DE69910987D1 - Mikrosphären mit verzögerter Wirkstoffabgabe - Google Patents
Mikrosphären mit verzögerter WirkstoffabgabeInfo
- Publication number
- DE69910987D1 DE69910987D1 DE69910987T DE69910987T DE69910987D1 DE 69910987 D1 DE69910987 D1 DE 69910987D1 DE 69910987 T DE69910987 T DE 69910987T DE 69910987 T DE69910987 T DE 69910987T DE 69910987 D1 DE69910987 D1 DE 69910987D1
- Authority
- DE
- Germany
- Prior art keywords
- microspheres
- drug delivery
- delayed drug
- delayed
- angstroms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99304616A EP1060741B1 (de) | 1999-06-14 | 1999-06-14 | Mikrosphären mit verzögerter Wirkstoffabgabe |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69910987D1 true DE69910987D1 (de) | 2003-10-09 |
DE69910987T2 DE69910987T2 (de) | 2004-05-19 |
Family
ID=8241454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69910987T Expired - Lifetime DE69910987T2 (de) | 1999-06-14 | 1999-06-14 | Mikrosphären mit verzögerter Wirkstoffabgabe |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1060741B1 (de) |
AT (1) | ATE248587T1 (de) |
DE (1) | DE69910987T2 (de) |
ES (1) | ES2207123T3 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6458387B1 (en) | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
WO2001076553A2 (en) * | 2000-04-06 | 2001-10-18 | Sontra Medical, Inc. | Method and device for enhanced transdermal drug delivery |
WO2002043580A2 (en) | 2000-10-27 | 2002-06-06 | Epic Therapeutics, Inc. | Production of microspheres |
PT1397155E (pt) | 2001-06-21 | 2015-12-07 | Genentech Inc | Formulação de libertação sustentada |
ES2425392T3 (es) | 2002-03-20 | 2013-10-15 | Mannkind Corporation | Cartucho para un aparato de inhalación |
US20050175693A1 (en) * | 2002-05-09 | 2005-08-11 | Peptron Co., Ltd | Substained release formulation of protein and preparation method thereof |
EP1646445A4 (de) * | 2003-07-18 | 2007-09-19 | Baxter Int | Verfahren zur herstellung, verwendungen und zusammensetzungen von durch kontrollierte phasentrennung hergestellten kleinen kugelförmigen teilchen |
CN103432079A (zh) | 2004-05-12 | 2013-12-11 | 巴克斯特国际公司 | 含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用 |
US8333995B2 (en) | 2004-05-12 | 2012-12-18 | Baxter International, Inc. | Protein microspheres having injectable properties at high concentrations |
DK2072040T3 (da) | 2004-05-12 | 2013-07-29 | Baxter Healthcare Sa | Terapeutisk anvendelse af nukleinsyremikrokugler |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
PL1791542T3 (pl) | 2004-08-23 | 2015-11-30 | Mannkind Corp | Sole diketopiperazyny do dostarczania leków |
AU2006290870B2 (en) | 2005-09-14 | 2013-02-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
AU2014271222B2 (en) * | 2005-09-14 | 2016-04-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
CA2818900C (en) * | 2005-09-14 | 2018-02-06 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
EP2497484A3 (de) | 2006-02-22 | 2012-11-07 | MannKind Corporation | Verfahren zur Verbesserung der pharmazeutischen Eigenschaften von Mikropartikeln mit Diketopiperazin und einem Wirkstoff |
US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
MX2009001226A (es) | 2006-08-04 | 2009-03-20 | Baxter Int | Composicion basada en microesferas para prevenir y/o revertir la diabetes autoinmune de nuevo inicio. |
CA2723192A1 (en) | 2008-05-07 | 2009-11-12 | Surmodics, Inc. | Delivery of nucleic acid complexes from particles |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
DK2570147T3 (da) | 2008-06-13 | 2018-01-29 | Mannkind Corp | Tørpulverinhalator og system til lægemiddelindgivelse |
KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8323685B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US8734845B2 (en) | 2009-06-12 | 2014-05-27 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
US8901092B2 (en) | 2010-12-29 | 2014-12-02 | Surmodics, Inc. | Functionalized polysaccharides for active agent delivery |
MY180552A (en) | 2011-04-01 | 2020-12-02 | Mannkind Corp | Blister package for pharmaceutical cartridges |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
WO2013063160A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
CA2878457C (en) | 2012-07-12 | 2021-01-19 | Mannkind Corporation | Dry powder drug delivery systems and methods |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
JP6254187B2 (ja) * | 2012-12-20 | 2017-12-27 | オムリックス・バイオファーマシューティカルズ・リミテッドOmrix Biopharmaceuticals Ltd. | ウイルス不活性化生物学的混合物 |
BR112015023168B1 (pt) | 2013-03-15 | 2021-08-10 | Mannkind Corporation | Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina |
CN114848614A (zh) | 2013-07-18 | 2022-08-05 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
WO2022008699A1 (en) * | 2020-07-09 | 2022-01-13 | F. Hoffmann-La Roche Ag | Concentrated compositions of proteins, their preparation and use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5160745A (en) * | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
JPH08225454A (ja) * | 1995-02-23 | 1996-09-03 | Chugai Pharmaceut Co Ltd | マイクロスフェア製剤 |
-
1999
- 1999-06-14 AT AT99304616T patent/ATE248587T1/de not_active IP Right Cessation
- 1999-06-14 EP EP99304616A patent/EP1060741B1/de not_active Expired - Lifetime
- 1999-06-14 ES ES99304616T patent/ES2207123T3/es not_active Expired - Lifetime
- 1999-06-14 DE DE69910987T patent/DE69910987T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2207123T3 (es) | 2004-05-16 |
EP1060741A1 (de) | 2000-12-20 |
DE69910987T2 (de) | 2004-05-19 |
EP1060741B1 (de) | 2003-09-03 |
ATE248587T1 (de) | 2003-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |