AR081774A1 - Composiciones farmaceuticas de co-cristales de tramadol y coxibs - Google Patents

Composiciones farmaceuticas de co-cristales de tramadol y coxibs

Info

Publication number
AR081774A1
AR081774A1 ARP110101933A ARP110101933A AR081774A1 AR 081774 A1 AR081774 A1 AR 081774A1 AR P110101933 A ARP110101933 A AR P110101933A AR P110101933 A ARP110101933 A AR P110101933A AR 081774 A1 AR081774 A1 AR 081774A1
Authority
AR
Argentina
Prior art keywords
tramadol
coxibs
crystals
pharmaceutical compositions
celecoxib
Prior art date
Application number
ARP110101933A
Other languages
English (en)
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of AR081774A1 publication Critical patent/AR081774A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide

Abstract

Procedimientos para la preparación de los mismos y su uso como medicamentos, más particularmente para el tratamiento del dolor.Reivindicación 1: Una composición farmacéutica que comprende un co-cristal de (rac)-tramadol×HCl - celecoxib (1:1) y al menos un polímero potenciador de la solubilidad.
ARP110101933A 2010-06-04 2011-06-03 Composiciones farmaceuticas de co-cristales de tramadol y coxibs AR081774A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10384002A EP2392319A1 (en) 2010-06-04 2010-06-04 Pharmaceutical compositions of co-crystals of tramadol and coxibs

Publications (1)

Publication Number Publication Date
AR081774A1 true AR081774A1 (es) 2012-10-17

Family

ID=42358396

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110101933A AR081774A1 (es) 2010-06-04 2011-06-03 Composiciones farmaceuticas de co-cristales de tramadol y coxibs

Country Status (32)

