BR112016017193A2 - Derivados de insulina, seus usos, e composição farmacêutica - Google Patents
Derivados de insulina, seus usos, e composição farmacêuticaInfo
- Publication number
- BR112016017193A2 BR112016017193A2 BR112016017193A BR112016017193A BR112016017193A2 BR 112016017193 A2 BR112016017193 A2 BR 112016017193A2 BR 112016017193 A BR112016017193 A BR 112016017193A BR 112016017193 A BR112016017193 A BR 112016017193A BR 112016017193 A2 BR112016017193 A2 BR 112016017193A2
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- pharmaceutical composition
- insulin derivatives
- insulin
- diabetes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
DERIVADOS DE INSULINA, SEUS USOS, E COMPOSIÇÃO FARMACÊUTICA. A presente invenção pertence ao campo terapêutico de fármacos para condições médicas relacionadas à diabetes. Mais especificamente, a invenção refere-se a novos derivados acilados de análogos de insulina humana. A invenção também fornece composições farmacêuticas incluindo tais derivados de insulina, e refere-se ao uso de tais derivados para o tratamento ou prevenção de condições médicas relacionadas à diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14157215 | 2014-02-28 | ||
PCT/EP2015/053989 WO2015128403A2 (en) | 2014-02-28 | 2015-02-26 | Novel insulin derivatives and the medical uses hereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016017193A2 true BR112016017193A2 (pt) | 2017-10-03 |
Family
ID=50184804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016017193A BR112016017193A2 (pt) | 2014-02-28 | 2015-02-26 | Derivados de insulina, seus usos, e composição farmacêutica |
Country Status (23)
Country | Link |
---|---|
US (1) | US10040839B2 (pt) |
EP (1) | EP3110840B1 (pt) |
JP (1) | JP6580583B2 (pt) |
KR (1) | KR20160125988A (pt) |
CN (1) | CN106459171B (pt) |
AR (1) | AR099569A1 (pt) |
AU (1) | AU2015222135B2 (pt) |
BR (1) | BR112016017193A2 (pt) |
CA (1) | CA2941103A1 (pt) |
DK (1) | DK3110840T3 (pt) |
ES (1) | ES2831848T3 (pt) |
HR (1) | HRP20201732T1 (pt) |
HU (1) | HUE051355T2 (pt) |
IL (1) | IL246757B (pt) |
MX (1) | MX368387B (pt) |
PL (1) | PL3110840T3 (pt) |
PT (1) | PT3110840T (pt) |
RS (1) | RS61137B1 (pt) |
RU (1) | RU2684456C2 (pt) |
SA (1) | SA516371705B1 (pt) |
SI (1) | SI3110840T1 (pt) |
TW (1) | TWI686403B (pt) |
WO (1) | WO2015128403A2 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170028031A1 (en) * | 2014-03-07 | 2017-02-02 | Klavs Holger Jørgensen | Novel fast acting insulin preparations |
CA2996455A1 (en) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
US11208453B2 (en) * | 2016-11-21 | 2021-12-28 | Case Western Reserve University | Rapid-acting insulin analogues of enhanced stability |
KR101909052B1 (ko) * | 2017-02-09 | 2018-10-17 | 강원대학교산학협력단 | 인슐린의 a 사슬로부터 유래된 펩타이드 단편 및 이를 포함하는 당뇨병 또는 당뇨병성 창상의 예방 또는 치료용 약학 조성물 |
JP2020513019A (ja) * | 2017-04-05 | 2020-04-30 | ノヴォ ノルディスク アー/エス | オリゴマー伸長インスリン−Fcコンジュゲート |
JOP20190273A1 (ar) * | 2017-05-26 | 2019-11-24 | Lilly Co Eli | مركب إنسولين معالج بأسيل |
MA49896A (fr) * | 2017-08-17 | 2020-06-24 | Novo Nordisk As | Nouveaux analogues d'insuline acylés et leurs utilisations |
US20190290736A1 (en) | 2017-10-19 | 2019-09-26 | Fourward Technology, LLC | Topical composition for improved healing of open wounds |
AU2019398579A1 (en) | 2018-12-11 | 2021-07-29 | Sanofi | Peptide binder |
US20220125941A1 (en) * | 2019-02-13 | 2022-04-28 | Sumitomo Dainippon Pharma Co., Ltd. | Hemiasterlin Derivative and Antibody-Drug Conjugate Thereof |
CA3148536A1 (en) * | 2019-08-27 | 2021-03-04 | Anne Pernille Tofteng SHELTON | Compstatin analogues and their medical uses |
MX2022006251A (es) | 2019-12-11 | 2022-06-22 | Novo Nordisk As | Analogos de insulina novedosos y usos de estos. |
KR20240013778A (ko) * | 2021-05-24 | 2024-01-30 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 신규한 아실화된 인슐린 유사체 |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3528960A (en) | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
US3869437A (en) | 1970-05-08 | 1975-03-04 | Nat Res Dev | Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin |
GB1381274A (en) | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
US3864325A (en) | 1971-11-18 | 1975-02-04 | Nat Res Dev | (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives |
JPH01254699A (ja) | 1988-04-05 | 1989-10-11 | Kodama Kk | インスリン誘導体及びその用途 |
HUT56857A (en) * | 1988-12-23 | 1991-10-28 | Novo Nordisk As | Human insulin analogues |
ES2072596T3 (es) * | 1989-12-21 | 1995-07-16 | Novo Nordisk As | Preparaciones de insulina que contienen acido nicotinico o nicotinamida. |
WO1995007931A1 (en) | 1993-09-17 | 1995-03-23 | Novo Nordisk A/S | Acylated insulin |
US6869930B1 (en) | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
US6703017B1 (en) * | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
US5461031A (en) | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
US5646242A (en) | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
WO1996029344A1 (en) | 1995-03-17 | 1996-09-26 | Novo Nordisk A/S | Insulin derivatives |
US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
US5905140A (en) | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
US5898067A (en) | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
CN1259142A (zh) | 1997-03-20 | 2000-07-05 | 诺沃挪第克公司 | 用于肺部的无锌胰岛素结晶组合物 |
CA2306877A1 (en) | 1997-10-24 | 1999-05-06 | Eli Lilly And Company | Insoluble insulin compositions |
EP1025125B1 (en) | 1997-10-24 | 2003-06-25 | Novo Nordisk A/S | Aggregates of human insulin derivatives |
US6451762B1 (en) | 1997-10-24 | 2002-09-17 | Novo Nordisk A/S | Aggregates of human insulin derivatives |
US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
ZA989744B (en) | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
CO4970787A1 (es) | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
JP2002500196A (ja) | 1998-01-09 | 2002-01-08 | ノヴォ ノルディスク アクティーゼルスカブ | 安定化させたインスリン組成物 |
JP2002518408A (ja) | 1998-06-12 | 2002-06-25 | キングス・カレツジ・ロンドン | インスリン類似体 |
WO2001000675A1 (en) | 1999-06-29 | 2001-01-04 | Eli Lilly And Company | Protamine-free insoluble acylated insulin compositions |
AU2001264789A1 (en) | 2000-06-08 | 2001-12-17 | Eli Lilly And Company | Protein powder for pulmonary delivery |
DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
JP2005526009A (ja) | 2001-12-02 | 2005-09-02 | ノボ ノルディスク アクティーゼルスカブ | 新規グルコース依存性インスリン |
PL374949A1 (en) | 2001-12-20 | 2005-11-14 | Eli Lilly And Company | Insulin molecule having protracted time action |
WO2003075950A1 (en) | 2002-03-13 | 2003-09-18 | Novo Nordisk A/S | Minimising body weight gain in insulin treatment |
US20040138099A1 (en) | 2002-11-29 | 2004-07-15 | Draeger Eberhard Kurt | Insulin administration regimens for the treatment of subjects with diabetes |
US20060217290A1 (en) | 2003-04-29 | 2006-09-28 | Kohn Wayne D | Insulin analogs having protracted time action |
US20060183667A1 (en) | 2003-07-11 | 2006-08-17 | Novo Nordisk A/S | Stabilised insulin compositions |
EP1644411A2 (en) | 2003-07-11 | 2006-04-12 | Novo Nordisk A/S | Stabilised insulin compositions |
PL2107069T3 (pl) | 2003-08-05 | 2013-06-28 | Novo Nordisk As | Nowe pochodne insuliny |
AU2004264958B2 (en) | 2003-08-13 | 2010-04-15 | Biocon, Ltd | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
JP2007532096A (ja) | 2003-11-14 | 2007-11-15 | ノボ ノルディスク アクティーゼルスカブ | アシル化されたインスリンの製造方法 |
JP5697831B2 (ja) | 2003-12-03 | 2015-04-08 | ノヴォ ノルディスク アー/エス | 単鎖インシュリン |
WO2006008238A1 (en) | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
AU2005269753B2 (en) | 2004-07-19 | 2011-08-18 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
EP2292653B1 (en) | 2005-02-02 | 2014-05-21 | Novo Nordisk A/S | Novel insulin derivatives |
EP1863840A1 (en) | 2005-03-18 | 2007-12-12 | Novo Nordisk A/S | Pegylated single-chain insulin |
JP4808785B2 (ja) | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー/エス | インスリン組成物および組成物の製造方法 |
ES2387955T3 (es) | 2006-02-27 | 2012-10-04 | Novo Nordisk A/S | Derivados de insulina |
ES2548393T3 (es) | 2006-05-09 | 2015-10-16 | Novo Nordisk A/S | Derivado de insulina |
US8796205B2 (en) | 2006-05-09 | 2014-08-05 | Novo Nordisk A/S | Insulin derivative |
EP2076242B8 (en) | 2006-07-27 | 2013-02-20 | Nektar Therapeutics | Aerosolizable formulation comprising insulin for pulmonary delivery |
CN101573133B (zh) | 2006-07-31 | 2014-08-27 | 诺沃-诺迪斯克有限公司 | Peg化延长的胰岛素 |
KR101729986B1 (ko) * | 2006-09-22 | 2017-04-25 | 노보 노르디스크 에이/에스 | 프로테아제 내성 인슐린 유사체 |
WO2008145721A2 (en) | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | N-terminal modification of polypeptides for protection against degradation by aminopeptidases |
WO2008152106A1 (en) | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
WO2009015456A1 (en) | 2007-07-30 | 2009-02-05 | Generex Pharmaceuticals Inc. | Pharmaceutical formulation in mixed micellar form and dispenser for oral delivery of agents as a spray |
KR20100053561A (ko) | 2007-08-15 | 2010-05-20 | 노보 노르디스크 에이/에스 | 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체 |
ES2543393T3 (es) | 2007-11-08 | 2015-08-18 | Novo Nordisk A/S | Derivado de insulina |
US8937042B2 (en) | 2007-11-16 | 2015-01-20 | Novo Nordisk A/S | Pharmaceutical compositions comprising GLP-1 peptides or extendin-4 and a basal insulin peptide |
US8946148B2 (en) | 2007-11-20 | 2015-02-03 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
WO2009112583A2 (en) * | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
EP2910569B1 (en) * | 2008-03-18 | 2016-10-05 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
US8637647B2 (en) | 2008-09-12 | 2014-01-28 | Novo Nordisk A/S | Method of acylating a peptide or protein |
US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
AU2009335715B2 (en) | 2008-12-19 | 2016-09-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
ES2611040T3 (es) | 2009-06-30 | 2017-05-04 | Novo Nordisk A/S | Derivados de insulina |
KR101759499B1 (ko) * | 2009-07-31 | 2017-07-19 | 사노피-아벤티스 도이칠란트 게엠베하 | 지속형 인슐린 조성물 |
KR20130092972A (ko) | 2010-05-10 | 2013-08-21 | 노보 노르디스크 에이/에스 | 인슐린-아연 복합체의 제조 방법 |
CN102947331B (zh) | 2010-06-23 | 2016-08-03 | 诺沃—诺迪斯克有限公司 | 包含额外的二硫键的胰岛素类似物 |
WO2011161125A1 (en) * | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Insulin derivatives containing additional disulfide bonds |
US9655974B2 (en) | 2010-07-20 | 2017-05-23 | Novo Nordisk A/S | N-terminal modified FGF21 compounds |
CN103596584B (zh) * | 2011-06-15 | 2016-12-14 | 诺沃—诺迪斯克有限公司 | 多取代的胰岛素 |
CN104010652A (zh) | 2011-10-27 | 2014-08-27 | 卡斯西部储备大学 | 超浓缩的速效胰岛素类似物制剂 |
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2015
- 2015-02-25 AR ARP150100559A patent/AR099569A1/es unknown
- 2015-02-26 DK DK15707102.8T patent/DK3110840T3/da active
- 2015-02-26 RS RS20201399A patent/RS61137B1/sr unknown
- 2015-02-26 CN CN201580010746.3A patent/CN106459171B/zh active Active
- 2015-02-26 JP JP2016554498A patent/JP6580583B2/ja active Active
- 2015-02-26 WO PCT/EP2015/053989 patent/WO2015128403A2/en active Application Filing
- 2015-02-26 SI SI201531416T patent/SI3110840T1/sl unknown
- 2015-02-26 RU RU2016135543A patent/RU2684456C2/ru active
- 2015-02-26 CA CA2941103A patent/CA2941103A1/en not_active Withdrawn
- 2015-02-26 US US15/121,206 patent/US10040839B2/en active Active
- 2015-02-26 EP EP15707102.8A patent/EP3110840B1/en active Active
- 2015-02-26 KR KR1020167024826A patent/KR20160125988A/ko not_active Application Discontinuation
- 2015-02-26 HU HUE15707102A patent/HUE051355T2/hu unknown
- 2015-02-26 MX MX2016010899A patent/MX368387B/es active IP Right Grant
- 2015-02-26 BR BR112016017193A patent/BR112016017193A2/pt not_active Application Discontinuation
- 2015-02-26 PT PT157071028T patent/PT3110840T/pt unknown
- 2015-02-26 ES ES15707102T patent/ES2831848T3/es active Active
- 2015-02-26 AU AU2015222135A patent/AU2015222135B2/en not_active Ceased
- 2015-02-26 PL PL15707102T patent/PL3110840T3/pl unknown
- 2015-02-26 TW TW104106145A patent/TWI686403B/zh not_active IP Right Cessation
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2016
- 2016-07-13 IL IL246757A patent/IL246757B/en active IP Right Grant
- 2016-08-21 SA SA516371705A patent/SA516371705B1/ar unknown
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2020
- 2020-10-27 HR HRP20201732TT patent/HRP20201732T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
RU2684456C2 (ru) | 2019-04-09 |
JP6580583B2 (ja) | 2019-09-25 |
HUE051355T2 (hu) | 2021-03-01 |
AR099569A1 (es) | 2016-08-03 |
IL246757A0 (en) | 2016-08-31 |
RU2016135543A3 (pt) | 2018-08-30 |
CA2941103A1 (en) | 2015-09-03 |
EP3110840B1 (en) | 2020-10-21 |
HRP20201732T1 (hr) | 2020-12-25 |
SI3110840T1 (sl) | 2020-12-31 |
PL3110840T3 (pl) | 2021-04-06 |
WO2015128403A2 (en) | 2015-09-03 |
CN106459171B (zh) | 2020-12-15 |
JP2017508741A (ja) | 2017-03-30 |
IL246757B (en) | 2020-04-30 |
SA516371705B1 (ar) | 2019-10-08 |
ES2831848T3 (es) | 2021-06-09 |
MX368387B (es) | 2019-10-01 |
RS61137B1 (sr) | 2020-12-31 |
EP3110840A2 (en) | 2017-01-04 |
AU2015222135B2 (en) | 2018-12-20 |
RU2016135543A (ru) | 2018-03-30 |
US10040839B2 (en) | 2018-08-07 |
CN106459171A (zh) | 2017-02-22 |
MX2016010899A (es) | 2016-11-18 |
DK3110840T3 (da) | 2020-11-02 |
PT3110840T (pt) | 2020-11-26 |
US20170008945A1 (en) | 2017-01-12 |
WO2015128403A3 (en) | 2015-12-10 |
KR20160125988A (ko) | 2016-11-01 |
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AU2015222135A1 (en) | 2016-07-28 |
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