PE20141684A1 - Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas - Google Patents

Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas

Info

Publication number
PE20141684A1
PE20141684A1 PE2014000097A PE2014000097A PE20141684A1 PE 20141684 A1 PE20141684 A1 PE 20141684A1 PE 2014000097 A PE2014000097 A PE 2014000097A PE 2014000097 A PE2014000097 A PE 2014000097A PE 20141684 A1 PE20141684 A1 PE 20141684A1
Authority
PE
Peru
Prior art keywords
pyrphenidone
pharmaceutical composition
procedure
manufacture
regression
Prior art date
Application number
PE2014000097A
Other languages
English (en)
Inventor
Borunda Juan Armendariz
Castro Jose Augustin Rogelio Magana
Guadarrama Jorge Cervantes
Original Assignee
Cell Therapy And Technology S A De C V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46940567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141684(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cell Therapy And Technology S A De C V filed Critical Cell Therapy And Technology S A De C V
Publication of PE20141684A1 publication Critical patent/PE20141684A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA FABRICACION DE UNA COMPOSICION FARMACEUTICA, QUE COMPRENDE: PASO 1). PIRFENIDONA Y DIOXIDO DE SILICIO SE TAMIZAN POR MALLA No. 30 EN UN GRANULADOR OSCILANTE, LUEGO SE COLOCAN EN UN MEZCLADOR DE LISTON Y MEZCLAR DURANTE 5 MINUTOS; PASO 2). LA CELULOSA MICROCRISTALINA, LAS HIDROXIPROPILMETILCELULOSAS (HPMC) DE BAJA VISCOSIDAD Y DE ALTA VISCOSIDAD SE TAMIZAN EN EL GRANULADOR OSCILANTE, SE COLOCAN EN EL MEZCLADOR DE LISTON DEL PASO 1 Y SE MEZCLAN DURANTE 15 MINUTOS; PASO 3). EL ESTEARIL FUMARATO DE SODIO SE TAMIZA EN EL GRANULADOR OSCILANTE, SE COLOCA EN EL MEZCLADOR DE LISTON DEL PASO 1 Y SE MEZCLA DURANTE 3 MINUTOS; Y PASO 4). EL GRANULADO OBTENIDO SE TABLETEA EN LA TABLETEADORA, PROVISTA DE PUNZONES DE FORMA OBLONDA CON LOS SIGUIENTES PARAMETROS DE COMPRESION: PESO PROMEDIO: 850MG + 5%; DUREZA: MAXIMO 10KG F; FRIABILIDAD: MENOR AL 1%. DICHA COMPOSICION FARMACEUTICA SE PRESENTA EN FORMA DE TABLETAS QUE COMPRENDE 100mg, 200mg, 400mg O 600mg DE PIRFENIDONA
PE2014000097A 2011-07-19 2012-07-13 Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas PE20141684A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX2011007675A MX2011007675A (es) 2011-07-19 2011-07-19 Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.

Publications (1)

Publication Number Publication Date
PE20141684A1 true PE20141684A1 (es) 2014-11-13

Family

ID=46940567

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014000097A PE20141684A1 (es) 2011-07-19 2012-07-13 Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas

Country Status (34)

Country Link
US (6) US9408836B2 (es)
EP (2) EP2735306A1 (es)
JP (1) JP6034380B2 (es)
KR (2) KR20160074016A (es)
CN (2) CN103957892A (es)
AR (1) AR087205A1 (es)
AU (1) AU2012284627B2 (es)
BR (1) BR112014001297B1 (es)
CA (1) CA2842654C (es)
CL (1) CL2014000131A1 (es)
CO (1) CO6970587A2 (es)
CR (1) CR20140019A (es)
CY (2) CY2200005T2 (es)
DE (1) DE15161929T1 (es)
DK (1) DK2907506T3 (es)
DO (1) DOP2014000010A (es)
EC (1) ECSP14013160A (es)
ES (1) ES2550227T3 (es)
HK (1) HK1208172A1 (es)
HR (1) HRP20180183T1 (es)
HU (1) HUE036511T2 (es)
LT (1) LT2907506T (es)
MX (1) MX2011007675A (es)
NO (1) NO2907506T3 (es)
PE (1) PE20141684A1 (es)
PL (1) PL2907506T3 (es)
PT (1) PT2907506T (es)
RS (1) RS56858B1 (es)
RU (1) RU2682177C2 (es)
SI (1) SI2907506T1 (es)
UA (1) UA114181C2 (es)
UY (1) UY34190A (es)
WO (1) WO2013012307A1 (es)
ZA (1) ZA201400386B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007009796A (es) 2007-08-14 2009-02-25 Cell Therapy And Technology S Gel conteniendo pirfenidona.
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
MX346763B (es) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné.
MX356551B (es) 2012-08-23 2018-06-04 Grupo Medifarma S A De C V Star Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné.
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
KR102237799B1 (ko) 2012-11-14 2021-04-08 더블유.알. 그레이스 앤드 캄파니-콘. 생물학적 활성 물질 및 비-정렬된 무기 산화물을 함유하는 조성물
CA2943363A1 (en) 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones
CA2937365C (en) * 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
CN105997302A (zh) * 2016-07-18 2016-10-12 青岛三帝生物科技有限公司 基于3d打印的防包膜挛缩乳房假体制作方法和乳房假体
MX364040B (es) * 2016-11-11 2019-04-11 Cell Therapy And Tech S A De C V Uso farmacéutico de una composición que contiene pirfenidona de liberación prolongada (pfd-lp) para la reversión y tratamiento de la esteatohepatitis humana (nafld/nash).
KR20180100869A (ko) * 2017-03-02 2018-09-12 영진약품 주식회사 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법
CN107080741A (zh) * 2017-04-28 2017-08-22 北京工业大学 吡非尼酮缓释制剂及制备方法
MX366086B (es) 2017-08-15 2019-06-27 Cell Therapy And Tech S A De C V Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel.
US10980747B2 (en) * 2017-11-27 2021-04-20 Shin-Etsu Chemical Co., Ltd. Composition for solid preparation, solid preparation, and method for producing the same
EP3511001B1 (en) 2018-01-12 2021-09-22 Alfred E. Tiefenbacher (GmbH & Co. KG) Pirfenidone-containing tablet and capsule formulation
BR112020021412A8 (pt) 2018-04-23 2022-07-05 Taiwan Liposome Co Ltd Composição lipossômica, inalável de liberação prolongada para uso no tratamento de doenças pulmonares
WO2020115774A1 (en) * 2018-12-06 2020-06-11 Cipla Limited High drug load extended release formulations
KR102199415B1 (ko) 2019-02-18 2021-01-06 충북대학교 산학협력단 중합체 및 채널링제를 포함하는 피르페니돈 또는 이의 약학적으로 허용가능한 염의 지연 방출용 정제
MX2022012986A (es) * 2020-04-14 2023-03-21 Excalibur Pharmaceuticals Inc Pirfenidona para el tratamiento del coronavirus.
WO2021215856A1 (ko) * 2020-04-22 2021-10-28 영진약품 주식회사 안전성과 안정성이 개선된 피르페니돈을 포함하는 장용성 제제 및 이의 제조방법

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042699A (en) 1972-12-18 1977-08-16 Affiliated Medical Research, Inc. Method for reducing serum glucose levels
US4052509A (en) 1972-12-18 1977-10-04 Affiliated Medical Research, Inc. Method for reducing serum uric acid levels
DE2366349C2 (de) 1972-12-18 1986-03-27 Affiliated Medical Research Inc., Princeton, N.J. Verfahren zur Herstellung von 5-Methyl-1-phenyl-2-(1H)-pyridon
CA1049411A (en) 1972-12-18 1979-02-27 Affiliated Medical Research N-substituted pyridone and general method for preparing pyridones
US3839346A (en) 1972-12-18 1974-10-01 Affiliated Med Res N-substituted pyridone and general method for preparing pyridones
US4105782A (en) 1975-03-07 1978-08-08 Yu Ruey J Treatment of acne and dandruff
JPS51128438A (en) 1975-04-26 1976-11-09 Yamanouchi Pharmaceut Co Ltd An antibacterial drug against fish diseases
SE430609B (sv) 1976-12-21 1983-11-28 Sca Development Ab Sett att ur cellulosaderivat framstella absorberande material
US4376118A (en) 1980-10-06 1983-03-08 Miles Laboratories, Inc. Stable nonaqueous solution of tetracycline salt
SU1719047A1 (ru) * 1989-11-09 1992-03-15 Воронежский инженерно-строительный институт Вибрационный гранул тор
US5310562A (en) 1989-11-22 1994-05-10 Margolin Solomon B Composition and method for reparation and prevention of fibrotic lesions
US5009895A (en) * 1990-02-02 1991-04-23 Merck & Co., Inc. Sustained release with high and low viscosity HPMC
ES2082723B1 (es) * 1994-07-20 1996-10-01 Lilly Sa Formulacion farmaceutica de fluoxetina en forma dispersable.
CZ293747B6 (cs) 1995-12-21 2004-07-14 Pfizer Inc. Vodný farmaceutický roztok vhodný pro injekční podávání hostiteli a jeho použití
US5958420A (en) 1997-03-13 1999-09-28 Nortrade Medical, Inc. Treatment of burns, cuts, and abrasions of the skin
US6365131B1 (en) 1997-10-31 2002-04-02 J. B. Chemicals & Pharmaceuticals Ltd. Pharmaceutical dental formulation for topical application of metronidazole benzoate, chlorhexidine gluconate and local anesthetic
CA2322994A1 (en) 1998-03-17 1999-09-23 Solomon B. Margolin Topical antiseptic compositions and methods
GB9810949D0 (en) 1998-05-22 1998-07-22 Hewlett Healthcare Limited Formulation
DE69810518D1 (de) 1998-09-18 2003-02-06 Mepha Ag Aesch Topisch verabreichbare alkyl-, phenyl-pyridone-arzneimittel
US6277407B1 (en) * 1998-11-10 2001-08-21 Frederick S. Marius Apparatus and method for tablet fabrication
HUP0104606A3 (en) * 1998-12-18 2003-01-28 Basf Ag A pharmaceutical mixture comprising a profen
IN191090B (es) 2000-08-29 2003-09-20 Ranbanx Lab Ltd
EP1356816B1 (en) * 2001-01-29 2009-12-23 Shionogi & Co., Ltd. Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
WO2004073713A1 (ja) 2003-02-21 2004-09-02 Shionogi & Co., Ltd. ピルフェニドンのゲル剤
EP1638625A4 (en) 2003-05-23 2009-08-19 David M Ott ORGANOSOUFRES PROMEDICAMENTS FOR PREVENTING AND TREATING INFECTIOUS DISEASES AND A PATHOLOGICAL REACTION OF THE IMMUNE SYSTEM
US20080025986A1 (en) 2003-06-06 2008-01-31 Ozes Osman N Methods of Treating Tnf-Mediated Disorders
US8168228B2 (en) * 2003-10-17 2012-05-01 Sandoz Ag Antibiotic clarithromycin micropellet compositions
US20060051339A1 (en) 2004-09-08 2006-03-09 Sivak Hannah N Composition for treatment of oily skin and acne prevention and methods of making and using same
US20060115503A1 (en) 2004-11-30 2006-06-01 Goyal Muna C Composition, system and method for treatment of skin
NZ591443A (en) * 2005-09-22 2013-04-26 Intermune Inc Granule formation of pirfenidone and pharmaceutically acceptable excipients
US20070203202A1 (en) * 2005-12-02 2007-08-30 Robinson Cynthia Y Methods of reducing adverse events associated with pirfenidone therapy
CA2631497C (en) 2005-12-05 2014-04-22 Bioartificial Gel Technologies Inc. Emulsions of a protein-crosslinked hydrogel matrix and dispersed hydrophobic phase
US20080050449A1 (en) * 2006-03-21 2008-02-28 Dafna Arieli Controlled release formulation of tolterodine
ATE533486T1 (de) * 2006-06-15 2011-12-15 Shanghai Genomics Inc Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzung
ATE506060T1 (de) * 2006-12-18 2011-05-15 Intermune Inc Verfahren zur bereitstellung einer pirfenidontherapie an einem patienten
JP2010520194A (ja) 2007-03-02 2010-06-10 ミロン、タリア 抗癌剤としてのメルカプトプリン誘導体
MX2007006347A (es) * 2007-05-29 2009-02-18 Cell Therapy And Technology S Nuevo uso de 5-metil-1-fenil-2-(1h)-piridona para el tratamiento y prevencion de cicatrices hipertroficas, y composicion conteniendo la misma.
EP2170828B1 (en) * 2007-06-20 2012-11-21 Auspex Pharmaceuticals, Inc. Substituted n-aryl pyridinones as fibrotic inhibitors
MX2007009796A (es) 2007-08-14 2009-02-25 Cell Therapy And Technology S Gel conteniendo pirfenidona.
CN101244045B (zh) * 2007-12-21 2010-06-30 东华大学 一种零级给药口服控释片剂及其制备方法
CN101972236A (zh) * 2010-10-13 2011-02-16 北京诚创康韵医药科技有限公司 一种含吡非尼酮的缓释制剂
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
MX346763B (es) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné.
MX356551B (es) 2012-08-23 2018-06-04 Grupo Medifarma S A De C V Star Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné.
MX352342B (es) 2013-07-12 2017-11-22 Moleculas Naturales S A De C V Star Un procedimiento para fabricar un complejo mejorado de cloruro de bencetonio-dialil oxido de disulfuro modificado, el complejo obtenido y sus usos.
MX364040B (es) 2016-11-11 2019-04-11 Cell Therapy And Tech S A De C V Uso farmacéutico de una composición que contiene pirfenidona de liberación prolongada (pfd-lp) para la reversión y tratamiento de la esteatohepatitis humana (nafld/nash).
MX366086B (es) 2017-08-15 2019-06-27 Cell Therapy And Tech S A De C V Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel.

Also Published As

Publication number Publication date
DK2907506T1 (en) 2015-10-12
CA2842654A1 (en) 2013-01-24
KR20140057248A (ko) 2014-05-12
PT2907506T (pt) 2018-02-22
US9962374B2 (en) 2018-05-08
US20160287567A1 (en) 2016-10-06
EP2907506B1 (en) 2017-11-15
CO6970587A2 (es) 2014-06-13
KR20160074016A (ko) 2016-06-27
US20180092893A1 (en) 2018-04-05
CY2200005T2 (el) 2016-04-13
ZA201400386B (en) 2015-04-29
CN112386579A (zh) 2021-02-23
MX2011007675A (es) 2012-07-11
HK1208172A1 (en) 2016-02-26
DK2907506T3 (en) 2018-02-19
AU2012284627A1 (en) 2014-02-27
RU2682177C2 (ru) 2019-03-15
JP2014522861A (ja) 2014-09-08
AR087205A1 (es) 2014-02-26
DE15161929T1 (de) 2015-11-12
BR112014001297B1 (pt) 2021-11-16
WO2013012307A1 (es) 2013-01-24
CN103957892A (zh) 2014-07-30
DOP2014000010A (es) 2014-06-30
RU2014101231A (ru) 2015-08-27
AU2012284627A8 (en) 2014-04-10
US20210386724A1 (en) 2021-12-16
US10383862B2 (en) 2019-08-20
RS56858B1 (sr) 2018-04-30
CR20140019A (es) 2014-05-20
SI2907506T1 (en) 2018-03-30
ES2550227T1 (es) 2015-11-05
JP6034380B2 (ja) 2016-11-30
UA114181C2 (uk) 2017-05-10
CA2842654C (en) 2020-09-15
EP2907506A1 (en) 2015-08-19
HUE036511T2 (hu) 2018-07-30
ES2550227T3 (es) 2018-03-16
US11052074B2 (en) 2021-07-06
US11040030B2 (en) 2021-06-22
NO2907506T3 (es) 2018-04-14
BR112014001297A2 (pt) 2017-02-21
AU2012284627B2 (en) 2017-07-20
HRP20180183T1 (hr) 2018-03-09
US20140296300A1 (en) 2014-10-02
US20200038386A1 (en) 2020-02-06
HUE15161929T1 (hu) 2016-06-28
LT2907506T (lt) 2018-03-12
KR101632332B1 (ko) 2016-06-22
US20190358213A1 (en) 2019-11-28
PL2907506T3 (pl) 2018-07-31
EP2735306A1 (en) 2014-05-28
UY34190A (es) 2013-02-28
ECSP14013160A (es) 2014-02-28
US9408836B2 (en) 2016-08-09
CL2014000131A1 (es) 2014-08-22
CY1119886T1 (el) 2018-06-27

Similar Documents

Publication Publication Date Title
PE20141684A1 (es) Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas
AR081774A1 (es) Composiciones farmaceuticas de co-cristales de tramadol y coxibs
AR065096A1 (es) Preparacion solida
CR20170361A (es) Forma de dosificación que incluye una solución sólida de drogas amorfas
PE20180522A1 (es) Unidad de dosificacion orodispersable que contiene un componente estetrol
CO6460753A2 (es) Procedimiento y composición para mejorar la absorción de agentes terapéuticos
MY174005A (en) Swallowable n-acetylcysteine tablets
AR081902A1 (es) Comprimidos de meloxicam de baja concentracion
ES2582309T3 (es) Uso de trinitrato de glicerilo para el tratamiento de edema traumático
EA201591568A1 (ru) Пероральная таблетированная фармацевтическая композиция двойного применения на основе сульфатных солей и способы ее применения
TW201129386A (en) Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients
EA202090913A1 (ru) Композиция таблеток с модифицированным высвобождением, содержащая мирабегрон
EA201990129A1 (ru) Таблетированный состав с улучшенным профилем растворения для лечения болезни паркинсона
CO2018010142A2 (es) Proceso de preparación de fórmulas solidas de mesalazina
GT201400044A (es) 2-(croman-6-iloxi)-tiazoles sustituidos y su uso como productos farmacéuticos
HRP20210969T1 (hr) Farmaceutski sastav koji sadrži darunavir i metoda za njegovu pripremu
RU2013127794A (ru) Фармацевтическая комбинация и композиция для лечения ожирения и ее применение
RU2014120368A (ru) Противовирусное лекарственное средство в виде капсул и способ его получения
DOP2019000035A (es) Composición mejorada de teneligliptina y metformina y proceso para prepararla
RU2013101117A (ru) Способ изготовления твердой фармацевтической композиции валсартана и гидрохлортиазида
TH164760A (th) เม็ด n-อะซีติลซิสเทอีนที่สามารถกลืนได้
RU2011109432A (ru) Фармацевтическая композиция для лечения сердца пролонгированного действия
DOP2014000047A (es) 2-(Croman-6-iloxi)-tiazoles sustituidos y su uso como farmacéuticos
TH147179A (th) กระบวนการสำหรับการเตรียมขององค์ประกอบทางเภสัชกรรมที่บรรจุเพียร์เฟนิโดนในรูปยาเม็ดชนิดปลดปล่อยเนิ่นนาน และการใช้ของสิ่งนั้นในการทุเลาของ ภาวะไตวายเรื้อรัง, ภาวะพังผืดหดรัดของเต้านม, และ ภาวะพังผืดที่ตับของมุนษย์
PL399712A1 (pl) Sposób wytwarzania tabletki o zwiekszonej dostepnosci farmaceutycznej worykonazolu

Legal Events

Date Code Title Description
FG Grant, registration