JP6326053B2 - 抗線維性ピリジノン - Google Patents
抗線維性ピリジノン Download PDFInfo
- Publication number
- JP6326053B2 JP6326053B2 JP2015534817A JP2015534817A JP6326053B2 JP 6326053 B2 JP6326053 B2 JP 6326053B2 JP 2015534817 A JP2015534817 A JP 2015534817A JP 2015534817 A JP2015534817 A JP 2015534817A JP 6326053 B2 JP6326053 B2 JP 6326053B2
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- group
- item
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261709075P | 2012-10-02 | 2012-10-02 | |
| US61/709,075 | 2012-10-02 | ||
| US201361777499P | 2013-03-12 | 2013-03-12 | |
| US61/777,499 | 2013-03-12 | ||
| US201361872157P | 2013-08-30 | 2013-08-30 | |
| US61/872,157 | 2013-08-30 | ||
| PCT/US2013/062910 WO2014055548A1 (en) | 2012-10-02 | 2013-10-01 | Anti-fibrotic pyridinones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018077667A Division JP6744355B2 (ja) | 2012-10-02 | 2018-04-13 | 抗線維性ピリジノン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016500661A JP2016500661A (ja) | 2016-01-14 |
| JP2016500661A5 JP2016500661A5 (enExample) | 2016-11-10 |
| JP6326053B2 true JP6326053B2 (ja) | 2018-05-16 |
Family
ID=50435378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534817A Active JP6326053B2 (ja) | 2012-10-02 | 2013-10-01 | 抗線維性ピリジノン |
| JP2018077667A Active JP6744355B2 (ja) | 2012-10-02 | 2018-04-13 | 抗線維性ピリジノン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018077667A Active JP6744355B2 (ja) | 2012-10-02 | 2018-04-13 | 抗線維性ピリジノン |
Country Status (35)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017512784A (ja) * | 2014-04-02 | 2017-05-25 | インターミューン, インコーポレイテッド | 抗線維性ピリジノン |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
| PT2861566T (pt) | 2012-06-13 | 2017-02-08 | Hoffmann La Roche | Novos diazaspirocicloalcanos e azaspirocicloalcanos |
| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
| AU2013322838B2 (en) | 2012-09-25 | 2018-02-01 | F. Hoffmann-La Roche Ag | New bicyclic derivatives |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| US9315464B1 (en) * | 2013-01-31 | 2016-04-19 | Nant Holdings Ip, Llc | Small molecule inhibitors of influenza A RNA-dependent RNA polymerase |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| AU2014356583B2 (en) | 2013-11-26 | 2019-02-28 | F. Hoffmann-La Roche Ag | New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl |
| EP4491180A1 (en) | 2014-01-10 | 2025-01-15 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| WO2015144609A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| AU2015238537B2 (en) | 2014-03-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| CA2953177C (en) | 2014-06-23 | 2019-07-23 | Dr. Reddy's Laboratories Ltd. | Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain |
| MA40940A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| MA40943A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| CN107108613B (zh) | 2014-11-10 | 2020-02-25 | 基因泰克公司 | 布罗莫结构域抑制剂及其用途 |
| JP6709792B2 (ja) | 2015-01-29 | 2020-06-17 | ジェネンテック, インコーポレイテッド | 治療用化合物およびその使用 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| EP3334717B1 (en) | 2015-08-11 | 2020-07-01 | Neomed Institute | Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals |
| WO2017024406A1 (en) | 2015-08-11 | 2017-02-16 | Neomed Institute | N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals |
| WO2017024412A1 (en) | 2015-08-12 | 2017-02-16 | Neomed Institute | Substituted benzimidazoles, their preparation and their use as pharmaceuticals |
| CN105085383B (zh) * | 2015-08-19 | 2017-09-01 | 四川大学 | 5‑甲基‑2(1h)吡啶酮衍生物及其制备方法和用途 |
| UA123362C2 (uk) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильні похідні |
| CR20180072A (es) | 2015-09-24 | 2018-02-26 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de atx |
| KR20180053408A (ko) | 2015-09-24 | 2018-05-21 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물 |
| CR20180057A (es) | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca. |
| AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| US10501459B2 (en) | 2015-10-21 | 2019-12-10 | Neomed Institute | Substituted imidazo[1,2-a]pyridines as bromodomain inhibitors |
| JP2018531266A (ja) * | 2015-10-22 | 2018-10-25 | セルビタ エス.エー. | ピリドン誘導体およびキナーゼ阻害剤としてのその使用 |
| US20180319813A1 (en) * | 2015-11-04 | 2018-11-08 | Idemitsu Kosan Co., Ltd | Benzimidazole fused heteroaryls |
| CN105330598B (zh) * | 2015-12-02 | 2017-11-14 | 新发药业有限公司 | 一种吡非尼酮的制备方法 |
| WO2017127930A1 (en) | 2016-01-28 | 2017-08-03 | Neomed Institute | Substituted [1,2,4]triazolo[4,3-a]pyridines, their preparation and their use as pharmaceuticals |
| CN105732497B (zh) * | 2016-02-02 | 2019-02-01 | 浙江工业大学 | 2-芳基-4-甲基环并吡啶-1(2h)-酮类衍生物及其合成方法与应用 |
| CN105541715B (zh) * | 2016-02-02 | 2019-04-09 | 浙江工业大学 | 多取代吡啶-1(2h)-酮衍生物及其合成方法与应用 |
| JP6923634B2 (ja) * | 2016-04-14 | 2021-08-25 | クワンチョウ ジョーヨー ファーマテック カンパニー,リミティド | 線維化および炎症性疾患を治療するためのヘテロ原子含有シクロブタン置換基を有するピリドン誘導体 |
| WO2017177955A1 (en) | 2016-04-15 | 2017-10-19 | Abbvie Inc. | Bromodomain inhibitors |
| WO2018019755A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| WO2018019721A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| CN116023327A (zh) * | 2016-08-08 | 2023-04-28 | 北京康蒂尼药业股份有限公司 | 一种羟尼酮的制备方法 |
| CN116082225A (zh) * | 2016-08-08 | 2023-05-09 | 北京康蒂尼药业股份有限公司 | 一种羟尼酮的制备方法 |
| GB201614934D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Chemical compounds |
| US11207304B2 (en) | 2016-11-30 | 2021-12-28 | Genentech, Inc. | Methods of administering anti-fibrotic therapy |
| SG11201908560SA (en) | 2017-03-16 | 2019-10-30 | Hoffmann La Roche | Heterocyclic compounds useful as dual atx/ca inhibitors |
| CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
| US10617680B2 (en) * | 2017-04-18 | 2020-04-14 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| CA3108048A1 (en) * | 2017-07-31 | 2019-02-07 | Washington University | Pirfenidone derivatives for modulation of b lymphocyte activity and organ protection |
| MX366086B (es) | 2017-08-15 | 2019-06-27 | Cell Therapy And Tech S A De C V | Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel. |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| EP3459939A1 (en) | 2017-09-26 | 2019-03-27 | Pragma Therapeutics | Novel heterocyclic compounds as modulators of mglur7 |
| WO2019072236A1 (zh) * | 2017-10-13 | 2019-04-18 | 石家庄智康弘仁新药开发有限公司 | 一种吡啶酮化合物的晶型、盐型及其制备方法 |
| SI3746441T1 (sl) * | 2018-02-02 | 2023-08-31 | Genentech Inc. | Farmacevtska spojina, njene soli, njene formulacije ter postopki izdelave in uporabe le-teh |
| EP3830093A1 (en) | 2018-07-27 | 2021-06-09 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
| US11171132B2 (en) * | 2019-10-03 | 2021-11-09 | Globalfoundries U.S. Inc. | Bi-directional breakdown silicon controlled rectifiers |
| EP4069227A1 (en) | 2019-12-04 | 2022-10-12 | Idorsia Pharmaceuticals Ltd | Combination of an azetidine lpa1 receptor antagonist with pirfenidone and/or nintedanib for use in the treatment of fibrotic diseases |
| US11897930B2 (en) | 2020-04-28 | 2024-02-13 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| AU2021314416B2 (en) * | 2020-07-23 | 2024-10-31 | Cytosinlab Therapeutics Co., Ltd. | Compound having kinase inhibitory activity |
| CN114129517A (zh) * | 2020-09-03 | 2022-03-04 | 苏州爱科百发生物医药技术有限公司 | 一种ak3287制剂及其制备方法和应用 |
| KR20230152692A (ko) * | 2021-02-02 | 2023-11-03 | 리미널 바이오사이언시스 리미티드 | Gpr84 길항제 및 이의 용도 |
| CN115364097B (zh) * | 2021-05-20 | 2023-07-25 | 广州嘉越医药科技有限公司 | 一种含杂原子环丁烷取代基的吡啶酮衍生物的应用 |
| CN113234013B (zh) * | 2021-05-21 | 2022-05-24 | 杭州医学院 | 一种抑制胶原合成和沉积的化合物及其应用 |
| KR20240133695A (ko) * | 2021-12-10 | 2024-09-04 | 프로테나 바이오사이언시즈 리미티드 | Dyrk1a 억제제로서의 헤테로시클릭 화합물 |
| CN116332947A (zh) * | 2021-12-24 | 2023-06-27 | 上海海和药物研究开发股份有限公司 | 具有mat2a抑制活性的嘧啶-2(1h)-酮并二环类化合物及其用途 |
| CN116514803A (zh) * | 2022-01-21 | 2023-08-01 | 上海赛岚生物科技有限公司 | 一种激酶抑制剂的盐晶型和自由碱晶型 |
| CN115925624B (zh) * | 2022-12-12 | 2025-06-27 | 浙江工业大学 | N-芳基-多元环并[c]-2-吡啶酮衍生物、合成方法及其应用 |
| WO2025209440A1 (zh) * | 2024-04-02 | 2025-10-09 | 广州嘉越医药科技有限公司 | 一种吡啶酮衍生物的药物组合物及其应用 |
Family Cites Families (558)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070639B (de) | 1959-12-10 | Farbenfabriken Bayer Aktiengesellschaft, Levenkusen-Bayerwerk | Verfahren zur Herstellung von Peptiderj | |
| DE149666C (enExample) | ||||
| CH312531A (de) | 1952-06-20 | 1955-12-31 | Ciba Geigy | Verfahren zur Herstellung eines Pyridazons. |
| CH312530A (de) | 1952-06-20 | 1955-12-31 | Ciba Geigy | Verfahren zur Herstellung eines Pyridazons. |
| GB788393A (en) | 1953-04-30 | 1958-01-02 | Ciba Ltd | Process for the manufacture of pyridazone compounds |
| CH333366A (de) | 1953-09-04 | 1958-10-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyridazone |
| DE1070639C2 (enExample) | 1958-09-30 | 1964-04-16 | ||
| US3014034A (en) | 1959-01-22 | 1961-12-19 | Ciba Pharm Prod Inc | 1, 3-diaryl, 5-amino-pyridazinones |
| GB889317A (en) | 1959-01-22 | 1962-02-14 | Ciba Ltd | New phenyl-diazines and a process for their manufacture |
| JPS422264Y1 (enExample) | 1966-08-10 | 1967-02-10 | ||
| US3622340A (en) | 1968-08-12 | 1971-11-23 | Eastman Kodak Co | 4-thiouracil compounds as fog inhibitors |
| US3644375A (en) * | 1968-10-18 | 1972-02-22 | Toray Industries | Lactam dicarboxylic acids and process for producing them |
| GB1237031A (en) * | 1969-03-07 | 1971-06-30 | Toray Industries | Lactam dicarboxylic acids and a process for their production |
| UST866035I4 (en) | 1969-05-05 | 1969-09-30 | Defensive publication | |
| FR2081572B1 (enExample) * | 1970-03-12 | 1973-04-06 | Rhone Poulenc Sa | |
| BE787523A (fr) | 1971-08-13 | 1973-02-12 | Chem Pharmac Fabrik Dr Hermann | Medicament a base de pyridone-2 |
| DE2143744A1 (de) | 1971-09-01 | 1973-03-08 | Hoechst Ag | 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung |
| GB1458048A (en) | 1972-12-18 | 1976-12-08 | Affiliated Med Res | Pharmaceutical composition |
| CA1049411A (en) | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| US3839346A (en) | 1972-12-18 | 1974-10-01 | Affiliated Med Res | N-substituted pyridone and general method for preparing pyridones |
| US4052509A (en) | 1972-12-18 | 1977-10-04 | Affiliated Medical Research, Inc. | Method for reducing serum uric acid levels |
| US4042699A (en) | 1972-12-18 | 1977-08-16 | Affiliated Medical Research, Inc. | Method for reducing serum glucose levels |
| AT333774B (de) | 1974-09-24 | 1976-12-10 | Chemie Linz Ag | Verfahren zur herstellung von 3-phenylpyridazonen |
| JPS51128438A (en) | 1975-04-26 | 1976-11-09 | Yamanouchi Pharmaceut Co Ltd | An antibacterial drug against fish diseases |
| DE2557342A1 (de) | 1975-12-19 | 1977-06-30 | Hoechst Ag | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
| US4258052A (en) | 1976-08-17 | 1981-03-24 | Yu Ruey J | Treatment of psoriasis with nicotinamide analogues |
| DE2707268A1 (de) | 1977-02-19 | 1978-08-31 | Hoechst Ag | Indol-3-carbaldehyd-oxime und verfahren zu ihrer herstellung |
| GB1596887A (en) | 1977-07-15 | 1981-09-03 | Rohm & Haas | 2-pyridone derivatives and their use as plant growth regulators |
| JPS557201A (en) | 1978-05-23 | 1980-01-19 | Shionogi & Co Ltd | Derivative of tetrahydrothiopyrano(2,3-b)indole |
| GB2042562B (en) | 1979-02-05 | 1983-05-11 | Sandoz Ltd | Stabilising polymers |
| DD149666A1 (de) | 1979-06-27 | 1981-07-22 | Karl Gewald | Verfahren zur herstellung von 6-amino-und 6-hydroxy-1-aryl-5-cyan-2(1h)-pyridinonen und-thionen |
| JPS5721388A (en) | 1980-07-11 | 1982-02-04 | Nippon Nohyaku Co Ltd | Condensed pyrazole derivative |
| JPS5777671A (en) | 1980-10-31 | 1982-05-15 | Yasumitsu Tamura | Preparation of hydroxyindoles ( or 1,4-dihydroisoquinolones) and their intermediate |
| US4404203A (en) | 1981-05-14 | 1983-09-13 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| US4476307A (en) | 1982-09-20 | 1984-10-09 | Pfizer Inc. | Heteroylidene indolone compounds |
| US4473696A (en) | 1982-10-07 | 1984-09-25 | Ici Americas Inc. | Synthesis of 2-substituted-5-methyl-pyridines |
| US4645839A (en) | 1982-12-17 | 1987-02-24 | Ici Americas Inc. | Sulphur dehydrogenation process to yield 5-methyl-2-pyridone |
| US4650804A (en) | 1984-03-30 | 1987-03-17 | Fujisawa Pharmaceutical Co., Ltd. | Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents |
| US4576942A (en) | 1984-07-12 | 1986-03-18 | Usv Pharmaceutical Corp. | Anti-allergic and anti-inflammatory bi- and tri- cyclo-1,4-thiazine derivatives, composition, and method of use therefor |
| EP0323441B1 (en) * | 1984-10-30 | 1996-04-24 | Otsuka Pharmaceutical Co., Ltd. | 5-Fluorouracil derivatives |
| EP0180188B1 (en) * | 1984-10-30 | 1992-04-15 | Otsuka Pharmaceutical Co., Ltd. | A composition for increasing the anti-cancer activity of an anti-cancer compound |
| JPS6256187A (ja) | 1985-09-05 | 1987-03-11 | Ricoh Co Ltd | 感熱記録材料 |
| US4760083A (en) | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
| US5173489A (en) | 1986-04-10 | 1992-12-22 | The Dupont Merck Pharmaceutical Co. | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers |
| GB8621217D0 (en) | 1986-09-03 | 1986-10-08 | Ici Plc | Chemical compounds |
| DE3805746C2 (de) | 1987-03-05 | 2003-04-10 | Clariant Finance Bvi Ltd | 1:2-Chromkomplexfarbstoffe |
| JPS63290821A (ja) | 1987-05-25 | 1988-11-28 | Otsuka Pharmaceut Co Ltd | 抗不整脈剤 |
| DK641487A (da) | 1987-12-07 | 1989-06-08 | Gluetech Aps | Fremgangsmaade til modificering af polymeroverflader |
| DE3807295A1 (de) | 1988-03-05 | 1989-09-14 | Basf Ag | Neue n-heteroaryl-tetrahydrophthalimidverbindungen |
| JP2614081B2 (ja) | 1988-05-27 | 1997-05-28 | 大塚化学株式会社 | 光学活性β−ラクタム誘導体の製造法 |
| JPH022264A (ja) | 1988-06-14 | 1990-01-08 | Canon Inc | メツセージ通信システム |
| US5167941A (en) | 1988-11-29 | 1992-12-01 | The Dow Chemical Company | Quaternary polyamines as sulfite oxidation inhibitors in amine scrubbing of SO2 |
| US5019365A (en) | 1988-11-29 | 1991-05-28 | The Dow Chemical Company | Quaternary polyamines as sulfite oxidation inhibitors |
| GB8901836D0 (en) | 1989-01-27 | 1989-03-15 | Sobio Lab | Compounds |
| US5047554A (en) | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| US5077142A (en) | 1989-04-20 | 1991-12-31 | Ricoh Company, Ltd. | Electroluminescent devices |
| FI920023A7 (fi) | 1989-07-07 | 1992-01-03 | Pfizer | Heteroaryylipiperatsiiniyhdisteet antipsykootteina |
| JPH0343744A (ja) | 1989-07-12 | 1991-02-25 | Hitachi Chem Co Ltd | 電子写真感光体 |
| US5518729A (en) | 1989-11-22 | 1996-05-21 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5716632A (en) | 1989-11-22 | 1998-02-10 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5310562A (en) | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| JPH05505610A (ja) | 1990-03-27 | 1993-08-19 | スミスクライン・ビーチャム・コーポレイション | 5―リポキシゲナーゼ阻害剤 |
| JPH0444235A (ja) | 1990-06-08 | 1992-02-14 | New Japan Radio Co Ltd | 高速バイポーラトランジスタの製造方法 |
| JPH0449567A (ja) | 1990-06-19 | 1992-02-18 | Matsushita Electric Ind Co Ltd | 磁気記録再生装置 |
| ATE180475T1 (de) | 1990-09-21 | 1999-06-15 | Rohm & Haas | Dihydropyridazinone und pyridazinone als fungizide |
| JPH04223457A (ja) | 1990-12-26 | 1992-08-13 | Konica Corp | ハロゲン化銀写真感光材料 |
| AU1191292A (en) | 1991-02-11 | 1992-09-07 | Schering Agrochemicals Limited | Imidazole pesticides |
| US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
| AU658646B2 (en) | 1991-05-10 | 1995-04-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| WO1992020816A1 (en) | 1991-05-15 | 1992-11-26 | Yale University | Determination of prodrugs metabolizable by the liver and therapeutic use thereof |
| JPH0519023A (ja) | 1991-07-11 | 1993-01-26 | Hitachi Ltd | 集積回路装置 |
| DE69115692T2 (de) | 1991-09-10 | 1996-08-01 | Agfa Gevaert Nv | Thermisch übertragbare fluoreszierende Verbindungen |
| EP0548680B1 (en) | 1991-12-26 | 1998-02-25 | Mitsubishi Chemical Corporation | Beta-oxo-beta-benzenepropanethioamide derivatives |
| US5241065A (en) | 1992-02-25 | 1993-08-31 | Schering Corporation | 2,3,4,5-tetrahydro-1h-3-benzazepines having anti-psychotic activity |
| JPH07507772A (ja) | 1992-04-16 | 1995-08-31 | ザ・デュポン・メルク・ファーマシュウティカル・カンパニー | 認識欠損治療用の置換された窒素含有スピロ化合物 |
| AU4376893A (en) | 1992-05-19 | 1993-12-13 | Immunopharmaceutics, Inc. | Compounds that modulate endothelin activity |
| DE4237656A1 (de) | 1992-06-13 | 1993-12-16 | Merck Patent Gmbh | Benzimidazolderivate |
| US5459269A (en) * | 1992-06-18 | 1995-10-17 | North Carolina State University | 14-halo-camptothecins |
| CA2099743A1 (en) | 1992-07-02 | 1994-01-03 | Akihiko Ishida | Pyridazinone derivatives and processes for preparing the same |
| US5457099A (en) | 1992-07-02 | 1995-10-10 | Sawai Pharmaceutical Co., Ltd. | Carbostyril derivatives and antiallergic agent |
| US5877278A (en) * | 1992-09-24 | 1999-03-02 | Chiron Corporation | Synthesis of N-substituted oligomers |
| US5356904A (en) | 1992-10-07 | 1994-10-18 | Merck & Co., Inc. | Carbostyril oxytocin receptor antagonists |
| DE4242451A1 (de) | 1992-12-16 | 1994-06-23 | Basf Ag | Verfahren zur Herstellung von 5-Ringheterocyclen |
| AU5891494A (en) | 1993-01-29 | 1994-08-15 | Nippon Soda Co., Ltd. | Heterocyclic derivative |
| JPH06256187A (ja) | 1993-03-02 | 1994-09-13 | Fujisawa Pharmaceut Co Ltd | キノリジノン化合物またはその塩を含有する鎮咳・去痰剤 |
| DE69431433T2 (de) | 1993-05-07 | 2003-12-04 | Solomon B. Margolin | Zusammensetzungen und verfahren zur reparatur und vorbeugung fibrotischer verletzungen |
| JP3507124B2 (ja) | 1993-05-26 | 2004-03-15 | 塩野義製薬株式会社 | ベンジリデン誘導体の製造法 |
| DE4423934A1 (de) | 1993-09-02 | 1995-03-09 | Basf Ag | 3(2H)-Pyridazinon-Derivate, Verfahren zu ihrer Herstellung und Verwendung |
| RU2146674C1 (ru) | 1993-10-15 | 2000-03-20 | Такеда Кемикал Индастриз, Лтд. | Производные триазина, способы их получения, антипротозойная композиция, добавка в пищу животных, способ ингибирования протозои у животных |
| JPH07128793A (ja) | 1993-11-05 | 1995-05-19 | Konica Corp | 染料の固体微粒子分散物および該分散物を含有するハロゲン化銀写真感光材料 |
| JP2649610B2 (ja) | 1993-11-10 | 1997-09-03 | 日本たばこ産業株式会社 | クロマン誘導体及びその医薬用途 |
| EP0734398B1 (en) | 1993-12-15 | 2002-02-27 | Smithkline Beecham Corporation | Compounds and methods |
| JPH07233072A (ja) | 1993-12-28 | 1995-09-05 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| EP0737193A1 (en) | 1993-12-29 | 1996-10-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine adenosine antagonists |
| JP3781200B2 (ja) | 1994-04-27 | 2006-05-31 | コニカミノルタホールディングス株式会社 | ハロゲン化銀写真感光材料の処理方法 |
| JP3261641B2 (ja) | 1994-04-28 | 2002-03-04 | コニカ株式会社 | ハロゲン化銀写真感光材料の処理方法 |
| US5466697A (en) | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
| JP2794392B2 (ja) | 1994-07-22 | 1998-09-03 | 大同テック株式会社 | 高圧ガス容器の保守装置 |
| JPH08134371A (ja) | 1994-11-02 | 1996-05-28 | Konica Corp | 固体微粒子分散物及びハロゲン化銀写真感光材料及び画像形成方法 |
| EP0717143A1 (de) | 1994-12-16 | 1996-06-19 | Lignozym GmbH | Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung |
| US6323201B1 (en) | 1994-12-29 | 2001-11-27 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
| US6090822A (en) | 1995-03-03 | 2000-07-18 | Margolin; Solomon B. | Treatment of cytokine growth factor caused disorders |
| AU697742B2 (en) | 1995-03-03 | 1998-10-15 | Intermune, Inc. | Treatment of cytokine growth factor caused disorders |
| US6114353A (en) | 1995-03-03 | 2000-09-05 | Margolin; Solomon B. | Compositions and method for treatment of lymphomas, leukemias, and leiomyomas |
| US5869428A (en) | 1995-03-13 | 1999-02-09 | Ishihara Sangyo Kaisha Ltd. | Pyridonesulfonylurea compounds, process for their production and herbicides containing them |
| US5635494A (en) | 1995-04-21 | 1997-06-03 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides |
| WO1996033994A1 (en) | 1995-04-28 | 1996-10-31 | Nippon Soda Co., Ltd. | Amino-substituted derivatives, process for the preparation thereof, and herbicide |
| DE19520613A1 (de) | 1995-06-06 | 1996-12-12 | Bayer Ag | Phenylpyridazinone |
| JPH0933072A (ja) | 1995-07-18 | 1997-02-07 | Hitachi Ltd | 蓄熱水槽及びマルチ氷蓄熱ユニット |
| EP0843660A1 (en) | 1995-07-31 | 1998-05-27 | Novo Nordisk A/S | Heterocyclic compounds, their preparation and use |
| EP0842176A1 (en) | 1995-07-31 | 1998-05-20 | Novo Nordisk A/S | Heterocyclic compounds, their preparation and use |
| AR003978A1 (es) | 1995-08-25 | 1998-09-30 | Rohm & Haas | Composiciones de acidos grasos y piridazinonas que tienen efectos fungitoxicos sinergicos y metodos para controlar hongos. |
| US5962478A (en) | 1995-09-19 | 1999-10-05 | Margolin; Solomon B. | Inhibition of tumor necrosis factor α |
| WO1997010712A1 (en) | 1995-09-19 | 1997-03-27 | Margolin Solomon B | Inhibition of tumor necrosis factor alpha |
| DE19535501A1 (de) | 1995-09-25 | 1997-03-27 | Bayer Ag | Pyridonmethidazofarbstoffe |
| JPH0995165A (ja) | 1995-09-29 | 1997-04-08 | Tachi S Co Ltd | シートの前後チルト機構 |
| JPH0995166A (ja) | 1995-10-02 | 1997-04-08 | Tatsuya Mikami | 乗物用座席 |
| JPH09249567A (ja) | 1996-01-12 | 1997-09-22 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
| JPH09204932A (ja) | 1996-01-25 | 1997-08-05 | Fujitsu Ltd | リチウム二次電池用電解液及びリチウム二次電池 |
| IT1286545B1 (it) | 1996-02-09 | 1998-07-15 | Antonio Guarna | Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi |
| JPH09244235A (ja) | 1996-03-14 | 1997-09-19 | Toshiba Corp | アルカリ現像用レジスト |
| GB9607503D0 (en) | 1996-04-11 | 1996-06-12 | Merck Frosst Canada Inc | Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors |
| EP0889878B1 (en) | 1996-03-29 | 2002-09-04 | Merck Frosst Canada & Co. | Bisarylcyclobutene derivates as cyclooxygenase inhibitors |
| JPH09319023A (ja) | 1996-05-27 | 1997-12-12 | Fuji Photo Film Co Ltd | 感熱記録材料 |
| ES2239357T3 (es) | 1996-06-10 | 2005-09-16 | MERCK & CO., INC. | Imidazoles sustituidos que tienen actividad inhibidora de citoquinas. |
| WO1998013361A1 (en) | 1996-09-26 | 1998-04-02 | Novartis Ag | Herbicidal composition |
| CA2216512A1 (en) | 1996-10-11 | 1998-04-11 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones their use as fungicides and insecticides |
| US5977134A (en) | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| DE19754348A1 (de) | 1996-12-11 | 1998-06-18 | Ciba Geigy Ag | Neue Herbizide |
| CA2276150A1 (en) | 1996-12-30 | 1998-07-09 | Steven D. Young | Inhibitors of farnesyl-protein transferase |
| US5855654A (en) | 1997-01-30 | 1999-01-05 | Rohm And Haas Company | Pyridazinones as marine antifouling agents |
| US6117973A (en) | 1997-02-24 | 2000-09-12 | Georgia Tech Research Corp. | PNA monomers with electron donor or acceptor |
| DE19708928A1 (de) | 1997-03-05 | 1998-09-10 | Bayer Ag | Substituierte aromatische Aminoverbindungen |
| DE19821263A1 (de) | 1997-05-12 | 1998-11-19 | Call Krimhild | Enzymatisches Bleichsystem mit enzymwirkungsverstärkenden Verbindungen zur Behandlung von Textilien |
| EP0983334A1 (de) | 1997-05-12 | 2000-03-08 | Call, Krimhild | Enzymatisches bleichsystem mit neuen enzymwirkungsverstärkenden verbindungen |
| JP3043744U (ja) | 1997-05-26 | 1997-11-28 | 株式会社新和 | バッグ |
| DE19726241A1 (de) | 1997-06-20 | 1998-12-24 | Call Krimhild | Erweitertes enzymatisches Multikomponentensystem zur Behandlung von Abwässern, zur Herstellung von Holzverbundstoffen, zum Deinken von Altpapier, Colour stripping von Altpapier, zum Einsatz als Oxidationssystem bei der organischen Synthese und zum Einsatz bei der Kohleverflüssigung |
| DE19729061A1 (de) | 1997-07-08 | 1999-01-14 | Agfa Gevaert Ag | Farbfotografisches Aufzeichnungsmaterial |
| SE9702651D0 (sv) | 1997-07-09 | 1997-07-09 | Astra Pharma Prod | Novel compounds |
| DE19731784A1 (de) | 1997-07-24 | 1999-02-04 | Bayer Ag | Substituierte N-Aryl-N-thioxocarbonyl-sulfonamide |
| SE9702794D0 (sv) | 1997-07-24 | 1997-07-24 | Astra Pharma Prod | New compounds |
| JPH1149755A (ja) | 1997-07-30 | 1999-02-23 | Nippon Kayaku Co Ltd | 新規含窒素ヘテロ環誘導体およびそれを有効成分とする殺虫殺ダニ組成物 |
| ITFI970193A1 (it) | 1997-08-01 | 1999-02-01 | Applied Research Systems | Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali |
| ES2260846T3 (es) | 1997-08-22 | 2006-11-01 | Abbott Laboratories | Inhibidores para la biosintesis de la prostaglandina h2 sintasa. |
| EP1007515A1 (en) | 1997-08-22 | 2000-06-14 | Abbott Laboratories | Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors |
| US6307047B1 (en) | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| DE69823843T2 (de) | 1997-09-09 | 2005-05-12 | Bristol-Myers Squibb Pharma Co. | Benzimidazolinone, benzoxazolinone, benzopiperazinone, indanone und deren derivate als faktor xa inhibitoren |
| EP1030843A4 (en) | 1997-10-27 | 2002-11-06 | Isk Americas Inc | SUBSTITUTED BENZENE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND HERBICIDES AND LEAVING COMPOSITIONS THAT CONTAIN THEM |
| EP1042320B1 (en) | 1997-11-21 | 2002-02-13 | AstraZeneca UK Limited | New compounds which are p2-purinoceptor 7-transmembrane (tm) g-protein coupled receptor antagonists |
| DK1042293T3 (da) | 1997-12-19 | 2008-07-14 | Amgen Inc | Substituerede pyridin- og pyridazinforbindelser og deres farmaceutiske anvendelse |
| US6174901B1 (en) | 1998-12-18 | 2001-01-16 | Amgen Inc. | Substituted pyridine and pyridazine compounds and methods of use |
| JPH11180952A (ja) | 1997-12-19 | 1999-07-06 | Maruho Co Ltd | 2−オキシインドール誘導体 |
| WO1999038846A1 (en) * | 1998-01-30 | 1999-08-05 | Procept, Inc. | Immunosuppressive agents |
| DE19803667A1 (de) | 1998-01-30 | 1999-08-05 | Max Planck Gesellschaft | Verfahren zur Herstellung von 5-Alkoxy (bzw. 5-Aroxy) -2,3-dihydrofuran-2-onen |
| FR2774986A1 (fr) | 1998-02-16 | 1999-08-20 | Rhodia Chimie Sa | Utilisation de pyrone(s) ou equivalent pour masquer des isocyanates, procede de masquage, isocyanates ainsi masques, composition en contenant, procede de revetement utilisant ces compositions, revetement aini obtenu |
| JP2002506820A (ja) | 1998-03-17 | 2002-03-05 | ビー マーゴリン、ソロモン | 局所用防腐組成物および方法 |
| WO1999050263A1 (en) | 1998-03-31 | 1999-10-07 | Warner-Lambert Company | Quinolones as serine protease inhibitors |
| CA2327806A1 (en) | 1998-04-09 | 1999-10-21 | Bayer Aktiengesellschaft | Substituted phenyl pyridazinones |
| CN1303378A (zh) | 1998-04-27 | 2001-07-11 | 国家科研中心 | 3-(氨基-或氨基烷基)吡啶酮衍生物和它们在hiv相关疾病治疗中的用途 |
| AU3536699A (en) | 1998-04-27 | 1999-11-16 | Ihara Chemical Industry Co. Ltd. | 3-arylphenyl sulfide derivatives and insecticides and miticides |
| EP1084710B1 (en) | 1998-06-01 | 2006-10-18 | Astellas Pharma Inc. | Adenosine a1 antagonists for male sterility |
| FR2779429B1 (fr) | 1998-06-03 | 2000-07-13 | Synthelabo | Derives d'oxindole, leurs preparations et leurs applications en therapeutique |
| DE19826671A1 (de) | 1998-06-16 | 1999-12-23 | Hoechst Schering Agrevo Gmbh | 1,3-Oxazolin- und 1,3-Thiazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| AU1226099A (en) | 1998-09-18 | 2000-04-10 | Mepha Ag | Topical formulation of alkyl-, phenyl-pyridone |
| WO2000025789A1 (en) | 1998-10-29 | 2000-05-11 | Merck & Co., Inc. | A method of treating endometriosis |
| JP3043744B1 (ja) | 1999-03-17 | 2000-05-22 | 日本ピラー工業株式会社 | 単結晶SiCの育成方法 |
| US6586447B1 (en) | 1999-04-01 | 2003-07-01 | Pfizer Inc | 3,3-disubstituted-oxindole derivatives useful as anticancer agents |
| DE19918725A1 (de) | 1999-04-24 | 2000-10-26 | Bayer Ag | Substituierte N-Cyano-sulfonsäureanilide |
| US6972296B2 (en) * | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| IL146312A0 (en) | 1999-05-07 | 2002-07-25 | Texas Biotechnology Corp | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| AU6762400A (en) | 1999-08-12 | 2001-03-13 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| FR2797629B1 (fr) | 1999-08-19 | 2001-09-21 | Rhodia Chimie Sa | Utilisation de pyrone(s) ou equivalent pour masquer des isocyanates, procede de masquage, isocyanates ainsi masques, composition en contenant, procede de revetement utilisant ces compositions, revetement ainsi obtenu |
| AT408223B (de) | 1999-12-27 | 2001-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von oxindolen |
| WO2001053288A1 (en) | 2000-01-20 | 2001-07-26 | Eisai Co., Ltd. | Novel piperidine compounds and drugs containing the same |
