JP4212470B2 - Ｏｐｇｌへの抗体 - Google Patents

Ｏｐｇｌへの抗体 Download PDF

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Publication number
JP4212470B2
JP4212470B2 JP2003509075A JP2003509075A JP4212470B2 JP 4212470 B2 JP4212470 B2 JP 4212470B2 JP 2003509075 A JP2003509075 A JP 2003509075A JP 2003509075 A JP2003509075 A JP 2003509075A JP 4212470 B2 JP4212470 B2 JP 4212470B2
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Japan
Prior art keywords
antibody
certain embodiments
opgl
chain
amino acid
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Expired - Lifetime
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JP2003509075A
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English (en)
Japanese (ja)
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JP2005506963A5 (enExample
JP2005506963A (ja
Inventor
ボイル，ウイリアム・ジエイ
マーテイン，フランシス・エイチ
コルバラン，ホセ・アール
デイビス，ジエフリー・シー
Original Assignee
アムジェン フレモント インク．
アムジエン・インコーポレーテツド
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23162250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4212470(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by アムジェン フレモント インク．, アムジエン・インコーポレーテツド filed Critical アムジェン フレモント インク．
Publication of JP2005506963A publication Critical patent/JP2005506963A/ja
Publication of JP2005506963A5 publication Critical patent/JP2005506963A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
JP2003509075A 2001-06-26 2002-06-25 Ｏｐｇｌへの抗体 Expired - Lifetime JP4212470B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30117201P 2001-06-26 2001-06-26
PCT/US2002/020181 WO2003002713A2 (en) 2001-06-26 2002-06-25 Antibodies to opgl

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008175541A Division JP4358282B2 (ja) 2001-06-26 2008-07-04 Ｏｐｇｌへの抗体

Publications (3)

Publication Number Publication Date
JP2005506963A JP2005506963A (ja) 2005-03-10
JP2005506963A5 JP2005506963A5 (enExample) 2005-12-22
JP4212470B2 true JP4212470B2 (ja) 2009-01-21

Family

ID=23162250

Family Applications (13)

Application Number Title Priority Date Filing Date
JP2003509075A Expired - Lifetime JP4212470B2 (ja) 2001-06-26 2002-06-25 Ｏｐｇｌへの抗体
JP2008175541A Expired - Lifetime JP4358282B2 (ja) 2001-06-26 2008-07-04 Ｏｐｇｌへの抗体
JP2009161406A Expired - Lifetime JP4927910B2 (ja) 2001-06-26 2009-07-08 Ｏｐｇｌへの抗体
JP2012006740A Expired - Lifetime JP5065529B2 (ja) 2001-06-26 2012-01-17 Ｏｐｇｌへの抗体
JP2012066632A Withdrawn JP2012153701A (ja) 2001-06-26 2012-03-23 Ｏｐｇｌへの抗体
JP2012148656A Expired - Lifetime JP5576903B2 (ja) 2001-06-26 2012-07-02 Ｏｐｇｌへの抗体
JP2014218929A Pending JP2015057408A (ja) 2001-06-26 2014-10-28 Ｏｐｇｌへの抗体
JP2014239576A Pending JP2015078205A (ja) 2001-06-26 2014-11-27 Ｏｐｇｌへの抗体
JP2016113389A Pending JP2016216464A (ja) 2001-06-26 2016-06-07 Ｏｐｇｌへの抗体
JP2017247287A Ceased JP2018154614A (ja) 2001-06-26 2017-12-25 Ｏｐｇｌへの抗体
JP2019107837A Pending JP2019214563A (ja) 2001-06-26 2019-06-10 Ｏｐｇｌへの抗体
JP2019232389A Pending JP2020073518A (ja) 2001-06-26 2019-12-24 Ｏｐｇｌへの抗体
JP2021128771A Pending JP2022000424A (ja) 2001-06-26 2021-08-05 Ｏｐｇｌへの抗体

Family Applications After (12)

Application Number Title Priority Date Filing Date
JP2008175541A Expired - Lifetime JP4358282B2 (ja) 2001-06-26 2008-07-04 Ｏｐｇｌへの抗体
JP2009161406A Expired - Lifetime JP4927910B2 (ja) 2001-06-26 2009-07-08 Ｏｐｇｌへの抗体
JP2012006740A Expired - Lifetime JP5065529B2 (ja) 2001-06-26 2012-01-17 Ｏｐｇｌへの抗体
JP2012066632A Withdrawn JP2012153701A (ja) 2001-06-26 2012-03-23 Ｏｐｇｌへの抗体
JP2012148656A Expired - Lifetime JP5576903B2 (ja) 2001-06-26 2012-07-02 Ｏｐｇｌへの抗体
JP2014218929A Pending JP2015057408A (ja) 2001-06-26 2014-10-28 Ｏｐｇｌへの抗体
JP2014239576A Pending JP2015078205A (ja) 2001-06-26 2014-11-27 Ｏｐｇｌへの抗体
JP2016113389A Pending JP2016216464A (ja) 2001-06-26 2016-06-07 Ｏｐｇｌへの抗体
JP2017247287A Ceased JP2018154614A (ja) 2001-06-26 2017-12-25 Ｏｐｇｌへの抗体
JP2019107837A Pending JP2019214563A (ja) 2001-06-26 2019-06-10 Ｏｐｇｌへの抗体
JP2019232389A Pending JP2020073518A (ja) 2001-06-26 2019-12-24 Ｏｐｇｌへの抗体
JP2021128771A Pending JP2022000424A (ja) 2001-06-26 2021-08-05 Ｏｐｇｌへの抗体

Country Status (33)

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US (8) US7364736B2 (enExample)
EP (5) EP1409016B9 (enExample)
JP (13) JP4212470B2 (enExample)
KR (2) KR20040023630A (enExample)
CN (2) CN103232539B (enExample)
AR (1) AR034637A1 (enExample)
AT (1) ATE464068T1 (enExample)
AU (2) AU2002320157C1 (enExample)
BR (1) BRPI0210579B8 (enExample)
CA (1) CA2451955C (enExample)
CY (5) CY1110196T1 (enExample)
DE (2) DE122010000047I1 (enExample)
DK (4) DK2087908T3 (enExample)
EA (1) EA021242B9 (enExample)
ES (5) ES2706902T3 (enExample)
FR (1) FR10C0050I2 (enExample)
IL (3) IL159512A0 (enExample)
LU (1) LU91757I2 (enExample)
ME (2) MEP32608A (enExample)
MX (1) MXPA04000134A (enExample)
MY (1) MY143582A (enExample)
NO (5) NO345566B1 (enExample)
NZ (4) NZ547695A (enExample)
PH (2) PH12012502440A1 (enExample)
PL (1) PL222211B1 (enExample)
PT (4) PT2295081T (enExample)
RS (1) RS54274B1 (enExample)
SG (3) SG173211A1 (enExample)
TR (3) TR201900581T4 (enExample)
TW (2) TWI326285B (enExample)
WO (1) WO2003002713A2 (enExample)
YU (1) YU103003A (enExample)
ZA (1) ZA200400521B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015057408A (ja) * 2001-06-26 2015-03-26 アムジェン フレモント インク． Ｏｐｇｌへの抗体

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* Cited by examiner, † Cited by third party
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IL117175A (en) * 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
WO1998028424A2 (en) * 1996-12-23 1998-07-02 Immunex Corporation Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily
NZ332995A (en) 1997-04-15 2000-07-28 Snow Brand Milk Products Co Ltd A protein which binds to osteoclastogenesis inhibitory factor (OCIF)
BR9808545A (pt) 1997-04-16 2000-05-23 Amgen Inc ácido nucleico isolado, vetor de expressão, célula hospedeira, processos para produzir uma proteìna de ligação da osteoprotegerina, para detectar a presença de uma proteìna de ligação à osteoprotegerina em uma amostra biológica, para avaliar a capacidade de um composto candidato de ligar-se a uma proteìna de ligação da osteoprotegerina e de um composto de teste para aumentar ou reduzir a ligação da proteìna de ligação da osteoprotegerina a odar, para regular a expressão de uma proteìna de ligação da osteoprotegerina em um animal e para prevenir ou tratar de doença óssea em um mamìfero, polipeptìdeo, protéina de ligação da osteroprotegerina purificada e isolada, ou seu fragmento, análogo ou derivado, e, anticorpo ou seu fragmento
US6316408B1 (en) * 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
ATE412746T1 (de) 1998-05-14 2008-11-15 Immunex Corp Verfahren zur hemmung der wirkung der osteoklasten
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JP2015078205A (ja) * 2001-06-26 2015-04-23 アムジェン フレモント インク． Ｏｐｇｌへの抗体
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JP2018154614A (ja) * 2001-06-26 2018-10-04 アムジェン フレモント インク． Ｏｐｇｌへの抗体
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JP2022000424A (ja) * 2001-06-26 2022-01-04 アムジェン フレモント インク． Ｏｐｇｌへの抗体

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NZ581637A (en) 2012-05-25
EP2295081A1 (en) 2011-03-16
EP3492100B1 (en) 2021-12-08
CY2010016I1 (el) 2012-01-25
WO2003002713A3 (en) 2003-08-14
IL159512A0 (en) 2004-06-01
RS20120347A2 (sr) 2013-04-30
JP2012153701A (ja) 2012-08-16
EP1409016B1 (en) 2010-04-14
EP2270052A2 (en) 2011-01-05
ES2706902T3 (es) 2019-04-01
AR034637A1 (es) 2004-03-03
IL235116A0 (en) 2014-11-30
AU2008261137A1 (en) 2009-01-15
TR201900581T4 (tr) 2019-02-21
EA021242B9 (ru) 2015-11-30
DE60235989D1 (de) 2010-05-27
JP2015078205A (ja) 2015-04-23
FR10C0050I1 (enExample) 2011-01-14
FR10C0050I2 (fr) 2011-12-30
EP2270052B1 (en) 2018-03-28
PH12012502439A1 (en) 2013-06-17
CY1120656T1 (el) 2019-12-11
ES2674888T3 (es) 2018-07-04
AU2008261137B2 (en) 2012-10-04
JP2015057408A (ja) 2015-03-26
US20200354464A1 (en) 2020-11-12
BRPI0210579B8 (pt) 2021-05-25
JP2009273466A (ja) 2009-11-26
JP5065529B2 (ja) 2012-11-07
NO20200535A1 (no) 2004-03-10
US7364736B2 (en) 2008-04-29
JP2009022280A (ja) 2009-02-05
JP4358282B2 (ja) 2009-11-04
EP2270052A3 (en) 2011-03-02
PT2270052T (pt) 2018-07-04
TW200630107A (en) 2006-09-01
JP2005506963A (ja) 2005-03-10
CY1110196T1 (el) 2012-01-25
CN1547486A (zh) 2004-11-17
TR201809008T4 (tr) 2018-07-23
PL222211B1 (pl) 2016-07-29
CN103232539B (zh) 2015-06-03
ES2675735T3 (es) 2018-07-12
CY2010016I2 (el) 2012-01-25
US20120087923A1 (en) 2012-04-12
YU103003A (sh) 2006-05-25
JP5576903B2 (ja) 2014-08-20
US20090274688A1 (en) 2009-11-05
US20040033535A1 (en) 2004-02-19
JP2016216464A (ja) 2016-12-22
EP1409016A2 (en) 2004-04-21
DK1409016T4 (da) 2020-09-14
US20200131271A1 (en) 2020-04-30
MY143582A (en) 2011-05-31
US8058418B2 (en) 2011-11-15
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EA200400063A1 (ru) 2005-02-24

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