PL2373681T3 - Kompozycje farmaceutyczne albiglutydu - Google Patents
Kompozycje farmaceutyczne albiglutyduInfo
- Publication number
- PL2373681T3 PL2373681T3 PL09832522T PL09832522T PL2373681T3 PL 2373681 T3 PL2373681 T3 PL 2373681T3 PL 09832522 T PL09832522 T PL 09832522T PL 09832522 T PL09832522 T PL 09832522T PL 2373681 T3 PL2373681 T3 PL 2373681T3
- Authority
- PL
- Poland
- Prior art keywords
- albiglutide
- pharmaceutical compositions
- pharmaceutical
- compositions
- Prior art date
Links
- OGWAVGNOAMXIIM-UHFFFAOYSA-N albiglutide Chemical group O=C(O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(N)CC=1(N=CNC=1))CCC(=O)O)C(O)C)CC2(=CC=CC=C2))C(O)C)CO)CC(=O)O)C(C)C)CO)CO)CC3(=CC=C(O)C=C3))CC(C)C)CCC(=O)O)CCC(=O)N)C)C)CCCCN)CCC(=O)O)CC4(=CC=CC=C4))C(CC)C)C)CC=6(C5(=C(C=CC=C5)NC=6)))CC(C)C)C(C)C)CCCCN)CCCNC(=N)N OGWAVGNOAMXIIM-UHFFFAOYSA-N 0.000 title 1
- 229960004733 albiglutide Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108700027806 rGLP-1 Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12122908P | 2008-12-10 | 2008-12-10 | |
| US15090909P | 2009-02-09 | 2009-02-09 | |
| US16399509P | 2009-03-27 | 2009-03-27 | |
| US23872309P | 2009-09-01 | 2009-09-01 | |
| EP09832522.8A EP2373681B1 (en) | 2008-12-10 | 2009-12-10 | Pharmaceutical compositions of albiglutide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2373681T3 true PL2373681T3 (pl) | 2017-07-31 |
Family
ID=42243062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09832522T PL2373681T3 (pl) | 2008-12-10 | 2009-12-10 | Kompozycje farmaceutyczne albiglutydu |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8748377B2 (pl) |
| EP (1) | EP2373681B1 (pl) |
| JP (1) | JP2012511586A (pl) |
| CY (1) | CY1118731T1 (pl) |
| DK (1) | DK2373681T3 (pl) |
| ES (1) | ES2620610T3 (pl) |
| HR (1) | HRP20170478T1 (pl) |
| HU (1) | HUE031900T2 (pl) |
| LT (1) | LT2373681T (pl) |
| PL (1) | PL2373681T3 (pl) |
| PT (1) | PT2373681T (pl) |
| SI (1) | SI2373681T1 (pl) |
| SM (1) | SMT201700189T1 (pl) |
| WO (1) | WO2010068735A1 (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2373681T3 (pl) | 2008-12-10 | 2017-07-31 | Glaxosmithkline Llc | Kompozycje farmaceutyczne albiglutydu |
| WO2011140176A1 (en) | 2010-05-04 | 2011-11-10 | Glaxosmithkline Llc | Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection |
| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| HRP20251088T1 (hr) | 2012-07-01 | 2025-11-07 | Novo Nordisk A/S | Upotreba dugodjelujućih peptida glp‑1 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| SG10201705097PA (en) | 2012-12-21 | 2017-07-28 | Sanofi Sa | Functionalized exendin-4 derivatives |
| US9849066B2 (en) | 2013-04-24 | 2017-12-26 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| LT3004155T (lt) | 2013-05-28 | 2021-12-27 | Takeda Pharmaceutical Company Limited | Peptidų junginys |
| US20140378374A1 (en) * | 2013-06-21 | 2014-12-25 | Glaxosmithkline Intellectual Property (No.2) Limited | Methods of treatment |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| WO2015200324A1 (en) * | 2014-06-25 | 2015-12-30 | Glaxosmithkline Llc | Pharmaceutical compositions |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| CN109477094B (zh) | 2016-05-24 | 2022-04-26 | 武田药品工业株式会社 | 肽化合物 |
| WO2019060653A1 (en) | 2017-09-22 | 2019-03-28 | Regeneron Pharmaceuticals, Inc. | GLP-1 RECEPTOR AGONISTS (GLUCAGON-LIKE PEPTIDE 1) AND USES THEREOF |
| IL322969A (en) | 2017-10-12 | 2025-10-01 | Novo Nordisk As | Semaglutide in medical therapy |
| KR20250075642A (ko) | 2022-09-21 | 2025-05-28 | 리제너론 파아마슈티컬스, 인크. | 비만, 당뇨병 및 간 기능 장애를 치료하는 방법 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69129226T2 (de) * | 1990-01-24 | 1998-07-30 | Douglas I. Woodside Calif. Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| ES2359031T3 (es) | 1996-08-08 | 2011-05-17 | Amylin Pharmaceuticals, Inc. | Composición farmacéutica que comprende un péptido de exendina-4. |