| EP1263754A1 (en) | 2000-02-01 | 2002-12-11 | Millennium Pharmaceuticals, Inc. | INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa |
| AU2001234690A1 (en) | 2000-02-01 | 2001-08-14 | Cor Therapeutics, Inc. | 2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa |
| US6906063B2 (en) | 2000-02-04 | 2005-06-14 | Portola Pharmaceuticals, Inc. | Platelet ADP receptor inhibitors |
| JP4574100B2 (ja) | 2000-02-04 | 2010-11-04 | ポートラ ファーマシューティカルズ, インコーポレイテッド | 血小板adpレセプターインヒビター |
| GB0002740D0 (en) | 2000-02-07 | 2000-03-29 | Novartis Ag | Organic compounds |
| AU2001230605A1 (en) | 2000-02-09 | 2001-08-20 | Shionogi And Co., Ltd. | Apoptosis inhibitor |
| IL151403A0 (en) | 2000-02-21 | 2003-04-10 | Cymar Inc | Compositions and methods for treatment of epilepsy |
| CA2404226A1 (en) | 2000-03-23 | 2001-09-27 | Takeda Chemical Industries, Ltd. | Furoisoquinoline derivatives, process for producing the same and use thereof |
| US6548517B2 (en) | 2000-03-24 | 2003-04-15 | Millennium Pharmaceuticals, Inc. | Oxindole inhibitors of factor Xa |
| DE10024938A1 (de) | 2000-05-19 | 2001-11-22 | Bayer Ag | Substituierte Iminoazine |
| US20030194748A1 (en) | 2000-05-29 | 2003-10-16 | Tohru Nagasaki | Method for labeling with tritium |
| CN1245386C (zh) | 2000-06-12 | 2006-03-15 | 卫材株式会社 | 1,2-二氢吡啶化合物及其制备方法和用途 |
| DE10034803A1 (de) | 2000-07-18 | 2002-01-31 | Bayer Ag | Substituierte Sulfonsäureanilide |
| RU2250898C2 (ru) | 2000-08-11 | 2005-04-27 | Эйсай Ко., Лтд. | Производные 2-аминопиридина, фармацевтическая композиция на их основе и способ лечения |
| US20020049211A1 (en) | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
| AU9022901A (en) | 2000-09-18 | 2002-03-26 | Eisai Co Ltd | Pyridazinones and triazinones and medicinal use thereof |
| ATE319706T1 (de) | 2000-09-19 | 2006-03-15 | Centre Nat Rech Scient | Pyridinon und pyridinethion-derivate mit hiv- hemmenden eigenschaften |
| CN1120151C (zh) | 2000-10-24 | 2003-09-03 | 大连化学工业股份有限公司 | 制备内酰胺的方法 |
| MXPA03004672A (es) | 2000-10-27 | 2004-04-20 | Dow Agrosciences Llc | 4,5-dihidro-1,2,4-triazin-6-onas sustituidas, 1,2,4-triazin-6-onas sustituidas, y su uso como fungicidas e insecticidas. |
| WO2002040448A1 (en) | 2000-11-20 | 2002-05-23 | Bristol-Myers Squibb Company | Pyridone derivatives as ap2 inhibitors |
| YU52403A (sh) | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
| US7160912B2 (en) | 2000-12-26 | 2007-01-09 | Dr.Reddy's Laboratories Ltd. | Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them |
| ATE438624T1 (de) | 2000-12-28 | 2009-08-15 | Shionogi & Co | 2-pyridonderivate mit affinität für den cannabinoid-typ-2-rezeptor |
| DE60234812D1 (de) | 2001-01-29 | 2010-02-04 | Shionogi & Co | Arzneipräparat, das als wirkstoff 5-methyl-1-phenyl-2-(1h)-pyridon enthält |
| US20040122223A1 (en) * | 2001-02-07 | 2004-06-24 | Davis Jeremy Martin | Non-natural nucleotides and dinucleotides |
| DE10108995A1 (de) | 2001-02-23 | 2002-09-05 | Abbott Gmbh & Co Kg | Substituierte Pyrimidinon-Derivate als Liganden von Integrinrezeptoren |
| JPWO2002085858A1 (ja) | 2001-04-20 | 2004-08-12 | 旭硝子株式会社 | 精製されたピペリジン誘導体の製造方法 |
| US6664269B2 (en) | 2001-05-08 | 2003-12-16 | Maybridge Plc | Isoquinolinone derivatives |
| WO2002098853A2 (en) | 2001-06-01 | 2002-12-12 | The Regents Of The University Of California | Inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction |
| JP2002371078A (ja) | 2001-06-12 | 2002-12-26 | Sankyo Co Ltd | キノリン誘導体及びキノロン誘導体 |
| JP4180254B2 (ja) | 2001-06-29 | 2008-11-12 | 独立行政法人科学技術振興機構 | 窒素含有6員環の製造方法 |
| JP2003021901A (ja) | 2001-07-05 | 2003-01-24 | Fuji Photo Film Co Ltd | 感光性平版印刷版の光重合方法 |
| WO2003014087A1 (fr) | 2001-08-06 | 2003-02-20 | Asahi Glass Company, Limited | Procede de preparation de 5-methyl-1-phenyl-2(1h)-pyridinone |
| WO2003035650A1 (en) | 2001-09-25 | 2003-05-01 | Takeda Chemical Industries, Ltd. | Entry inhibitor |
| GB0124848D0 (en) | 2001-10-16 | 2001-12-05 | Celltech R&D Ltd | Chemical compounds |
| TWI330183B (enExample) | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| TWI301834B (en) | 2001-10-22 | 2008-10-11 | Eisai R&D Man Co Ltd | Pyrimidone compound and pharmaceutical composition including the same |
| CN1257901C (zh) | 2001-11-08 | 2006-05-31 | 中国科学院上海药物研究所 | 一类四氢喹啉酮哌啶类化合物及其制备方法和用途 |
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| GB0129391D0 (en) | 2001-12-07 | 2002-01-30 | Syngenta Participations Ag | Microbiocidal n-phenyl-n-[4-(4-pyridyl)-2-pyrimidin-2-yl]-amine derivatives |
| JP2005170790A (ja) | 2002-01-09 | 2005-06-30 | Ajinomoto Co Inc | N−アルキルスルフォニル置換アミド誘導体 |
| JP2005519895A (ja) | 2002-01-18 | 2005-07-07 | ファルマシア・コーポレーション | P38阻害剤としての置換ピリダジノン |
| PL218749B1 (pl) | 2002-02-14 | 2015-01-30 | Pharmacia Corp | Pochodna pirydynonu oraz jej zastosowanie do wytwarzania leku |
| JP2003238611A (ja) | 2002-02-18 | 2003-08-27 | Japan Polyolefins Co Ltd | オレフィン類重合用触媒成分、オレフィン類重合用触媒及びポリオレフィン類の製造方法 |
| PT1477186E (pt) | 2002-02-19 | 2010-02-11 | Shionogi & Co | Antipruriginosos |
| JP2003261535A (ja) | 2002-03-08 | 2003-09-19 | Mitsubishi Chemicals Corp | 2−ヒドロキシ−5−メチルピリジンの製造方法 |
| WO2003076405A1 (en) | 2002-03-14 | 2003-09-18 | Bayer Healthcare Ag | Monocyclic aroylpyridinones as antiinflammatory agents |
| WO2003082265A2 (en) | 2002-04-02 | 2003-10-09 | Fujisawa Pharmaceutical Co | Pharmaceutical composition for treating or preventing virus infectious diseases |
| GB0210127D0 (en) | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| CA2484631A1 (en) | 2002-05-13 | 2003-11-27 | Merck & Co., Inc. | Phenyl substituted imidazopyridines and phenyl substituted benzimidazoles |
| JP2004043458A (ja) | 2002-05-22 | 2004-02-12 | Kyorin Pharmaceut Co Ltd | 4−アリール−5−ヒドロキシイソキノリン誘導体およびその製造法 |
| CN1218942C (zh) | 2002-06-11 | 2005-09-14 | 中南大学湘雅医学院 | 抗纤维化吡啶酮化合物及其生产工艺方法 |
| US6921821B2 (en) | 2002-06-12 | 2005-07-26 | Abbott Laboratories | Antagonists of melanin concentrating hormone receptor |
| US20040006135A1 (en) | 2002-06-19 | 2004-01-08 | Pfizer Inc. | Combination treatment for depression and anxiety |
| GB0214268D0 (en) | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| WO2004006906A2 (en) | 2002-07-15 | 2004-01-22 | Combinatorx, Incorporated | Methods for the treatment of neoplasms |
| AU2003249484A1 (en) | 2002-07-22 | 2004-02-09 | Orchid Chemicals And Pharmaceuticals Ltd | Novel bio-active molecules |
| CA2493234A1 (en) * | 2002-07-24 | 2004-01-29 | Kyorin Pharmaceutical Co., Ltd. | 4-(substituted aryl)-5-hydroxyisoquinolinone derivative |
| GB0218630D0 (en) | 2002-08-10 | 2002-09-18 | Tanabe Seiyaku Co | Novel compounds |
| JP2006501215A (ja) | 2002-08-13 | 2006-01-12 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | マトリックスメタロプロテイナーゼ阻害剤としての単環式誘導体 |
| JP2006502152A (ja) | 2002-08-28 | 2006-01-19 | インターミューン インコーポレイテッド | 線維性疾患治療用の併用療法 |
| AU2003264386A1 (en) | 2002-09-10 | 2004-04-30 | Kyorin Pharmaceutical Co., Ltd. | 4-(substituted aryl)-5-hydroxyisoquinolinone derivative |
| JP2006506352A (ja) | 2002-09-11 | 2006-02-23 | メルク エンド カムパニー インコーポレーテッド | Hivインテグラーゼ阻害剤として有用なジヒドロキシピリドピラジン−1,6−ジオン化合物 |
| CH696420A5 (de) | 2002-09-13 | 2007-06-15 | Mepha Ag | Neue stabile Zubereitungen von Alkyl-, Phenyl-Pyridonen für topische Anwendung. |
| EP1400243A1 (en) | 2002-09-19 | 2004-03-24 | Tanabe Seiyaku Co., Ltd. | Calcium-activated K channel activator |
| GB0222743D0 (en) | 2002-10-01 | 2002-11-06 | Celltech R&D Ltd | Chemical compounds |
| US20040077635A1 (en) | 2002-10-02 | 2004-04-22 | Qiao Jennifer X. | Lactam-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor Xa inhibitors |
| WO2004035563A1 (en) * | 2002-10-17 | 2004-04-29 | Syngenta Participations Ag | 3-heterocyclylpyridine derivatives useful as herbicides |
| AU2003274652A1 (en) | 2002-10-23 | 2004-05-13 | Obetherapy Biotechnology | Compounds, compositions and methods for modulating fat metabolism |
| US6930117B2 (en) | 2002-11-09 | 2005-08-16 | The Procter & Gamble Company | N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones |
| PE20040844A1 (es) | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
| JP4542743B2 (ja) | 2002-12-26 | 2010-09-15 | Kdl株式会社 | ピリドン誘導体の溶液状医薬組成物 |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US20040142950A1 (en) | 2003-01-17 | 2004-07-22 | Bunker Amy Mae | Amide and ester matrix metalloproteinase inhibitors |
| AR042956A1 (es) | 2003-01-31 | 2005-07-13 | Vertex Pharma | Inhibidores de girasa y usos de los mismos |
| US7569591B2 (en) | 2003-01-31 | 2009-08-04 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US7582641B2 (en) | 2003-01-31 | 2009-09-01 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US7618974B2 (en) | 2003-01-31 | 2009-11-17 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US20040157738A1 (en) | 2003-02-12 | 2004-08-12 | Ishihara Sangyo Kaisha, Ltd. | Novel oxygen containing fused cyclic derivatives and herbicidal, desiccant and defoliate compositions containing them |
| CL2004000234A1 (es) | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
| JP2006517976A (ja) | 2003-02-14 | 2006-08-03 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
| US7012088B2 (en) | 2003-02-24 | 2006-03-14 | Pharmacia & Upjohn Company | Indolone oxazolidinones and derivatives thereof |
| EP1599171A2 (en) | 2003-02-28 | 2005-11-30 | Intermune, Inc. | Combination therapy for treating alphavirus infection and liver fibrosis |
