US3622053A - Aerosol inhaler with flip-up nozzle - Google Patents

Aerosol inhaler with flip-up nozzle Download PDF

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Publication number
US3622053A
US3622053A US3622053DA US3622053A US 3622053 A US3622053 A US 3622053A US 3622053D A US3622053D A US 3622053DA US 3622053 A US3622053 A US 3622053A
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container
hood
dispenser
open
end
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John V Ryden
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Merck Sharp and Dohme Corp
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Merck Sharp and Dohme Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0021Mouthpieces therefor
    • A61M15/0023Mouthpieces therefor retractable

Abstract

A dispenser for dispensing a composition confined, under pressure, in a container having a valve which, when pushed downward toward the container, opens and dispenses the composition, the dispenser comprising a housing having a skirt open at its lower end for receiving the container and a dispensing head, the dispensing head having a valve activator therein including a boss having an opening for engaging and gripping the valve stem on the container for maintaining the container in the dispenser and a nozzle hood pivotally mounted on the dispensing head for receiving a metered amount of medication from the container and mixing such metered amount of medication with the air drawn through such hood by the patient, the nozzle hood including means, when said nozzle hood is closed, for abutting said container and for preventing said container from being moved axially of said dispenser for opening said valve.

Description

United States Patent 56] References Cited UNITED STATES PATENTS 3,107,670 10/1963 Silson 3,169,673 2/1965 Focht... 3,191,867 6/1965 Helms...

ZZZ/402.1 X 222/402.12X

3,361,306 1/1968 Grim ZZZ/402.13 3,506,004 4/1970 Mann 128/208 FOREIGN PATENTS 1,131,644 10/1968 Great Britain ZZZ/402.12

Primary E.raminerRobert B. Reeves Assistant Examiner-Thomas E. Kocovsky Attorney-Morgan. Finnegan. Durham & Pine ABSTRACT: A dispenser for dispensing a composition confined. under pressure, in a container having a valve which, when pushed downward toward the container, opens and dispenses the composition. the dispenser comprising a housing having a skirt open at its lower end for receiving the container and a dispensing head, the dispensing head having a valve activator therein including a boss having an opening for engaging and gripping the valve stem on the container for maintaining the container in the dispenser and a nozzle hood pivotally mounted on the dispensing head for receiving a metered amount of medication from the container and mixing such metered amount of medication with the air drawn through such hood by the patient, the nozzle hood including means, when said nozzle hood is closed, for abutting said container and for preventing said container from being moved axially of said dispenser for opening said valve PATENTEDN 23 I l 3.622 O53 (iLllligli li INVENTOR. Id/m M RVOfA/ @7d, W M! ATTORNEYS 1 AEROSOL INHALER WITH FLIP-UP NOZZLE This invention relates to a dispensing device for aerosol products, that is, for products that are confined under pressure within a container and dispensed therefrom in the fonn of 5 The-administration of medicinal agents by inhalation has many advantages as compared with alternate methods. Inhalationis quick and easy and may be accomplished by the patient without assistance or difficulty. In addition, response to this type of administration is prompt because of the direct application of the medicinal agent to the affected area. Prompt response and administration by the patient are of particular importance where the patient is subject to attacks, such as, for example, asthma attacks, where such attacks are unpredictable and may occur at any time.

One means found to be particularly effective in the administration of medical agents by inhalation is by packaging the medicament, as for example antibiotics, anesthetics, antiseptics, antihistamines, and the like, and combinations thereof, in a container with a propellant, such as Freon. Such container is provided with a valve which, when depressed, discharges the medicament in a mist or spray. Such containers are relatively small and can be carried in a pocketbook, purse or pocket so that, when needed, it is readily available and a portion of the contents might be easily dispensed. Thus, as an attack is coming on or during the initial stage, the required medicament may be administered by the patient and the attack lessened and relieved. The contents of the container are not dispensed at one time but, rather, over a period of time depending upon the frequency and severity of attacks. A patient may carry such a container in a pocketbook, purse or pocket for weeks and even months, before the contents of the container are exhausted.

