ATE248587T1 - Mikrosphären mit verzögerter wirkstoffabgabe - Google Patents
Mikrosphären mit verzögerter wirkstoffabgabeInfo
- Publication number
- ATE248587T1 ATE248587T1 AT99304616T AT99304616T ATE248587T1 AT E248587 T1 ATE248587 T1 AT E248587T1 AT 99304616 T AT99304616 T AT 99304616T AT 99304616 T AT99304616 T AT 99304616T AT E248587 T1 ATE248587 T1 AT E248587T1
- Authority
- AT
- Austria
- Prior art keywords
- microspheres
- delayed release
- angstroms
- diameter
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99304616A EP1060741B1 (de) | 1999-06-14 | 1999-06-14 | Mikrosphären mit verzögerter Wirkstoffabgabe |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE248587T1 true ATE248587T1 (de) | 2003-09-15 |
Family
ID=8241454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99304616T ATE248587T1 (de) | 1999-06-14 | 1999-06-14 | Mikrosphären mit verzögerter wirkstoffabgabe |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1060741B1 (de) |
AT (1) | ATE248587T1 (de) |
DE (1) | DE69910987T2 (de) |
ES (1) | ES2207123T3 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6458387B1 (en) | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
WO2001076553A2 (en) * | 2000-04-06 | 2001-10-18 | Sontra Medical, Inc. | Method and device for enhanced transdermal drug delivery |
DE60138641D1 (de) * | 2000-10-27 | 2009-06-18 | Baxter Healthcare Sa | Herstellung von mikrokügelchen |
AU2002320122B2 (en) | 2001-06-21 | 2007-07-26 | Genentech, Inc. | Sustained release formulation |
ES2300568T3 (es) | 2002-03-20 | 2008-06-16 | Mannkind Corporation | Aparato de inhalacion. |
KR100508911B1 (ko) * | 2002-05-09 | 2005-08-18 | 주식회사 펩트론 | 서방성 단백질 약물 제형 및 이의 제조방법 |
SG135204A1 (en) * | 2003-07-18 | 2007-09-28 | Baxter Int | Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation |
WO2005112885A2 (en) | 2004-05-12 | 2005-12-01 | Baxter International Inc. | Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1 |
WO2005112893A1 (en) | 2004-05-12 | 2005-12-01 | Baxter International Inc. | Microspheres comprising protein and showing injectability at high concentrations of said agent |
EP1765294B1 (de) | 2004-05-12 | 2008-09-24 | Baxter International Inc. | Nukleinsäure-mikrokügelchen, ihre herstellung und abgabe |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
MX2007001903A (es) | 2004-08-20 | 2007-08-02 | Mannkind Corp | Catalisis de sintesis de dicetopiperazina. |
KR101306384B1 (ko) | 2004-08-23 | 2013-09-09 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염 |
CN101262849A (zh) * | 2005-09-14 | 2008-09-10 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
AU2014271222B2 (en) * | 2005-09-14 | 2016-04-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
JP5465878B2 (ja) * | 2005-09-14 | 2014-04-09 | マンカインド コーポレイション | 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法 |
CN104383546B (zh) | 2006-02-22 | 2021-03-02 | 曼金德公司 | 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法 |
US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
MX2009001226A (es) | 2006-08-04 | 2009-03-20 | Baxter Int | Composicion basada en microesferas para prevenir y/o revertir la diabetes autoinmune de nuevo inicio. |
EP2296630A2 (de) | 2008-05-07 | 2011-03-23 | SurModics, Inc. | Abgabe von nukleinsäurekomplexen aus teilchen |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CN104689432B (zh) | 2008-06-13 | 2018-07-06 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
JP5479465B2 (ja) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | 吸入努力をリアルタイムにプロファイルする対話式機器および方法 |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323685B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
PL2405963T3 (pl) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Urządzenie, układ i sposób pomiaru oporu inhalatora |
EP2440184B1 (de) | 2009-06-12 | 2023-04-05 | MannKind Corporation | Diketopiperazin-mikropartikel mit definierten spefiischen oberflächenbereichen |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
RU2571331C1 (ru) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
US8901092B2 (en) | 2010-12-29 | 2014-12-02 | Surmodics, Inc. | Functionalized polysaccharides for active agent delivery |
DK2694402T3 (en) | 2011-04-01 | 2017-07-03 | Mannkind Corp | BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
AU2012328885B2 (en) | 2011-10-24 | 2017-08-31 | Mannkind Corporation | Methods and compositions for treating pain |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
JP6254187B2 (ja) * | 2012-12-20 | 2017-12-27 | オムリックス・バイオファーマシューティカルズ・リミテッドOmrix Biopharmaceuticals Ltd. | ウイルス不活性化生物学的混合物 |
EP3587404B1 (de) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Mikrokristalline diketopiperazinzusammensetzungen, verfahren zur herstellung und deren verwendung |
BR112016000937A8 (pt) | 2013-07-18 | 2021-06-22 | Mannkind Corp | formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco |
JP2016530930A (ja) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | 通気装置及び方法 |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
JP2023533173A (ja) * | 2020-07-09 | 2023-08-02 | エフ. ホフマン-ラ ロシュ アーゲー | タンパク質の濃縮組成物、それらの調製及びそれらの使用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5160745A (en) * | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
JPH08225454A (ja) * | 1995-02-23 | 1996-09-03 | Chugai Pharmaceut Co Ltd | マイクロスフェア製剤 |
-
1999
- 1999-06-14 DE DE69910987T patent/DE69910987T2/de not_active Expired - Lifetime
- 1999-06-14 EP EP99304616A patent/EP1060741B1/de not_active Expired - Lifetime
- 1999-06-14 AT AT99304616T patent/ATE248587T1/de not_active IP Right Cessation
- 1999-06-14 ES ES99304616T patent/ES2207123T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69910987T2 (de) | 2004-05-19 |
DE69910987D1 (de) | 2003-10-09 |
ES2207123T3 (es) | 2004-05-16 |
EP1060741A1 (de) | 2000-12-20 |
EP1060741B1 (de) | 2003-09-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |