MX2011007675A - Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. - Google Patents

Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.

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Publication number
MX2011007675A
MX2011007675A MX2011007675A MX2011007675A MX2011007675A MX 2011007675 A MX2011007675 A MX 2011007675A MX 2011007675 A MX2011007675 A MX 2011007675A MX 2011007675 A MX2011007675 A MX 2011007675A MX 2011007675 A MX2011007675 A MX 2011007675A
Authority
MX
Mexico
Prior art keywords
regression
pirfenidone
sustained
humans
pharmaceutical composition
Prior art date
Application number
MX2011007675A
Other languages
English (en)
Inventor
Juan Armendariz Borunda
Jose Agustin Rogelio Magana Castro
Jorge Cervantes Guadarrama
Original Assignee
Cell Therapy And Technology S A De C V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46940567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011007675(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cell Therapy And Technology S A De C V filed Critical Cell Therapy And Technology S A De C V
Priority to MX2011007675A priority Critical patent/MX2011007675A/es
Priority to UY0001034190A priority patent/UY34190A/es
Publication of MX2011007675A publication Critical patent/MX2011007675A/es
Priority to ES15161929.3T priority patent/ES2550227T3/es
Priority to AU2012284627A priority patent/AU2012284627B2/en
Priority to BR112014001297-0A priority patent/BR112014001297B1/pt
Priority to HUE15161929A priority patent/HUE036511T2/hu
Priority to DE15161929.3T priority patent/DE15161929T1/de
Priority to CN201280045648.XA priority patent/CN103957892A/zh
Priority to RS20180168A priority patent/RS56858B1/sr
Priority to DK15161929.3T priority patent/DK2907506T3/en
Priority to PL15161929T priority patent/PL2907506T3/pl
Priority to PE2014000097A priority patent/PE20141684A1/es
Priority to KR1020167015898A priority patent/KR20160074016A/ko
Priority to EP12766487.8A priority patent/EP2735306A1/en
Priority to PCT/MX2012/000067 priority patent/WO2013012307A1/es
Priority to EP15161929.3A priority patent/EP2907506B1/en
Priority to PT15161929T priority patent/PT2907506T/pt
Priority to SI201231198T priority patent/SI2907506T1/en
Priority to NO15161929A priority patent/NO2907506T3/no
Priority to CN202011071995.2A priority patent/CN112386579A/zh
Priority to RU2014101231A priority patent/RU2682177C2/ru
Priority to US14/233,600 priority patent/US9408836B2/en
Priority to LTEP15161929.3T priority patent/LT2907506T/lt
Priority to JP2014521581A priority patent/JP6034380B2/ja
Priority to CA2842654A priority patent/CA2842654C/en
Priority to KR1020147002065A priority patent/KR101632332B1/ko
Priority to UAA201401623A priority patent/UA114181C2/uk
Priority to ARP120102578A priority patent/AR087205A1/es
Priority to CR20140019A priority patent/CR20140019A/es
Priority to CL2014000131A priority patent/CL2014000131A1/es
Priority to CO14008053A priority patent/CO6970587A2/es
Priority to ZA2014/00386A priority patent/ZA201400386B/en
Priority to DO2014000010A priority patent/DOP2014000010A/es
Priority to ECSP14013160 priority patent/ECSP14013160A/es
Priority to HK15108824.8A priority patent/HK1208172A1/xx
Priority to CY20152200005T priority patent/CY2200005T2/el
Priority to US15/177,760 priority patent/US9962374B2/en
Priority to US15/831,650 priority patent/US10383862B2/en
Priority to HRP20180183TT priority patent/HRP20180183T1/hr
Priority to CY20181100141T priority patent/CY1119886T1/el
Priority to US16/460,407 priority patent/US11040030B2/en
Priority to US16/544,643 priority patent/US11052074B2/en
Priority to US17/351,151 priority patent/US20210386724A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Abstract

La presente invención se relaciona con un procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada que comprende desde 600 miligramos hasta 2400 miligramos de Pirfenidona (PFD), de manera tal que el fármaco que lo contiene esté biodisponible durante un periodo de tiempo prolongado de 12 horas a partir de su administración. De esta manera se optimiza la acción anti-fibrótica y anti-inflamatoria del medicamento Pirfenidona. Además, la presente invención ofrece ventajas y una mejor eficacia terapéutica sobre otras formas farmacéuticas de Pirfenidona para su administración oral y su aplicación terapéutica en la regresión de la insuficiencia renal crónica secundaria a glomeruloesclerosis primaria; presenta una mejor actividad en la disminución y/o regresión de los efectos nocivos en la contractura capsular mamaria observados después la implantación quirúrgica de implantes mamarios en humanos y ejerce una importante acción anti-TNF-a y anti-TGF-ß1 para el tratamiento de fibrosis hepática.
MX2011007675A 2011-07-19 2011-07-19 Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. MX2011007675A (es)

Priority Applications (43)

Application Number Priority Date Filing Date Title
MX2011007675A MX2011007675A (es) 2011-07-19 2011-07-19 Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
UY0001034190A UY34190A (es) 2011-07-19 2012-07-09 Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresión de la insuficiencia renal crónica, contractura capsular mamaria y fibrosis hepatica humana
KR1020147002065A KR101632332B1 (ko) 2011-07-19 2012-07-13 피르페니돈을 함유하는 서방성 정제형의 약학적 조성물의 제조방법 및 인간에서의 만성 신부전, 유방 구형 구축 및 간 섬유증의 회귀에서 그것의 적용
UAA201401623A UA114181C2 (uk) 2011-07-19 2012-07-13 Спосіб виготовлення фармацевтичної композиції, яка містить пірфенідон, у вигляді таблетки з пролонгованою дією та її застосування в період регресії ниркової недостатності, капсулярної контрактури та фіброзу печінки
CN202011071995.2A CN112386579A (zh) 2011-07-19 2012-07-13 缓释片剂形式的含吡非尼酮药物组合物的制备方法及应用
JP2014521581A JP6034380B2 (ja) 2011-07-19 2012-07-13 徐放錠の形態でピルフェニドンを含有する医薬組成物の調製のためのプロセスならびにヒトの慢性腎不全、乳房被膜拘縮および肝線維症の退行におけるその適用
BR112014001297-0A BR112014001297B1 (pt) 2011-07-19 2012-07-13 Composição farmacêutica em forma de tabletes de liberação prolongada contendo pirfenidona, seu processo de fabricação e uso de pirfenidona na regressão da insuficiência renal crônica, na contratura capsular mamária e na fibrose hepática
HUE15161929A HUE036511T2 (hu) 2011-07-19 2012-07-13 Eljárás pirferint tartalmazó, nyújtott leadású tabletta formájában lévõ gyógyászati készítmény elõállítására, és a készítmény alkalmazása krónikus veseelégtelenség, mell tokzsugorodás, és májfibrózis visszaszorítására embernél
DE15161929.3T DE15161929T1 (de) 2011-07-19 2012-07-13 Verfahren zur herstellung einer pharmazeutischen zusammensetzung in form von retard-tabletten mit pirfenidon und verwendung davon bei der regression von chronischer niereninsuffizienz, kapselkontraktur und eberfibrose bei menschen
CN201280045648.XA CN103957892A (zh) 2011-07-19 2012-07-13 以缓释片剂形式制备含有吡非尼酮的药物组合物的方法及其在人慢性肾功能衰竭、乳房包膜挛缩和肝纤维化的复原中的应用
RS20180168A RS56858B1 (sr) 2011-07-19 2012-07-13 Postupak proizvodnje farmaceutske kompozicije u obliku tableta sa produženim-oslobađanjem koje sadrže pirfenidon i njihova upotreba u regresiji hronične renalne insuficijencije, kapsularne kontrakture grudi i hepatičke fibroze kod ljudi
DK15161929.3T DK2907506T3 (en) 2011-07-19 2012-07-13 Process for the preparation of a pharmaceutical composition in the form of prolonged-release tablets containing pirfenidone and its use in regression of chronic renal failure, capsule contracture and hepatic fibrosis in humans
PL15161929T PL2907506T3 (pl) 2011-07-19 2012-07-13 Sposób wytwarzania kompozycji farmaceutycznej w postaci tabletek o przedłużonym uwalnianiu zawierających pirfenidon i jej zastosowanie w regresji przewlekłej niewydolności nerek, przykurczu torebkowego piersi zwłóknienia wątroby u ludzi.
PE2014000097A PE20141684A1 (es) 2011-07-19 2012-07-13 Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas
KR1020167015898A KR20160074016A (ko) 2011-07-19 2012-07-13 피르페니돈을 함유하는 서방성 정제형의 약학적 조성물의 제조방법 및 인간에서의 만성 신부전, 유방 구형 구축 및 간 섬유증의 회귀에서 그것의 적용
EP12766487.8A EP2735306A1 (en) 2011-07-19 2012-07-13 Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans
PCT/MX2012/000067 WO2013012307A1 (es) 2011-07-19 2012-07-13 Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresión de la insuficiencia renal crónica, contractura capsular mamaria y fibrosis hepatica humanas
EP15161929.3A EP2907506B1 (en) 2011-07-19 2012-07-13 Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans
PT15161929T PT2907506T (pt) 2011-07-19 2012-07-13 Método para fabrico de uma composição farmacêutica sob a forma de comprimidos de libertação prolongada que contém pirfenidona e uso da mesma na regressão da insuficiência renal crónica, contração capsular da mama e fibrose hepática em humanos
SI201231198T SI2907506T1 (en) 2011-07-19 2012-07-13 A process for the manufacture of a pharmaceutical composition in the form of prolonged-release tablets containing pirfenidone and the use thereof in regression of chronic renal insufficiency, capsular breast contracture and hepatic fibrosis in humans
NO15161929A NO2907506T3 (es) 2011-07-19 2012-07-13
ES15161929.3T ES2550227T3 (es) 2011-07-19 2012-07-13 Método para fabricar una composición farmacéutica en forma de comprimidos de liberación prolongada que contienen pirfenidona y uso de la misma en la regresión de insuficiencia renal crónica, contractura capsular de mama y fibrosis hepática en seres humanos
RU2014101231A RU2682177C2 (ru) 2011-07-19 2012-07-13 Способ получения фармацевтической композиции в форме таблетки с замедленным высвобождением, содержащей пирфенидон, и её применение для ослабления симптомов хронической почечной недостаточности, капсулярной контрактуры молочной железы и фиброза печени человека
US14/233,600 US9408836B2 (en) 2011-07-19 2012-07-13 Pharmaceutical composition containing pirfenidone in sustained-release tablet form
LTEP15161929.3T LT2907506T (lt) 2011-07-19 2012-07-13 Nepertraukiamo atpalaidavimo tabletės formos farmacinės kompozicijos, turinčios pirfenidono, gavimo būdas ir jos panaudojimas žmonių lėtinio inkstų napakankamumo, krūties kapsulinės kontraktūros ir hepatitinės fibrozės regresijai
AU2012284627A AU2012284627B2 (en) 2011-07-19 2012-07-13 Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing Pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans
CA2842654A CA2842654C (en) 2011-07-19 2012-07-13 Process for the preparation of a pharmaceutical composition containing pirfenidone in sustained-release tablet form and its application in the regression of human chronic renal failure, breast capsular contracture and hepatic fibrosis
ARP120102578A AR087205A1 (es) 2011-07-19 2012-07-16 Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas
CR20140019A CR20140019A (es) 2011-07-19 2014-01-16 Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresión de la insuficiencia real crónica, contractura capsular mamaria y ...
ZA2014/00386A ZA201400386B (en) 2011-07-19 2014-01-17 Process for the preparation of a pharmaceutical composition containing pirfenidone in sustained-release tablet form and its application in the regression of human chronic renal failure, breast capsular contracture and hepatic fibrosis
CL2014000131A CL2014000131A1 (es) 2011-07-19 2014-01-17 Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada que comprende pirfenidona; y su uso para el tratamiento o regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica.
CO14008053A CO6970587A2 (es) 2011-07-19 2014-01-17 Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresión de la insuficiencia renal crónica, contractura capsular mamaria y fibrosis hepatica humanas
DO2014000010A DOP2014000010A (es) 2011-07-19 2014-01-20 Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresion de la insuficiencia renal crónica, contractura capsular mamaria y fibrosis hepatica humanas.
ECSP14013160 ECSP14013160A (es) 2011-07-19 2014-01-21 Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresión de la insuficiencia renal crónica, contractura capsular mamaria y fibrosis hepatica hu
HK15108824.8A HK1208172A1 (en) 2011-07-19 2015-09-10 Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans
CY20152200005T CY2200005T2 (el) 2011-07-19 2015-12-16 Μεθοδος βιομηχανικης κατασκευης μιας φαρμακευτικης συνθεσης στην μορφη παρατεταμενης-απελευθερωσης που περιεχουν πιρφενιδονη και χρηση αυτων στην υποστροφη χρονιας νεφρικης ανεπαρκειας, καψικης συσπασης μαστου και ηπατικης ινωσης σε ανθρωπους
US15/177,760 US9962374B2 (en) 2011-07-19 2016-06-09 Process for the preparation of a pharmaceutical composition containing pirfenidone in sustained-release tablet form and its application in the regression of human chronic renal failure, breast capsular contracture and hepatic fibrosis
US15/831,650 US10383862B2 (en) 2011-07-19 2017-12-05 Methods of using a pharmaceutical composition containing pirfenidone in sustained-release tablet form
HRP20180183TT HRP20180183T1 (hr) 2011-07-19 2018-01-31 Postupak za proizvodnju farmaceutskog pripravka u obliku tableta s produljenim otpuštanjem koje sadrže pirfenidon i njihova uporaba za regresiju kronične bubrežne insuficijencije, kapsularne kontrakture dojke i fibroze jetre kod ljudi
CY20181100141T CY1119886T1 (el) 2011-07-19 2018-02-05 Μεθοδος βιομηχανικης κατασκευης μιας φαρμακευτικης συνθεσης στην μορφη δισκιων παρατεταμενης απελευθερωσης που περιεχουν πιρφενιδονη και χρηση αυτων στην υποστροφη χρονιας νεφρικης ανεπαρκειας, καψικης συσπασης μαστου και ηπατικης ινωσης σε ανθρωπους
US16/460,407 US11040030B2 (en) 2011-07-19 2019-07-02 Methods of using a pharmaceutical composition containing pirfenidone in sustained-release tablet form
US16/544,643 US11052074B2 (en) 2011-07-19 2019-08-19 Process for the preparation of a pharmaceutical composition containing pirfenidone in sustained-release tablet form and its application in the regression of human chronic renal failure, breast capsular contracture and hepatic fibrosis
US17/351,151 US20210386724A1 (en) 2011-07-19 2021-06-17 Methods of using a pharmaceutical composition containing pirfenidone in sustained-release tablet form

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