CN115698077A - 结合bcma的单可变结构域及抗原结合分子 - Google Patents
结合bcma的单可变结构域及抗原结合分子 Download PDFInfo
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- CN115698077A CN115698077A CN202180041402.4A CN202180041402A CN115698077A CN 115698077 A CN115698077 A CN 115698077A CN 202180041402 A CN202180041402 A CN 202180041402A CN 115698077 A CN115698077 A CN 115698077A
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C07K2317/72—Increased effector function due to an Fc-modification
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Abstract
提供了一种结合BCMA的免疫球蛋白单可变结构域及抗原结合分子,具体地包括免疫球蛋白单可变结构域及抗原结合分子、编码它们的核酸、包含该核酸的载体、包含该载体的细胞、包含它们的药物组合物,还提供了其治疗用途。
Description
PCT国内申请,说明书已公开。
Claims (15)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010842501 | 2020-08-20 | ||
CN202010842501X | 2020-08-20 | ||
PCT/CN2021/112758 WO2022037528A1 (zh) | 2020-08-20 | 2021-08-16 | 结合bcma的单可变结构域及抗原结合分子 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN115698077A true CN115698077A (zh) | 2023-02-03 |
Family
ID=80323414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202180041402.4A Pending CN115698077A (zh) | 2020-08-20 | 2021-08-16 | 结合bcma的单可变结构域及抗原结合分子 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230265181A1 (zh) |
EP (1) | EP4201960A1 (zh) |
JP (1) | JP2023539453A (zh) |
KR (1) | KR20230045095A (zh) |
CN (1) | CN115698077A (zh) |
WO (1) | WO2022037528A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4324853A1 (en) * | 2021-04-15 | 2024-02-21 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Multi-specific antibody targeting bcma |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6061469B2 (ja) * | 2009-03-10 | 2017-01-25 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | 抗bcma抗体 |
UA112434C2 (uk) * | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | Антигензв'язувальний білок, який специфічно зв'язується з всма |
CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
BR112019026907A2 (pt) * | 2017-06-20 | 2020-06-30 | Teneobio, Inc. | Anticorpos apenas de cadeia pesadaanti-bcma, polinucleotídeo, vetor, célula,composição farmacêutica, seus usos e método paraproduzir os mesmos |
CN111601825B (zh) * | 2018-02-01 | 2022-11-29 | 信达生物制药(苏州)有限公司 | 全人源的抗b细胞成熟抗原(bcma)单链抗体及其应用 |
-
2021
- 2021-08-16 CN CN202180041402.4A patent/CN115698077A/zh active Pending
- 2021-08-16 EP EP21857623.9A patent/EP4201960A1/en active Pending
- 2021-08-16 US US18/020,584 patent/US20230265181A1/en active Pending
- 2021-08-16 JP JP2023510435A patent/JP2023539453A/ja active Pending
- 2021-08-16 WO PCT/CN2021/112758 patent/WO2022037528A1/zh unknown
- 2021-08-16 KR KR1020237008715A patent/KR20230045095A/ko unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023539453A (ja) | 2023-09-14 |
EP4201960A1 (en) | 2023-06-28 |
WO2022037528A1 (zh) | 2022-02-24 |
US20230265181A1 (en) | 2023-08-24 |
KR20230045095A (ko) | 2023-04-04 |
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