AR082461A1 - Inmunoglobulinas con dominio variable dual y usos de las mismas - Google Patents

Inmunoglobulinas con dominio variable dual y usos de las mismas

Info

Publication number
AR082461A1
AR082461A1 ARP110102792A ARP110102792A AR082461A1 AR 082461 A1 AR082461 A1 AR 082461A1 AR P110102792 A ARP110102792 A AR P110102792A AR P110102792 A ARP110102792 A AR P110102792A AR 082461 A1 AR082461 A1 AR 082461A1
Authority
AR
Argentina
Prior art keywords
binding protein
fragment
agent
antigen
immunoassay
Prior art date
Application number
ARP110102792A
Other languages
English (en)
Inventor
Peter Isakson
Tariq Ghayur
Junjian Liu
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR082461A1 publication Critical patent/AR082461A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

El vector que lo comprende, una célula huésped, un método para producir una proteína de unión.Reivindicación 1: Una proteína de unión que une un par de antígenos, caracterizada porque comprende una cadena de polipéptidos, en donde dicha cadena de polipéptidos comprende: VD1-(X1)n-VD2-C-(X2)n en donde: VD1 es un primer dominio variable de la cadena pesada; VD2 es un segundo dominio variable de la cadena pesada; C es un dominio constante de la cadena pesada; X1 es un conector con la condición que no sea CH1; X2 es una región Fc; (X1)n es (X1)0 o (X1)1; y (X2)n es (X2)0 o (X2)1; en donde la proteína de unión tiene la capacidad de unirse a la IL-1b y a la IL-17. Reivindicación 29: Un conjugado de una proteína de unión, caracterizado porque comprende una proteína de unión de acuerdo con cualquiera de las reivindicaciones 1, 3, 6, 24 ó 25, donde dicho conjugado de proteína de unión comprende además una molécula de inmunoadhesión, un agente para obtener imágenes, un agente terapéutico y un agente citotóxico. Reivindicación 37: Un ácido nucleico aislado, caracterizado porque codifica una secuencia de aminoácidos de la proteína de unión de acuerdo con cualquiera de las reivindicaciones 1, 3, 6, 24 ó 25. Reivindicación 56: Una composición farmacéutica, caracterizada porque comprende la proteína de unión de cualquiera de las reivindicaciones 1 - 36 y 55, y un vehículo farmacéuticamente aceptable. Reivindicación 58: La composición farmacéutica de la reivindicación 57, caracterizada porque dicho agente terapéutico adicional es un agente terapéutico, un agente para determinar imágenes, un agente citotóxico, inhibidores de la angiogénesis; inhibidores de quinasa; bloqueantes de moléculas de co-estimulación; bloqueantes de moléculas de adhesión; un anticuerpo anticitoquina o un fragmento funcional del mismo; metotrexato; ciclosporina; rapamicina; FK506; una marca o informante detectable; un antagonista de TNF; un antirreumático; un relajante muscular, un narcótico, una droga antiinflamatoria no esteroide (NSAID), un analgésico, un anestésico, un sedante, un anestésico local, un bloqueante neuromuscular, un antimicrobiano, un antipsoriático, un corticosteriode, un esteroide anabólico, una eritropoyetina, una inmunización, una inmunoglobulina, un inmunosupresor, una hormona del crecimiento, una droga de reemplazo hormonal, un radiofármaco, un antidepresivo, un antipsicótico, un estimulante, una medicación para el asma, un b agonista, un esteroide inhalado, un esteroide oral, una epinefrina o un análogo, una citoquina o un antagonista de citoquina. Reivindicación 82: Un método para determinar la cantidad o la concentración de un antígeno o de un fragmento de éste en una muestra de prueba a través de un inmunoensayo, caracterizado porque (a) en el inmunoensayo se emplea al menos una proteína de unión y al menos una marca detectable y (b) el inmunoensayo comprende comparar la señal generada por la marca detectable con un control o un calibrador que comprende el antígeno o un fragmento de éste, donde el calibrador opcionalmente es parte de una serie de calibradores en la que cada calibrador difiere de los otros por la concentración del antígeno o de un fragmento de éste, y donde la al menos una proteína de unión comprende la proteína de unión de la reivindicación 1, 3, 6, 24, 25 ó 55.
ARP110102792A 2010-08-03 2011-08-02 Inmunoglobulinas con dominio variable dual y usos de las mismas AR082461A1 (es)

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