JP5719099B2 - 糖尿病治療における優れた血糖コントロール - Google Patents
糖尿病治療における優れた血糖コントロール Download PDFInfo
- Publication number
- JP5719099B2 JP5719099B2 JP2008504512A JP2008504512A JP5719099B2 JP 5719099 B2 JP5719099 B2 JP 5719099B2 JP 2008504512 A JP2008504512 A JP 2008504512A JP 2008504512 A JP2008504512 A JP 2008504512A JP 5719099 B2 JP5719099 B2 JP 5719099B2
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- glucose
- meal
- blood glucose
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66739305P | 2005-03-31 | 2005-03-31 | |
| US60/667,393 | 2005-03-31 | ||
| US11/329,686 | 2006-01-10 | ||
| US11/329,686 US9006175B2 (en) | 1999-06-29 | 2006-01-10 | Potentiation of glucose elimination |
| PCT/US2006/012366 WO2006105501A2 (en) | 2005-03-31 | 2006-03-31 | Control of blood glucose in diabetes treatment using pulmonarily administered insulin in combination with basal insulin |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012238430A Division JP5788374B2 (ja) | 2005-03-31 | 2012-10-29 | 糖尿病治療における優れた血糖コントロール |
| JP2015020034A Division JP2015110631A (ja) | 2005-03-31 | 2015-02-04 | 糖尿病治療における優れた血糖コントロール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008534622A JP2008534622A (ja) | 2008-08-28 |
| JP2008534622A5 JP2008534622A5 (enExample) | 2009-05-14 |
| JP5719099B2 true JP5719099B2 (ja) | 2015-05-13 |
Family
ID=37054222
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504512A Expired - Fee Related JP5719099B2 (ja) | 2005-03-31 | 2006-03-31 | 糖尿病治療における優れた血糖コントロール |
| JP2012238430A Expired - Fee Related JP5788374B2 (ja) | 2005-03-31 | 2012-10-29 | 糖尿病治療における優れた血糖コントロール |
| JP2015020034A Pending JP2015110631A (ja) | 2005-03-31 | 2015-02-04 | 糖尿病治療における優れた血糖コントロール |
| JP2016048575A Pending JP2016147883A (ja) | 2005-03-31 | 2016-03-11 | 糖尿病治療における優れた血糖コントロール |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012238430A Expired - Fee Related JP5788374B2 (ja) | 2005-03-31 | 2012-10-29 | 糖尿病治療における優れた血糖コントロール |
| JP2015020034A Pending JP2015110631A (ja) | 2005-03-31 | 2015-02-04 | 糖尿病治療における優れた血糖コントロール |
| JP2016048575A Pending JP2016147883A (ja) | 2005-03-31 | 2016-03-11 | 糖尿病治療における優れた血糖コントロール |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US9006175B2 (enExample) |
| EP (4) | EP2027870B1 (enExample) |
| JP (4) | JP5719099B2 (enExample) |
| KR (1) | KR101244028B1 (enExample) |
| CN (1) | CN101151047A (enExample) |
| AT (2) | ATE411040T1 (enExample) |
| AU (2) | AU2006230576B2 (enExample) |
| BR (1) | BRPI0608271A2 (enExample) |
| CA (1) | CA2601860C (enExample) |
| DE (2) | DE602006003228D1 (enExample) |
| DK (2) | DK2027870T3 (enExample) |
| ES (2) | ES2362220T3 (enExample) |
| IL (1) | IL186182A (enExample) |
| MX (1) | MX2007012102A (enExample) |
| WO (1) | WO2006105501A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| EP1808438B1 (en) * | 1999-06-29 | 2014-10-01 | MannKind Corporation | Purification and stabilization of peptide and proteins in pharmaceutical agents |
| US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
| US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| ES2425392T3 (es) | 2002-03-20 | 2013-10-15 | Mannkind Corporation | Cartucho para un aparato de inhalación |
| US20070027063A1 (en) * | 2004-01-12 | 2007-02-01 | Mannkind Corporation | Method of preserving the function of insulin-producing cells |
| DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
| WO2007033372A2 (en) | 2005-09-14 | 2007-03-22 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
| DK1986679T3 (da) | 2006-02-22 | 2017-11-20 | Mannkind Corp | Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof |
| HUE025485T2 (en) * | 2007-10-24 | 2016-02-29 | Mannkind Corp | Respiratory dry powder formulation containing GLP-1 for use in the treatment of hyperglycemia and diabetes by pulmonary administration |
| US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
| JP5667041B2 (ja) * | 2008-03-27 | 2015-02-12 | マンカインド コーポレイション | 乾燥粉末吸入システム |
| AU2015201158B2 (en) * | 2008-03-27 | 2017-04-13 | Mannkind Corporation | A dry powder inhalation system |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CA3153292A1 (en) | 2008-06-13 | 2009-12-17 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
| AU2014200952B2 (en) * | 2008-06-13 | 2014-12-11 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
| AU2015275293B2 (en) * | 2008-06-13 | 2018-06-07 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
| CN102065942B (zh) * | 2008-06-20 | 2013-12-11 | 曼金德公司 | 用于对吸入工作进行实时描绘的交互式设备和方法 |
| US11110151B2 (en) * | 2008-08-11 | 2021-09-07 | Mannkind Corporation | Composition and method for reducing hypoglycemia events in diabetes treatment |
| TWI532497B (zh) * | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2379100T3 (en) * | 2009-01-08 | 2014-12-01 | Mannkind Corp | Treatment of hyperglycemia with GLP-1 |
| CN102369031B (zh) * | 2009-02-04 | 2015-11-25 | 赛诺菲-安万特德国有限公司 | 用于血糖控制的医疗设备和方法 |
| EP2403490B1 (en) * | 2009-03-04 | 2019-08-07 | MannKind Corporation | An improved dry powder drug delivery system |
| AU2014200960B2 (en) * | 2009-03-04 | 2016-02-11 | Mannkind Corporation | An improved dry powder drug delivery system |
| PL2405963T3 (pl) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Urządzenie, układ i sposób pomiaru oporu inhalatora |
| BRPI1010722B1 (pt) | 2009-06-12 | 2019-12-10 | Mannkind Corp | micropartículas de dicetopiperazina com teores de isômero definidos, pó seco, uso de uma formulação de pó seco compreendendo micropartículas de dicetopiperazina, método de preparar micropartículas e método para sintetizar uma dicetopiperazina |
| KR20180036807A (ko) | 2009-06-12 | 2018-04-09 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| RU2638794C2 (ru) | 2009-11-02 | 2017-12-15 | Мэннкайнд Корпорэйшн | Способ криогрануляции фармацевтической композиции |
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| RU2571331C1 (ru) * | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
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| EP2776053A1 (en) | 2011-10-24 | 2014-09-17 | MannKind Corporation | Methods and compositions for treating pain |
| CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
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| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| CA2918369C (en) | 2013-07-18 | 2021-06-29 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| WO2015021041A2 (en) * | 2013-08-05 | 2015-02-12 | Hygieia, Inc. | Systems, devices, and methods for alleviating glucotoxicity and restoring pancreatic beta-cell function in advanced diabetes mellitus |
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| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
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| EP3458133B1 (en) | 2016-05-19 | 2023-11-15 | MannKind Corporation | Apparatus, system and method for detecting and monitoring inhalations |
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| WO2020077030A1 (en) * | 2018-10-11 | 2020-04-16 | The Cleveland Clinic Foundation | Aggf1 and aggf1-primed cells for treating diseases and conditions |
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