When not in use, the medicament and propellant are maintained under pressure in the container. Just before the contents are exhausted, the spray discharged from the container decreases, indicating to the patient that a new container is required. This might occur weeks, and even months, after such container has been placed in use.

To minimize cost and, at the same time, provide a unit that is compact, may be carried in pocketbook, purse or pocket,

will be readily available and easy to use, the medicament and propellant are packaged in a pressure tight container of metal or other material and the container is provided with a valve. Such container is inserted into a dispenser having a nozzle into which the container valve is inserted and, usually, the dispenser is provided with a head through which the spray, from the container, is dispensed. Such dispenser is usually purchased by the patient with the initial container of medicament and propellant. When the contents of the container are exhausted, the dispenser is removed, the exhausted container is thrown away and a new container, purchased separately, is inserted in the dispenser.

While making the-dispenser and container separate units and replacing the container, when exhausted, with a new container minimizes the cost of such unit, if the dispenser and container become separated, neither unit can be used. Furthermore, when separated, such as in a purse, pocketbook or pocket, the container valve may become clogged or such valve might he accidentally opened and discharge the contents of the container.

In the dispenser of the instant invention, the nozzle and head are situated in a head at the top of the dispenser and the dispenser is provided with a skirt that extends downwardly from the head. The dispenser head is provided with a boss into which the valve stem on the container is inserted. In the illustrated embodiment, the boss frictionally grips and locks the container in the dispenser. Other locking means, such as detents, recesses, and the like, on the dispenser and container may be employed. The container is inserted in the dispenser through the open bottom of the skirt, the valve stem on the container is aligned with the opening in the boss in the dispenser head and the stem is pushed into the boss so that the stem is frictionally gripped by the boss to hold the container in the dispenser. The dispenser skirt extends downward along the container body and one side of the skirt, at the lower end, is cutaway so that, by placing one finger on the bottom of the container, at the skirt recess, and another finger on the dispenser head, the container can be pressed into the dispenser to open the container valve and discharge a spray through the dispenser nozzle. The cutaway at the skirt bottom also allows the container, when empty, to be pulled out so that a new container can be substituted. Preferably, the skirt extends beyond the lower end of the container and is rounded so that, if the dispenser, with the container therein, is placed on a table with the valve end up, the dispenser will fall over. In this way, the possibility of drainage of the metered charge out of the metering valve is avoided.

In the dispenser of the instant invention, the nozzle hood is pivotally mounted on the dispenser head. When closed, the hood prevents dust, dirt, and the like, from entering the dispenser head thus assuring that the head, and nozzle therein, will not become dirty and clogged. When closed, the head engages the end of the container to prevent the container from being accidentally pushed into the dispenser and the valve from being accidentally opened to discharge the container contents. When opened, the hood forms, with the dispenser head, an air passage through which air can enter the dispenser head, receive the metered spray of medication and discharge the mixture of medication and air to the patient.

When inserted and locked in the dispenser, the container, except where the dispenser skirt is cutaway, is housed within the skirt. Thus, the container is protected, when in a pocketbook, purse or pocket, from being accidentally separated from the dispenser. This along with the engagement of the closed head with the container end, prevents accidental discharge and assures that, when needed by the patient, spray will be available. The flow of air into the dispenser head and the discharge thereof through the nozzle head with the metered amount of medication assures that the patient using the dispenser will receive the prescribed medication.

The invention will be more fully understood when considered with the following description and attached drawings in which:

FIG. 1 is a perspective side elevational view of the dispensing device;

FIG. 2 is a sectional view of FIG. I taken along line 22;

FIG. 3 is a sectional view of the dispenser taken along line 3-3 of FIG. 2; and

FIG. 4 is a sectional view of the valve line 44 of FIG. 2.

Referring now to the drawing, illustrating the preferred embodiment of the present invention, a conventional pressure container, generally designated 2, for the self-propelling composition, which container can be made of material such as steel, aluminum, etc., has a neck or extension 4 housing a metering valve, not shown, for dispensing the composition. The valve has a valve stem 6, with a passage therethrough, which when pushed into the container, opens the valve to discharge a metered amount of medication and, when released, permits the valve to close and recharge.

The dispenser, to which the instant invention is particularly directed, includes head portion, generally designated 10, and skirt 12, extending downward from head 10. As best shown in FIG. I, skirt 12 is cylindrical to receive the cylindrical body of container 2 but may be of any shape to conform with the shape of the container, for example, rectangular, elliptical, etc.

At its lower end, skirt 12 is open and is cutaway at I4, to expose a portion or the container side for purposes more apparent hereinafter. Preferably, the lower end of skirt 12, where not cutaway, extends downward beyond the container end and is rounded at 16. Valve stem boss 24, having a nozzle 26 and longitudinal passageway 28, with steps 27, 29, for

actuator taken along receiving valve stem 6, projects downward from the top 30 of head 10. Top 30 has an indented finger engaging area 32, roughened to grip the finger, for purposes more apparent hereinafter. Nozzle 26, in boss 24, faces open side 34 of head between walls 36, 38. Nozzle hood 40, having a front wall 42 and a rear wall 44, when the hood is closed, is pivotally mounted by pivot 46, 47, on hood sidewalls 49, 51. Pivots 46, 47, project into recess in walls 36, 38 of open side 34. When closed, as shown in full line F K]. 2, wall 44 is adjacent neck 4 of container 2, with the end of wall 44 above the top of container 2, for purposes more apparent hereinafter. When hood 40 is closed, wall 42 forms a closure over open side 34 of head 10. Hood 40, is open at its end 48 and has an opening 50 at its opposite end which, when the hood is open to the phantom line in FIG. 2, is aligned with nozzle 26.

Dispenser 10 may be made of any suitable material but, preferably, is molded from rigid or semirigid plastic. Container 2 is inserted through the open end of skirt 12, valve end forward, valve stem 6 is aligned with passageway 28 and the container is pushed into the dispenser. With hood 40 closed, at the top of the container abuts the end of hood wall 44, and prevents the container from being moved further into the dispenser to open the valve and discharge the container contents.

With container 2 in the dispenser and locked therein, container 2 and the dispenser cannot become accidentally separated. Skirt 12, extending downward along the container, prevents container 2 from being jarred or displaced, relative to the dispenser. Furthermore, the end of the skirt and the end of hood wall 44 prevent container 2 from being pushed into the dispenser to open the container valve.

When the patient requires the medicament, the dispenser, with the container therein, is withdrawn from the pocketbook, purse or pocket, and hood 40 is flipped open to the phantom line of FIG. 2. The patient can then place one finger in recess 32 on the top of head 10 and another finger on the bottom of the container at cutaway 14 in skirt l2 and, by pushing the container into the dispenser, open the -valve and discharge a metered amount of spray through nozzle 26 and into the air moving through hood opening 50 and the open end of hood 40. After treatment, the patient can reclose hood 40 and returns the dispenser, with the container therein, to the patient's pocketbook, purse, pocket or wherever else the patient might select to carry the dispenser until use is again required.

As best shown in FIG. 2, when closed, wall 42 of hood 40 forms a closure over open side 34 of dispenser hood 10 but, when open, hood 40 occupies only the upper portion of open side 34. Thus, below hood 40, with hood 40 open, air can pass into head 10 of the dispenser.

When the patient requires the medicament, withdraws the dispense from the pocketbook, purse or pocket and flips open hood 40, the patient places the open end of hood 40 close to the mouth and, while pushing the container into the dispenser, inhales. lnhaling is, of course, necessary to the administration of the medicament. Such inhaling draws air out of the open end of hood 40 and causes air to enter dispensing head 10 through open side 34 below the open hood. Thus, the air flows into head 10 under the open hood and through hood opening 50 into hood 40. As such air flows past nozzle 26 and through opening 50 into hood 40, the medicament, sprayed through nozzle 26, mixes with the air and is discharged through the forward open end of hood 40. Open end 48 of hood 40 is in or relatively close to the patient's mouth. Because the top, bottom and side of hood 40 are closed, and open end 48 of hood 40 is in or in close proximity to the patients mouth, little, if any, of the medicament is lost to the atmosphere irrespective of whether the dispenser is used indoors or out of doors. This is of particular importance to administration of the medicament.

After the contents of the container are exhausted, which may be weeks or months after a full container is inserted into the dispenser, depending on frequency of use by the patient,

the end of the empttylcontainer is grasgiby finger at cutout l4 and, while holding e dispenser, con ner 2 IS pulled out of the dispenser. The empty container is thrown away and a new container is inserted through the open end of skirt l2 and pushed into the dispenser. Empty containers can be removed and new container can be inserted in the container any number of times.

The terms and expressions which have been employed are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible.

What is claimed is:

l. A dispenser for dispensing a composition confined under pressure in a container having metering valve means including a stem portion projecting from the top of the container which stem portion, when pushed toward the container, opens said valve for dispensing metered amount of the composition under pressure therein and, when released, closes said valve, said container having a body portion extending downward from said valve, said dispenser comprising a housing having a skirt portion extending downward for receiving and housing a container inserted therein and a dispensing head having a boss therein for engaging the stem portion of the metering valve means of such container, a nozzle in said boss, said dispensing head having an opening in one side thereof, a hood mounted in said opening in said head for pivotal movement between an open position and a close position, means on said hood for engaging the end of a container when said hood is closed for preventing said container from being pushed into said dispenser to open said valve means, an outer wall on said hood for forming a closure over said opening when said hood is closed, an inner wall on said hood, said hood, when open, having an opening in the rear wall thereof in alignment with said nozzle in said boss and a front, open wall, said hood, when open, forming a closed passageway between said opening in alignment with said nozzle and said open end of said hood for the passage of air drawn through said opening in said one side of said dispensing head and discharged through the open end of said hood with a metered amount of the composition sprayed into said hood through said nozzle, said inner wall of said hood, when said hood is opened, forming a divider between the air drawn into said dispensing hood opening and said air discharged through the open end of said hood with said metered amount of the composition sprayed.

2. A dispenser, as recited in claim 1, in which said means on said hood for engaging the end of a container is said inner wall of said hood when said hood is closed.

3. A dispenser, as recited in claim I, in which said skirt portion extends downward beyond the end of a container inserted therein.

4. A dispenser, as recited in claim 3, in which said skirt portion extending downward beyond the end of a container inserted therein is cutaway at one side of its lower end for exposing the bottom and a portion of one side of the container.

5. A dispenser, as recited in claim 4, in which the bottom of said skirt portion extending downward beyond the end of the container is rounded.

1! m e nt

Claims (5)

1. A dispenser for dispensing a composition confined under pressure in a container having metering valve means including a stem portion projecting from the top of the container which stem portion, when pushed toward the container, opens said valve for dispensing metered amount of the composition under pressure therein and, when released, closes said valve, said container having a body portion extending downward from said valve, said dispenser comprising a housing having a skirt portion extending downward for receiving and housing a container inserted therein and a dispensing head having a boss therein for engaging the stem portion of the metering valve means of such container, a nozzle in said boss, said dispensing head having an opening in one side thereof, a hood mounted in said opening in said head for pivotal movement between an open position and a close position, means on said hood for engaging the end of a container when said hood is closed for preventing said container from being pushed into said dispenser to open said valve means, an outer wall on said hood for forming a closure over said opeNing when said hood is closed, an inner wall on said hood, said hood, when open, having an opening in the rear wall thereof in alignment with said nozzle in said boss and a front, open wall, said hood, when open, forming a closed passageway between said opening in alignment with said nozzle and said open end of said hood for the passage of air drawn through said opening in said one side of said dispensing head and discharged through the open end of said hood with a metered amount of the composition sprayed into said hood through said nozzle, said inner wall of said hood, when said hood is opened, forming a divider between the air drawn into said dispensing hood opening and said air discharged through the open end of said hood with said metered amount of the composition sprayed.
2. A dispenser, as recited in claim 1, in which said means on said hood for engaging the end of a container is said inner wall of said hood when said hood is closed.
3. A dispenser, as recited in claim 1, in which said skirt portion extends downward beyond the end of a container inserted therein.
4. A dispenser, as recited in claim 3, in which said skirt portion extending downward beyond the end of a container inserted therein is cutaway at one side of its lower end for exposing the bottom and a portion of one side of the container.
5. A dispenser, as recited in claim 4, in which the bottom of said skirt portion extending downward beyond the end of the container is rounded.
US3622053D 1969-12-10 1969-12-10 Aerosol inhaler with flip-up nozzle Expired - Lifetime US3622053A (en)

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CA (1) CA948599A (en)
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DK (1) DK129392C (en)
FR (1) FR2073152A5 (en)
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Cited By (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4114615A (en) * 1975-12-12 1978-09-19 Aktiebolaget Draco Aerosol inhalation device
US4114811A (en) * 1977-04-12 1978-09-19 Ciba-Geigy Corporation Spray dispenser with easily actuable mouthpiece
US4456007A (en) * 1980-12-12 1984-06-26 Combi Co., Ltd. Inhaler
US4509515A (en) * 1982-02-23 1985-04-09 Fisons Plc Inhalation device
US4805812A (en) * 1987-12-11 1989-02-21 Delshar Industries, Inc. Spray can actuation device with locking mechanism
US4819832A (en) * 1986-08-18 1989-04-11 The English Glass Company Limited Pump type dispenser with swivellable nozzle for locking the pump
US4969578A (en) * 1988-05-09 1990-11-13 Bespak Plc Dispensing apparatus
US5611444A (en) * 1989-02-03 1997-03-18 Senetics, Inc. Indicator device responsive to axial force
EP0937505A1 (en) * 1998-02-24 1999-08-25 L'oreal Packaging and dispensing unit and use of such a unit for packaging cosmetical, pharmaceutical or dermopharmaceutical products
US6032835A (en) * 1993-01-19 2000-03-07 Glaxo Group Ltd. Aerosol dispenser and method
WO2000018458A1 (en) * 1998-09-26 2000-04-06 Glaxo Group Limited Inhalation device
WO2000018456A1 (en) * 1998-09-26 2000-04-06 Glaxo Group Limited Inhalation device
US20030066525A1 (en) * 1998-11-25 2003-04-10 Chiesi Farmaceutici S.P.A. Pressurised metered dose inhalers (MDI)
US6575162B1 (en) 1998-09-26 2003-06-10 Smithkline Beecham Corporation Inhalation device
US6612302B1 (en) 1998-09-26 2003-09-02 Smithkline Beecham Corporation Inhalation device
US20030190289A1 (en) * 2000-05-12 2003-10-09 David Lewis Formulations containing a glucocorticoid drug for the treatment of bronchopulmonary diseases
US20030190287A1 (en) * 1997-06-13 2003-10-09 Chiesi Farmaceutici S.P.A. Pharaceutical aerosol composition
US20030218029A1 (en) * 2002-05-24 2003-11-27 Harvey Brody Spray can holding and actuating device
US20040033201A1 (en) * 1999-06-18 2004-02-19 3M Innovative Properties Company Process for making chemically stable C-17/21 OH 20-ketosteroid aerosol products
US20040139964A1 (en) * 2003-01-17 2004-07-22 Langford Stanley C. Actuation inhibitor for metered dose inhalers
US20040222245A1 (en) * 2003-04-24 2004-11-11 Lindal Ventil Gmbh Spraying cap
US20050034720A1 (en) * 2000-01-07 2005-02-17 Gaetano Brambilla Aerosol inhaler
US6860412B1 (en) * 1993-01-19 2005-03-01 Glaxo Group Limited Aerosol dispenser with ultrasonically welded closure and method of making
US20050154013A1 (en) * 2002-03-01 2005-07-14 Chiesi Farmaceutici S.P.A. Pressurised metered dose inhalers containing solutions of beta-2 agonists
US20050163722A1 (en) * 2001-07-02 2005-07-28 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
WO2005087299A1 (en) * 2004-03-10 2005-09-22 Glaxo Group Limited A dispensing device
US6964759B2 (en) 2000-02-22 2005-11-15 Chiesi Farmaceutici S.P.A. Formulations containing an anticholinergic drug for the treatment of chronic obstructive pulmonary disease
US6967017B1 (en) 1999-07-23 2005-11-22 Chiesi Farmaceutici S.P.A. Formulations of steroid solutions for inhalatory administration
US7018618B2 (en) 2000-05-22 2006-03-28 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
US20070181120A1 (en) * 2005-11-22 2007-08-09 Andrew Wright Aerosol dispensing apparatus
US20070284383A1 (en) * 2006-05-26 2007-12-13 Andrew Wright Dispensing apparatus
US7316334B1 (en) 2002-05-24 2008-01-08 Delshar Industries, Inc. Spray can holding and actuating device
US7381402B2 (en) 2004-02-27 2008-06-03 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
US20080127970A1 (en) * 1999-07-23 2008-06-05 Mannkind Corporation Unit Dose Capsules and Dry Powder Inhaler
US20090241949A1 (en) * 2008-03-27 2009-10-01 Smutney Chad C Dry powder inhalation system
CN1950122B (en) 2004-03-10 2010-09-29 葛兰素集团有限公司 A dispensing device
US20110049191A1 (en) * 2009-01-16 2011-03-03 Colgate-Palmolive Company Dispensing container
US8291898B2 (en) 2006-05-26 2012-10-23 Consort Medical Plc Dispensing apparatus
US8950397B2 (en) 1999-07-23 2015-02-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
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US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
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US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
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US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
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US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52156644U (en) * 1976-05-21 1977-11-28
FR2626254B1 (en) * 1988-01-27 1990-07-06 Valois Sa Push Case with security system
IT233948Y1 (en) * 1994-07-20 2000-02-16 Plastiape Spa Pocket dispenser, particolrmente designed to enter into the mouth sprayed medicinal substances
GB2534986B (en) * 2015-12-02 2017-03-22 Mirror 5 Ltd Inhaler housing

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3107670A (en) * 1962-03-12 1963-10-22 Revlon Actuator for aerosol medication spray dispensers
US3169673A (en) * 1963-06-18 1965-02-16 Precision Valve Corp Combined cap and valve operating member for aerosol dispensers
US3191867A (en) * 1963-10-23 1965-06-29 Revlon Atomizer
US3361306A (en) * 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
GB1131644A (en) * 1965-07-29 1968-10-23 Boehringer Sohn Ingelheim Tubular dispensing device for an aerosol dispensing container
US3506004A (en) * 1967-07-10 1970-04-14 Dart Ind Inc Inhalation device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3107670A (en) * 1962-03-12 1963-10-22 Revlon Actuator for aerosol medication spray dispensers
US3169673A (en) * 1963-06-18 1965-02-16 Precision Valve Corp Combined cap and valve operating member for aerosol dispensers
US3191867A (en) * 1963-10-23 1965-06-29 Revlon Atomizer
GB1131644A (en) * 1965-07-29 1968-10-23 Boehringer Sohn Ingelheim Tubular dispensing device for an aerosol dispensing container
US3361306A (en) * 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3506004A (en) * 1967-07-10 1970-04-14 Dart Ind Inc Inhalation device

Cited By (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4114615A (en) * 1975-12-12 1978-09-19 Aktiebolaget Draco Aerosol inhalation device
US4114811A (en) * 1977-04-12 1978-09-19 Ciba-Geigy Corporation Spray dispenser with easily actuable mouthpiece
US4456007A (en) * 1980-12-12 1984-06-26 Combi Co., Ltd. Inhaler
US4509515A (en) * 1982-02-23 1985-04-09 Fisons Plc Inhalation device
US4819832A (en) * 1986-08-18 1989-04-11 The English Glass Company Limited Pump type dispenser with swivellable nozzle for locking the pump
US4805812A (en) * 1987-12-11 1989-02-21 Delshar Industries, Inc. Spray can actuation device with locking mechanism
US4969578A (en) * 1988-05-09 1990-11-13 Bespak Plc Dispensing apparatus
US5611444A (en) * 1989-02-03 1997-03-18 Senetics, Inc. Indicator device responsive to axial force
US6860412B1 (en) * 1993-01-19 2005-03-01 Glaxo Group Limited Aerosol dispenser with ultrasonically welded closure and method of making
US6032835A (en) * 1993-01-19 2000-03-07 Glaxo Group Ltd. Aerosol dispenser and method
US7601336B2 (en) 1997-06-13 2009-10-13 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US20090311196A1 (en) * 1997-06-13 2009-12-17 Chiesi Farmaceutici S.P.A Pharmaceutical aerosol composition
US20040062720A1 (en) * 1997-06-13 2004-04-01 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US20030206870A1 (en) * 1997-06-13 2003-11-06 Chiesi Farmaceutici S.P.A. Pharaceutical aerosol composition
US20030190287A1 (en) * 1997-06-13 2003-10-09 Chiesi Farmaceutici S.P.A. Pharaceutical aerosol composition
US8420058B2 (en) 1997-06-13 2013-04-16 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
EP0937505A1 (en) * 1998-02-24 1999-08-25 L'oreal Packaging and dispensing unit and use of such a unit for packaging cosmetical, pharmaceutical or dermopharmaceutical products
US6053363A (en) * 1998-02-24 2000-04-25 L'oreal Packaging and dispensing assembly for a cosmetic, pharmaceutical or dermo-pharmaceutical product
FR2775258A1 (en) * 1998-02-24 1999-08-27 Oreal Packaging and distribution, and use of such an assembly for packaging a cosmetic, pharmaceutical or dermopharmaceutical
US6612302B1 (en) 1998-09-26 2003-09-02 Smithkline Beecham Corporation Inhalation device
US6575162B1 (en) 1998-09-26 2003-06-10 Smithkline Beecham Corporation Inhalation device
US6568389B1 (en) 1998-09-26 2003-05-27 Smithkline Beecham Corporation Inhalation device
WO2000018456A1 (en) * 1998-09-26 2000-04-06 Glaxo Group Limited Inhalation device
WO2000018458A1 (en) * 1998-09-26 2000-04-06 Glaxo Group Limited Inhalation device
US6748946B1 (en) * 1998-09-26 2004-06-15 Smithkline Beecham Corporation Inhalation device
US6748948B2 (en) 1998-09-26 2004-06-15 Smithkline Beecham Corporation Inhalation device
US20030066525A1 (en) * 1998-11-25 2003-04-10 Chiesi Farmaceutici S.P.A. Pressurised metered dose inhalers (MDI)
US20080115782A1 (en) * 1998-11-25 2008-05-22 Chiesi Farmaceutici S.P.A. Pressurised metered dose inhalers (mdi)
US7223381B2 (en) 1998-11-25 2007-05-29 Chiesi Farmaceutici S.P.A. Pressurised metered dose inhalers (MDI)
US7347199B1 (en) * 1998-11-25 2008-03-25 Chiesi Farmaceutici S.P.A. Pressurised metered dose inhalers (MDI)
US20050142071A1 (en) * 1998-11-25 2005-06-30 Chiesi Farmaceutici S.P.A. Pressurised metered dose inhalers (MDI)
US20040033201A1 (en) * 1999-06-18 2004-02-19 3M Innovative Properties Company Process for making chemically stable C-17/21 OH 20-ketosteroid aerosol products
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
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US8671937B2 (en) 1999-07-23 2014-03-18 Mannkind Corporation Unit dose capsules and dry powder inhaler
US6967017B1 (en) 1999-07-23 2005-11-22 Chiesi Farmaceutici S.P.A. Formulations of steroid solutions for inhalatory administration
US8950397B2 (en) 1999-07-23 2015-02-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US20080127970A1 (en) * 1999-07-23 2008-06-05 Mannkind Corporation Unit Dose Capsules and Dry Powder Inhaler
US9061111B2 (en) 1999-07-23 2015-06-23 Mannkind Corporation Unit dose capsules and dry powder inhaler
US20050034720A1 (en) * 2000-01-07 2005-02-17 Gaetano Brambilla Aerosol inhaler
US6964759B2 (en) 2000-02-22 2005-11-15 Chiesi Farmaceutici S.P.A. Formulations containing an anticholinergic drug for the treatment of chronic obstructive pulmonary disease
US20030190289A1 (en) * 2000-05-12 2003-10-09 David Lewis Formulations containing a glucocorticoid drug for the treatment of bronchopulmonary diseases
US7018618B2 (en) 2000-05-22 2006-03-28 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
US20060083693A1 (en) * 2000-05-22 2006-04-20 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurised metered dose inhalers
US8168598B2 (en) 2001-07-02 2012-05-01 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
US20110212912A1 (en) * 2001-07-02 2011-09-01 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
US20100098642A1 (en) * 2001-07-02 2010-04-22 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
US7696178B2 (en) 2001-07-02 2010-04-13 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
US20050163722A1 (en) * 2001-07-02 2005-07-28 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
US7939502B2 (en) 2001-07-02 2011-05-10 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
US20050154013A1 (en) * 2002-03-01 2005-07-14 Chiesi Farmaceutici S.P.A. Pressurised metered dose inhalers containing solutions of beta-2 agonists
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US7121435B2 (en) * 2002-05-24 2006-10-17 Delshar Industries, Inc. Spray can holding an actuating device
US7216784B2 (en) 2002-05-24 2007-05-15 Delshar Industries, Inc. Spray can holding and actuating device
US6981622B2 (en) 2002-05-24 2006-01-03 Delshar Industries, Inc. Spray can holding and actuating device
US20030218029A1 (en) * 2002-05-24 2003-11-27 Harvey Brody Spray can holding and actuating device
US20060076367A1 (en) * 2002-05-24 2006-04-13 Delshar Industries, Inc. Spray can holding and actuating device
US7316334B1 (en) 2002-05-24 2008-01-08 Delshar Industries, Inc. Spray can holding and actuating device
US20070084884A1 (en) * 2002-05-24 2007-04-19 Delshar Industries, Inc. Spray can holding and actuating device
US6971381B2 (en) 2003-01-17 2005-12-06 Stanley C. Langford Actuation inhibitor for metered dose inhalers
US20040139964A1 (en) * 2003-01-17 2004-07-22 Langford Stanley C. Actuation inhibitor for metered dose inhalers
WO2004064906A1 (en) * 2003-01-17 2004-08-05 Langford Stanley C Actuation inhibitor for metered dose inhalers
US7004359B2 (en) * 2003-04-24 2006-02-28 Lindal Ventil Gmbh Spraying cap
US20040222245A1 (en) * 2003-04-24 2004-11-11 Lindal Ventil Gmbh Spraying cap
US7381402B2 (en) 2004-02-27 2008-06-03 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
AU2005221383B2 (en) * 2004-03-10 2010-07-22 Glaxo Group Limited A dispensing device
US20080105253A1 (en) * 2004-03-10 2008-05-08 Glaxo Group Limited Dispensing Device
US9327087B2 (en) 2004-03-10 2016-05-03 Glaxo Group Limited Dispensing device
US8397714B2 (en) * 2004-03-10 2013-03-19 Glaxo Group Limited Dispensing device
WO2005087299A1 (en) * 2004-03-10 2005-09-22 Glaxo Group Limited A dispensing device
CN1950122B (en) 2004-03-10 2010-09-29 葛兰素集团有限公司 A dispensing device
US9796688B2 (en) 2004-08-20 2017-10-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
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US9446001B2 (en) 2005-09-14 2016-09-20 Mannkind Corporation Increasing drug affinity for crystalline microparticle surfaces
US10143655B2 (en) 2005-09-14 2018-12-04 Mannkind Corporation Method of drug formulation
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9717689B2 (en) 2005-09-14 2017-08-01 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US20070181120A1 (en) * 2005-11-22 2007-08-09 Andrew Wright Aerosol dispensing apparatus
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
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US8291898B2 (en) 2006-05-26 2012-10-23 Consort Medical Plc Dispensing apparatus
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Also Published As

Publication number Publication date
DK129392B (en) 1974-10-07
DK129392C (en) 1975-02-24
CH515157A (en) 1971-11-15
JPS4933050B1 (en) 1974-09-04
CA948599A1 (en)
FR2073152A5 (en) 1971-09-24
CA948599A (en) 1974-06-04
GB1333438A (en) 1973-10-10
DE2060583A1 (en) 1971-06-16
NL7017959A (en) 1971-06-14

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