| EP1603563A4 (en) | 2003-02-28 | 2007-08-22 | Morgan Lee R | RESONANCE MODULATOR FOR DIAGNOSIS AND THERAPY |
| JP2004269469A (ja) | 2003-03-12 | 2004-09-30 | Yamanouchi Pharmaceut Co Ltd | ピリミジン誘導体又はその塩 |
| EP1613607B1 (de) | 2003-04-08 | 2013-01-09 | Basf Se | Benzolsulfonamid-derivate als herbizide oder desikkante/defoliante verbindungen |
| JP4089491B2 (ja) | 2003-04-14 | 2008-05-28 | コニカミノルタホールディングス株式会社 | 重合開始剤、重合組成物、ラジカル発生方法、平版印刷版材料および平版印刷版の作製方法 |
| WO2004105684A2 (en) | 2003-05-16 | 2004-12-09 | Intermune, Inc. | Combination therapy for proliferative disorders |
| WO2004110245A2 (en) | 2003-05-16 | 2004-12-23 | Intermune, Inc. | Combination therapy for cancer treatment |
| WO2004103296A2 (en) | 2003-05-16 | 2004-12-02 | Intermune, Inc. | Methods of treating idiopathic pulmonary fibrosis |
| JP2004359641A (ja) | 2003-06-06 | 2004-12-24 | Ono Pharmaceut Co Ltd | Ccr5活性化剤 |
| US20080025986A1 (en) | 2003-06-06 | 2008-01-31 | Ozes Osman N | Methods of Treating Tnf-Mediated Disorders |
| JP2007516161A (ja) | 2003-06-20 | 2007-06-21 | セルテック アール アンド ディ リミテッド | キナーゼ阻害剤としてのチエノピリドン誘導体 |
| CA2528603A1 (en) | 2003-06-20 | 2004-12-29 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
| JP4667241B2 (ja) | 2003-06-27 | 2011-04-06 | 旭化成株式会社 | 細胞分化抑制剤、これを用いた細胞培養方法、培養液及び培養された細胞株 |
| JP2005013152A (ja) | 2003-06-27 | 2005-01-20 | Asahi Kasei Corp | 細胞分化抑制剤及びこれを用いた細胞培養方法、培養液、培養された細胞 |
| WO2005000818A1 (en) | 2003-06-27 | 2005-01-06 | Warner-Lambert Company Llc | 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors |
| US20060025337A1 (en) | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| AU2004253579B2 (en) | 2003-07-01 | 2010-12-23 | Biomol International L.P. | Sirt1 modulators for manipulating cells/organism lifespan/stress response |
| WO2005007632A1 (en) | 2003-07-18 | 2005-01-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| CN1829709A (zh) | 2003-08-01 | 2006-09-06 | 健亚生物科技公司 | 对抗黄病毒的双环咪唑衍生物 |
| CL2004002050A1 (es) | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
| AU2004270187A1 (en) | 2003-09-04 | 2005-03-17 | Aventis Pharmaceuticals Inc. | Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP) |
| US20050065144A1 (en) | 2003-09-08 | 2005-03-24 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| DE10345648A1 (de) | 2003-10-01 | 2005-04-21 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von TMC-69-6H und verwandten Pyridonderivaten und deren Verwendung als Phosphatase-Inhibitoren |
| US7407973B2 (en) | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| WO2005039598A1 (en) | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Method of treating alcoholic liver disease |
| JP4170198B2 (ja) | 2003-11-14 | 2008-10-22 | 一丸ファルコス株式会社 | 化粧料組成物 |
| JP4614884B2 (ja) | 2003-11-14 | 2011-01-19 | シャンハイ ゲノミックス インク | ピリドンの誘導体とその使用 |
| US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
| JP4869075B2 (ja) | 2003-11-19 | 2012-02-01 | アレイ バイオファーマ、インコーポレイテッド | Mekの複素環阻害剤及びその使用方法 |
| EP1690863A1 (en) * | 2003-11-26 | 2006-08-16 | Dainippon Sumitomo Pharma Co., Ltd. | Novel condensed imidazole derivative |
| DE10358004A1 (de) | 2003-12-11 | 2005-07-14 | Abbott Gmbh & Co. Kg | Ketolactam-Verbindungen und ihre Verwendung |
| US20070191336A1 (en) | 2003-12-24 | 2007-08-16 | Flynn Daniel L | Anti-inflammatory medicaments |
| DE602005005167T2 (de) | 2004-01-29 | 2009-04-30 | Pfizer Inc. | 1-isopropyl-2-oxo-1,2-dihydropyridin-3-carbonsäureamidderivate mit agonistischer wirkung am 5-ht4-rezeptor |
| GB0402812D0 (en) | 2004-02-09 | 2004-03-10 | Tanabe Seiyaku Co | Novel compounds |
| JP2005255675A (ja) | 2004-02-09 | 2005-09-22 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| US7872123B2 (en) | 2004-02-20 | 2011-01-18 | Japan Science And Technology Agency | Process of making α-aminooxyketone/α-aminooxyaldehyde and α-hydroxyketone/α-hydroxyaldehyde compounds and a process making reaction products from cyclic α,β-unsaturated ketone substrates and nitroso substrates |
| JPWO2005085200A1 (ja) | 2004-03-05 | 2008-01-17 | 萬有製薬株式会社 | ピリドン誘導体 |
| PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
| JP4790703B2 (ja) | 2004-04-07 | 2011-10-12 | 武田薬品工業株式会社 | 環式化合物 |
| NZ551027A (en) | 2004-04-08 | 2011-01-28 | Targegen Inc | Benzotriazine inhibitors of kinases |
| TWI326282B (en) | 2004-04-28 | 2010-06-21 | Mitsubishi Tanabe Pharma Corp | Heterocyclic compound |
| JPWO2005105743A1 (ja) | 2004-04-28 | 2008-03-13 | 小野薬品工業株式会社 | 含窒素複素環化合物およびその医薬用途 |
| DE102004028973A1 (de) | 2004-06-16 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydro-2H-isochinolin-1-on-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| BRPI0512273A (pt) | 2004-06-18 | 2008-02-19 | Millennium Pharm Inc | inibidores do fator xa |
| US7696352B2 (en) | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| AU2005274852B2 (en) | 2004-07-19 | 2011-12-08 | The Johns Hopkins University | FLT3 inhibitors for immune suppression |
| WO2006011024A2 (en) | 2004-07-19 | 2006-02-02 | Glenmark Pharmaceuticals Ltd. | New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| CA2575808A1 (en) | 2004-08-02 | 2006-02-16 | Osi Pharmaceuticals, Inc. | Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds |
| EP1786803A1 (en) | 2004-08-31 | 2007-05-23 | Biogen Idec MA, Inc. | Pyrimidinylpyrazoles as tgf-beta inhibitors |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| US7694674B2 (en) * | 2004-09-21 | 2010-04-13 | Carleton Life Support Systems, Inc. | Oxygen generator with storage and conservation modes |
| ES2349358T3 (es) | 2004-09-22 | 2010-12-30 | Janssen Pharmaceutica Nv | Inhibidores de la interacción entre mdm2 y p53. |
| US20060069260A1 (en) | 2004-09-28 | 2006-03-30 | Huiping Zhang | Preparation of N-aryl pyridones |
| JP4223457B2 (ja) | 2004-10-06 | 2009-02-12 | 本田技研工業株式会社 | 車両の電動ステアリング装置 |
| WO2006038734A1 (en) | 2004-10-08 | 2006-04-13 | Astellas Pharma Inc. | Pyridazinone derivatives cytokines inhibitors |
| RU2407736C2 (ru) | 2004-10-12 | 2010-12-27 | Декод Дженетикс Ехф | Пери-замещенные арилсульфонамидные бициклические соединения, предназначенные для лечения окклюзионного заболевания артерий |
| TW200843761A (en) | 2004-10-28 | 2008-11-16 | Shionogi & Co | 3-carbamoyl-2-pyridone derivatives |
| JP4973191B2 (ja) | 2004-11-10 | 2012-07-11 | 小野薬品工業株式会社 | 含窒素複素環化合物およびその医薬用途 |
| JP2006142666A (ja) | 2004-11-19 | 2006-06-08 | Mitsubishi Chemicals Corp | 光学記録媒体用色素 |
| US20060206269A1 (en) | 2004-11-19 | 2006-09-14 | Pharmacopeia Drug Discovery, Inc. | One-dimensional QSAR models |
| EP1814866A2 (en) | 2004-11-23 | 2007-08-08 | Wyeth a Corporation of the State of Delaware | Gonadotropin releasing hormone receptor antagonists |
| JP5055129B2 (ja) | 2004-11-24 | 2012-10-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 3−[2−(3−アシルアミノ−2−オキソ−2h−ピリジン−1−イル)−アセチルアミノ]−4−オキソ−ペンタン酸誘導体、およびカスパーゼ阻害剤としてのそれらの使用 |
| US20070293544A1 (en) | 2004-11-24 | 2007-12-20 | Ulrich Abel | Novel 4-Arylamino Pyridone Derivatives as Mek Inhibitors for the Treatment of Hyper-Proliferative Disorders |
| EP1833480A2 (en) | 2004-11-30 | 2007-09-19 | Artesian Therapeutics, Inc. | Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase |
| EP1820797A4 (en) | 2004-12-01 | 2009-10-28 | Banyu Pharma Co Ltd | SUBSTITUTED PYRIDONE DERIVATIVE |
| AR054214A1 (es) | 2004-12-17 | 2007-06-13 | Anadys Pharmaceuticals Inc | Compuestos derivados de 1, 1 - dioxotiadiazina, composiciones farmaceuticas que los contienen y su uso en el tratamiento de la infeccion por el virus de la hepatitis c. |
| ATE479662T1 (de) | 2004-12-23 | 2010-09-15 | Hui Yao | Pyrimidinonverbindungen, ihre herstellung und ihre verwendung |
| US20060148842A1 (en) * | 2004-12-29 | 2006-07-06 | Scialdone Mark A | Nepetalactams and N-substituted derivatives thereof |
| CN101090890A (zh) * | 2004-12-29 | 2007-12-19 | 纳幕尔杜邦公司 | 二氢荆芥内酰胺及其n-取代衍生物 |
| AU2005321861A1 (en) * | 2004-12-29 | 2006-07-06 | E. I. Du Pont De Nemours And Company | Dihydronepetalactams and N-substituted derivatives thereof |
| CN101090889A (zh) * | 2004-12-29 | 2007-12-19 | 纳幕尔杜邦公司 | 荆芥内酰胺及其n-取代衍生物 |
| AU2006204699B2 (en) | 2005-01-13 | 2012-04-26 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| WO2006079021A2 (en) | 2005-01-20 | 2006-07-27 | Sirtris Pharmaceuticals, Inc. | Use of sirtuin-activating compounds for treating flushing and drug induced weight gain |
| EP1847535A4 (en) * | 2005-02-04 | 2011-03-09 | Eisai R&D Man Co Ltd | 1- (piperidin-4-yl) -1H-indole derivatives |
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| CN1676518B (zh) | 2005-03-17 | 2010-05-12 | 南开大学 | 4-取代苯基哒嗪类化合物及除草活性 |
| ME01224B (me) | 2005-04-04 | 2013-06-20 | Eisai R&D Man Co Ltd | Jedinjenja dihidropiridina za liječenje neurodegenerativnih bolesti i demencije |
| RU2007141401A (ru) | 2005-04-08 | 2009-05-20 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Терапевтический агент для лечения дискинезии |
| CN1846699A (zh) | 2005-04-13 | 2006-10-18 | 中南大学湘雅医院 | 1-(取代苯基)-5-甲基-2-(1h) 吡啶酮(i)化合物用于制备抗除肾间质纤维化外其他器官纤维化或组织纤维化药物的应用 |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| JP5053997B2 (ja) | 2005-04-28 | 2012-10-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 炎症性疾患の治療用の新規化合物 |
| PT1928454E (pt) | 2005-05-10 | 2014-12-04 | Intermune Inc | Derivativos da piridona para modulação do sistema de proteína quinase ativada pelo stress |
| GB0511190D0 (en) | 2005-06-01 | 2005-07-06 | Sterix Ltd | Use |
| JP5002592B2 (ja) | 2005-06-07 | 2012-08-15 | フアーマコペイア・インコーポレイテツド | うつ病およびストレス疾患のためのアジノンおよびジアジノンv3阻害剤 |
| CA2610396A1 (en) | 2005-06-08 | 2006-12-14 | Novartis Ag | Organic compounds |
| AU2006254758B2 (en) | 2005-06-10 | 2012-04-05 | Merck Patent Gmbh | Oxindoles as kinase inhibitors |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| US20060287319A1 (en) | 2005-06-15 | 2006-12-21 | Shibo Jiang | Anti-viral compositions comprising heterocyclic substituted phenyl furans and related compounds |
| JP2009500357A (ja) | 2005-07-07 | 2009-01-08 | サートリス ファーマシューティカルズ, インコーポレイテッド | 肥満、インスリン抵抗性障害およびミトコンドリア関連障害を処置または予防するための方法および関連する組成物 |
| TW200740755A (en) | 2005-07-13 | 2007-11-01 | Bayer Cropscience Sa | Dihalogenation of N,O-disubstituted hydroxypyridones and their uses |
| JP2007063268A (ja) | 2005-08-05 | 2007-03-15 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| JP2007056213A (ja) | 2005-08-26 | 2007-03-08 | Fujifilm Corp | 焼結含油軸受油用組成物、並びにそれを用いた軸受け装置及び摺動部材 |
| WO2007026950A1 (en) | 2005-09-01 | 2007-03-08 | Astellas Pharma Inc. | Pyridazinone derivatives used for the treatment of pain |
| NZ591443A (en) | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
| WO2007037543A1 (ja) | 2005-09-29 | 2007-04-05 | Banyu Pharmaceutical Co., Ltd. | ビアリールアミド誘導体 |
| CA2623813A1 (en) | 2005-10-03 | 2007-04-12 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compound and pharmaceutical application thereof |
| WO2007044796A2 (en) | 2005-10-11 | 2007-04-19 | Nps Pharmaceuticals, Inc. | Pyridazinone compounds as calcilytics |
| EP1948663B1 (en) | 2005-10-21 | 2011-09-14 | Exelixis, Inc. | Pyrazolo-pyrimidines as casein kinase ii (ck2) modulators |
| JP2007145819A (ja) | 2005-10-28 | 2007-06-14 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| WO2007053610A2 (en) | 2005-11-01 | 2007-05-10 | The Regents Of The University Of California | Methods of treating atrial fibrillation wtih pirfenidone |
| EP1966199B1 (en) | 2005-11-18 | 2010-10-20 | F. Hoffmann-La Roche AG | Azaindole-2-carboxamide derivatives |
| WO2007058392A1 (ja) | 2005-11-21 | 2007-05-24 | Japan Tobacco Inc. | ヘテロ環化合物およびその医薬用途 |
| EP2426134A3 (en) | 2005-11-23 | 2012-07-04 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
| JP5144532B2 (ja) | 2005-11-30 | 2013-02-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | c−Met阻害剤及び用法 |
| JPWO2007072869A1 (ja) | 2005-12-21 | 2009-06-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 1,2−ジヒドロピリジン化合物の非晶質体 |
| US20090088574A1 (en) | 2005-12-21 | 2009-04-02 | Eisai R&D Management Co., Ltd. | Crystal of 1,2-dihydropyridine compound (type iv) |
| WO2007076104A1 (en) | 2005-12-23 | 2007-07-05 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| US20090221611A1 (en) * | 2006-01-11 | 2009-09-03 | Devita Robert J | Fused Triazole Tachykinin Receptor Antagonists |
| UY30117A1 (es) | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compuesto amina trisustituido |
| WO2007088876A1 (ja) | 2006-02-02 | 2007-08-09 | Kumiai Chemical Industry Co., Ltd. | ピリドン誘導体及び除草剤 |
| TW200803855A (en) | 2006-02-24 | 2008-01-16 | Kalypsys Inc | Quinolones useful as inducible nitric oxide synthase inhibitors |
| US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| JP5302012B2 (ja) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
| JP2009533326A (ja) | 2006-03-13 | 2009-09-17 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症の治療用眼科用組成物 |
| CN100396669C (zh) | 2006-03-15 | 2008-06-25 | 浙江省医学科学院 | 一种抗纤维化药物吡非尼酮的制备方法 |
| WO2007107545A1 (en) | 2006-03-22 | 2007-09-27 | Janssen Pharmaceutica N.V. | Cyclic-alkylaminederivatives as inhibitors of the interaction between mdm2 and p53 |
| US20090264428A1 (en) | 2006-04-05 | 2009-10-22 | Baldwin John J | Renin Inhibitors |
| US20090275581A1 (en) | 2006-04-05 | 2009-11-05 | Baldwin John J | Renin inhibitors |
| WO2007120842A2 (en) | 2006-04-13 | 2007-10-25 | Cornell Research Foundation, Inc. | Methods and compositions for targeting c-rel |
| WO2007127475A2 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Pyridazines for demyelinating diseases and neuropathic pain |
| CA2650711A1 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| DK2013175T5 (da) | 2006-05-04 | 2020-12-21 | Macrophage Pharma Ltd | p38 Map-kinase-inhibitorer |
| EP2016072B1 (en) | 2006-05-05 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| WO2007139150A1 (ja) | 2006-05-30 | 2007-12-06 | The University Of Tokushima | TNFα阻害物質を含有してなる抗インフルエンザウイルス剤 |
| EP2035005A4 (en) | 2006-06-09 | 2011-07-06 | Kemia Inc | THERAPY BASED ON CYTOKINE INHIBITORS |
| EP2036555B1 (en) | 2006-06-15 | 2011-11-16 | Shanghai Genomics, Inc. | The use of pyridone derivatives for preventing and treating radiation injury of lungs |
| GB0724349D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| US8933130B2 (en) | 2006-06-23 | 2015-01-13 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
| JP2009543865A (ja) | 2006-07-19 | 2009-12-10 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド | ピリジノンジケト酸:併用療法におけるhiv複製の阻害剤 |
| CA2658462C (en) | 2006-07-20 | 2011-09-27 | Amgen Inc. | Substituted pyridone compounds and methods of use |
| JP5335675B2 (ja) | 2006-07-25 | 2013-11-06 | セファロン、インク. | ピリジジノン誘導体 |
| JP4747985B2 (ja) | 2006-08-02 | 2011-08-17 | コニカミノルタオプト株式会社 | 光学フィルム、それを用いた偏光板及び液晶表示装置 |
| EA015886B1 (ru) | 2006-08-02 | 2011-12-30 | Эл Джи Лайф Сайенсиз Лтд. | Ингибиторы каспазы на основе пиридазинонового каркаса |
| RU2453543C2 (ru) | 2006-08-25 | 2012-06-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые производные пиридона, обладающие антагонистической активностью в отношении mch, и лекарственные средства, включающие такие соединения |
| CN100516126C (zh) | 2006-09-06 | 2009-07-22 | 北京理工大学 | 一种离子液体 |
| AR063706A1 (es) | 2006-09-11 | 2009-02-11 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden. |
| JP2008076948A (ja) | 2006-09-25 | 2008-04-03 | Konica Minolta Medical & Graphic Inc | 感光性平版印刷版材料 |
| US20110046125A1 (en) * | 2006-10-19 | 2011-02-24 | Synta Pharmaceuticals Corp. | Method for treating infections |
| CA2669266C (en) | 2006-11-08 | 2014-04-29 | Bristol-Myers Squibb Company | Pyridinone compounds |
| KR20080045538A (ko) | 2006-11-20 | 2008-05-23 | 에스케이케미칼주식회사 | 피리딘 화합물을 포함하는 염증 및 면역질환 치료용 약제조성물 |
| CN1962642A (zh) | 2006-11-21 | 2007-05-16 | 南开大学 | 具有除草活性的三氟甲基苯基哒嗪类衍生物及制备方法 |
| GB0624105D0 (en) | 2006-12-01 | 2007-01-10 | Sterix Ltd | Use |
| MX2009005908A (es) | 2006-12-05 | 2009-06-16 | Janssen Pharmaceutica Nv | Derivados novedosos de diaza-espiro-piridinona sustituidos para usarse en las enfermedades mediadas por la hormona concentradora de melanina 1. |
| PL2094662T3 (pl) | 2006-12-14 | 2012-09-28 | Astellas Pharma Inc | Związki oparte na policyklicznych kwasach użyteczne jako antagoniści rCRTH2 oraz jako środki przeciwalergiczne |
| BRPI0721086A2 (pt) | 2006-12-14 | 2014-02-25 | Lilly Co Eli | Derivados de 5-[4-(azetidin-3-ilóxi)-fenil]-2-fenil-5h-tiazolo[5,4-c]piri din-4-ona e seu emprego como antago-nistas de receptor de mch |
| JP5419706B2 (ja) | 2006-12-20 | 2014-02-19 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼアクチベーター |
| US9562019B2 (en) | 2006-12-21 | 2017-02-07 | Sloan-Kettering Institute For Cancer Research | Substituted pyridazines as EGFR and/or KRAS inhibitors |
| WO2008079277A1 (en) | 2006-12-22 | 2008-07-03 | Millennium Pharmaceuticals, Inc. | Certain pyrazoline derivatives with kinase inhibitory activity |
| KR101517154B1 (ko) | 2006-12-27 | 2015-04-30 | 사노피 | Rho-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| BRPI0806371A2 (pt) | 2007-01-22 | 2011-09-13 | Gtx Inc | agentes ligação de receptor nuclear |
| CN101235030A (zh) | 2007-01-30 | 2008-08-06 | 中南大学 | 1-取代-5-三氟甲基-2-(1h)吡啶酮化合物、制备方法及其用途 |
| DE102007007751A1 (de) | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| AU2008219166B2 (en) | 2007-02-16 | 2013-05-16 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-Met inhibitors |
| WO2008106202A1 (en) | 2007-02-27 | 2008-09-04 | Housey Gerard M | Theramutein modulators |
| JP5134834B2 (ja) | 2007-03-01 | 2013-01-30 | 東ソー株式会社 | 5,5−二置換−3−ピロリン−2−オン誘導体の製造方法 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| GB0722769D0 (en) | 2007-11-21 | 2008-01-02 | Biolipox Ab | New compounds |
| US8586619B2 (en) | 2007-03-12 | 2013-11-19 | Vm Therapeutics Llc | Agents of calcium ion channel modulators |
| CL2008000725A1 (es) | 2007-03-15 | 2008-11-14 | Schering Corp | Compuestos derivados de heterociclos aromaticos; composicion farmaceutica; kit farmceuticos; uso de la composicion y de los compuestos como inhibidores de glucano sintasa para el tratamiento o prevencion del crecimiento de patogenos fungicos en planta y para tratar o prevenir infecciones producidas por hongos. |
| JP2010522163A (ja) | 2007-03-20 | 2010-07-01 | キュリス,インコーポレイテッド | 亜鉛結合部位を含むRafキナーゼインヒビター |
| CA2706017A1 (en) | 2007-03-30 | 2008-10-09 | Jorge R. Barrio | In vivo imaging of sulfotransferases |
| BRPI0809498A2 (pt) | 2007-04-02 | 2014-09-23 | Inst Oneworld Health | Compostos inibidores de cftr e seus usos |
| UA101611C2 (ru) | 2007-04-03 | 2013-04-25 | Аррей Байофарма Инк. | СОЕДИНЕНИЯ ИМИДАЗО[1,2-а]ПИРИДИНА КАК ИНГИБИТОРЫ ТИРОЗИНКИНАЗЫ РЕЦЕПТОРОВ |
| US20100179109A1 (en) | 2007-04-05 | 2010-07-15 | Baldwin Jonh J | Renin inhibitors |
| TW200845988A (en) | 2007-04-05 | 2008-12-01 | Astrazeneca Ab | New compounds and their uses 707 |
| US20100130471A1 (en) | 2007-04-05 | 2010-05-27 | Baldwin John J | Renin Inhibitors |
| US20100129933A1 (en) | 2007-04-26 | 2010-05-27 | Forschungszentrum Karlsruhe Gmbh | Method for detecting the binding between mdm2 and the proteasome |
| TW200904421A (en) | 2007-05-03 | 2009-02-01 | Astellas Pharma Inc | New compounds |
| NZ581259A (en) | 2007-05-09 | 2012-07-27 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
| US8178091B2 (en) | 2007-05-21 | 2012-05-15 | University Of Washington | Compositions and methods for the treatment of respiratory disorders |
| MX2007006349A (es) | 2007-05-29 | 2009-02-18 | Cell Therapy And Technology S | Nuevo proceso de sintesis para la obtencion de 5-metil-1-fenil-2-(ih)-piridona, composicion y uso de la misma. |
| WO2008147169A2 (es) | 2007-05-29 | 2008-12-04 | Cell Therapy Technology, S.A. De C.V. | Microemolsion conteniendo pirfenidona |
| US9603848B2 (en) | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| US7928111B2 (en) | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
| DE102007028406A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| KR101767849B1 (ko) | 2007-06-20 | 2017-08-11 | 오스펙스 파마슈티칼스, 인코포레이티드 | 섬유증 저해제로서의 치환된 n-아릴 피리디논 |
| EP2164488A1 (en) | 2007-07-13 | 2010-03-24 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists and aldose reductase inhibitors for neuropathic pain |
| JP2010533126A (ja) | 2007-07-13 | 2010-10-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経因性疼痛の治療ためのampa受容体アンタゴニストとアセチルコリンエステラーゼ阻害剤との併用 |
| JP2010533128A (ja) | 2007-07-13 | 2010-10-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経因性疼痛のためのampa受容体アンタゴニストおよびゾニサミド |
| US7928230B2 (en) | 2007-07-17 | 2011-04-19 | Bristol-Myers Squibb Company | Method for modulating GPR119 G protein-coupled receptor and selected compounds |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| JP5436211B2 (ja) | 2007-08-10 | 2014-03-05 | クミアイ化学工業株式会社 | 有害生物防除剤組成物及び有害生物防除方法 |
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| CN101371833A (zh) | 2007-08-23 | 2009-02-25 | 中南大学 | 1-芳基-2(1h)-吡啶酮类化合物在制备治疗皮肤瘙痒药物中的应用 |
| WO2009029625A1 (en) | 2007-08-27 | 2009-03-05 | Kalypsys, Inc. | 4- [heterocyclyl-methyl] -8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors |
| WO2009035598A1 (en) | 2007-09-10 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
| CN101652138B (zh) | 2007-09-19 | 2011-07-06 | 中南大学 | 1-取代芳基-2(1h)-吡啶酮化合物的新医药用途 |
| CN101121697A (zh) * | 2007-09-20 | 2008-02-13 | 东北师范大学 | 一种多取代吡啶-2(1h)-酮类化合物的合成方法 |
| WO2009054544A1 (en) | 2007-10-26 | 2009-04-30 | Eisai R & D Management Co., Ltd. | Ampa receptor antagonists for parkinson's disease and movement disorders |
| WO2009054543A1 (en) | 2007-10-26 | 2009-04-30 | Eisai R & D Management Co., Ltd. | Ampa receptor antagonists and zonisamide for parkinson's disease and movement disorders |
| CA2699631A1 (en) | 2007-10-31 | 2009-05-07 | Nissan Chemical Industries, Ltd. | Pyridazinone compounds and p2x7 receptor inhibitors |
| WO2009060835A1 (ja) | 2007-11-05 | 2009-05-14 | Kyoto University | 新規ユビキリン結合性小分子 |
| US20120149698A1 (en) | 2007-11-22 | 2012-06-14 | Boehringer Ingelheim International Gmbh | Nouvel compounds |
| CA2932121A1 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics Corporation | Ido inhibitors |
| CA2708780A1 (en) | 2007-12-11 | 2009-06-18 | Research Development Foundation | Small molecules for neuronal differentiation of embryonic stem cells |
| US20100256191A1 (en) | 2007-12-26 | 2010-10-07 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists and zonisamide for epilepsy |
| EP2254577A1 (en) | 2007-12-26 | 2010-12-01 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists for epilepsy, mental disorders or deficits in sensory organ |
| WO2009094427A1 (en) | 2008-01-23 | 2009-07-30 | Bristol-Myers Squibb Company | 4-pyridinone compounds and their use for cancer |
| JP5524082B2 (ja) | 2008-01-30 | 2014-06-18 | セファロン、インク. | ヒスタミン−3(h3)受容体リガンドとしての置換スピロ環状ピペリジン誘導体 |
| AU2009217543A1 (en) | 2008-02-25 | 2009-09-03 | Merck Sharp & Dohme Corp. | Tetrahydro-1H-pyrrolo fused pyridones |
| EP2262501B1 (en) | 2008-03-07 | 2014-08-13 | Solanan, Inc. | Treatment of sepsis with 5-ethyl-1-phenyl-2(1h)-pyridone |
| US8349864B2 (en) | 2008-03-25 | 2013-01-08 | New Mexico Technical Research Foundation | Pyrano [3,2-C] pyridones and related heterocyclic compounds as pharmaceutical agents for treating disorders responsive to apoptosis, antiproliferation or vascular disruption, and the use thereof |
| WO2009146034A2 (en) | 2008-03-31 | 2009-12-03 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors and methods of use thereof |
| WO2009124119A2 (en) | 2008-04-01 | 2009-10-08 | The Trustes of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
| WO2009124553A2 (en) | 2008-04-09 | 2009-10-15 | Neurokey A/S | Use of hypothermia inducing drugs |
| CN102015682B (zh) | 2008-05-05 | 2014-07-16 | 埃科特莱茵药品有限公司 | 作为肾素抑制剂的3,4-取代的哌啶衍生物 |
| EP2328586A2 (en) | 2008-05-20 | 2011-06-08 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| EP2306828A4 (en) | 2008-06-25 | 2011-06-29 | Glaxosmithkline Llc | INHIBITORS OF PROLYL HYDROXYLASES |
| WO2009158393A1 (en) | 2008-06-25 | 2009-12-30 | Envivo Pharmaceuticals, Inc. | 1, 2 disubstituted heterocyclic compounds |
| SG192439A1 (en) | 2008-06-27 | 2013-08-30 | Novartis Ag | Organic compounds |
| ES2429129T3 (es) | 2008-07-11 | 2013-11-13 | Irm Llc | 4-Fenoximetilpiperidinas como moduladores de la actividad de GPR119 |
| TW201006821A (en) | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
| US20110166124A1 (en) | 2008-07-23 | 2011-07-07 | Mccormick Kevin D | Tricyclic spirocycle derivatives and methods of use |
| JP2012500260A (ja) | 2008-08-18 | 2012-01-05 | イェール・ユニヴァーシティー | Mifモジュレーター |
| EP2326179A4 (en) | 2008-08-25 | 2011-08-17 | Smithkline Beecham Corp | PROLYLHYDROXYLASEHEMMER |
| CA2736970A1 (en) | 2008-09-12 | 2010-03-18 | Biolipox Ab | Pyrimidinone derivatives for use as medicaments |
| EP2350053B1 (en) | 2008-10-17 | 2013-12-11 | Whitehead Institute For Biomedical Research | Modulators of MTOR Complexes |
| US8703962B2 (en) | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
| WO2010048716A1 (en) | 2008-10-29 | 2010-05-06 | Pacific Therapeutics Ltd. | Composition and method for treating fibrosis |
| US7635707B1 (en) | 2008-11-10 | 2009-12-22 | Intermune, Inc. | Pirfenidone treatment for patients with atypical liver function |
| WO2010065755A1 (en) | 2008-12-04 | 2010-06-10 | Concert Pharmaceuticals, Inc. | Deuterated pyridinones |
| NZ593937A (en) | 2008-12-08 | 2014-05-30 | Vm Pharma Llc | Compositions of protein receptor tyrosine kinase inhibitors |
| JP2012511514A (ja) | 2008-12-10 | 2012-05-24 | メルク・カナダ・インコーポレイテツド | レニン阻害剤としての3,4−置換ピペリジン誘導体 |
| EP3210603A1 (en) | 2008-12-11 | 2017-08-30 | Shionogi & Co., Ltd | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| US20120122889A1 (en) | 2008-12-23 | 2012-05-17 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
| CA2749031A1 (en) | 2009-01-07 | 2010-07-15 | Henkel Corporation | Hydrogen peroxide complexes and their use in the cure system of anaerobic adhesives |
| AP2011005824A0 (en) | 2009-01-26 | 2011-08-31 | Intermune Inc | Methods for treating acute myocardial infarctions and associated disorders. |
| WO2010088177A1 (en) * | 2009-02-02 | 2010-08-05 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| BRPI1008498B8 (pt) | 2009-02-05 | 2021-05-25 | Takeda Pharmaceuticals Co | compostos de piridazinona úteis como inibidores da fosfodiesterase 10a, composição farmacêutica, e, uso de um composto |
| US8278316B2 (en) | 2009-03-09 | 2012-10-02 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| EP2405913A1 (en) | 2009-03-09 | 2012-01-18 | Bristol-Myers Squibb Company | Pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| EP2408863B1 (en) | 2009-03-16 | 2018-01-10 | Promega Corporation | Nucleic acid binding dyes and uses therefor |
| CN106478496A (zh) | 2009-03-27 | 2017-03-08 | 阿迪生物科学公司 | 作为mek抑制剂的二氢吡啶磺酰胺和二氢吡啶硫酰胺 |
| EP2601840B1 (en) | 2009-04-20 | 2017-02-01 | Marrone Bio Innovations, Inc. | Chemical and biological agents for the control of molluscs |
| CN102459179A (zh) | 2009-04-27 | 2012-05-16 | 艾伦药物公司 | α-4整联蛋白的吡啶酮拮抗剂 |
| JP2012131708A (ja) | 2009-04-28 | 2012-07-12 | Nissan Chem Ind Ltd | 4位置換ピリダジノン化合物及びp2x7受容体阻害剤 |
| WO2010129467A1 (en) | 2009-05-04 | 2010-11-11 | Plexxikon, Inc. | Compounds and methods for inhibition of renin, and indications therefor |
| WO2010132864A1 (en) | 2009-05-15 | 2010-11-18 | Intermune, Inc. | Methods of treating hiv patients with anti-fibrotics |
| WO2010135470A1 (en) | 2009-05-19 | 2010-11-25 | Intermune, Inc. | Pifenidone derivatives for treating bronchial asthma |
| US8426407B2 (en) | 2009-05-25 | 2013-04-23 | Central South University | Preparation of 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compounds and salts thereof and their applications |
| ES2536200T3 (es) | 2009-05-25 | 2015-05-21 | Central South University | Preparación de compuestos de tipo 1-(bencilo sustituido)-5-trifluorometil-2-(1H)piridona, sales de estos y sus aplicaciones |
