MX2021004510A - Calibracion automatica y mantenimiento automatico de modelos espectroscopicos de raman para predicciones en tiempo real. - Google Patents
Calibracion automatica y mantenimiento automatico de modelos espectroscopicos de raman para predicciones en tiempo real.Info
- Publication number
- MX2021004510A MX2021004510A MX2021004510A MX2021004510A MX2021004510A MX 2021004510 A MX2021004510 A MX 2021004510A MX 2021004510 A MX2021004510 A MX 2021004510A MX 2021004510 A MX2021004510 A MX 2021004510A MX 2021004510 A MX2021004510 A MX 2021004510A
- Authority
- MX
- Mexico
- Prior art keywords
- observation
- data sets
- biopharmaceutical
- automatic
- real
- Prior art date
Links
- 238000001069 Raman spectroscopy Methods 0.000 title abstract 2
- 238000012423 maintenance Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 9
- 229960000074 biopharmaceutical Drugs 0.000 abstract 4
- 238000004458 analytical method Methods 0.000 abstract 3
- 230000003595 spectral effect Effects 0.000 abstract 2
- 238000012544 monitoring process Methods 0.000 abstract 1
- 238000004611 spectroscopical analysis Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N20/00—Machine learning
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N5/00—Computing arrangements using knowledge-based models
- G06N5/04—Inference or reasoning models
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N2021/8411—Application to online plant, process monitoring
- G01N2021/8416—Application to online plant, process monitoring and process controlling, not otherwise provided for
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/127—Calibration; base line adjustment; drift compensation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/129—Using chemometrical methods
Abstract
Un método para monitorizar y/o controlar un proceso biofarmacéutico incluye determinar un punto de consulta asociado con la exploración del proceso mediante un sistema de espectroscopía (por ejemplo, un sistema de espectroscopía de Raman), y consultar una base de datos de observación que contiene conjuntos de datos de observación asociados con observaciones pasadas de procesos biofarmacéuticos. Cada uno de los conjuntos de datos de observación incluye datos espectrales y una medición analítica real correspondiente. Consultar la base de datos de observación incluye seleccionar como datos de entrenamiento, de entre los conjuntos de datos de observación, los conjuntos de datos que satisfacen uno o más criterios de relevancia con respecto al punto de consulta. El método también incluye usar los datos de entrenamiento seleccionados para calibrar un modelo local específico para el proceso biofarmacéutico. El modelo local (por ejemplo, un modelo de proceso gaussiano) se entrena para predecir mediciones analíticas basándose en entradas de datos espectrales. El método también incluye usar el modelo local para predecir una medición analítica del proceso biofarmacéutico.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862749359P | 2018-10-23 | 2018-10-23 | |
| US201962833044P | 2019-04-12 | 2019-04-12 | |
| US201962864565P | 2019-06-21 | 2019-06-21 | |
| PCT/US2019/057513 WO2020086635A1 (en) | 2018-10-23 | 2019-10-23 | Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021004510A true MX2021004510A (es) | 2021-06-08 |
Family
ID=70331744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021004510A MX2021004510A (es) | 2018-10-23 | 2019-10-23 | Calibracion automatica y mantenimiento automatico de modelos espectroscopicos de raman para predicciones en tiempo real. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20220128474A1 (es) |
| EP (1) | EP3870957A1 (es) |
| JP (1) | JP2022512775A (es) |
| KR (1) | KR20210078531A (es) |
| CN (1) | CN112912716A (es) |
| AU (1) | AU2019365102A1 (es) |
| BR (1) | BR112021007611A2 (es) |
| CA (1) | CA3115296A1 (es) |
| CL (1) | CL2021001024A1 (es) |
| IL (1) | IL281977A (es) |
| MX (1) | MX2021004510A (es) |
| SG (1) | SG11202103232WA (es) |
| TW (1) | TW202033949A (es) |
| WO (1) | WO2020086635A1 (es) |
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| JP2021535739A (ja) | 2018-08-27 | 2021-12-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 下流精製でのラマン分光法の使用 |
| WO2020251997A2 (en) * | 2019-06-10 | 2020-12-17 | Waters Technologies Corporation | Techniques for analytical instrument performance diagnostics |
| MX2023003687A (es) * | 2020-10-01 | 2023-04-20 | Amgen Inc | Modelado predictivo hibrido y el control de cultivo celular. |
| US20220138557A1 (en) * | 2020-11-04 | 2022-05-05 | Adobe Inc. | Deep Hybrid Graph-Based Forecasting Systems |
| DE102021100531B3 (de) * | 2021-01-13 | 2022-03-31 | BioThera Institut GmbH | Apparatur zum Steuern eines Prozesses sowie zugehöriges Steuerungsverfahren |
| EP4352200A1 (en) * | 2021-06-09 | 2024-04-17 | Amgen Inc. | Assessing packed cell volume for cell cultures |
| WO2023076318A1 (en) | 2021-10-27 | 2023-05-04 | Amgen Inc. | Deep learning-based prediction for monitoring of pharmaceuticals using spectroscopy |
| JP2023124433A (ja) * | 2022-02-25 | 2023-09-06 | 株式会社日立製作所 | 評価システム及び評価方法 |
| US20230279332A1 (en) * | 2022-03-01 | 2023-09-07 | Amgen Inc. | Hybrid Predictive Modeling for Control of Cell Culture |
| WO2024046603A1 (en) * | 2022-08-29 | 2024-03-07 | Büchi Labortechnik AG | Methods for providing a predictive model for spectroscopy and calibrating a spectroscopic device |
| WO2024049725A1 (en) * | 2022-08-29 | 2024-03-07 | Amgen Inc. | Predictive model to evaluate processing time impacts |
| WO2024059092A1 (en) | 2022-09-14 | 2024-03-21 | Amgen Inc. | Just-in-time learning with variational autoencoder for cell culture process monitoring and/or control |
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| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US5862060A (en) * | 1996-11-22 | 1999-01-19 | Uop Llc | Maintenance of process control by statistical analysis of product optical spectrum |
| TR200003087T2 (tr) | 1998-04-21 | 2001-02-21 | Micromet Ag | Yeni CD19 X CD3 Spesifik polipeptidler ve kullanımları |
| US7398119B2 (en) * | 1998-07-13 | 2008-07-08 | Childrens Hospital Los Angeles | Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
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| BRPI0415457A (pt) | 2003-10-16 | 2006-12-05 | Micromet Ag | constructo de ligação especìfico de cd3 citotoxicamente ativo, seu processo de produção, composição compreendendo o mesmo, seqüência de ácido nucléico, vetor, hospedeiro, seus usos na preparação de uma composição farmacêutica e kit compreendendo os mesmo |
| PL2520590T3 (pl) | 2007-04-03 | 2019-02-28 | Amgen Research (Munich) Gmbh | Domena wiążąca wykazująca krzyżową swoistość gatunkową |
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| EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
-
2019
- 2019-10-23 CA CA3115296A patent/CA3115296A1/en active Pending
- 2019-10-23 AU AU2019365102A patent/AU2019365102A1/en active Pending
- 2019-10-23 CN CN201980068986.7A patent/CN112912716A/zh active Pending
- 2019-10-23 MX MX2021004510A patent/MX2021004510A/es unknown
- 2019-10-23 EP EP19848831.4A patent/EP3870957A1/en active Pending
- 2019-10-23 US US17/284,551 patent/US20220128474A1/en active Pending
- 2019-10-23 SG SG11202103232WA patent/SG11202103232WA/en unknown
- 2019-10-23 TW TW108138146A patent/TW202033949A/zh unknown
- 2019-10-23 JP JP2021521530A patent/JP2022512775A/ja active Pending
- 2019-10-23 WO PCT/US2019/057513 patent/WO2020086635A1/en unknown
- 2019-10-23 KR KR1020217015045A patent/KR20210078531A/ko active Search and Examination
- 2019-10-23 BR BR112021007611-5A patent/BR112021007611A2/pt unknown
-
2021
- 2021-04-01 IL IL281977A patent/IL281977A/en unknown
- 2021-04-22 CL CL2021001024A patent/CL2021001024A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW202033949A (zh) | 2020-09-16 |
| EP3870957A1 (en) | 2021-09-01 |
| BR112021007611A2 (pt) | 2021-07-27 |
| CN112912716A (zh) | 2021-06-04 |
| IL281977A (en) | 2021-05-31 |
| AU2019365102A1 (en) | 2021-04-29 |
| WO2020086635A1 (en) | 2020-04-30 |
| JP2022512775A (ja) | 2022-02-07 |
| KR20210078531A (ko) | 2021-06-28 |
| CL2021001024A1 (es) | 2021-09-24 |
| US20220128474A1 (en) | 2022-04-28 |
| CA3115296A1 (en) | 2020-04-30 |
| SG11202103232WA (en) | 2021-05-28 |
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