CN113330038A - Cd20组合靶向的工程化免疫细胞 - Google Patents
Cd20组合靶向的工程化免疫细胞 Download PDFInfo
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Abstract
本发明提供了CD20组合靶向，特别是同时靶向CD20和CD19的嵌合抗原受体免疫细胞，还添加了细胞自杀元件，以控制CAR‑T细胞的活性和CRS等相关毒性，增强安全性；在scFv间使用了特定的接头增加弹性空间，最大可能保留scFv的亲和力，并减少不同scFv之间的相互干扰。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910059192 | 2019-01-22 | ||
| CN2019100591926 | 2019-01-22 | ||
| PCT/CN2020/073873 WO2020151752A1 (zh) | 2019-01-22 | 2020-01-22 | Cd20组合靶向的工程化免疫细胞 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113330038A true CN113330038A (zh) | 2021-08-31 |
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| CN202080010291.6A Pending CN113330038A (zh) | 2019-01-22 | 2020-01-22 | Cd20组合靶向的工程化免疫细胞 |
Country Status (2)
| Country | Link |
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| CN (1) | CN113330038A (zh) |
| WO (1) | WO2020151752A1 (zh) |
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| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技（香港）有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| WO2022179563A1 (en) * | 2021-02-24 | 2022-09-01 | Hangzhou Qihan Biotechnology Co., Ltd. | Systems and compositions for enhanced immunotherapies and methods thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105384825A (zh) * | 2015-08-11 | 2016-03-09 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| WO2016100232A1 (en) * | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| CN107034235A (zh) * | 2017-05-19 | 2017-08-11 | 尹荣 | 联合靶向pd‑1及egfr的嵌合性抗原t细胞肿瘤免疫方法 |
| CN108350058A (zh) * | 2015-04-08 | 2018-07-31 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法 |
| CN108383914A (zh) * | 2018-02-23 | 2018-08-10 | 北京美康基免生物科技有限公司 | 一种基于cd19的嵌合抗原受体及其应用 |
| CN108384760A (zh) * | 2018-03-16 | 2018-08-10 | 北京多赢时代转化医学研究院 | 携带cd20/cd19双特异性嵌合抗原受体的人t淋巴细胞及制备方法和应用 |
| CN109055380A (zh) * | 2018-09-19 | 2018-12-21 | 深圳市菲鹏生物治疗股份有限公司 | 一种通用型car-t细胞的制备方法 |
-
2020
- 2020-01-22 WO PCT/CN2020/073873 patent/WO2020151752A1/zh active Application Filing
- 2020-01-22 CN CN202080010291.6A patent/CN113330038A/zh active Pending
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| WO2016100232A1 (en) * | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| CN108350058A (zh) * | 2015-04-08 | 2018-07-31 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法 |
| CN105384825A (zh) * | 2015-08-11 | 2016-03-09 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
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| CN109055380A (zh) * | 2018-09-19 | 2018-12-21 | 深圳市菲鹏生物治疗股份有限公司 | 一种通用型car-t细胞的制备方法 |
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