JP2019527557A5 - - Google Patents
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- JP2019527557A5 JP2019527557A5 JP2019506627A JP2019506627A JP2019527557A5 JP 2019527557 A5 JP2019527557 A5 JP 2019527557A5 JP 2019506627 A JP2019506627 A JP 2019506627A JP 2019506627 A JP2019506627 A JP 2019506627A JP 2019527557 A5 JP2019527557 A5 JP 2019527557A5
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 230000027455 binding Effects 0.000 claims 8
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-N-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-N,1-N-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 5
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 5
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 5
- 230000004068 intracellular signaling Effects 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102100019461 CD28 Human genes 0.000 claims 4
- 101700033362 CD28 Proteins 0.000 claims 4
- -1 CD86 Proteins 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 102100009537 TNFRSF9 Human genes 0.000 claims 3
- 101710040535 TNFRSF9 Proteins 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000038129 antigens Human genes 0.000 claims 3
- 108091007172 antigens Proteins 0.000 claims 3
- 230000000139 costimulatory Effects 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 102100008191 CD8A Human genes 0.000 claims 2
- 101700054655 CD8A Proteins 0.000 claims 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 230000001086 cytosolic Effects 0.000 claims 2
- 201000009251 multiple myeloma Diseases 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 101700056583 CD27 Proteins 0.000 claims 1
- 102100019459 CD27 Human genes 0.000 claims 1
- 102100019456 CD276 Human genes 0.000 claims 1
- 101700015421 CD276 Proteins 0.000 claims 1
- 102100013077 CD4 Human genes 0.000 claims 1
- 101700022938 CD4 Proteins 0.000 claims 1
- 101710040446 CD40 Proteins 0.000 claims 1
- 102100013137 CD40 Human genes 0.000 claims 1
- 102100019451 CD80 Human genes 0.000 claims 1
- 101700080477 CD80 Proteins 0.000 claims 1
- 102100008186 CD83 Human genes 0.000 claims 1
- 101700013105 CD83 Proteins 0.000 claims 1
- 101700078717 ERAL1 Proteins 0.000 claims 1
- 102100001475 ITGB2 Human genes 0.000 claims 1
- 102100012225 KLRC2 Human genes 0.000 claims 1
- 101710036391 KLRC2 Proteins 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 101710040448 TNFRSF4 Proteins 0.000 claims 1
- 102100013135 TNFRSF4 Human genes 0.000 claims 1
- 101710040533 TNFRSF8 Proteins 0.000 claims 1
- 102100009538 TNFRSF8 Human genes 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000000306 recurrent Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Claims (29)
- ポリペプチドを含むキメラ抗原受容体（ＣＡＲ）であって、
（ａ）第１のＢＣＭＡ結合部分及び第２のＢＣＭＡ結合部分を含む細胞外抗原結合ドメインであって、前記第１のＢＣＭＡ結合部分が、第１の抗ＢＣＭＡ ｓｄＡｂであり、前記第２のＢＣＭＡ結合部分が、第２の抗ＢＣＭＡ ｓｄＡｂであり、前記第１の及び第２のｓｄＡｂのそれぞれがＶ Ｈ Ｈドメインである、細胞外抗原結合ドメインと、
（ｂ）膜貫通ドメインと、
（ｃ）細胞内シグナル伝達ドメインと、を含み、
（ｉ）前記第１の抗ＢＣＭＡ ｓｄＡｂが、配列番号１０のアミノ酸配列を含むＣＤＲ１、配列番号４８のアミノ酸配列を含むＣＤＲ２、及び配列番号８６のアミノ酸配列を含むＣＤＲ３を含み、
（ｉｉ）前記第２の抗ＢＣＭＡ ｓｄＡｂが、配列番号３のアミノ酸配列を含むＣＤＲ１、配列番号４１のアミノ酸配列を含むＣＤＲ２、及び配列番号７９のアミノ酸配列を含むＣＤＲ３を含む、
前記キメラ抗原受容体（ＣＡＲ）。 - 前記第１の抗ＢＣＭＡ ｓｄＡｂが、配列番号１２４のアミノ酸配列を含み、前記第２の抗ＢＣＭＡ ｓｄＡｂが、配列番号１１７のアミノ酸配列を含む、請求項１に記載のＣＡＲ。
- 前記膜貫通ドメインが、ＣＤ８α、ＣＤ４、ＣＤ２８、ＣＤ１３７、ＣＤ８０、ＣＤ８６、ＣＤ１５２、及びＰＤ１から成る群から選択される分子に由来する、請求項１または２に記載のＣＡＲ。
- 前記膜貫通ドメインが、ＣＤ８αまたはＣＤ２８に由来する、請求項３に記載のＣＡＲ。
- 前記細胞内シグナル伝達ドメインが、免疫エフェクター細胞の一次細胞内シグナル伝達ドメインを含む、請求項１〜４のいずれか１項に記載のＣＡＲ。
- 前記一次細胞内シグナル伝達ドメインが、ＣＤ３ζに由来する、請求項５に記載のＣＡＲ。
- 前記細胞内シグナル伝達ドメインが、共刺激シグナル伝達ドメインを含む、請求項１〜６のいずれか１項に記載のＣＡＲ。
- 前記共刺激シグナル伝達ドメインが、ＣＤ２７、ＣＤ２８、ＣＤ１３７、ＯＸ４０、ＣＤ３０、ＣＤ４０、ＣＤ３、ＬＦＡ−１、ＩＣＯＳ、ＣＤ２、ＣＤ７、ＬＩＧＨＴ、ＮＫＧ２Ｃ、Ｂ７−Ｈ３、ＣＤ８３のリガンド、及びこれらの組み合わせから成る群から選択される共刺激分子に由来する、請求項７に記載のＣＡＲ。
- 前記共刺激シグナル伝達ドメインが、ＣＤ２８の細胞質ドメイン及び／またはＣＤ１３７の細胞質ドメインを含む、請求項８に記載のＣＡＲ。
- 前記細胞外抗原結合ドメインのＣ末端と前記膜貫通ドメインのＮ末端との間に位置するヒンジドメインをさらに含む、請求項１〜９のいずれか１項に記載のＣＡＲ。
- 前記ヒンジドメインが、ＣＤ８αに由来する、請求項１０に記載のＣＡＲ。
- 前記ポリペプチドのＮ末端に位置するシグナルペプチドをさらに含む、請求項１〜１１のいずれか１項に記載のＣＡＲ。
- 前記シグナルペプチドが、ＣＤ８αに由来する、請求項１２に記載のＣＡＲ。
- 配列番号３００〜３０５から成る群から選択されるアミノ酸配列を含む、キメラ抗原受容体（ＣＡＲ）。
- 前記ＣＡＲが、配列番号３００のアミノ酸配列を含む、請求項１４に記載のＣＡＲ。
- 前記ＣＡＲが、配列番号３０１のアミノ酸配列を含む、請求項１４に記載のＣＡＲ。
- 前記ＣＡＲが、配列番号３０２のアミノ酸配列を含む、請求項１４に記載のＣＡＲ。
- 前記ＣＡＲが、配列番号３０３のアミノ酸配列を含む、請求項１４に記載のＣＡＲ。
- 前記ＣＡＲが、配列番号３０４のアミノ酸配列を含む、請求項１４に記載のＣＡＲ。
- 前記ＣＡＲが、配列番号３０５のアミノ酸配列を含む、請求項１４に記載のＣＡＲ。
- 請求項１〜２０のいずれか１項に記載のＣＡＲをコードする核酸配列を含む、単離された核酸。
- 前記単離された核酸が、配列番号３３８〜３４３から成る群から選択される核酸配列を含む、請求項２１に記載の単離された核酸。
- 請求項２１または２２に記載の単離された核酸を含む、ベクター。
- 請求項１〜２０のいずれか１項に記載のＣＡＲ、請求項２１または２２に記載の単離された核酸、または請求項２３に記載のベクターを含む、操作された免疫エフェクター細胞。
- 前記免疫エフェクター細胞が、Ｔ細胞である、請求項２４に記載の操作された免疫エフェクター細胞。
- 請求項２４または２５に記載の操作された免疫エフェクター細胞、及び薬学的に許容される担体を含む、薬学的組成物。
- 固体におけるがんを治療するための医薬品の製造における、請求項２４または２５に記載の操作された免疫エフェクター細胞の使用であって、前記がんが、ＢＣＭＡを発現する細胞を含むものである、前記使用。
- 前記がんが、多発性骨髄腫である、請求項２７に記載の使用。
- 前記がんが、難治性または再発性の多発性骨髄腫である、請求項２７に記載の使用。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510490002 | 2015-08-11 | ||
| CNPCT/CN2016/094408 | 2016-08-10 | ||
| PCT/CN2016/094408 WO2017025038A1 (en) | 2015-08-11 | 2016-08-10 | Chimeric antigen receptors based on single-domain antibodies and methods of use thereof |
| PCT/CN2017/096938 WO2018028647A1 (en) | 2015-08-11 | 2017-08-10 | Chimeric antigen receptors targeting bcma and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021037374A Division JP2021087455A (ja) | 2015-08-11 | 2021-03-09 | Ｂｃｍａを標的とするキメラ抗原受容体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527557A JP2019527557A (ja) | 2019-10-03 |
| JP2019527557A5 true JP2019527557A5 (ja) | 2020-12-17 |
| JP6851461B2 JP6851461B2 (ja) | 2021-03-31 |
Family
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Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526984A Active JP6859347B2 (ja) | 2015-08-11 | 2016-08-10 | 単一ドメイン抗体に基づくキメラ抗原受容体及びその使用方法 |
| JP2019506627A Active JP6851461B2 (ja) | 2015-08-11 | 2017-08-10 | Ｂｃｍａを標的とするキメラ抗原受容体及びその使用方法 |
| JP2021037374A Pending JP2021087455A (ja) | 2015-08-11 | 2021-03-09 | Ｂｃｍａを標的とするキメラ抗原受容体及びその使用方法 |
| JP2021052453A Active JP7168173B2 (ja) | 2015-08-11 | 2021-03-25 | 単一ドメイン抗体に基づくキメラ抗原受容体及びその使用方法 |
| JP2022167222A Pending JP2022183283A (ja) | 2015-08-11 | 2022-10-18 | 単一ドメイン抗体に基づくキメラ抗原受容体及びその使用方法 |
| JP2022210140A Pending JP2023024810A (ja) | 2015-08-11 | 2022-12-27 | Ｂｃｍａを標的とするキメラ抗原受容体及びその使用方法 |
| JP2024014929A Pending JP2024032975A (ja) | 2015-08-11 | 2024-02-02 | 単一ドメイン抗体に基づくキメラ抗原受容体及びその使用方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526984A Active JP6859347B2 (ja) | 2015-08-11 | 2016-08-10 | 単一ドメイン抗体に基づくキメラ抗原受容体及びその使用方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021037374A Pending JP2021087455A (ja) | 2015-08-11 | 2021-03-09 | Ｂｃｍａを標的とするキメラ抗原受容体及びその使用方法 |
| JP2021052453A Active JP7168173B2 (ja) | 2015-08-11 | 2021-03-25 | 単一ドメイン抗体に基づくキメラ抗原受容体及びその使用方法 |
| JP2022167222A Pending JP2022183283A (ja) | 2015-08-11 | 2022-10-18 | 単一ドメイン抗体に基づくキメラ抗原受容体及びその使用方法 |
| JP2022210140A Pending JP2023024810A (ja) | 2015-08-11 | 2022-12-27 | Ｂｃｍａを標的とするキメラ抗原受容体及びその使用方法 |
| JP2024014929A Pending JP2024032975A (ja) | 2015-08-11 | 2024-02-02 | 単一ドメイン抗体に基づくキメラ抗原受容体及びその使用方法 |
Country Status (32)
| Country | Link |
|---|---|
| US (5) | US10934363B2 (ja) |
| EP (7) | EP4063397B1 (ja) |
| JP (7) | JP6859347B2 (ja) |
| KR (5) | KR20180035918A (ja) |
| CN (9) | CN105384825B (ja) |
| AU (5) | AU2016305075B2 (ja) |
| BR (2) | BR112018002844A2 (ja) |
| CA (3) | CA2994579C (ja) |
| CL (4) | CL2018000378A1 (ja) |
| CO (2) | CO2018001405A2 (ja) |
| CR (4) | CR20180153A (ja) |
| DK (2) | DK4063397T3 (ja) |
| EA (2) | EA201890302A1 (ja) |
| ES (1) | ES2966992T3 (ja) |
| FI (2) | FI4063397T3 (ja) |
| HR (1) | HRP20231542T1 (ja) |
| HU (1) | HUE064534T2 (ja) |
| IL (3) | IL294683A (ja) |
| LT (2) | LT4063397T (ja) |
| MX (3) | MX2018001739A (ja) |
| MY (2) | MY188362A (ja) |
| NZ (1) | NZ750366A (ja) |
| PH (2) | PH12018500295A1 (ja) |
| PL (1) | PL3896091T3 (ja) |
| PT (2) | PT4063397T (ja) |
| RS (2) | RS65866B1 (ja) |
| SA (2) | SA518390904B1 (ja) |
| SG (2) | SG10201913485QA (ja) |
| SI (1) | SI3896091T1 (ja) |
| UA (2) | UA125818C2 (ja) |
| WO (2) | WO2017025038A1 (ja) |
| ZA (2) | ZA201800703B (ja) |
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