SE9702651D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE9702651D0
SE9702651D0 SE9702651A SE9702651A SE9702651D0 SE 9702651 D0 SE9702651 D0 SE 9702651D0 SE 9702651 A SE9702651 A SE 9702651A SE 9702651 A SE9702651 A SE 9702651A SE 9702651 D0 SE9702651 D0 SE 9702651D0
Authority
SE
Sweden
Prior art keywords
pct
sec
novel compounds
date
pub
Prior art date
Application number
SE9702651A
Other languages
English (en)
Inventor
Nicholas Kindon
Premji Meghani
Stephen Thom
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9702651A priority Critical patent/SE9702651D0/sv
Publication of SE9702651D0 publication Critical patent/SE9702651D0/sv
Priority to PT98934002T priority patent/PT996617E/pt
Priority to AT98934002T priority patent/ATE211737T1/de
Priority to DE69803458T priority patent/DE69803458T2/de
Priority to DK98934002T priority patent/DK0996617T3/da
Priority to EP98934002A priority patent/EP0996617B1/en
Priority to JP2000502029A priority patent/JP2001509506A/ja
Priority to US09/155,612 priority patent/US6107297A/en
Priority to AU83611/98A priority patent/AU8361198A/en
Priority to PCT/SE1998/001240 priority patent/WO1999002501A1/en
Priority to ES98934002T priority patent/ES2171300T3/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
SE9702651A 1997-07-09 1997-07-09 Novel compounds SE9702651D0 (sv)

Priority Applications (11)

Application Number Priority Date Filing Date Title
SE9702651A SE9702651D0 (sv) 1997-07-09 1997-07-09 Novel compounds
ES98934002T ES2171300T3 (es) 1997-07-09 1998-06-25 Compuestos de 2,4-diti(oxo)-piridin-5-ilo que presentan un sustituyente triciclico, utiles como antagonistas de p2-purinoceptores.
DK98934002T DK0996617T3 (da) 1997-07-09 1998-06-25 2,4-Dithi(oxo)-pyridin-5-yl-forbindelser, der bærer en tricyklisk substituent, der er nyttige som P2-purinoceptor-antagonist
AT98934002T ATE211737T1 (de) 1997-07-09 1998-06-25 Tricyclisch substituierte 2,4-dithi(oxo)- pyrimidin-5-yl-verbindungen als p2- purinoceptor- antagonisten
DE69803458T DE69803458T2 (de) 1997-07-09 1998-06-25 Tricyclisch substituierte 2,4-Dithi(oxo)-pyrimidin-5-yl-Verbindungen als P2- Purinoceptor-Antagonisten
PT98934002T PT996617E (pt) 1997-07-09 1998-06-25 Compostos de 2,4-diti (oxo) - piridin-5-ilo com um substituinte triciclico uteis como antagonistas de purinoceptores p2
EP98934002A EP0996617B1 (en) 1997-07-09 1998-06-25 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists
JP2000502029A JP2001509506A (ja) 1997-07-09 1998-06-25 新規な化合物
US09/155,612 US6107297A (en) 1997-07-09 1998-06-25 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists
AU83611/98A AU8361198A (en) 1997-07-09 1998-06-25 Novel compounds
PCT/SE1998/001240 WO1999002501A1 (en) 1997-07-09 1998-06-25 Novel compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9702651A SE9702651D0 (sv) 1997-07-09 1997-07-09 Novel compounds

Publications (1)

Publication Number Publication Date
SE9702651D0 true SE9702651D0 (sv) 1997-07-09

Family

ID=20407699

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9702651A SE9702651D0 (sv) 1997-07-09 1997-07-09 Novel compounds

Country Status (11)

Country Link
US (1) US6107297A (sv)
EP (1) EP0996617B1 (sv)
JP (1) JP2001509506A (sv)
AT (1) ATE211737T1 (sv)
AU (1) AU8361198A (sv)
DE (1) DE69803458T2 (sv)
DK (1) DK0996617T3 (sv)
ES (1) ES2171300T3 (sv)
PT (1) PT996617E (sv)
SE (1) SE9702651D0 (sv)
WO (1) WO1999002501A1 (sv)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999026944A1 (en) * 1997-11-21 1999-06-03 Astrazeneka Uk Limited New compounds which are p2-purinoceptor 7-transmembrane (tm) g-protein coupled receptor antagonists
MXPA03011391A (es) * 2001-06-12 2004-07-01 Neurogen Corp 2,5-diarilpirazinas, 2,5-diarilpiridinas y 2,5-diarilpirimidinas como moudladores de receptor crf1.
AUPS160602A0 (en) 2002-04-08 2002-05-16 University Of Queensland, The Therapeutic method
US7179481B2 (en) * 2002-09-19 2007-02-20 Kimberly-Clark Worldwide, Inc. Vaginal health products
AU2002952086A0 (en) * 2002-10-16 2002-11-07 The University Of Queensland Treatment of osteoarthritis
US7098189B2 (en) * 2002-12-16 2006-08-29 Kimberly-Clark Worldwide, Inc. Wound and skin care compositions
US7056889B2 (en) 2002-12-16 2006-06-06 Kimberly-Clark, Worldwide, Inc. Compounds that bind P2Y2 or P2Y1 receptors
WO2005039506A2 (en) * 2003-10-24 2005-05-06 Exelixis, Inc. P70s6 kinase modulators and method of use
US7485666B2 (en) * 2004-06-17 2009-02-03 Kimberly-Clark Worldwide, Inc. Vaginal health products
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
JP4431099B2 (ja) 2005-09-06 2010-03-10 富士通株式会社 波長変換方式、光集積素子及び波長変換方法
WO2009088192A2 (ko) 2008-01-04 2009-07-16 Lg Life Sciences Ltd. 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
JP5709999B2 (ja) 2011-08-01 2015-04-30 大日本住友製薬株式会社 ウラシル誘導体およびその医薬用途
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类
CN104292267A (zh) * 2014-09-11 2015-01-21 北京诺泓医药科技有限公司 1-羟基-2-(咪唑并[1,2-a]吡啶-3-基)乙烷-1,1-双膦酸的制备方法
WO2023209183A1 (en) 2022-04-29 2023-11-02 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts P2ry2 activity modulators

Also Published As

Publication number Publication date
WO1999002501A1 (en) 1999-01-21
US6107297A (en) 2000-08-22
DK0996617T3 (da) 2002-04-29
PT996617E (pt) 2002-06-28
EP0996617B1 (en) 2002-01-09
EP0996617A1 (en) 2000-05-03
AU8361198A (en) 1999-02-08
DE69803458D1 (de) 2002-02-28
ATE211737T1 (de) 2002-01-15
ES2171300T3 (es) 2002-09-01
DE69803458T2 (de) 2002-09-12
JP2001509506A (ja) 2001-07-24

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