| WO2010141592A2 (en) | 2009-06-02 | 2010-12-09 | Marquette University | Chemical fragment screening and assembly utilizing common chemistry for nmr probe introduction and fragment linkage |
| EP2437600A4 (en) | 2009-06-03 | 2012-11-07 | Glaxosmithkline Llc | BIS-PYRIDYLPYRIDONE AS MELANIN CONCENTRATION HORMONE RECEPTOR-1 ANTAGONISTS |
| WO2010141538A1 (en) | 2009-06-03 | 2010-12-09 | Glaxosmithkline Llc | Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists |
| EP2437601A4 (en) | 2009-06-03 | 2012-10-31 | Glaxosmithkline Llc | BIS-PYRIDYLPYRIDONE AS MELANIN CONCENTRATION HORMONE RECEPTOR-1 ANTAGONISTS |
| TWI434833B (zh) | 2009-06-03 | 2014-04-21 | Intermune Inc | 用於合成吡非尼酮(pirfenidone)的改良方法 |
| WO2010141539A1 (en) | 2009-06-03 | 2010-12-09 | Glaxosmithkline Llc | Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists |
| WO2011055270A1 (en) * | 2009-11-04 | 2011-05-12 | Wyeth Llc | Indole based receptor crth2 antagonists |
| US8084475B2 (en) | 2009-12-04 | 2011-12-27 | Intermune, Inc. | Pirfenidone therapy and inducers of cytochrome P450 |
| TW201143768A (en) | 2009-12-15 | 2011-12-16 | Lundbeck & Co As H | Pyridone derivatives as NK3 antagonists |
| JPWO2011077711A1 (ja) | 2009-12-22 | 2013-05-02 | 興和株式会社 | 新規な2−ピリドン誘導体及びこれを含有する医薬 |
| JP2013523822A (ja) * | 2010-04-08 | 2013-06-17 | ブリストル−マイヤーズ スクイブ カンパニー | Gpr119修飾因子としてのピリミジニルピペリジニルオキシピリジノ類似体 |
| WO2011133722A2 (en) | 2010-04-23 | 2011-10-27 | Kineta, Inc. | Anti-viral compounds |
| PE20130376A1 (es) | 2010-06-28 | 2013-03-30 | Merck Patent Gmbh | [1,8]naftiridinas sustituidas por 2,4-diarilo como inhibidores de quinasas para uso contra el cancer |
| KR20120011357A (ko) * | 2010-07-23 | 2012-02-08 | 현대약품 주식회사 | 치환된 피리디논 유도체 및 이의 제조방법 |
| WO2012020742A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
| JP2013537210A (ja) | 2010-09-16 | 2013-09-30 | ノバルティス アーゲー | 17α−ヒドロキシラーゼ/C17,20−リアーゼ阻害剤 |
| CN102432598A (zh) * | 2010-09-29 | 2012-05-02 | 江苏恒瑞医药股份有限公司 | 三环化合物、其制备方法及其在医药上的应用 |
| CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
| US8643700B2 (en) * | 2010-11-17 | 2014-02-04 | Dell Products L.P. | 3D content adjustment system |
| WO2012075917A1 (en) | 2010-12-06 | 2012-06-14 | Glaxo Group Limited | Compounds |
| CN102558147B (zh) * | 2010-12-23 | 2014-09-17 | 江苏先声药物研究有限公司 | 化合物、制备方法及应用 |
| KR101928505B1 (ko) | 2011-01-28 | 2018-12-12 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
| KR101925971B1 (ko) | 2011-01-28 | 2018-12-06 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| JP6021117B2 (ja) | 2011-01-31 | 2016-11-02 | ジェノア ファーマシューティカルズ,インク. | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| WO2012107831A1 (en) | 2011-02-11 | 2012-08-16 | Signa S.A. De C.V. | Method of making a pyridone compound, 5-ethyl-1-phenyl-2-(1h)-pyridone, and intermediates thereof |
| AU2012225611B2 (en) | 2011-03-08 | 2016-09-15 | Auspex Pharmaceuticals, Inc. | Substituted N-Aryl pyridinones |
| FI20115234A0 (fi) * | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| CA2835438A1 (en) | 2011-05-25 | 2012-11-29 | Intermune, Inc. | Pirfenidone and anti-fibrotic therapy in selected patients |
| JP2014517757A (ja) * | 2011-05-27 | 2014-07-24 | イェンセン・デンマーク・アクティーゼルスカブ | 布片を送給するための方法及びフィーダ |
| CN102816175B (zh) | 2011-06-09 | 2015-12-16 | 上海汇伦生命科技有限公司 | 一种杂环并吡啶酮类化合物,其中间体、制备方法和用途 |
| WO2012175514A1 (en) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Pyridinone derivatives and pharmaceutical compositions thereof |
| WO2013004652A1 (de) * | 2011-07-04 | 2013-01-10 | Bayer Intellectual Property Gmbh | Verwendung substituierter isochinolinone, isochinolindione, isochinolintrione und dihydroisochinolinone oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress |
| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| JPWO2013018685A1 (ja) | 2011-07-29 | 2015-03-05 | 東レ株式会社 | ラクタム誘導体及びその医薬用途 |
| CN102276616B (zh) * | 2011-08-04 | 2013-09-04 | 中国科学院长春应用化学研究所 | 一种呋喃[3,2-c]吡啶-4(5H)-酮类化合物合成方法 |
| AU2012297569B2 (en) | 2011-08-16 | 2017-11-09 | Baker Heart and Diabetes Institute | Controlled-release formulation |
| US20130116241A1 (en) * | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| HUE050431T2 (hu) * | 2011-11-30 | 2020-12-28 | Hoffmann La Roche | Új biciklusos dihidroizokinolin-1-on származékok |
| PL2820009T3 (pl) | 2012-03-01 | 2018-09-28 | Array Biopharma, Inc. | Inhibitory kinaz serynowo/treoninowych |
| WO2013142390A1 (en) | 2012-03-21 | 2013-09-26 | Gtx, Inc. | Aldo-keto reductase subfamily 1c3 (akr1c3) inhibitors |
| MX2015000830A (es) | 2012-07-18 | 2015-10-26 | Sunshine Lake Pharma Co Ltd | Derivados heterociclicos nitrogenosos y su aplicacion en farmacos. |
| JP6501264B2 (ja) | 2012-07-24 | 2019-04-17 | アヴァリン ファーマ インク. | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| US20140094456A1 (en) | 2012-10-02 | 2014-04-03 | Intermune, Inc. | Anti-fibrotic pyridinones |
| UA111305C2 (uk) * | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| JP6256187B2 (ja) | 2014-05-14 | 2018-01-10 | 株式会社デンソー | 判定帰還型等化器 |
-
2013
- 2013-09-30 AR ARP130103530A patent/AR092742A1/es active IP Right Grant
- 2013-10-01 EA EA201590477A patent/EA027120B1/ru unknown
- 2013-10-01 RS RS20201510A patent/RS61225B1/sr unknown
- 2013-10-01 LT LTEP13843717.3T patent/LT2903991T/lt unknown
- 2013-10-01 PT PT138437173T patent/PT2903991T/pt unknown
- 2013-10-01 MX MX2020010037A patent/MX392621B/es unknown
- 2013-10-01 JP JP2015534817A patent/JP6326053B2/ja active Active
- 2013-10-01 MY MYPI2015000553A patent/MY174897A/en unknown
- 2013-10-01 US US14/043,121 patent/US9359379B2/en active Active
- 2013-10-01 CN CN201380061942.4A patent/CN104822687B/zh active Active
- 2013-10-01 NZ NZ745814A patent/NZ745814A/en unknown
- 2013-10-01 CN CN201810401768.8A patent/CN108503575A/zh active Pending
- 2013-10-01 SI SI201331821T patent/SI2903991T1/sl unknown
- 2013-10-01 CA CA3147961A patent/CA3147961A1/en active Pending
- 2013-10-01 NZ NZ707083A patent/NZ707083A/en unknown
- 2013-10-01 HR HRP20201934TT patent/HRP20201934T1/hr unknown
- 2013-10-01 EP EP13843717.3A patent/EP2903991B1/en active Active
- 2013-10-01 PL PL13843717T patent/PL2903991T3/pl unknown
- 2013-10-01 DK DK13843717.3T patent/DK2903991T3/da active
- 2013-10-01 AU AU2013327505A patent/AU2013327505B2/en active Active
- 2013-10-01 MX MX2015003918A patent/MX375381B/es active IP Right Grant
- 2013-10-01 CA CA2884251A patent/CA2884251C/en active Active
- 2013-10-01 KR KR1020157011627A patent/KR102176667B1/ko active Active
- 2013-10-01 US US14/432,881 patent/US20150266899A1/en not_active Abandoned
- 2013-10-01 HU HUE13843717A patent/HUE051581T2/hu unknown
- 2013-10-01 SG SG11201501751RA patent/SG11201501751RA/en unknown
- 2013-10-01 BR BR112015006341-1A patent/BR112015006341B1/pt active IP Right Grant
- 2013-10-01 EA EA201790137A patent/EA034171B1/ru unknown
- 2013-10-01 PE PE2015000433A patent/PE20151415A1/es unknown
- 2013-10-01 UA UAA201503004A patent/UA120908C2/uk unknown
- 2013-10-01 KR KR1020207031786A patent/KR102277608B1/ko active Active
- 2013-10-01 WO PCT/US2013/062910 patent/WO2014055548A1/en not_active Ceased
- 2013-10-01 ES ES13843717T patent/ES2835331T3/es active Active
- 2013-10-02 TW TW107140885A patent/TWI734049B/zh active
- 2013-10-02 TW TW102135721A patent/TWI644898B/zh active
-
2015
- 2015-03-09 IL IL237629A patent/IL237629B/en active IP Right Grant
- 2015-04-01 CL CL2015000816A patent/CL2015000816A1/es unknown
- 2015-04-01 PH PH12015500735A patent/PH12015500735B1/en unknown
- 2015-04-01 SA SA515360217A patent/SA515360217B1/ar unknown
- 2015-04-13 ZA ZA2015/02457A patent/ZA201502457B/en unknown
- 2015-04-16 CO CO15084654A patent/CO7350637A2/es unknown
- 2015-04-30 CR CR20150225A patent/CR20150225A/es unknown
- 2015-04-30 EC ECIEPI201517109A patent/ECSP15017109A/es unknown
-
2016
- 2016-05-23 US US15/162,214 patent/US9675593B2/en active Active
-
2017
- 2017-04-20 US US15/492,828 patent/US10376497B2/en active Active
-
2018
- 2018-04-13 JP JP2018077667A patent/JP6744355B2/ja active Active
- 2018-07-05 AU AU2018204894A patent/AU2018204894B2/en active Active
-
2019
- 2019-06-27 US US16/454,623 patent/US10898474B2/en active Active
- 2019-11-04 IL IL270414A patent/IL270414B/en unknown
-
2020
- 2020-09-14 IL IL277341A patent/IL277341B2/en unknown
-
2021
- 2021-01-05 PE PE2021000008A patent/PE20211501A1/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017512784A (ja) * | 2014-04-02 | 2017-05-25 | インターミューン, インコーポレイテッド | 抗線維性ピリジノン |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6326053B2 (ja) | 抗線維性ピリジノン | |
| JP6745926B2 (ja) | 抗線維性ピリジノン | |
| US20140094456A1 (en) | Anti-fibrotic pyridinones | |
| HK1212981B (en) | Anti-fibrotic pyridinones | |
| HK1260632A1 (en) | Anti-fibrotic pyridinones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160921 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160921 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170628 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170629 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20170927 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20171115 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171228 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180316 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180413 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6326053 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |