AU2001258567A1 - Humanised antibodies to the epidermal growth factor receptor - Google Patents

Humanised antibodies to the epidermal growth factor receptor

Info

Publication number
AU2001258567A1
AU2001258567A1 AU2001258567A AU5856701A AU2001258567A1 AU 2001258567 A1 AU2001258567 A1 AU 2001258567A1 AU 2001258567 A AU2001258567 A AU 2001258567A AU 5856701 A AU5856701 A AU 5856701A AU 2001258567 A1 AU2001258567 A1 AU 2001258567A1
Authority
AU
Australia
Prior art keywords
antibodies
growth factor
factor receptor
epidermal growth
humanised antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001258567A
Inventor
Linda Gillian Durrant
John Robert Maxwell Ellis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scancell Ltd
Original Assignee
Scancell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0011981A external-priority patent/GB0011981D0/en
Priority claimed from GB0020794A external-priority patent/GB0020794D0/en
Application filed by Scancell Ltd filed Critical Scancell Ltd
Publication of AU2001258567A1 publication Critical patent/AU2001258567A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/467—Igs with modifications in the FR-residues only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a humanised form of the antibody 340 obtainable from the cell line deposited with the ECACC under accession number 97021428. Such antibodies have been found to have an increased ability to kill cells compared to the murine antibody 340. Also provided are nucleic acids encoding such antibodies, as well as the use of the antibodies in medicine, in particular in the treatment of cancer.
AU2001258567A 2000-05-19 2001-05-21 Humanised antibodies to the epidermal growth factor receptor Abandoned AU2001258567A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0011981 2000-05-19
GB0011981A GB0011981D0 (en) 2000-05-19 2000-05-19 Complementary determining regions of antibodies that show amino acid homology with peptide ligand
GB0020794A GB0020794D0 (en) 2000-08-24 2000-08-24 Humanised antibodies
GB0020794 2000-08-24
PCT/GB2001/002226 WO2001088138A1 (en) 2000-05-19 2001-05-21 Humanised antibodies to the epidermal growth factor receptor

Publications (1)

Publication Number Publication Date
AU2001258567A1 true AU2001258567A1 (en) 2001-11-26

Family

ID=26244299

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001258567A Abandoned AU2001258567A1 (en) 2000-05-19 2001-05-21 Humanised antibodies to the epidermal growth factor receptor

Country Status (12)

Country Link
US (3) US20040091485A1 (en)
EP (1) EP1278851B1 (en)
JP (1) JP2003533987A (en)
KR (1) KR100480985B1 (en)
CN (1) CN1239701C (en)
AT (1) ATE316137T1 (en)
AU (1) AU2001258567A1 (en)
BR (1) BR0110927A (en)
CA (1) CA2409361A1 (en)
DE (1) DE60116753T2 (en)
ES (1) ES2259030T3 (en)
WO (1) WO2001088138A1 (en)

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US20060240003A1 (en) 2006-10-26
DE60116753T2 (en) 2006-09-14
WO2001088138A1 (en) 2001-11-22
US20080260735A1 (en) 2008-10-23
ES2259030T3 (en) 2006-09-16
EP1278851A1 (en) 2003-01-29
BR0110927A (en) 2003-03-11
CN1239701C (en) 2006-02-01
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KR20030021161A (en) 2003-03-12
CN1432063A (en) 2003-07-23

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