BR112012030704A2 - composições farmacêuticas de cocristais de tramadol e coxibs - Google Patents

composições farmacêuticas de cocristais de tramadol e coxibs

Info

Publication number
BR112012030704A2
BR112012030704A2 BR112012030704A BR112012030704A BR112012030704A2 BR 112012030704 A2 BR112012030704 A2 BR 112012030704A2 BR 112012030704 A BR112012030704 A BR 112012030704A BR 112012030704 A BR112012030704 A BR 112012030704A BR 112012030704 A2 BR112012030704 A2 BR 112012030704A2
Authority
BR
Brazil
Prior art keywords
tramadol
pharmaceutical compositions
coxibs
cocrystals
copirstals
Prior art date
Application number
BR112012030704A
Other languages
English (en)
Inventor
Albert Falivene Aldea
Luis Soler Ranzani
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of BR112012030704A2 publication Critical patent/BR112012030704A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide

Abstract

composições farmacêuticas de cocristais de tramadol e coxibs. a presente invenção refere-se às composições farmacêuticas orais compreendendo co-cirstais de tramadol e celecoxrib, processos para a preparação dos mesmos e o seu uso como medicamentos, mais particularmente para o tratamento da dor.
BR112012030704A 2010-06-04 2011-06-03 composições farmacêuticas de cocristais de tramadol e coxibs BR112012030704A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10384002A EP2392319A1 (en) 2010-06-04 2010-06-04 Pharmaceutical compositions of co-crystals of tramadol and coxibs
PCT/EP2011/002749 WO2011151080A1 (en) 2010-06-04 2011-06-03 Pharmaceutical compositions of co-crystals of tramadol and coxibs

Publications (1)

Publication Number Publication Date
BR112012030704A2 true BR112012030704A2 (pt) 2016-09-13

Family

ID=42358396

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012030704A BR112012030704A2 (pt) 2010-06-04 2011-06-03 composições farmacêuticas de cocristais de tramadol e coxibs

Country Status (32)

Country Link
US (1) US8846744B2 (pt)
EP (3) EP2392319A1 (pt)
JP (1) JP5800016B2 (pt)
KR (1) KR101556700B1 (pt)
CN (1) CN102946871B (pt)
AR (1) AR081774A1 (pt)
AU (1) AU2011260608B2 (pt)
BR (1) BR112012030704A2 (pt)
CA (1) CA2798090C (pt)
CO (1) CO6660469A2 (pt)
CY (1) CY1118813T1 (pt)
DK (1) DK2575778T3 (pt)
EC (1) ECSP13012368A (pt)
ES (1) ES2622192T3 (pt)
HR (1) HRP20170594T1 (pt)
HU (1) HUE033999T2 (pt)
IL (1) IL222731A (pt)
LT (1) LT2575778T (pt)
MX (1) MX351507B (pt)
MY (1) MY156859A (pt)
NZ (1) NZ603457A (pt)
PL (1) PL2575778T3 (pt)
PT (1) PT2575778T (pt)
RS (1) RS55878B1 (pt)
RU (1) RU2567843C2 (pt)
SG (1) SG185385A1 (pt)
SI (1) SI2575778T1 (pt)
TN (1) TN2012000515A1 (pt)
TW (1) TWI508722B (pt)
UA (1) UA109661C2 (pt)
WO (1) WO2011151080A1 (pt)
ZA (1) ZA201208767B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2177215A1 (en) * 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
EP2311446A1 (en) * 2009-10-16 2011-04-20 Laboratorios Del. Dr. Esteve, S.A. Compositions comprising Tramadol and Celecoxib in the treatment of pain
CA2902971A1 (en) 2013-03-12 2014-09-18 Patheon, Inc. Drug delivery system
US20180104197A9 (en) 2014-05-01 2018-04-19 Sun Pharmaceutical Industries Limited Extended release liquid compositions of metformin
US10258583B2 (en) 2014-05-01 2019-04-16 Sun Pharmaceutical Industries Limited Extended release liquid compositions of guanfacine
WO2015166473A1 (en) 2014-05-01 2015-11-05 Sun Pharmaceutical Industries Limited Extended release suspension compositions
AU2015294912A1 (en) 2014-07-30 2017-02-16 Sun Pharmaceutical Industries Limited Dual-chamber pack
CA2947515A1 (en) * 2014-05-01 2015-11-05 Sun Pharmaceutical Industries Limited Extended release liquid compositions of metformin
US9962336B2 (en) 2014-05-01 2018-05-08 Sun Pharmaceutical Industries Limited Extended release suspension compositions
WO2016046693A1 (en) * 2014-09-25 2016-03-31 Nathwani Sandeep Vinodkumar A co-processed pharmaceutical excipient
CN104276960B (zh) * 2014-09-26 2016-09-28 安徽省逸欣铭医药科技有限公司 盐酸他喷他多和塞来昔布共晶及其组合物和制备方法
US10238803B2 (en) 2016-05-02 2019-03-26 Sun Pharmaceutical Industries Limited Drug delivery device for pharmaceutical compositions
US10369078B2 (en) 2016-05-02 2019-08-06 Sun Pharmaceutical Industries Limited Dual-chamber pack for pharmaceutical compositions
WO2018031577A1 (en) * 2016-08-09 2018-02-15 Autotelic Llc Fixed dose combination for pain relief without edema
DE102016012746A1 (de) 2016-10-25 2018-04-26 WindplusSonne GmbH Vorprodukte zur Herstellung von porösen, mineralischen Leichtbaumaterialien, Verfahren zur Herstellung von porösen, mineralischen Leichtbaumaterialien und ihre Verwendung
EP3554547A4 (en) 2016-12-14 2020-08-12 Druggability Technologies IP Holdco Limited PHARMACEUTICAL COMPOSITION CONTAINING CELECOXIB
CN107595792A (zh) * 2017-11-06 2018-01-19 刘丽 一种盐酸他喷他多塞来昔布片剂及其制备方法
CN110101673A (zh) * 2019-05-07 2019-08-09 安徽金太阳生化药业有限公司 一种盐酸曲马多分散片的制备方法
MA55954A (fr) 2019-05-14 2022-03-23 Esteve Pharmaceuticals Sa Utilisation de co-cristaux de tramadol et de célécoxib pour traiter la douleur tout en réduisant le risque d'abus de tramadol
CN112007024A (zh) * 2019-05-28 2020-12-01 江苏恒瑞医药股份有限公司 艾瑞昔布与曲马多联合在制备治疗疼痛的药物中的用途
CN115251264B (zh) * 2022-08-05 2023-11-21 齐鲁工业大学 含桑叶提取物的共结晶粉末功能性饮料及其制备方法

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JP2002538176A (ja) * 1999-03-01 2002-11-12 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド トラマドール物質および選択的ｃｏｘ−２阻害薬を含んで成る組成物
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US20030105141A1 (en) * 2001-04-17 2003-06-05 Ping Gao Finely self-emulsifiable pharmaceutical composition
NZ535500A (en) * 2002-02-19 2006-09-29 Adcock Ingram Ltd Pharmaceutical combinations of COX-2 inhibitors i.e. meloxicam, opiates i.e. codeine and centrally acting cox inhibitors i.e. paracetamol
JP2005154334A (ja) * 2003-11-25 2005-06-16 Toa Yakuhin Kk アズレンスルホン酸塩水溶液剤
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EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs

Also Published As

Publication number Publication date
HRP20170594T1 (hr) 2017-06-16
JP2013530952A (ja) 2013-08-01
KR101556700B1 (ko) 2015-10-01
IL222731A (en) 2016-05-31
SI2575778T1 (sl) 2017-07-31
RU2567843C2 (ru) 2015-11-10
EP2392319A1 (en) 2011-12-07
PL2575778T3 (pl) 2017-09-29
WO2011151080A1 (en) 2011-12-08
TN2012000515A1 (en) 2014-04-01
UA109661C2 (uk) 2015-09-25
EP2575778B1 (en) 2017-01-18
RU2012157256A (ru) 2014-07-20
MY156859A (en) 2016-04-15
AU2011260608B2 (en) 2015-05-07
US20130109659A1 (en) 2013-05-02
ECSP13012368A (es) 2013-01-31
HUE033999T2 (en) 2018-01-29
CA2798090C (en) 2017-02-28
AR081774A1 (es) 2012-10-17
CN102946871B (zh) 2019-03-08
JP5800016B2 (ja) 2015-10-28
LT2575778T (lt) 2017-04-10
EP2575778A1 (en) 2013-04-10
MX2012014087A (es) 2013-02-27
EP3158994A1 (en) 2017-04-26
ES2622192T3 (es) 2017-07-05
KR20130093015A (ko) 2013-08-21
AU2011260608A1 (en) 2012-11-22
CA2798090A1 (en) 2011-12-08
TW201143760A (en) 2011-12-16
TWI508722B (zh) 2015-11-21
CY1118813T1 (el) 2018-03-07
IL222731A0 (en) 2012-12-31
US8846744B2 (en) 2014-09-30
RS55878B1 (sr) 2017-08-31
MX351507B (es) 2017-10-18
CN102946871A (zh) 2013-02-27
NZ603457A (en) 2014-10-31
SG185385A1 (en) 2012-12-28
PT2575778T (pt) 2017-04-21
ZA201208767B (en) 2013-07-31
CO6660469A2 (es) 2013-04-30
DK2575778T3 (en) 2017-04-18

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: ESTEVE PHARMACEUTICALS, S.A. (ES)

B25G Requested change of headquarter approved

Owner name: ESTEVE PHARMACEUTICALS, S.A. (ES)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]