1998-10-23 | |
US?60/105,371? | 1998-10-23 | ||
US09/428,082 US6660843B1 (en) | 1998-10-23 | 1999-10-22 | Modified peptides as therapeutic agents |
US?09/428,082? | 1999-10-22 | ||
PCT/US1999/025044 WO2000024782A2 (en) | 1998-10-23 | 1999-10-25 | Modified peptides, comprising an fc domain, as therapeutic agents |
Related Parent Applications (1)
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KR1020017004982A Division KR100753303B1 (ko) | 1998-10-23 | 1999-10-25 | 치료제로서 사용되는 변이 펩티드를 함유한 화합물로 이루어진 조성물 및 이 화합물의 제조방법 |
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KR20070050977A KR20070050977A (ko) | 2007-05-16 |
KR100753304B1 true KR100753304B1 (ko) | 2007-08-29 |
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Application Number | Title | Priority Date | Filing Date |
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KR1020017004982A KR100753303B1 (ko) | 1998-10-23 | 1999-10-25 | 치료제로서 사용되는 변이 펩티드를 함유한 화합물로 이루어진 조성물 및 이 화합물의 제조방법 |
KR1020077006961A KR100753305B1 (ko) | 1998-10-23 | 1999-10-25 | 치료제로서 사용되는 변이 펩티드를 함유한 화합물로이루어진 조성물 및 이 화합물의 제조방법 |
KR1020077006958A KR100753304B1 (ko) | 1998-10-23 | 1999-10-25 | 치료제로서 사용되는 변이 펩티드를 함유한 화합물로이루어진 조성물 및 이 화합물의 제조방법 |
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KR1020017004982A KR100753303B1 (ko) | 1998-10-23 | 1999-10-25 | 치료제로서 사용되는 변이 펩티드를 함유한 화합물로 이루어진 조성물 및 이 화합물의 제조방법 |
KR1020077006961A KR100753305B1 (ko) | 1998-10-23 | 1999-10-25 | 치료제로서 사용되는 변이 펩티드를 함유한 화합물로이루어진 조성물 및 이 화합물의 제조방법 |
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US (7) | US6660843B1 (ko) |
EP (1) | EP1144454B2 (ko) |
JP (9) | JP2003512011A (ko) |
KR (3) | KR100753303B1 (ko) |
CN (8) | CN1721447A (ko) |
AT (1) | ATE380828T1 (ko) |
AU (3) | AU767725B2 (ko) |
BG (1) | BG65721B1 (ko) |
BR (1) | BR9914708A (ko) |
CA (1) | CA2347131C (ko) |
CY (1) | CY1107881T1 (ko) |
CZ (1) | CZ304242B6 (ko) |
DE (1) | DE69937752T3 (ko) |
DK (1) | DK1144454T4 (ko) |
EA (1) | EA005404B1 (ko) |
ES (1) | ES2299278T5 (ko) |
HK (2) | HK1042097B (ko) |
HU (1) | HU229485B1 (ko) |
IL (2) | IL142365A0 (ko) |
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NO (1) | NO331733B1 (ko) |
NZ (2) | NZ528882A (ko) |
PL (1) | PL211164B1 (ko) |
PT (1) | PT1144454E (ko) |
RS (1) | RS51852B (ko) |
SI (1) | SI1144454T2 (ko) |
SK (1) | SK287037B6 (ko) |
WO (1) | WO2000024782A2 (ko) |
ZA (1) | ZA200102753B (ko) |
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