JP6373270B2 - 二重ｇｌｐ１／グルカゴンアゴニストとしてのエキセンディン−４誘導体 - Google Patents

二重ｇｌｐ１／グルカゴンアゴニストとしてのエキセンディン−４誘導体 Download PDF

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JP6373270B2
JP6373270B2 JP2015535054A JP2015535054A JP6373270B2 JP 6373270 B2 JP6373270 B2 JP 6373270B2 JP 2015535054 A JP2015535054 A JP 2015535054A JP 2015535054 A JP2015535054 A JP 2015535054A JP 6373270 B2 JP6373270 B2 JP 6373270B2
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carboxy
butyryl
amino acid
ethoxy
acid residue
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JP2015532297A5 (enExample
JP2015532297A (ja
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トールステン・ハーク
ミヒャエル・ワーグナー
ベルント・ヘンケル
ジークフリート・シュテンゲリン
アンドレアス・エバース
マルティン・ボスアルト
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    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
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JP2015535054A 2012-10-09 2013-10-08 二重ｇｌｐ１／グルカゴンアゴニストとしてのエキセンディン−４誘導体 Active JP6373270B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12306232 2012-10-09
EP12306232.5 2012-10-09
EP13305222 2013-02-27
EP13305222.5 2013-03-27
PCT/EP2013/070882 WO2014056872A1 (en) 2012-10-09 2013-10-08 Exendin-4 derivatives as dual glp1/glucagon agonists

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JP2015532297A JP2015532297A (ja) 2015-11-09
JP2015532297A5 JP2015532297A5 (enExample) 2016-11-24
JP6373270B2 true JP6373270B2 (ja) 2018-08-15

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US (3) US9365632B2 (enExample)
EP (1) EP2906595B1 (enExample)
JP (1) JP6373270B2 (enExample)
KR (1) KR102179751B1 (enExample)
CN (1) CN104837864B (enExample)
AR (1) AR092925A1 (enExample)
AU (1) AU2013328802B2 (enExample)
BR (1) BR112015007685A2 (enExample)
CA (1) CA2887272C (enExample)
CL (2) CL2015000811A1 (enExample)
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UA (1) UA116217C2 (enExample)
UY (1) UY35072A (enExample)
WO (1) WO2014056872A1 (enExample)
ZA (1) ZA201501694B (enExample)

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AR110299A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico
AR110301A1 (es) * 2016-12-02 2019-03-13 Sanofi Sa Compuestos como agonistas peptídicos de receptores de glp1 / glucagón / gip
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ES2953631T3 (es) 2017-08-09 2023-11-14 Sanofi Sa Agonistas del receptor de GLP-1/glucagón en el tratamiento de la enfermedad de la esteatosis hepática y la esteatohepatitis
ES3027617T3 (en) 2017-12-21 2025-06-16 Sanofi Sa Liquid pharmaceutical composition
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TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
CN110452952B (zh) * 2018-05-08 2024-01-16 宜昌东阳光长江药业股份有限公司 一种glp-1类似物生物活性的检测方法
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