| US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| US6380357B2 (en) | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
| US7259136B2 (en) | 1999-04-30 | 2007-08-21 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treating peripheral vascular disease |
| US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| EP1180121B9 (en) | 1999-05-17 | 2004-09-08 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
| EP1076066A1 (en) * | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| WO2001089554A2 (en) | 2000-05-19 | 2001-11-29 | Bionebraska, Inc. | Treatment of acute coronary syndrome with glp-1 |
| PT1324776E (pt) | 2000-10-12 | 2009-12-23 | Genentech Inc | Formulações de proteína concentradas de viscosidade reduzida |
| WO2002034285A2 (en) | 2000-10-20 | 2002-05-02 | Coolidge Thomas R | Treatment of hibernating myocardium and diabetic cardiomyopathy with a glp-1 peptide |
| UA93662C2 (uk) | 2000-12-07 | 2011-03-10 | Эли Лилли Энд Компани | Гетерологічний пептидильований глюкагон-подібний білок та його застосування для виготовлення лікарського засобу для лікування пацієнтів, що страждають на ожиріння або інсулінонезалежний цукровий діабет |
| EP1390061A2 (en) | 2000-12-13 | 2004-02-25 | Eli Lilly And Company | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| AR036711A1 (es) | 2001-10-05 | 2004-09-29 | Bayer Corp | Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico |
| HUP0700151A2 (en) | 2001-10-18 | 2007-05-29 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
| AU2002364587A1 (en) | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
| MXPA04006679A (es) | 2002-01-08 | 2004-11-10 | Lilly Co Eli | Analogos extendidos de peptido-1 de tipo glucagon. |
| JP2005535569A (ja) | 2002-04-04 | 2005-11-24 | ノボ・ノルデイスク・エー/エス | Glp−1アゴニスト及び心臓血管合併症 |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| EP1610811A4 (en) | 2002-12-17 | 2008-03-26 | Amylin Pharmaceuticals Inc | PREVENTION AND TREATMENT OF CARDIAC ARRHYTHMIAS |
| EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | HYBRID PROTEINS OF ALBUMIN |
| EP1729795B1 (en) | 2004-02-09 | 2016-02-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP2008501765A (ja) | 2004-06-11 | 2008-01-24 | ノボ ノルディスク アクティーゼルスカブ | Glp−1アゴニストを用いた薬剤誘発性肥満の中和 |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| CA2592065A1 (en) | 2004-12-22 | 2007-04-26 | Centocor, Inc. | Glp-1 agonists, compositions, methods and uses |
| AU2005323063B2 (en) | 2004-12-24 | 2011-01-27 | Amylin Pharmaceuticals, Llc | Use of GLP-1 and agonists thereof to prevent cardiac myocyte apoptosis |
| WO2006105527A2 (en) | 2005-03-31 | 2006-10-05 | Amylin Pharmaceuticals, Inc. | Amylin and amylin agonists for treating psychiatric diseases and disorders |
| US20080200383A1 (en) * | 2005-04-08 | 2008-08-21 | Amylin Pharmaceuticals, Inc. | Pharmaceutical Formulations Comprising Incretin Peptide and Aprotic Polar Solvent |
| US8946149B2 (en) | 2005-04-11 | 2015-02-03 | Amylin Pharmaceuticals, Llc | Use of exendin and analogs thereof to delay or prevent cardiac remodeling |
| JP2009514900A (ja) | 2005-11-04 | 2009-04-09 | スミスクライン・ビーチャム・コーポレイション | 血糖降下剤の投与方法 |
| KR20090031368A (ko) | 2006-05-26 | 2009-03-25 | 아밀린 파마슈티칼스, 인크. | 울혈성 심부전 치료용 조성물 및 방법 |
| EP2021014A1 (en) | 2006-05-26 | 2009-02-11 | Brystol-Myers Squibb Company | Sustained release glp-1 receptor modulators |
| BRPI0714334A2 (pt) | 2006-07-18 | 2013-05-14 | Centocor Inc | mimeticorpos de glp-1 humano aperfeiÇoados, composiÇÕes, mÉtodos e usos |
| WO2008019143A2 (en) | 2006-08-04 | 2008-02-14 | Amylin Pharmaceuticals, Inc | Use of exendins and glp-i receptor agonists for altering lipoprotein particle size and subclass composition |
| PE20121528A1 (es) * | 2006-09-13 | 2012-12-12 | Smithkline Beecham Corp | Metodos para administrar agentes hipoglucemiantes de larga duracion |
| EP2163243A1 (en) | 2008-09-12 | 2010-03-17 | Biocompatibles UK Limited | Treatment of acute myocardial infarction (AMI) using encapsulated cells encoding and secreting GLP-1 peptides or analogs thereof |
| PL2373681T3 (pl) | 2008-12-10 | 2017-07-31 | Glaxosmithkline Llc | Kompozycje farmaceutyczne albiglutydu |
-
2009
- 2009-12-10 PL PL09832522T patent/PL2373681T3/pl unknown
- 2009-12-10 LT LTEP09832522.8T patent/LT2373681T/lt unknown
- 2009-12-10 HR HRP20170478TT patent/HRP20170478T1/hr unknown
- 2009-12-10 SM SM20170189T patent/SMT201700189T1/it unknown
- 2009-12-10 EP EP09832522.8A patent/EP2373681B1/en active Active
- 2009-12-10 DK DK09832522.8T patent/DK2373681T3/en active
- 2009-12-10 ES ES09832522.8T patent/ES2620610T3/es active Active
- 2009-12-10 SI SI200931639A patent/SI2373681T1/sl unknown
- 2009-12-10 JP JP2011540882A patent/JP2012511586A/ja active Pending
- 2009-12-10 US US13/133,976 patent/US8748377B2/en not_active Expired - Fee Related
- 2009-12-10 HU HUE09832522A patent/HUE031900T2/en unknown
- 2009-12-10 PT PT98325228T patent/PT2373681T/pt unknown
- 2009-12-10 WO PCT/US2009/067469 patent/WO2010068735A1/en not_active Ceased
-
2014
- 2014-04-25 US US14/261,641 patent/US20140228284A1/en not_active Abandoned
- 2014-04-25 US US14/261,602 patent/US20140228288A1/en not_active Abandoned
-
2017
- 2017-03-16 CY CY20171100337T patent/CY1118731T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2373681T3 (en) | 2017-04-24 |
| EP2373681A4 (en) | 2013-11-06 |
| HRP20170478T1 (hr) | 2017-05-19 |
| ES2620610T3 (es) | 2017-06-29 |
| EP2373681B1 (en) | 2017-01-18 |
| LT2373681T (lt) | 2017-04-10 |
| US8748377B2 (en) | 2014-06-10 |
| US20140228288A1 (en) | 2014-08-14 |
| PT2373681T (pt) | 2017-04-11 |
| US20140228284A1 (en) | 2014-08-14 |
| US20110301080A1 (en) | 2011-12-08 |
| CY1118731T1 (el) | 2017-07-12 |
| JP2012511586A (ja) | 2012-05-24 |
| HUE031900T2 (en) | 2017-08-28 |
| WO2010068735A1 (en) | 2010-06-17 |
| SI2373681T1 (sl) | 2017-05-31 |
| SMT201700189T1 (it) | 2017-05-08 |
| EP2373681A1 (en) | 2011-10-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT2373681T (pt) | Composições farmacêuticas de albiglutida | |
| GB0814695D0 (en) | Pharmaceutical compositions | |
| PT2323623T (pt) | Composições farmacêuticas | |
| IL228817A0 (en) | Pharmaceutical compounds | |
| IL211886A0 (en) | Solid pharmaceutical composition | |
| IL208387A0 (en) | Pharmaceutical composition | |
| ZA201104670B (en) | Pharmaceutical composition comprising aleglitazar | |
| ZA201100871B (en) | Solid pharmaceutical composition | |
| EP2296687A4 (en) | PHARMACEUTICAL COMPOSITIONS OF SOMATOSTATIN DOPAMINE CONJUGATES | |
| ZA201006224B (en) | Pharmaceutical composition | |
| ZA201101053B (en) | Pharmaceutical compositions of samatotrophic hormones | |
| IL206487A0 (en) | Pharmaceutical compositions | |
| GB2464200B (en) | Pharmaceutical composition | |
| GB0902648D0 (en) | Pharmaceutical compounds and compositions | |
| GB0817969D0 (en) | Pharmaceutical composition | |
| GB0908317D0 (en) | Pharmaceutical compounds and compositions | |
| GB0800659D0 (en) | Pharmaceutical Compositions | |
| EP2236135A4 (en) | STABLE PHARMACEUTICAL COMPOSITION | |
| GB0805807D0 (en) | Novel pharmaceutical compositions | |
| GB0804485D0 (en) | Novel pharmaceutical compositions | |
| GB0806156D0 (en) | Pharmaceutical compositions | |
| GB0802024D0 (en) | Pharmaceutical compositions | |
| GB0806283D0 (en) | Pharmaceutical compositions | |
| EP2308842A4 (en) | PHARMACEUTICAL COMPOSITIONS | |
| HU0800741D0 (en) | Improved pharmaceutical composition |