ATE533486T1 - Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzung - Google Patents
Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzungInfo
- Publication number
- ATE533486T1 ATE533486T1 AT06791093T AT06791093T ATE533486T1 AT E533486 T1 ATE533486 T1 AT E533486T1 AT 06791093 T AT06791093 T AT 06791093T AT 06791093 T AT06791093 T AT 06791093T AT E533486 T1 ATE533486 T1 AT E533486T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridone derivatives
- preventing
- lung injury
- radiotherapy
- related lung
- Prior art date
Links
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title abstract 4
- 208000004852 Lung Injury Diseases 0.000 title abstract 3
- 231100000515 lung injury Toxicity 0.000 title abstract 3
- 206010069363 Traumatic lung injury Diseases 0.000 title 1
- 238000001959 radiotherapy Methods 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 230000005855 radiation Effects 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 abstract 1
- 229960003073 pirfenidone Drugs 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80491406P | 2006-06-15 | 2006-06-15 | |
| PCT/CN2006/002504 WO2007147297A1 (fr) | 2006-06-15 | 2006-09-25 | Utilisation de dérivés de pyridone destinés à prévenir et traiter par radioactivité une lésion des poumons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE533486T1 true ATE533486T1 (de) | 2011-12-15 |
Family
ID=38833053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06791093T ATE533486T1 (de) | 2006-06-15 | 2006-09-25 | Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8765726B2 (de) |
| EP (1) | EP2036555B1 (de) |
| JP (1) | JP5213852B2 (de) |
| CN (1) | CN101484167B (de) |
| AT (1) | ATE533486T1 (de) |
| CA (1) | CA2656017C (de) |
| WO (1) | WO2007147297A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513320A (ja) | 2006-12-18 | 2010-04-30 | インターミューン インコーポレイテッド | ピルフェニドン治療を患者に提供する方法 |
| JP5627574B2 (ja) * | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| EP2389227A4 (de) * | 2009-01-26 | 2012-08-08 | Intermune Inc | Verfahren zur behandlung von akuten myokardinfarkten und damit assoziierten erkrankungen |
| MX2011007675A (es) * | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP2968292A4 (de) | 2013-03-15 | 2016-11-23 | Intermune Inc | Verfahren zur verbesserung der mikrovaskulären integrität |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| US10233195B2 (en) | 2014-04-02 | 2019-03-19 | Intermune, Inc. | Anti-fibrotic pyridinones |
| ES3040783T3 (en) * | 2015-02-05 | 2025-11-04 | Memorial Sloan Kettering Cancer Center | Tacrolimus for use for the treatment of lymphedema |
| US20210008052A1 (en) * | 2019-05-13 | 2021-01-14 | Bio Med Sciences, Inc. | Active ingredient woundcare and scar management products, process of manufacture and useful articles thereof |
| CN119136801A (zh) * | 2021-04-19 | 2024-12-13 | 上海睿星基因技术有限公司 | 用于疾病的药物羟尼酮配制品 |
| CN115429802A (zh) * | 2021-06-04 | 2022-12-06 | 北京康蒂尼药业股份有限公司 | 包含羟尼酮与右美沙芬的药物组合物及其治疗肺纤维化的应用 |
| CN113274389B (zh) * | 2021-07-09 | 2022-11-08 | 中南大学 | 氟非尼酮在制备治疗急性肺损伤药物中的应用 |
| WO2026077441A1 (en) * | 2024-10-12 | 2026-04-16 | Beijing Continent Pharmaceuticals Co., Ltd. | Compositions and methods for preventing and treating chronic kidney disease |
| WO2026077440A1 (en) * | 2024-10-12 | 2026-04-16 | Beijing Continent Pharmaceuticals Co., Ltd. | Compositions and methods for preventing and treating chronic renal failure |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1049411A (en) | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| AU5427080A (en) | 1979-01-08 | 1980-07-17 | Margolin, B. | Pirfenidone in the treatment of pulmonary interstitial fibrosis |
| JPH02215719A (ja) | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
| CA2161648A1 (en) | 1993-05-07 | 1994-11-24 | Solomon B. Margolin | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5789426A (en) | 1995-01-20 | 1998-08-04 | Cornell Research Foundation, Inc. | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation |
| US6114353A (en) * | 1995-03-03 | 2000-09-05 | Margolin; Solomon B. | Compositions and method for treatment of lymphomas, leukemias, and leiomyomas |
| US6090822A (en) | 1995-03-03 | 2000-07-18 | Margolin; Solomon B. | Treatment of cytokine growth factor caused disorders |
| AU784523B2 (en) * | 2000-01-24 | 2006-04-27 | Intermune, Inc. | Treatment of lymphomas, leukemias, breast carcinomas, astrocytomas, melanomas, leiomyomas, and related tumors |
| AU2001230605A1 (en) * | 2000-02-09 | 2001-08-20 | Shionogi And Co., Ltd. | Apoptosis inhibitor |
| AU2003258305A1 (en) * | 2002-08-28 | 2004-03-19 | Intermune, Inc. | Combination therapy for treatment of fibrotic disorders |
| US20080025986A1 (en) * | 2003-06-06 | 2008-01-31 | Ozes Osman N | Methods of Treating Tnf-Mediated Disorders |
| US7407973B2 (en) * | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| CA2545813C (en) * | 2003-11-14 | 2011-01-04 | Shanghai Genomics, Inc. | The derivatives of pyridone and use thereof |
| CN100542532C (zh) * | 2004-05-24 | 2009-09-23 | 上海睿星基因技术有限公司 | 吡非尼酮在制备治疗肝损伤坏死和急性肺损伤的药物中的用途 |
-
2006
- 2006-09-25 WO PCT/CN2006/002504 patent/WO2007147297A1/zh not_active Ceased
- 2006-09-25 AT AT06791093T patent/ATE533486T1/de active
- 2006-09-25 JP JP2009514614A patent/JP5213852B2/ja active Active
- 2006-09-25 CA CA2656017A patent/CA2656017C/en active Active
- 2006-09-25 CN CN2006800549309A patent/CN101484167B/zh active Active
- 2006-09-25 EP EP06791093A patent/EP2036555B1/de active Active
-
2007
- 2007-12-17 US US11/958,353 patent/US8765726B2/en active Active
-
2014
- 2014-05-12 US US14/275,562 patent/US20140249347A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101484167B (zh) | 2012-07-04 |
| WO2007147297A1 (fr) | 2007-12-27 |
| EP2036555B1 (de) | 2011-11-16 |
| EP2036555A1 (de) | 2009-03-18 |
| US8765726B2 (en) | 2014-07-01 |
| CA2656017C (en) | 2014-02-04 |
| EP2036555A4 (de) | 2009-11-11 |
| CN101484167A (zh) | 2009-07-15 |
| CA2656017A1 (en) | 2007-12-27 |
| US20140249347A1 (en) | 2014-09-04 |
| JP5213852B2 (ja) | 2013-06-19 |
| JP2009539887A (ja) | 2009-11-19 |
| US20080161361A1 (en) | 2008-07-03 |
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