Country Link
US (1) US8846744B2 (es)
EP (3) EP2392319A1 (es)
JP (1) JP5800016B2 (es)
KR (1) KR101556700B1 (es)
CN (1) CN102946871B (es)
AR (1) AR081774A1 (es)
AU (1) AU2011260608B2 (es)
BR (1) BR112012030704A2 (es)
CA (1) CA2798090C (es)
CO (1) CO6660469A2 (es)
CY (1) CY1118813T1 (es)
DK (1) DK2575778T3 (es)
EC (1) ECSP13012368A (es)
ES (1) ES2622192T3 (es)
HR (1) HRP20170594T1 (es)
HU (1) HUE033999T2 (es)
IL (1) IL222731A (es)
LT (1) LT2575778T (es)
MX (1) MX351507B (es)
MY (1) MY156859A (es)
NZ (1) NZ603457A (es)
PL (1) PL2575778T3 (es)
PT (1) PT2575778T (es)
RS (1) RS55878B1 (es)
RU (1) RU2567843C2 (es)
SG (1) SG185385A1 (es)
SI (1) SI2575778T1 (es)
TN (1) TN2012000515A1 (es)
TW (1) TWI508722B (es)
UA (1) UA109661C2 (es)
WO (1) WO2011151080A1 (es)
ZA (1) ZA201208767B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
EP2311446A1 (en) * 2009-10-16 2011-04-20 Laboratorios Del. Dr. Esteve, S.A. Compositions comprising Tramadol and Celecoxib in the treatment of pain
US9138425B2 (en) 2013-03-12 2015-09-22 Patheon Inc. Drug delivery system to increase bioavailability
US10258583B2 (en) 2014-05-01 2019-04-16 Sun Pharmaceutical Industries Limited Extended release liquid compositions of guanfacine
US20180104197A9 (en) 2014-05-01 2018-04-19 Sun Pharmaceutical Industries Limited Extended release liquid compositions of metformin
WO2015166472A1 (en) * 2014-05-01 2015-11-05 Sun Pharmaceutical Industries Limited Extended release liquid compositions of metformin
US9962336B2 (en) 2014-05-01 2018-05-08 Sun Pharmaceutical Industries Limited Extended release suspension compositions
PL3137060T5 (pl) 2014-05-01 2024-04-08 Sun Pharmaceutical Industries Ltd Kompozycje zawiesinowe o przedłużonym uwalnianiu
RU2017106010A (ru) 2014-07-30 2018-08-28 Сан Фармасьютикал Индастриз Лимитед Двухкамерная упаковка
WO2016046693A1 (en) * 2014-09-25 2016-03-31 Nathwani Sandeep Vinodkumar A co-processed pharmaceutical excipient
CN104276960B (zh) * 2014-09-26 2016-09-28 安徽省逸欣铭医药科技有限公司 盐酸他喷他多和塞来昔布共晶及其组合物和制备方法
US10369078B2 (en) 2016-05-02 2019-08-06 Sun Pharmaceutical Industries Limited Dual-chamber pack for pharmaceutical compositions
US10238803B2 (en) 2016-05-02 2019-03-26 Sun Pharmaceutical Industries Limited Drug delivery device for pharmaceutical compositions
WO2018031577A1 (en) * 2016-08-09 2018-02-15 Autotelic Llc Fixed dose combination for pain relief without edema
DE102016012746A1 (de) 2016-10-25 2018-04-26 WindplusSonne GmbH Vorprodukte zur Herstellung von porösen, mineralischen Leichtbaumaterialien, Verfahren zur Herstellung von porösen, mineralischen Leichtbaumaterialien und ihre Verwendung
JP2020510625A (ja) 2016-12-14 2020-04-09 ナンジェネックス ナノテクノロジー インコーポレーテッドＮａｎｇｅｎｅｘ Ｎａｎｏｔｅｃｈｎｏｌｏｇｙ Ｉｎｃｏｒｐｏｒａｔｅｄ セレコキシブを含有する医薬組成物
CN107595792A (zh) * 2017-11-06 2018-01-19 刘丽 一种盐酸他喷他多塞来昔布片剂及其制备方法
CN110101673A (zh) * 2019-05-07 2019-08-09 安徽金太阳生化药业有限公司 一种盐酸曲马多分散片的制备方法
CA3137381A1 (en) * 2019-05-14 2020-11-19 Esteve Pharmaceuticals, S.A. Use of co-crystals of tramadol and celecoxib for treating pain while reducing the abuse liability of tramadol
CN112007024A (zh) * 2019-05-28 2020-12-01 江苏恒瑞医药股份有限公司 艾瑞昔布与曲马多联合在制备治疗疼痛的药物中的用途
CN115251264B (zh) * 2022-08-05 2023-11-21 齐鲁工业大学 含桑叶提取物的共结晶粉末功能性饮料及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2364127A1 (en) * 1999-03-01 2000-09-08 Ortho-Mcneil Pharmaceutical, Inc. Composition comprising a tramadol material and a selective cox-2 inhibitor drug
DE10014588A1 (de) * 2000-03-27 2001-10-04 Basf Ag Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
US20030105141A1 (en) * 2001-04-17 2003-06-05 Ping Gao Finely self-emulsifiable pharmaceutical composition
US20050090517A1 (en) * 2002-02-19 2005-04-28 Norris Michael C. Pharmaceutical combinations of cox-2 inhibitors and opiates
JP2005154334A (ja) * 2003-11-25 2005-06-16 Toa Yakuhin Kk アズレンスルホン酸塩水溶液剤
DE102006044694A1 (de) * 2006-09-22 2008-03-27 Krewel Meuselbach Gmbh Perorale feste Schmerzmittelzubereitung
WO2008085674A1 (en) * 2007-01-04 2008-07-17 Transform Pharmaceuticals, Inc. Pharmaceutical compositions comprising celecoxib co-crystals
CN101254180B (zh) * 2008-03-28 2010-11-10 辽宁正鑫药物研究有限公司 一种内容物为半固体组合物的尼莫地平胶囊剂及制备方法
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs

Also Published As

Publication number Publication date
RU2012157256A (ru) 2014-07-20
MX2012014087A (es) 2013-02-27
CO6660469A2 (es) 2013-04-30
EP2575778A1 (en) 2013-04-10
CA2798090C (en) 2017-02-28
CY1118813T1 (el) 2018-03-07
RS55878B1 (sr) 2017-08-31
IL222731A0 (en) 2012-12-31
WO2011151080A1 (en) 2011-12-08
PL2575778T3 (pl) 2017-09-29
EP2575778B1 (en) 2017-01-18
LT2575778T (lt) 2017-04-10
MY156859A (en) 2016-04-15
EP2392319A1 (en) 2011-12-07
BR112012030704A2 (pt) 2016-09-13
KR20130093015A (ko) 2013-08-21
TWI508722B (zh) 2015-11-21
CN102946871A (zh) 2013-02-27
KR101556700B1 (ko) 2015-10-01
TW201143760A (en) 2011-12-16
HRP20170594T1 (hr) 2017-06-16
JP5800016B2 (ja) 2015-10-28
SG185385A1 (en) 2012-12-28
US20130109659A1 (en) 2013-05-02
ES2622192T3 (es) 2017-07-05
ZA201208767B (en) 2013-07-31
TN2012000515A1 (en) 2014-04-01
US8846744B2 (en) 2014-09-30
PT2575778T (pt) 2017-04-21
CA2798090A1 (en) 2011-12-08
NZ603457A (en) 2014-10-31
EP3158994A1 (en) 2017-04-26
ECSP13012368A (es) 2013-01-31
AU2011260608B2 (en) 2015-05-07
CN102946871B (zh) 2019-03-08
IL222731A (en) 2016-05-31
JP2013530952A (ja) 2013-08-01
MX351507B (es) 2017-10-18
DK2575778T3 (en) 2017-04-18
UA109661C2 (uk) 2015-09-25
SI2575778T1 (sl) 2017-07-31
HUE033999T2 (en) 2018-01-29
AU2011260608A1 (en) 2012-11-22
RU2567843C2 (ru) 2015-11-10

Similar Documents

Publication Publication Date Title
AR081774A1 (es) Composiciones farmaceuticas de co-cristales de tramadol y coxibs
CR20160518A (es) Compuestos para tratar atrofia muscular espinal
ECSP10010489A (es) Nuevas formulaciones, comprimidos que comprenden tales formulaciones, su uso y procedimiento para su preparación
CO6491060A2 (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
CU20170009A7 (es) 2-(morfolin-4-il)-1,7-naftiridinas útiles en el tratamiento o la profilaxis de enfermedades hiperproliferativas
CR20150326A (es) Inhibidores de autotaxina
CL2012002355A1 (es) Compuestos derivados de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina; composicion farmaceutica que los comprende; kit farmaceutico; y su uso como inhibidores de la integrasa del vih para el tratamiento de una enfermedad infecciosa del vih.
CO6501131A2 (es) Antagonistas de espiro-oxindol de mdm2
UY31350A1 (es) (carboxilalquilenfenil)feniloxamidas, procedimiento para su preparación y su utilización como medicamentos
CU20130036A7 (es) Triazina-oxidazoles
UY36665A (es) Derivados de ciclohexano sustituidos con amidas
CR20140399A (es) Pirrolidina-2-carboxamidas sustituidas
CL2013000063A1 (es) Un método para tratar a un sujeto que comprende administrar n-etil-n-fenil1,2-dihidroxi-4-hodroxi-5-cloro-1-metil-2-oxoquinolina-3-carboxamida opcionalmente deuterada, para el tratamiento de una enfermedad autoinmunitaria; una mezcla de los mismos; composición farmaceutica y su proceso de preparacion.
ECSP088747A (es) Pirazoles como inhibidores de la 11-beta-hsd1
UY33183A (es) Compuestos inhibidores de virus flaviviridae, composición farmaceutica que los contiene y su uso en la manufactura de un medicamento
CL2009001248A1 (es) Compuestos derivados de indazolilo sustituido con fenilo, que actúan como moduladores de glucocorticoides; composición y combinación farmacéutica que comprenden a uno de los compuestos; y uso de los compuestos en la preparación de medicamentos para el tratamiento de enfermedades inflamatorias y respiratorias.
CR20110599A (es) Composiciones farmacéuticamente activas que comprenden moduladores de estrés oxidativo (osm), nuevas entidades químicas, composiciones y usos
UY31351A1 (es) (ciclopropilfenil)feniloxamidas, procedimiento para su preparación y su uso como medicamentos
CO6480932A2 (es) Antagonistas de la trayectoria hedgehog de ftalazina disustituida.
UY34111A (es) Nuevos co-cristales de agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
CL2012002551A1 (es) Combinacion farmaceutica que comprende por lo menos un 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol de fórmula (i) y por lo menos un antagonista de nmda; composicion farmaceutica; y uso para el tratamiento del dolor.
CL2013000488A1 (es) Co-cristales de compuestos derivados de (2r)-5-oxo-1-(bencilpiperidin-4-il)-n-(piridin-2-il)pirrolidin-2-carboxamida y un agente de formacion de co-cristales; sales de los compuestos; compuestos intermediarios; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias e infecciosas.
CR20150266A (es) Formulaciones de liberación modificada para oprozomib
CO6511248A2 (es) Cocristales de tramadol y coxibs
PE20150167A1 (es) (r)-nifuratel, su uso para el tratamiento de las infecciones y sintesis de (r) y (s)-nifuratel

Legal Events

Date Code Title Description
FC Refusal