CN107698499A - 一种羟尼酮的制备方法 - Google Patents
一种羟尼酮的制备方法 Download PDFInfo
- Publication number
- CN107698499A CN107698499A CN201610642515.0A CN201610642515A CN107698499A CN 107698499 A CN107698499 A CN 107698499A CN 201610642515 A CN201610642515 A CN 201610642515A CN 107698499 A CN107698499 A CN 107698499A
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- CN
- China
- Prior art keywords
- formula
- compound
- ethyl acetate
- refined
- ethanol
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Abstract
Description
物料名称 | 物理参数 |
2-羟基-5-甲基吡啶 | 黄色或微黄色结晶固体 |
对溴苯甲醚 | 无色透明液体 |
DMAC | 无色透明液体 |
DMF | 无色透明液体 |
物料名称 | 摩尔比例 | 摩尔量(mol) | 投料量(kg) |
2-羟基-5-甲基吡啶 | 1.00 | 390 | 35.0 |
对溴苯甲醚 | 1.20 | 468 | 74.0 |
碘化亚铜 | 0.02 | 7.8 | 1.22 |
无水碳酸钾 | 1.20 | 468 | 65.0 |
DMAC | - | - | 190.0 |
物料名称 | 摩尔比例 | 摩尔量(mol) | 投料量(kg) |
2-羟基-5-甲基吡啶 | 1.00 | 367 | 40.0 |
对溴苯甲醚 | 1.10 | 403.7 | 75.0 |
五水硫酸铜 | 0.12 | 43.26 | 10.8 |
无水碳酸钾 | 2.13 | 781.42 | 108.0 |
DMF | - | - | 230.0 |
Claims (10)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310048439.0A CN116082225A (zh) | 2016-08-08 | 2016-08-08 | 一种羟尼酮的制备方法 |
CN201610642515.0A CN107698499A (zh) | 2016-08-08 | 2016-08-08 | 一种羟尼酮的制备方法 |
PCT/CN2017/095882 WO2018028508A1 (zh) | 2016-08-08 | 2017-08-03 | 一种羟尼酮的制备方法 |
CN201780048603.0A CN109563039A (zh) | 2016-08-08 | 2017-08-03 | 一种羟尼酮的制备方法 |
JP2019507241A JP6764999B2 (ja) | 2016-08-08 | 2017-08-03 | ヒドロニドンの製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610642515.0A CN107698499A (zh) | 2016-08-08 | 2016-08-08 | 一种羟尼酮的制备方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202310048439.0A Division CN116082225A (zh) | 2016-08-08 | 2016-08-08 | 一种羟尼酮的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107698499A true CN107698499A (zh) | 2018-02-16 |
Family
ID=61161577
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202310048439.0A Pending CN116082225A (zh) | 2016-08-08 | 2016-08-08 | 一种羟尼酮的制备方法 |
CN201610642515.0A Pending CN107698499A (zh) | 2016-08-08 | 2016-08-08 | 一种羟尼酮的制备方法 |
CN201780048603.0A Pending CN109563039A (zh) | 2016-08-08 | 2017-08-03 | 一种羟尼酮的制备方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CN202310048439.0A Pending CN116082225A (zh) | 2016-08-08 | 2016-08-08 | 一种羟尼酮的制备方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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CN201780048603.0A Pending CN109563039A (zh) | 2016-08-08 | 2017-08-03 | 一种羟尼酮的制备方法 |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP6764999B2 (zh) |
CN (3) | CN116082225A (zh) |
WO (1) | WO2018028508A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111004173A (zh) * | 2019-12-31 | 2020-04-14 | 北京康蒂尼药业有限公司 | 一种羟尼酮的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005047256A1 (fr) * | 2003-11-14 | 2005-05-26 | Shanghai Genomics, Inc. | Derives de pyridone, et utilisation correspondante |
CN101165051A (zh) * | 2007-08-07 | 2008-04-23 | 中国科学院长春应用化学研究所 | 树枝状主体材料及该化合物制备的有机电致发光器件 |
CN101723883A (zh) * | 2008-10-24 | 2010-06-09 | 上海睿星基因技术有限公司 | 一种羟尼酮的制备方法 |
CN102099036A (zh) * | 2008-06-03 | 2011-06-15 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
CN102766041A (zh) * | 2012-08-17 | 2012-11-07 | 济南大学 | 一种水杨醛衍生物中间体的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0129260D0 (en) * | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
PE20080150A1 (es) * | 2006-06-02 | 2008-04-11 | Janssen Pharmaceutica Nv | Derivados de piridinona n-aril y n-heteroaril sustituidos como antagonistas del receptor de la hormona concentradora de melanina (mch) |
AU2007328979B2 (en) * | 2006-12-05 | 2013-05-09 | Janssen Pharmaceutica N.V. | Novel substituted diaza spiro pyridinone derivatives for use in MCH-1 mediated diseases |
WO2008076562A1 (en) * | 2006-12-14 | 2008-06-26 | Eli Lilly And Company | 5- [4- (azetidin-3-yl0xy) -phenyl] -2-phenyl-5h-thiaz0l0 [5,4-c] pyridin-4-0ne derivatives and their use as mch receptor antagonists |
AR092742A1 (es) * | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
EP3411450A4 (en) * | 2016-02-01 | 2019-09-18 | 3M Innovative Properties Company | ADHESIVE COMPOSITIONS |
-
2016
- 2016-08-08 CN CN202310048439.0A patent/CN116082225A/zh active Pending
- 2016-08-08 CN CN201610642515.0A patent/CN107698499A/zh active Pending
-
2017
- 2017-08-03 CN CN201780048603.0A patent/CN109563039A/zh active Pending
- 2017-08-03 WO PCT/CN2017/095882 patent/WO2018028508A1/zh active Application Filing
- 2017-08-03 JP JP2019507241A patent/JP6764999B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005047256A1 (fr) * | 2003-11-14 | 2005-05-26 | Shanghai Genomics, Inc. | Derives de pyridone, et utilisation correspondante |
CN101165051A (zh) * | 2007-08-07 | 2008-04-23 | 中国科学院长春应用化学研究所 | 树枝状主体材料及该化合物制备的有机电致发光器件 |
CN102099036A (zh) * | 2008-06-03 | 2011-06-15 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
CN101723883A (zh) * | 2008-10-24 | 2010-06-09 | 上海睿星基因技术有限公司 | 一种羟尼酮的制备方法 |
CN102766041A (zh) * | 2012-08-17 | 2012-11-07 | 济南大学 | 一种水杨醛衍生物中间体的制备方法 |
Non-Patent Citations (2)
Title |
---|
CHUN SING LI等: "An efficient copper-catalyzed coupling reaction of pyridin-2-ones with aryl and heterocyclic halides based on Buchwald’s protocol", 《TETRAHEDRON LETTERS》 * |
能源部西安热工研究所主编: "《热工技术手册》", 30 June 1993 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111004173A (zh) * | 2019-12-31 | 2020-04-14 | 北京康蒂尼药业有限公司 | 一种羟尼酮的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
JP2019525946A (ja) | 2019-09-12 |
CN109563039A (zh) | 2019-04-02 |
WO2018028508A1 (zh) | 2018-02-15 |
JP6764999B2 (ja) | 2020-10-07 |
CN116082225A (zh) | 2023-05-09 |
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PB01 | Publication | ||
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TA01 | Transfer of patent application right |
Effective date of registration: 20190711 Address after: Room 302-37, Room 3, Building No. 400 Fangchun Road, China (Shanghai) Free Trade Pilot Area, Pudong New Area, Shanghai Applicant after: SHANGHAI GENOMICS, Inc. Address before: Six Blocks 230 Chuanhong Road, Chuansha Town, Pudong New Area, Shanghai Applicant before: Luo Ying |
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TA01 | Transfer of patent application right |
Effective date of registration: 20201229 Address after: 101300 No.60, Shunkang Road, Linhe Industrial Development Zone, Shunyi District, Beijing Applicant after: BEIJING CONTINENT PHARMACEUTICAL Co.,Ltd. Address before: Room 302-37, 3 / F, building 1, 400 Fangchun Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai, 201203 Applicant before: SHANGHAI GENOMICS, Inc. |
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Address after: 101300 No.60, Shunkang Road, Linhe Industrial Development Zone, Shunyi District, Beijing Applicant after: Beijing kangdini Pharmaceutical Co.,Ltd. Address before: 101300 No.60, Shunkang Road, Linhe Industrial Development Zone, Shunyi District, Beijing Applicant before: BEIJING CONTINENT PHARMACEUTICAL Co.,Ltd. |
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